CN114209758A - Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof - Google Patents
Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof Download PDFInfo
- Publication number
- CN114209758A CN114209758A CN202210064826.9A CN202210064826A CN114209758A CN 114209758 A CN114209758 A CN 114209758A CN 202210064826 A CN202210064826 A CN 202210064826A CN 114209758 A CN114209758 A CN 114209758A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- blood sugar
- maintaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 75
- 239000008280 blood Substances 0.000 title claims abstract description 63
- 210000004369 blood Anatomy 0.000 title claims abstract description 63
- 239000000203 mixture Substances 0.000 title claims abstract description 58
- 150000001875 compounds Chemical class 0.000 title claims abstract description 50
- 230000036541 health Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 240000000249 Morus alba Species 0.000 claims abstract description 18
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 18
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract description 17
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 17
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 16
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 16
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 16
- 235000006533 astragalus Nutrition 0.000 claims abstract description 16
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 241000045403 Astragalus propinquus Species 0.000 claims abstract description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 29
- 239000008103 glucose Substances 0.000 claims description 29
- 241000209020 Cornus Species 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 241001061264 Astragalus Species 0.000 claims description 7
- 201000001421 hyperglycemia Diseases 0.000 claims description 7
- 210000004233 talus Anatomy 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 235000013402 health food Nutrition 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 3
- 239000000843 powder Substances 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 239000000284 extract Substances 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims description 2
- 229940023488 pill Drugs 0.000 claims 2
- 235000017784 Mespilus germanica Nutrition 0.000 claims 1
- 244000182216 Mimusops elengi Species 0.000 claims 1
- 235000000560 Mimusops elengi Nutrition 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 235000007837 Vangueria infausta Nutrition 0.000 claims 1
- 229940046011 buccal tablet Drugs 0.000 claims 1
- 239000006189 buccal tablet Substances 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 229940068682 chewable tablet Drugs 0.000 claims 1
- 239000007919 dispersible tablet Substances 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000007938 effervescent tablet Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000007902 hard capsule Substances 0.000 claims 1
- 229940040145 liniment Drugs 0.000 claims 1
- 239000000865 liniment Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 238000010992 reflux Methods 0.000 claims 1
- 239000007901 soft capsule Substances 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 17
- 206010012601 diabetes mellitus Diseases 0.000 abstract description 14
- 231100000331 toxic Toxicity 0.000 abstract description 6
- 230000002588 toxic effect Effects 0.000 abstract description 6
- 230000004069 differentiation Effects 0.000 abstract description 3
- 230000008506 pathogenesis Effects 0.000 abstract description 3
- 208000024891 symptom Diseases 0.000 abstract description 3
- 208000011580 syndromic disease Diseases 0.000 abstract description 3
- 241000142975 Cornaceae Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 description 16
- 229940079593 drug Drugs 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 235000005911 diet Nutrition 0.000 description 5
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 4
- HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
- 230000037213 diet Effects 0.000 description 4
- 229930003944 flavone Natural products 0.000 description 4
- 150000002212 flavone derivatives Chemical class 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin hydrochloride Natural products CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 4
- ZUKLFFYDSALIQW-MSUKCBDUSA-N Iridoid glycoside Chemical compound [H][C@]12CC[C@H](C(O)=O)[C@@]1([H])[C@H](OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)OC=C2 ZUKLFFYDSALIQW-MSUKCBDUSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000002218 hypoglycaemic effect Effects 0.000 description 3
- 229930182489 iridoid glycoside Natural products 0.000 description 3
- 230000027939 micturition Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010067484 Adverse reaction Diseases 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000006838 adverse reaction Effects 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 239000003472 antidiabetic agent Substances 0.000 description 2
- 229940107666 astragalus root Drugs 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 229960004329 metformin hydrochloride Drugs 0.000 description 2
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229940123208 Biguanide Drugs 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 150000004283 biguanides Chemical class 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 235000021256 carbohydrate metabolism Nutrition 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 208000035474 group of disease Diseases 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000003094 microcapsule Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- XPFJYKARVSSRHE-UHFFFAOYSA-K trisodium;2-hydroxypropane-1,2,3-tricarboxylate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O XPFJYKARVSSRHE-UHFFFAOYSA-K 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Polymers & Plastics (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine compound composition with a function of maintaining blood sugar health level and a preparation method thereof, wherein the traditional Chinese medicine compound composition comprises 4-16 parts of astragalus membranaceus, 2-8 parts of wolfberry fruits, 1-8 parts of mulberry leaves, 2-10 parts of dogwoods and 1-3 parts of salvia miltiorrhiza. Under the guidance of the traditional Chinese medicine theory, syndrome differentiation treatment is adopted, the pathogenesis and the onset symptoms of diabetes are combined, and a formula is screened, the proportion of the whole composition is scientific and reasonable, and experimental results show that the traditional Chinese medicine compound composition provided by the invention has a good effect of maintaining the health level of blood sugar, can be used for preventing and treating diabetes, is prepared from medicinal and edible raw materials, can be used as a health-care product, and has the advantages of good curative effect, low toxic and side effects and high safety.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine compound composition capable of maintaining blood sugar health level and application thereof.
Background
Diabetes mellitus is characterized by a group of disorders of carbohydrate metabolism combined with disorders of protein and fat metabolism, which are caused by various etiologies. Diabetes is mainly caused by an increase in fasting blood glucose. Treatment of diabetes includes diet control, exercise, and medication. The traditional Chinese and western medicine hypoglycemic drugs in the prior art comprise biguanides and sulfonamides, have certain clinical curative effects, but have adverse reactions or contraindications.
The traditional Chinese medicine has unique curative effect in the aspect of preventing and treating diabetes, and mainly has good clinical safety and small toxic and side effects, so that a traditional Chinese medicine compound composition which has good blood sugar health level maintenance and low toxic and side effects and adverse reactions is preferably selected under the guidance of the traditional Chinese medicine theory.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to overcome the defects of the prior art and provide the traditional Chinese medicine compound composition which adopts medicine-food homology and raw materials which can be used for health care products, has scientific and reasonable proportioning, good curative effect of maintaining the health level of blood sugar, small toxic and side effects and safe clinical medication. The invention also aims to provide the application of the traditional Chinese medicine compound composition in preparing a medicine for preventing and treating diabetes.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine compound composition for maintaining blood sugar health level is prepared from the following raw materials in parts by weight:
4-16 parts of astragalus membranaceus, 2-8 parts of wolfberry fruits, 1-8 parts of mulberry leaves, 2-10 parts of dogwood fruits and 1-3 parts of salvia miltiorrhiza.
As a preferred scheme, the traditional Chinese medicine compound composition capable of maintaining the healthy level of blood sugar is prepared from the following raw materials in parts by weight:
4-12 parts of astragalus membranaceus, 2-6 parts of wolfberry fruits, 2-6 parts of mulberry leaves, 3-7 parts of dogwood fruits and 1-2 parts of salvia miltiorrhiza.
As a more preferable scheme, the traditional Chinese medicine compound composition for maintaining the healthy level of blood sugar is prepared from the following raw materials in parts by weight:
4 parts of astragalus membranaceus, 2 parts of wolfberry fruit, 2 parts of mulberry leaf, 3 parts of dogwood and 1 part of salvia miltiorrhiza.
The traditional Chinese medicine compound composition capable of maintaining the blood sugar health level is prepared into oral liquid, capsules, tablets, granules, dripping pills or micro-capsules by using a pharmaceutically acceptable carrier.
When the traditional Chinese medicine compound composition provided by the invention is prepared into tablets, the traditional Chinese medicine compound composition and a carrier sodium carboxymethylcellulose are added with a lubricant magnesium stearate if necessary, and are uniformly mixed and then tabletted to prepare the tablets.
When the traditional Chinese medicine compound composition provided by the invention is prepared into capsules, the traditional Chinese medicine compound composition and the sodium carboxymethyl cellulose are uniformly mixed, granulated and then encapsulated to prepare the capsules.
When the traditional Chinese medicine composition provided by the invention is prepared into granules, the traditional Chinese medicine composition and diluent carboxymethylcellulose sodium are uniformly mixed, sized, dried and prepared into granules.
The traditional Chinese medicine compound composition provided by the invention has a good effect of maintaining the healthy level of blood sugar, and can be applied to preparation of diabetes drugs or health care products.
Under the guidance of the traditional Chinese medicine theory, the invention treats the disease based on syndrome differentiation, combines the pathogenesis and the onset symptoms of diabetes, screens the formula, and has sweet and warm taste of astragalus root, and the astragalus root can tonify qi and strengthen superficies. The astragalus contains various bioactive components, is rich in antidiabetic components such as polysaccharide, saponin, flavone and the like, and has better effect on diabetic complications. It is a clear and tonic herb with mild property and suitable for long-term use. Wolfberry fruit is sweet in taste and neutral in nature, and can nourish liver and kidney. Wolfberry polysaccharides, flavonoids, alkaloids, unsaturated fatty acids and the like have hypoglycemic activity to a certain degree; is widely applied to Chinese patent medicines, health-care foods and medicated diet for beauty treatment. Mulberry leaf, folium Mori, sweet in taste, bitter in taste and slightly cold in nature, can dispel wind-heat. Modern pharmacological research finds that mulberry leaves contain polysaccharide, alkaloid and the like and have the function of reducing blood sugar. Mulberry leaves, as a traditional health food used as both medicine and food in China, were recorded in Shen nong's herbal Jing. Dogwood is sour and warm in taste and can tonify liver and kidney. Modern pharmacological research shows that the dogwood has the function of reducing blood sugar; salvia miltiorrhiza, being bitter in taste and cold in nature, activates blood and unblocks meridians. Modern pharmacological research proves that the salvia miltiorrhiza has the function of reducing blood sugar; the two herbs are used together to guide qi upward by promoting blood circulation, tonify liver and kidney, and promote blood circulation and qi circulation. The medicines are combined to play the effects of nourishing yin, clearing heat, tonifying qi and activating blood.
The preparation method of the traditional Chinese medicine compound composition provided by the invention comprises the following steps:
adding 5-15 times of 0-70% ethanol into astragalus, wolfberry fruit, mulberry leaf, dogwood and salvia miltiorrhiza according to the weight parts, extracting for 1-3 times, 0.5-2 hours each time, combining the extracting solutions, concentrating under reduced pressure or normal pressure, and drying in vacuum or spray to obtain extract dry powder.
The invention provides application of a traditional Chinese medicine compound composition in preparing medicines for nourishing yin, clearing heat, tonifying liver and kidney, tonifying qi and activating blood.
Has the advantages that: compared with the prior art, the traditional Chinese medicine compound composition provided by the invention has the following advantages:
under the guidance of the traditional Chinese medicine theory, syndrome differentiation treatment is adopted, the pathogenesis and the onset symptoms of diabetes are combined, and a formula is screened, so that the proportion of the whole composition is scientific and reasonable, and experimental results show that the traditional Chinese medicine compound composition provided by the invention has the good effect of maintaining the health level of blood sugar, can be used for preventing and treating diabetes, is prepared from medicinal and edible raw materials which can be used for health care products, and has the advantages of good curative effect, low toxic and side effects and safer clinical medication.
The traditional Chinese medicine compound composition provided by the invention can be prepared into various dosage forms of medicines with pharmaceutically acceptable carriers, and is convenient for clinical medication.
Detailed Description
The invention will be better understood from the following examples. However, those skilled in the art will readily appreciate that the specific material ratios, process conditions and results thereof described in the examples are illustrative only and should not be taken as limiting the invention as detailed in the claims.
Example 1
1. A traditional Chinese medicine compound composition for maintaining blood sugar health level is prepared from the following raw materials in parts by weight:
16 parts of astragalus, 8 parts of wolfberry, 6 parts of mulberry leaf, 10 parts of dogwood and 3 parts of salvia miltiorrhiza.
2. The preparation process comprises the following steps: taking 16 parts of astragalus, 8 parts of wolfberry, 6 parts of mulberry leaf, 10 parts of dogwood and 3 parts of salvia miltiorrhiza, adding ethanol with the volume concentration of 70 percent, the volume of which is 12 times of the weight of the medicinal materials, extracting for 2 times and 2 hours each time, combining the extracting solutions, concentrating under reduced pressure at 60 ℃ to obtain concentrated solution, and drying in vacuum at 70 ℃ to obtain the traditional Chinese medicine composition. Wherein, the sample components mainly comprise 20 percent of total polysaccharide, 30 percent of total flavone and 10 percent of iridoid glycoside.
Example 2
1. A traditional Chinese medicine compound composition for maintaining blood sugar health level is prepared from the following raw materials in parts by weight:
8 parts of astragalus membranaceus, 4 parts of wolfberry fruit, 3 parts of mulberry leaf, 5 parts of dogwood and 2 parts of salvia miltiorrhiza.
2. The preparation process comprises the following steps:
extracting radix astragali 8 parts, fructus Lycii 4 parts, folium Mori 3 parts, Corni fructus 5 parts, and Saviae Miltiorrhizae radix 2 parts with 10 times of 30% ethanol for 3 times (1 hr each time), mixing extractive solutions, concentrating under reduced pressure at 80 deg.C to obtain concentrated solution, and vacuum drying at 80 deg.C. The sample mainly contains 25% of total polysaccharide, 24% of total flavone and 9% of iridoid glycoside.
Example 3
1. A traditional Chinese medicine compound composition for maintaining blood sugar health level is prepared from the following raw materials in parts by weight:
4 parts of astragalus membranaceus, 2 parts of wolfberry fruit, 1.5 parts of mulberry leaf, 2.5 parts of dogwood and 1 part of salvia miltiorrhiza.
2. The preparation method comprises the following steps:
4 parts of astragalus, 2 parts of wolfberry fruit, 1.5 parts of mulberry leaf, 2.5 parts of dogwood and 1 part of salvia miltiorrhiza, 8 times of water is added for 3 times, 1 hour is spent each time, the extracting solution is combined, the extracting solution is decompressed and concentrated at 80 ℃, the concentrated solution is obtained, and vacuum drying is carried out at 80 ℃ to obtain the traditional Chinese medicine. The sample mainly contains 32% of total polysaccharide, 18% of total flavone and 8% of iridoid glycoside.
Example 4 hypoglycemic Activity test
1. Pharmacological experiments:
1.1 materials and methods
1.1.1 drugs and materials
The compound traditional Chinese medicine composition prepared in the embodiment 1.
Metformin hydrochloride tablets, gehuazhi, lot number: 1511011. the designed dose of mice in the experiment was 0.25 g/kg.
Alloxan, bi yun sky, lot number: A7413-10G.
Citric acid sodium citrate buffer solution, Shanghai leaf company, lot number Y-231566
1.1.2 instruments
TD6001 electronic balance, tianma instruments factory, tianjin;
electronic analytical balance (FA1104N), shanghai precision instruments ltd;
blood glucose test paper (FAD glucose dehydrogenase method), bayer pharmaceutical health limited;
bai an kang contourr TS glucometer, bayer medicine health ltd.
1.1.3 animals: clean grade ICR male mice, provided by vintongli limited, weighing 22-24g, production license number: SCXK (Zhe) 2019-. Is used for a high-sugar model blood sugar reduction experiment and a normal mouse blood sugar reduction experiment.
1.1.4 raising conditions: the experimental animals are all fed with complete pellet feed, and provided by the synergy center of south Beijing Jiangning district. Temperature: 19-24 ℃; humidity: 48-67%.
1.1.5 Experimental methods and results:
1.1.5.1 test for lowering blood sugar of normal animal
(1) Grouping, molding and administration method
A clean-grade ICR male mouse is taken, adapted to be fed for 3 days, fasted for 7 hours, and the fasting blood glucose value before administration is measured. Then randomly divided into two groups of 15 each, which were (1) blank control groups: 20ml/kg of physiological saline; (2) the high-dose group of the traditional Chinese medicine compound composition of embodiment 1-3 comprises: 1.34 g/kg. Gavage is carried out for 1 time every day, fasting is carried out for 7h after continuous administration for 30 days, and fasting blood glucose value after administration is measured.
(2) Observation index
General conditions
Mice were observed daily for diet, water intake, and urination.
② blood sugar level
Fasting is carried out for 8h after continuous administration for 30 days, and fasting blood glucose value is measured.
(3) Results
General observation
The blank control group and the high-dose group of the Chinese herbal compound composition mice have normal diet and drinking water conditions and normal urination conditions.
② influence on fasting blood glucose of normal mouse
The experimental results show that: the high-dose group of the traditional Chinese medicine compound composition in the examples 1-3 has no obvious influence on the fasting blood glucose of normal mice, and has no significant difference (p is more than 0.05) compared with a blank control group, which is shown in table 1.
TABLE 1 influence of the Chinese medicinal composition on fasting plasma glucose (mmol/L) of normal mice: (
n＝15)
1.1.5.2 hyperglycemia model hypoglycemic experiments
(1) Grouping, molding and administration method
Taking SPF-level ICR male mice, after fasting for 24 hours, injecting alloxan 120mg/kg in the abdominal cavity, after 7 days, fasting for 7 hours, and measuring blood sugar, wherein the blood sugar value is 10-25 mmol/L, which is the animal successfully molded by a hyperglycemia model.
Selecting hyperglycemia model animals, and dividing the hyperglycemia model animals into 11 groups according to blood sugar values; (1) model group: 20ml/kg of physiological saline; (2) metformin group: 0.25g/kg of metformin hydrochloride solution; (3) the low-dose group of the traditional Chinese medicine compound composition prepared in the embodiment 1-3 comprises: 0.34 g/kg; (4) the traditional Chinese medicine compound composition comprises the following dosage groups: 0.67 g/kg; (5) the high dose group of the traditional Chinese medicine compound composition is 1.34 g/kg; after continuous administration for 30 days, fasting is carried out for 8 hours, and the fasting blood sugar value after administration is measured; alternatively, 10 normal mice were used as a blank group, and after 30 days, fasting was performed for 8 hours, and fasting blood glucose level after administration was measured.
(2) Observation index
General conditions
Mice were observed daily for diet, water intake, and urination.
② blood sugar level
Fasting was carried out for 7 hours after continuous administration for 30 days, and fasting blood glucose level was measured.
③ sugar tolerance
After continuous administration for 30 days, fasting for 7h, and measuring the fasting blood sugar value after administration, namely the blood sugar value before administration of glucose (0 h); after 15min, 2.0g/kg of glucose was orally administered to each group, and blood glucose levels of 0.5 and 2 hours after glucose administration were measured in each group of mice. The change in area under the blood glucose curve (AUC) was calculated.
The area under the blood glucose curve is 0.25 × (0h blood glucose level +4 × 0.5h blood glucose level +3 × 2h blood glucose level).
(3) Results
General observation
(1) Model group: the food intake and the water intake are both increased, and more urine is excreted; (2) the metformin group and the traditional Chinese medicine compound composition in the embodiment 1-3 have the advantages that the dietary water intake and the urine discharge are reduced to some extent in the low, medium and high dosage groups compared with the model group.
② the influence on fasting blood glucose of diabetic mice
The experimental results show that: after the traditional Chinese medicine compound composition solution with different doses is administrated to the mice by gavage for 30 days, the fasting blood glucose values of the mice in the traditional Chinese medicine compound composition and the mice in the high dose group are obviously reduced (p is less than 0.01) compared with the blood glucose values in the model group, and the blood glucose values are shown in a table 2.
TABLE 2 influence of the Chinese medicinal composition on fasting blood glucose (mmol/L) of hyperglycemia model animals
Influence on glucose tolerance of diabetic mice
The experimental results show that: after continuous administration for 30 days, the three high and medium dose groups of the traditional Chinese medicine compound composition can reduce the glucose tolerance of mice, wherein the difference between the high and medium dose groups is obvious (p is less than 0.01) compared with a model group, and the table 3 shows.
TABLE 3 influence of the Compound Chinese medicinal composition on glucose tolerance of hyperglycemia model mice
The experimental results show that the medium and high doses of the traditional Chinese medicine compound composition have obvious difference in blood sugar and sugar tolerance levels, and the traditional Chinese medicine compound composition provided by the invention has good efficacy of maintaining blood sugar health level and has good prevention and treatment effects on diabetes. The raw materials of the traditional Chinese medicine compound composition provided by the invention are medicinal and edible materials, have low toxic and side effects, are safer in clinical medication, and can be developed into a new medicine for maintaining the health level of blood sugar.
The above embodiments are merely illustrative of the technical concept and features of the present invention, and the present invention is not limited thereto, and equivalent changes and modifications made according to the spirit of the present invention should be covered thereby.
Claims (10)
1. A traditional Chinese medicine compound composition capable of maintaining blood sugar health level is characterized by being prepared from the following raw materials in parts by weight: 4-16 parts of astragalus membranaceus, 2-8 parts of wolfberry fruits, 1-8 parts of mulberry leaves, 2-10 parts of dogwood fruits and 1-3 parts of salvia miltiorrhiza.
2. The compound traditional Chinese medicine composition for maintaining the healthy level of blood sugar as claimed in claim 1, is prepared from the following raw materials in parts by weight:
16 parts of astragalus, 8 parts of wolfberry, 6 parts of mulberry leaf, 10 parts of dogwood and 3 parts of salvia miltiorrhiza.
3. The compound traditional Chinese medicine composition for maintaining the healthy level of blood sugar as claimed in claim 1, is prepared from the following raw materials in parts by weight:
8 parts of astragalus membranaceus, 4 parts of wolfberry fruit, 3 parts of mulberry leaf, 5 parts of dogwood and 2 parts of salvia miltiorrhiza.
4. The compound traditional Chinese medicine composition for maintaining the healthy level of blood sugar as claimed in claim 1, is prepared from the following raw materials in parts by weight:
4 parts of astragalus membranaceus, 2 parts of wolfberry fruit, 1.5 parts of mulberry leaf, 2.5 parts of dogwood and 1 part of salvia miltiorrhiza.
5. The method for preparing a health food of a compound composition for maintaining healthy level of blood glucose according to claim 1, comprising the steps of:
(1) solvent extraction: refluxing or ultrasonic extracting with 5-15 times of water and 70% ethanol for 1-3 times, and each time for 0.5-2 h.
(2) Concentration: the concentration method comprises the steps of reduced pressure concentration at 50-80 ℃ and normal pressure concentration at 100 ℃.
(3) And (3) drying: drying modes include vacuum and spray drying.
6. The method for preparing a health food of a compound composition for maintaining healthy level of blood glucose according to claim 5, comprising the steps of:
taking astragalus, medlar, mulberry leaf, dogwood and salvia miltiorrhiza according to the weight parts, adding ethanol with the volume of 5 to 15 times of the weight of the traditional Chinese medicinal materials and the concentration of 0 to 70 percent, extracting for 1 to 3 times, 0.5 to 2 hours each time, combining the extracting solutions, concentrating under reduced pressure or normal pressure, and drying in vacuum or spray to obtain the dry extract powder.
7. The health food or Chinese medicinal preparation for maintaining blood sugar health level according to claim 5 or 6, wherein the preparation is oral preparation or external preparation comprising tablet, dispersible tablet, effervescent tablet, orally disintegrating tablet, buccal tablet, chewable tablet, hard capsule, soft capsule, granule, pill, powder, drop pill, oral liquid, spray, gel, ointment, cataplasma, patch, liniment, lotion, and plastics.
8. The use of the compound traditional Chinese medicine composition of claim 1 in the preparation of a medicament or health product for treating hyperglycemia.
9. The use of the compound traditional Chinese medicine composition of claim 1 in the preparation of a medicament or health product for treating type 1 diabetes.
10. The use of the compound traditional Chinese medicine composition of claim 1 in the preparation of a medicament or health product for treating type 2 diabetes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210064826.9A CN114209758A (en) | 2022-01-20 | 2022-01-20 | Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210064826.9A CN114209758A (en) | 2022-01-20 | 2022-01-20 | Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114209758A true CN114209758A (en) | 2022-03-22 |
Family
ID=80708894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210064826.9A Pending CN114209758A (en) | 2022-01-20 | 2022-01-20 | Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114209758A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533811A (en) * | 2019-06-05 | 2022-05-27 | 四川万格农业科技有限公司 | Traditional Chinese medicine composition with blood sugar reducing effect and preparation method and application thereof |
| CN114680335A (en) * | 2022-04-27 | 2022-07-01 | 上海诚明圣源生物科技有限公司 | Health-care food composition with auxiliary hypoglycemic function and preparation method and application thereof |
-
2022
- 2022-01-20 CN CN202210064826.9A patent/CN114209758A/en active Pending
Non-Patent Citations (4)
| Title |
|---|
| 冯一帆等: "杞丹方对糖尿病小鼠降血糖作用及机制研究", 《南京中医药大学学报》 * |
| 崔玲: "降糖Ⅰ号胶囊治疗气阴两虚型老年2型糖尿病98例报告", 《中国临床康复》 * |
| 徐明等: "《应用功能性食物防治糖尿病》", 31 May 2010, 人民军医出版社 * |
| 擂茶侠: ""黄芪丹参"和"枸杞"泡水喝会有什么影响呢？", 《HTTPS://WWW.SOHU.COM/A/308206881_471663》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114533811A (en) * | 2019-06-05 | 2022-05-27 | 四川万格农业科技有限公司 | Traditional Chinese medicine composition with blood sugar reducing effect and preparation method and application thereof |
| CN114680335A (en) * | 2022-04-27 | 2022-07-01 | 上海诚明圣源生物科技有限公司 | Health-care food composition with auxiliary hypoglycemic function and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103285231B (en) | Medicine composition for diabetes adjunctive therapy and preparation method thereof | |
| CN106692297B (en) | Composition for assisting in reducing blood sugar and preparation method and application thereof | |
| CN111840363B (en) | Natto-assisted hypoglycemic health-care composition and preparation method and application thereof | |
| CN101856450B (en) | Chinese medicinal composition for treating diabetic nephropathy | |
| CN1947757B (en) | Leave of glutinous rehmannia extractive, its preparation method and use, medicines prepared with said extractives | |
| CN106819833A (en) | A kind of noodles of hypoglycemic Adjust-blood lipid and preparation method thereof | |
| CN114209758A (en) | Traditional Chinese medicine compound composition capable of maintaining blood sugar health level and preparation method and application thereof | |
| CN103520376A (en) | Chinese medicine health-maintenance preparation with auxiliary hypoglycemic activity | |
| CN113730464A (en) | New application of rhizoma coptidis pill, extract and pharmaceutical composition thereof and rhizoma coptidis pill product | |
| CN100534461C (en) | Pharmaceutical composition for treating diabetes and impaired glucose tolerance and preparation method thereof | |
| CN101491605A (en) | Combination with blood sugar reducing function and preparation method thereof | |
| CN101336965A (en) | Chinese prepared medicine for improving sugar tolerance and reducing blood sugar and preparation method thereof | |
| CN104940428B (en) | Hypoglycemic composition containing wolfberry fruits and application thereof | |
| CN108686094B (en) | Traditional Chinese medicine for reducing blood sugar and preparation method thereof | |
| CN113476561A (en) | Traditional Chinese medicine formula for treating diabetes | |
| CN102485263B (en) | Medicinal composition for treating chronic cough of children and its preparation method | |
| CN107349362B (en) | A pharmaceutical composition for the treatment of diabetic retinopathy | |
| CN105031033B (en) | Blood sugar reducing pharmaceutical composition containing boxthorn leaves and preparation method and application thereof | |
| CN101491581A (en) | Combination with blood sugar reducing function and preparation method thereof | |
| CN116920061B (en) | Traditional Chinese medicine composition for treating hyperglycemia and preparation method thereof | |
| CN102225082A (en) | Medicament for preventing and treating diabetes and complications thereof and preparation method thereof | |
| CN114601891B (en) | Composition with anti-ulcerative colitis effect and preparation method thereof | |
| CN111803559B (en) | Eggplant peel composition with blood sugar reducing effect and preparation method and application thereof | |
| CN104940427B (en) | Blood sugar reducing composition containing wolfberry fruits and application and preparation method thereof | |
| CN101491584A (en) | Combination with blood sugar reducing function and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220322 |
|
| RJ01 | Rejection of invention patent application after publication |