CN109497562A - A kind of selenium-rich vitamin E soft capsule and preparation method thereof - Google Patents
A kind of selenium-rich vitamin E soft capsule and preparation method thereof Download PDFInfo
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- CN109497562A CN109497562A CN201811603739.6A CN201811603739A CN109497562A CN 109497562 A CN109497562 A CN 109497562A CN 201811603739 A CN201811603739 A CN 201811603739A CN 109497562 A CN109497562 A CN 109497562A
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- rich vitamin
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title claims abstract description 121
- 239000011669 selenium Substances 0.000 title claims abstract description 78
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 69
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 69
- 235000019165 vitamin E Nutrition 0.000 title claims abstract description 58
- 239000011709 vitamin E Substances 0.000 title claims abstract description 58
- 229930003427 Vitamin E Natural products 0.000 title claims abstract description 57
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 229940046009 vitamin E Drugs 0.000 title claims abstract description 57
- 239000007901 soft capsule Substances 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000002775 capsule Substances 0.000 claims abstract description 60
- 239000002994 raw material Substances 0.000 claims abstract description 18
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims abstract description 13
- 239000004014 plasticizer Substances 0.000 claims abstract description 13
- 239000003605 opacifier Substances 0.000 claims abstract description 12
- 239000000725 suspension Substances 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 108010010803 Gelatin Proteins 0.000 claims abstract description 8
- 229920000159 gelatin Polymers 0.000 claims abstract description 8
- 239000008273 gelatin Substances 0.000 claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 claims abstract description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 8
- 235000004835 α-tocopherol Nutrition 0.000 claims abstract description 7
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 7
- 229960000984 tocofersolan Drugs 0.000 claims abstract description 6
- 239000002076 α-tocopherol Substances 0.000 claims abstract description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 239000004408 titanium dioxide Substances 0.000 claims description 11
- 239000003921 oil Substances 0.000 claims description 8
- 235000019198 oils Nutrition 0.000 claims description 8
- 239000003549 soybean oil Substances 0.000 claims description 7
- 235000012424 soybean oil Nutrition 0.000 claims description 7
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- 235000005979 Citrus limon Nutrition 0.000 claims description 6
- 244000131522 Citrus pyriformis Species 0.000 claims description 6
- 235000019486 Sunflower oil Nutrition 0.000 claims description 6
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 6
- 239000004006 olive oil Substances 0.000 claims description 6
- 235000008390 olive oil Nutrition 0.000 claims description 6
- 239000002600 sunflower oil Substances 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000000465 moulding Methods 0.000 claims description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims description 5
- 230000003068 static effect Effects 0.000 claims description 5
- 235000013871 bee wax Nutrition 0.000 claims description 4
- 239000012166 beeswax Substances 0.000 claims description 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 3
- 239000001856 Ethyl cellulose Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- UGMCXQCYOVCMTB-UHFFFAOYSA-K dihydroxy(stearato)aluminium Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[Al](O)O UGMCXQCYOVCMTB-UHFFFAOYSA-K 0.000 claims description 3
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 3
- 229920001249 ethyl cellulose Polymers 0.000 claims description 3
- 239000011787 zinc oxide Substances 0.000 claims description 3
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 2
- 239000010936 titanium Substances 0.000 claims description 2
- 229910052719 titanium Inorganic materials 0.000 claims description 2
- 230000003647 oxidation Effects 0.000 abstract description 7
- 238000007254 oxidation reaction Methods 0.000 abstract description 7
- 230000036039 immunity Effects 0.000 abstract description 6
- 230000009469 supplementation Effects 0.000 abstract description 4
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 24
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 24
- 239000008108 microcrystalline cellulose Substances 0.000 description 24
- 229940016286 microcrystalline cellulose Drugs 0.000 description 24
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 description 16
- 239000011246 composite particle Substances 0.000 description 13
- 230000000694 effects Effects 0.000 description 11
- 150000002978 peroxides Chemical class 0.000 description 9
- 230000006378 damage Effects 0.000 description 7
- 150000003254 radicals Chemical class 0.000 description 7
- 210000000170 cell membrane Anatomy 0.000 description 5
- 239000002245 particle Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000001914 filtration Methods 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 235000016709 nutrition Nutrition 0.000 description 3
- 230000035764 nutrition Effects 0.000 description 3
- 239000000047 product Substances 0.000 description 3
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- 102000004190 Enzymes Human genes 0.000 description 2
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- 208000027418 Wounds and injury Diseases 0.000 description 2
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- 239000003795 chemical substances by application Substances 0.000 description 2
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- 229940088598 enzyme Drugs 0.000 description 2
- 235000013402 health food Nutrition 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- PTHCMJGKKRQCBF-UHFFFAOYSA-N Cellulose, microcrystalline Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC)C(CO)O1 PTHCMJGKKRQCBF-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000006587 Glutathione peroxidase Human genes 0.000 description 1
- 108700016172 Glutathione peroxidases Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 239000000232 Lipid Bilayer Substances 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 102000019280 Pancreatic lipases Human genes 0.000 description 1
- 108050006759 Pancreatic lipases Proteins 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 206010039921 Selenium deficiency Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000002115 aflatoxin B1 Substances 0.000 description 1
- OQIQSTLJSLGHID-WNWIJWBNSA-N aflatoxin B1 Chemical compound C=1([C@@H]2C=CO[C@@H]2OC=1C=C(C1=2)OC)C=2OC(=O)C2=C1CCC2=O OQIQSTLJSLGHID-WNWIJWBNSA-N 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 150000002432 hydroperoxides Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- -1 lipid free radical Chemical class 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 229940116369 pancreatic lipase Drugs 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000003617 peroxidasic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 150000008442 polyphenolic compounds Chemical class 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- SCWQRZHMKQEINE-UHFFFAOYSA-N selenous acid;sodium Chemical compound [Na].O[Se](O)=O SCWQRZHMKQEINE-UHFFFAOYSA-N 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 150000003772 α-tocopherols Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to soft capsule technical fields, more particularly to a kind of selenium-rich vitamin E soft capsule and preparation method thereof, soft capsule includes content and capsule skin, and the content includes the raw material of following parts by weight: 10-20 parts of Se-enriched yeast, 20-40 parts of d- alpha-tocopherol, oily 400-500 parts and 10-20 parts of suspension aid of phase；The capsule skin includes the raw material of following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier and 300-350 parts of water.Selenium-rich vitamin E soft capsule of the invention is suitble to require supplementation with the adult of selenium and vitamin E, can be improved the immunity of the human body with oxidation and removing free radicals, safely and effectively, can be taken for a long time, and the shelf-life, at 24 months or more, product stability is strong.
Description
Technical field
The present invention relates to soft capsule technical fields, and in particular to a kind of selenium-rich vitamin E soft capsule and preparation method thereof.
Background technique
Selenium is that growth in humans develops a kind of essential microelement, and selenium is the ingredient of GSH-Px, and GSH-Px has anti-
Oxidative function, the formation and its attack to unsaturated fatty acid that can prevent harmful free radicals, catalysis peroxide are reduced to second
Alcohol protects large biological molecule and biofilm structure to damage from peroxide to remove harmful hydroperoxides in tissue,
Its role is to convert peroxide to be relevant alcohols (or water) and can remove free radical.The study found that with selenium concentration
The activity of variation GSH-Px also changes, and Enzyme activities always lag the variation of selenium concentration.When selenium deficiency, the work of the enzyme
Property reduce, cannot sufficiently catalytic peroxide cause the accumulation of lipid free radical and peroxide so as to cell membrane and cell
Wall generates peroxide injury.
Vitamin E can inhibit lipid with extending part in originating for lipid oxidation in the integrated distribution of membrane lipid bilayer
Oxidation, therefore can be using vitamin E as the scavenger of free radical.Vitamin E is a kind of nonspecific biological anti-oxidant,
Vitamin E, which is incorporated on cell membrane, makes cell from free radical attack and peroxide injury, and selenium passes through the blockings such as GSH-Px certainly
Damage by base to body, and selenium is the essential component of GSH-Px.Selenium protect cell membrane from oxidation in terms of, to dimension give birth to
Plain E plays a part of compensation and coordination.Selenium can also defend the E that is deficient in vitamin by the different function of glutathione peroxidase
Damage to liver.So selenium and vitamin E play synergistic effect in anti-oxidant.
Vitamin E is the first line of defence for preventing peroxide from generating, and the GSH-Px containing selenium plays the work in second defence line
With.Vitamin E and selenium have complementation in terms of preventing Peroxidative damage.The plasma structure of protection cell membrane is complete jointly
Property.The synergistic effect of selenium and vitamin E is mainly manifested in: (1) vitamin E amount needed for selenium can reduce protection cell membrane；(2) selenium
It is microelement necessary to maintaining pancreas normal physiological function, trypsase, the pancreatic lipase of pancreatic secretion facilitate fat
Digestion and absorption, to improve the absorption rate of vitamin E；(3) Plasma Selenium is positively correlated with plasma vitamin E content, mends
Selenium helps to maintain the vitamin E of body tissue higher level；(4) vitamin E can maintain internal selenium activity, reduce body selenium damage
It loses；(5) vitamin E is fatty membrane component, the generation of lipid oxidation and activating oxide (ROS) can be prevented, therefore, in vitamin
GSH-Px amount needed for the lower removing ROS of E effect is reduced, and is also reduced therewith to selenium requirement.
The prior art lacks the health food that can supplement human body selenium element and vitamin E simultaneously.
Summary of the invention
In order to overcome shortcoming and defect existing in the prior art, the purpose of the present invention is to provide a kind of selenium-rich vitamins
E soft capsule and preparation method thereof.
The purpose of the invention is achieved by the following technical solution:
A kind of selenium-rich vitamin E soft capsule, including content and capsule skin, the content include the original of following parts by weight
Material: 10-20 parts of Se-enriched yeast, 20-40 parts of d- alpha-tocopherol, oily 400-500 parts and 10-20 parts of suspension aid of phase；The capsule skin
Raw material including following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier and water 300-350
Part.
Se-enriched yeast is worth by the way that selenium element is added during culture yeasts, and when yeast growth is absorbed and utilized
Selenium makes selenium be converted into Biological Selenium in conjunction with the intracorporal protein of yeast and polysaccharide organic, to eliminate chemical selenium (such as selenous acid
Sodium) toxicity and stomach of human body are stimulated, enable that selenium is more efficient, be more safely absorbed by the body utilization.Se-enriched yeast
It is also selenium-replenishing preparation most efficient, most safe, nutrition is most balanced domestic so far.Selenium is microelement necessary to human body,
There is critically important physiological function, it is closely related with the health of the mankind.There is research to confirm, selenium has following effect: 1. antioxidation；
2. improving immunity；3. anti-aging effects；4. antitumor action；5. detoxication；6. nourishing and protecting liver acts on；7. protection is cardiovascular
And Myocardial Effects；8. protecting organs of vision effect.Se-enriched yeast is used cooperatively with vitamin E, and radical scavenging activity can be enhanced
Power improves the immunity of the human body, and lower to the irritation of stomach.
Wherein, the oil is mutually at least one of soybean oil, peanut oil, sunflower oil and olive oil.Oily phase is as molten
The stability of content can be improved in agent, it is preferable that the oil is mutually by soybean oil, sunflower oil and olive oil by weight 1-2:
The ratio of 1-2:1 forms, and soybean oil microelement rich in, cost is relatively low, and inoxidizability is strong；Sunflower oil tocopherol contains
Amount is abundant, and 95% the above are biologically active alpha-tocopherols；Olive oil contains a variety of active ingredients, as olive polyphenol,
Squalene, chlorogenic acid, vitamin E, carrotene etc. can enrich the nutrition of capsule.The present invention compounds the oil selected mutually chemistry
Property is stablized, full of nutrition, and shelf-life and the health properties of capsule can be improved.
Wherein, the suspension aid is at least one of beeswax, aluminum monostearate and ethyl cellulose.Preferably, institute
Stating suspension aid is beeswax, improves product stability.
Wherein, the plasticizer is at least one of glycerol and polyethylene glycol.Plasticizer can increase the toughness of soft capsule
And machinability, it is preferable that the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 1-3:1, easy to form,
Soft capsule batch quality is stablized, and capsule skin is fine and close, and surface is smooth, and color is thick and solid, the influence of light aging is effectively reduced, greatly
It extends the shelf life.
Wherein, the opacifier is at least one of titanium dioxide, calcium carbonate and zinc oxide.Preferably, the shading
Agent is micron-sized titanium dioxide, i.e., conventional titanium dioxide, whiteness is high, and light-proofness is strong, and with certain shielding ultraviolet rays
Effect.
When opacifier reaches Nano grade, such as nano-titanium dioxide, light absorpting ability enhancing, the shielding action of ultraviolet light
Also it can enhance, and have from antibacterial functions, the example that nano-titanium dioxide is added in capsule at present is more and more.But
Nano-titanium dioxide can not be decomposed by human body, and the nano particle entered in blood is virose to cell tool, but
The dosage of nano material is very little in capsule at present, can almost ignore its influence to human body, not yet cause people's
Pay attention to.But as health food, it is more much higher than drug to take frequency, if take frequency it is excessively high if, inevitably to sensitive body
The human body of matter will cause side reaction.
For this purpose, capsule skin further includes the composite particles of 4-10 parts by weight in the present invention, the composite particles are by microcrystalline cellulose
With nano-titanium dioxide by weight 2-4:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nanometer
Titanium dioxide carries out ultrasonic disperse, filtration drying by weight the ratio of 2-4:1 in water, can be prepared by.
Nano-titanium dioxide, which is added, in the present invention can preferably improve the stability of capsule skin, and in order to solve nano-silica
The metabolic problems for changing titanium, in advance disperse nano-titanium dioxide on the surface of microcrystalline cellulose, microcrystalline cellulose water absorption and swelling is received
Human body can be easily discharged in rice titanium dioxide therewith；And microcrystalline cellulose can also be improved the disintegrating property of capsule, and human body is internal
Tolerant absorption efficiency is higher；Furthermore microcrystalline cellulose also has certain light-proofness, and synergic nano titanium dioxide improves ultraviolet
Shielding action.
Preferably, the partial size of the nano-titanium dioxide is 80-100nm, and the particle diameter distribution D50 of the microcrystalline cellulose is
40-60 μm, nano-titanium dioxide can preferably be scattered in the surface of microcrystalline cellulose.
Wherein, the capsule skin further includes that 0.05-0.1 parts by weight of lemon Huang and the temptation of 0.009-0.01 parts by weight are red.Pass through
Specific pigment is added, makes capsule skin in orange-yellow, matches with lurid content, uniform color is consistent, and enhances shading
Property, stability further gets a promotion.
The preparation method of selenium-rich vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) content and capsule liquid the preparation of selenium-rich vitamin E soft capsule: are pressed into flexible glue in soft capsule molding machine
Capsule to get arrive the selenium-rich vitamin E soft capsule.
Wherein, the temperature of mixed sols is 70-80 DEG C in the step (2), time 50-70min.
Wherein, the viscosity of the capsule liquid is 18000-30000mpas.
The specification of selenium-rich vitamin E soft capsule of the invention is 0.5g/, and every contains selenium >=10 μ g, containing vitamin E >=
20mg is suitble to require supplementation with the adult of selenium and vitamin E, and by once a day, two frequencies are oral every time, can be with anti-oxidant clear
It except free radical, improves the immunity of the human body, safely and effectively, can take for a long time, and the shelf-life, at 24 months or more, product is stablized
Property is strong.
The beneficial effects of the present invention are: selenium-rich vitamin E soft capsule of the invention is suitble to require supplementation with selenium and vitamin E
Adult, can be improved the immunity of the human body with oxidation and removing free radicals, safely and effectively, can be taken for a long time, and the shelf-life exists
24 months or more, product stability was strong.
Specific embodiment
For the ease of the understanding of those skilled in the art, below with reference to embodiment, the present invention is further illustrated, real
The content that the mode of applying refers to not is limitation of the invention.
Embodiment 1
A kind of selenium-rich vitamin E soft capsule, including content and capsule skin, the content include the original of following parts by weight
Material: 15 parts of Se-enriched yeast, 30 parts of d- alpha-tocopherol, oily 440 parts and 15 parts of suspension aid of phase；The capsule skin includes following parts by weight
Several raw material: 300 parts of gelatin, 120 parts of plasticizer, 2.4 parts of opacifier and 330 parts of water.
Wherein, the oil is mutually soybean oil.
Wherein, the suspension aid is beeswax.
Wherein, the plasticizer is glycerol.
Wherein, the opacifier is micron-sized titanium dioxide.
Wherein, the capsule skin further includes that 0.075 parts by weight of lemon Huang and the temptation of 0.0095 parts by weight are red.
The preparation method of selenium-rich vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) content and capsule liquid the preparation of selenium-rich vitamin E soft capsule: are pressed into flexible glue in soft capsule molding machine
Capsule to get arrive the selenium-rich vitamin E soft capsule.
Wherein, the temperature of mixed sols is 75 DEG C in the step (2), time 60min.
Wherein, the viscosity of the capsule liquid is 24000mpas.
Embodiment 2
A kind of selenium-rich vitamin E soft capsule, including content and capsule skin, the content include the original of following parts by weight
Material: 10 parts of Se-enriched yeast, 20 parts of d- alpha-tocopherol, oily 400 parts and 10 parts of suspension aid of phase；The capsule skin includes following parts by weight
Several raw material: 250 parts of gelatin, 100 parts of plasticizer, 2 parts of opacifier and 300 parts of water.
Wherein, ratio of the oil mutually by soybean oil, sunflower oil and olive oil by weight 1:1:1 forms.
Wherein, the suspension aid is aluminum monostearate.
Wherein, the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 1:1.
Wherein, the opacifier is micron-sized calcium carbonate.
Wherein, the capsule skin further includes that 0.05 parts by weight of lemon Huang and the temptation of 0.009 parts by weight are red.
The preparation method of selenium-rich vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) content and capsule liquid the preparation of selenium-rich vitamin E soft capsule: are pressed into flexible glue in soft capsule molding machine
Capsule to get arrive the selenium-rich vitamin E soft capsule.
Wherein, the temperature of mixed sols is 70 DEG C in the step (2), time 50min.
Wherein, the viscosity of the capsule liquid is 18000mpas.
Embodiment 3
A kind of selenium-rich vitamin E soft capsule, including content and capsule skin, the content include the original of following parts by weight
Material: 20 parts of Se-enriched yeast, 40 parts of d- alpha-tocopherol, oily 500 parts and 20 parts of suspension aid of phase；The capsule skin includes following parts by weight
Several raw material: 350 parts of gelatin, 140 parts of plasticizer, 3 parts of opacifier and 350 parts of water.
Wherein, ratio of the oil mutually by soybean oil, sunflower oil and olive oil by weight 2:2:1 forms.
Wherein, the suspension aid is ethyl cellulose.
Wherein, the plasticizer is made of glycerol and polyethylene glycol by weight the ratio of 3:1.
Wherein, the opacifier is micron-sized zinc oxide.
Wherein, the capsule skin further includes that 0.1 parts by weight of lemon Huang and the temptation of 0.01 parts by weight are red.
The preparation method of selenium-rich vitamin E soft capsule as described above, includes the following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get arriving
The capsule liquid；
(3) content and capsule liquid the preparation of selenium-rich vitamin E soft capsule: are pressed into flexible glue in soft capsule molding machine
Capsule to get arrive the selenium-rich vitamin E soft capsule.
Wherein, the temperature of mixed sols is 80 DEG C in the step (2), time 70min.
Wherein, the viscosity of the capsule liquid is 30000mpas.
Embodiment 4
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 7 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 3:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 3:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 90nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 50 μ
m。
Embodiment 5
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 4 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 2:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 2:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 80nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 40 μ
m。
Embodiment 6
The present embodiment the difference from embodiment 1 is that:
Capsule skin further includes the composite particles of 10 parts by weight in the present embodiment, and the composite particles are by microcrystalline cellulose and nanometer
Titanium dioxide by weight 4:1 ratio form, composite particles the preparation method comprises the following steps: taking microcrystalline cellulose and nano-titanium dioxide
Ultrasonic disperse, filtration drying are carried out in water by weight the ratio of 4:1, can be prepared by.
Preferably, the partial size of the nano-titanium dioxide is 100nm, and the particle diameter distribution D50 of the microcrystalline cellulose is 60 μ
m。
Comparative example 1
This comparative example capsule skin further includes the microcrystalline cellulose of 7 parts by weight, and the particle diameter distribution D50 of the microcrystalline cellulose is 50
μm
To embodiment 1-6 carry out organoleptic requirements, physical and chemical index, microbiological indicator, functional component index test, meet as
Lower index request:
1.1 organoleptic requirements
1.2 physical and chemical index
| Project | Index | Detection method |
| Acid value, mg/g | ≤3.0 | GB 5009.229 |
| Peroxide value, g/100g | ≤0.25 | GB 5009.227 |
| Disintegration time limited, min | ≤60 | The Pharmacopoeia of the People's Republic of China |
| Ash content, % | ≤5.0 | GB 5009.4 |
| Lemon yellow, g/kg | ≤0.1 | GB 5009.35 |
| Lure red, g/kg | ≤0.1 | SN/T 1743 |
| Aflatoxin B1, μ g/kg | ≤10 | GB 5009.22 |
| Lead, mg/kg | ≤2.0 | GB 5009.12 |
| Total arsenic, mg/kg | ≤1.0 | GB 5009.11 |
| Total mercury, mg/kg | ≤0.3 | GB 5009.17 |
1.3 microbiological indicator
| Project | Index | Detection method |
| Total plate count, CFU/g | ≤30000 | GB 4789.2 |
| Escherichia coli, MPN/100g | ≤0.92 | GB 4789.3 |
| Mould and yeast, CFU/g | ≤50 | GB 4789.15 |
| Staphylococcus aureus | ≤0/25g | GB 4789.10 |
| Salmonella | ≤0/25g | GB 4789.4 |
1.4 functional component indexs
| Project | Index | Detection method |
| Every contains selenium, μ g | 7.5-12.5 | GB 5009.93 |
| Every contains vitamin E, mg | 16-36 | GB 5009.82 |
By These parameters test it is found that soft capsule of the invention is safe and effective, be suitble to require supplementation with selenium and vitamin E at
People can be improved the immunity of the human body with oxidation and removing free radicals.
In order to verify the effect of composite particles of the present invention, the present invention is by the soft capsule of embodiment 1, embodiment 4 and comparative example 1
Room temperature ((25 DEG C ± 2 DEG C of temperature, RH60 ± 10%) place 12,24 months, test disintegration time limited, obtain following table:
From the comparative analysis of initial burst time limit, it is known that microcrystalline cellulose can promote the disintegration of capsule, but not have in itself
There is the soft capsule of microcrystalline cellulose that there is preferable disintegration, therefore the castering action of microcrystalline cellulose and non-significant.
From lateral time comparative analysis, the soft capsule disintegration time limited of embodiment 1 always is highest, though and comparative example 1
Right disintegration time limited is consistently lower than embodiment 1, it is contemplated that the initial burst time limit with regard to low reason, what microcrystalline cellulose primarily served
Effect is raising disintegration, but for delaying gelatin to have no obvious effect, and the present invention is mixed into nanometer in microcrystalline cellulose
After titanium dioxide, disintegration timeliness obviously decreases, it was demonstrated that nano-titanium dioxide plays the role of ultraviolet shielded well and certainly anti-
Bacterium effect has delayed gelatin aging, therefore is disintegrated timeliness and maintains lower level always.
Above-described embodiment is the preferable implementation of the present invention, and in addition to this, the present invention can be realized with other way,
Do not depart under the premise of present inventive concept it is any obviously replace it is within the scope of the present invention.
Claims (9)
1. a kind of selenium-rich vitamin E soft capsule, including content and capsule skin, it is characterised in that: the content includes following weight
Measure the raw material of number: 10-20 parts of Se-enriched yeast, 20-40 parts of d- alpha-tocopherol, 400-500 parts of oily phase and suspension aid 10-20
Part；The capsule skin includes the raw material of following parts by weight: 250-350 parts of gelatin, 100-140 parts of plasticizer, 2-3 parts of opacifier and
300-350 parts of water.
2. a kind of selenium-rich vitamin E soft capsule according to claim 1, it is characterised in that: the oil is mutually soybean oil, flower
At least one of oil generation, sunflower oil and olive oil.
3. a kind of selenium-rich vitamin E soft capsule according to claim 1, it is characterised in that: the suspension aid be beeswax,
At least one of aluminum monostearate and ethyl cellulose.
4. a kind of selenium-rich vitamin E soft capsule according to claim 1, it is characterised in that: the plasticizer be glycerol and
At least one of polyethylene glycol.
5. a kind of selenium-rich vitamin E soft capsule according to claim 1, it is characterised in that: the opacifier is titanium dioxide
At least one of titanium, calcium carbonate and zinc oxide.
6. a kind of selenium-rich vitamin E soft capsule according to claim 1, it is characterised in that: the capsule skin further includes 0.05-
0.1 parts by weight of lemon Huang and the temptation of 0.009-0.01 parts by weight are red.
7. a kind of preparation method of selenium-rich vitamin E soft capsule as claimed in any one of claims 1 to 6, it is characterised in that: packet
Include following steps:
(1) preparation of content: the raw material of content is weighed after mixing to get to the content by formula ratio；
(2) preparation of capsule liquid: mixed sols is carried out by the raw material that formula ratio weighs capsule skin, is vacuumized, static to get described in
Capsule liquid；
(3) preparation of selenium-rich vitamin E soft capsule: content and capsule liquid are pressed into soft capsule in soft capsule molding machine, i.e.,
Obtain the selenium-rich vitamin E soft capsule.
8. a kind of preparation method of selenium-rich vitamin E soft capsule according to claim 7, it is characterised in that: the step
(2) temperature of mixed sols is 70-80 DEG C in, time 50-70min.
9. a kind of preparation method of selenium-rich vitamin E soft capsule according to claim 7, it is characterised in that: the capsule
The viscosity of liquid is 18000-30000mpas.
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| CN112353778A (en) * | 2021-01-11 | 2021-02-12 | 广东银珠医药科技有限公司 | Carboxyaminetriazole soft capsule and preparation method thereof |
| CN113662194A (en) * | 2021-08-31 | 2021-11-19 | 硒养健康产业(山东)有限公司 | Nutrient supplement capable of being disintegrated and absorbed easily and supplementing selenium and vitamins and preparation method thereof |
| CN113694037A (en) * | 2021-08-25 | 2021-11-26 | 南宁富莱欣生物科技有限公司 | Soft capsule with high calcium content and preparation key technology |
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| CN108888601A (en) * | 2018-08-02 | 2018-11-27 | 济源希健生物医药科技发展有限公司 | A kind of vitamin E selenium microcapsules tablet, preparation method and its usage |
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| CN113694037A (en) * | 2021-08-25 | 2021-11-26 | 南宁富莱欣生物科技有限公司 | Soft capsule with high calcium content and preparation key technology |
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