CN109387646A - Chemical illumination immunity analysis instrument - Google Patents
Chemical illumination immunity analysis instrument Download PDFInfo
- Publication number
- CN109387646A CN109387646A CN201811498317.7A CN201811498317A CN109387646A CN 109387646 A CN109387646 A CN 109387646A CN 201811498317 A CN201811498317 A CN 201811498317A CN 109387646 A CN109387646 A CN 109387646A
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- 238000004458 analytical method Methods 0.000 title claims abstract description 25
- 239000000126 substance Substances 0.000 title claims abstract description 23
- 238000005286 illumination Methods 0.000 title claims abstract description 22
- 230000036039 immunity Effects 0.000 title claims abstract description 22
- 238000006243 chemical reaction Methods 0.000 claims abstract description 167
- 238000004140 cleaning Methods 0.000 claims abstract description 68
- 238000011282 treatment Methods 0.000 claims abstract description 56
- 238000003860 storage Methods 0.000 claims abstract description 39
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 35
- 239000012895 dilution Substances 0.000 claims abstract description 22
- 238000010790 dilution Methods 0.000 claims abstract description 22
- 238000011084 recovery Methods 0.000 claims abstract description 14
- 239000012898 sample dilution Substances 0.000 claims abstract description 14
- 230000033001 locomotion Effects 0.000 claims abstract description 8
- 230000007246 mechanism Effects 0.000 claims description 41
- 238000002156 mixing Methods 0.000 claims description 40
- 238000007667 floating Methods 0.000 claims description 34
- 239000007788 liquid Substances 0.000 claims description 30
- 230000001360 synchronised effect Effects 0.000 claims description 29
- 238000005406 washing Methods 0.000 claims description 23
- 238000001514 detection method Methods 0.000 claims description 18
- 230000005540 biological transmission Effects 0.000 claims description 13
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 claims description 11
- 239000000758 substrate Substances 0.000 claims description 11
- 238000003825 pressing Methods 0.000 claims description 9
- 239000002699 waste material Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 230000004888 barrier function Effects 0.000 claims description 6
- 230000003068 static effect Effects 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000009434 installation Methods 0.000 claims description 4
- 239000000243 solution Substances 0.000 claims description 4
- 238000004064 recycling Methods 0.000 claims description 3
- 210000002421 cell wall Anatomy 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 19
- 239000000463 material Substances 0.000 abstract description 8
- 239000000523 sample Substances 0.000 description 124
- 238000010586 diagram Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 9
- 230000006870 function Effects 0.000 description 8
- 230000008569 process Effects 0.000 description 8
- 230000009471 action Effects 0.000 description 5
- 238000005213 imbibition Methods 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- 239000011324 bead Substances 0.000 description 4
- 238000012864 cross contamination Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 3
- 238000012423 maintenance Methods 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 239000004519 grease Substances 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 238000007259 addition reaction Methods 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000009924 canning Methods 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 210000005069 ears Anatomy 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000005283 ground state Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000003405 preventing effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000006862 quantum yield reaction Methods 0.000 description 1
- -1 reaction cup Substances 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000007569 slipcasting Methods 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/0092—Scheduling
- G01N35/0095—Scheduling introducing urgent samples with priority, e.g. Short Turn Around Time Samples [STATS]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1004—Cleaning sample transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1011—Control of the position or alignment of the transfer device
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00534—Mixing by a special element, e.g. stirrer
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a kind of chemical illumination immunity analysis instruments, including shell, it is disposed with sample storage unit, discarded reaction cup recovery unit, reaction cup feed unit and reaction reagent storage unit in shell on workbench from left to right, it is provided with warm bath cleaning unit in the shell on rear side of reaction reagent storage unit and warm bath surveys light unit, reaction reagent sample-adding unit is provided between warm bath cleaning unit and reaction reagent storage unit;Sliding is provided with dilution sample-adding unit, the first handgrip unit and the second handgrip unit from left to right on the lateral vertical plate of shell vertical portion, is provided with Sample Dilution position on the shell below dilution sample-adding unit;Scram button is provided on shell.The present invention uses one-line layout, can guarantee the context between each unit, reduces handgrip element number, shortens dilution sample-adding unit and handgrip unit motion stroke, and convenient for memory, consumptive material replacement is simple, easy to operate, has emergency treatment and urgent effect.
Description
Technical field
The present invention relates to vitro detection equipment, more particularly, to a kind of chemical illumination immunity analysis instrument.
Background technique
Chemical illumination immunity analysis instrument is formed using the oxidation of catalysis and oxidant of the chemiluminescent substance through catalyst
Intermediate is marked directly on antigen or antibody or enzyme effect is in luminous substrate, swashs when this by the intermediate of one excitation state
When hair state intermediate returns to stable ground state, while launching photon, measures quantum yield of luminscence using luminous signal measuring instrument.
Chemical illumination immunity analysis instrument is a kind of common sample analysis apparatus, when diagnosing in vitro testing staff usually require addition or
A variety of consumptive materials, such as reaction reagent, signal reagent, reaction cup, ash can and cleaning solution are replaced, while also needing to add on instrument
Load sample sheet takes sample away from instrument.Existing chemical illumination immunity analysis instrument mainly has sample storage area, handgrip unit, sample-adding
Unit and warm bath cleaning unit and temperature detecting unit are constituted, and are primarily present following problems:
Firstly, being laid out confusion between each unit, at least needing three handgrip units to be just able to satisfy Sample Dilution, cleaning and detection is needed
It asks, occupied space is big, and consumptive material (including reaction cup, reaction reagent and signal reagent) replacement difficulty is big, while being not easy to examine
Survey personnel pick and place consumptive material.
Secondly, available sample storage unit does not have emergency treatment and sudden-stop function, when thering are urgent sample needs to jump a queue to handle,
It is generally necessary to place into emergency treatment sample after shutting down, troublesome in poeration and machine stand-by time is long;The sample line area of sample storage unit
For fixed plate, the frictional force between sample rack and fixed plate is big, and sample rack is easy to appear in transmit process and topples over phenomenon, increases
Machine maintenance workload.
The hair washing component of third, existing warm bath cleaning unit is easily damaged, as patent of invention CN103599898A is disclosed
A kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device, including the lifting punch block driven by spindle motor, dipping needle
It is staggered on frame four and spits liquid needle and four aspirating needles, the reaction cup of transmission mechanism driving is correspondingly arranged below lifting punch block
Rotating disk has the following problems when going up and down punch block entire lowering: due to not can guarantee imbibition when rigging error lifting punch block decline
Needle bottoms out simultaneously, and then not can guarantee raffinate amount;(reaction cup is not accurate in place), imbibition when reaction cup has transmission error
Needle and/or injection needle are easy to touch reaction cup and/or transmission device during decline, and hair washing component, which continues decline, leads to imbibition
Needle and/or injection needle are scrapped, high failure rate, increase maintenance cost;While the cleaning needle assemblies for component of washing hair are only by injection needle
It is constituted with aspirating needle, cleaning effect is poor and has a single function.
4th, the evenly mixing device of warm bath cleaning unit is the key factor for influencing sample cleaning effect, existing evenly mixing device
Liquid is easy to splash on machine in blending process, increases maintenance difficulties, as application for a patent for invention CN103599898A is disclosed
A kind of Full-automatic chemiluminescence immunoassay analysis meter magnetic bead cleaning device passes through and mixes eccentric friction pulley (being driven by motor) and squeeze
Reaction cup rotation, when friction pulley long axis is close to reaction cup, reaction cup is tilted to jacking mechanism, and the spring of jacking mechanism is in pressure
Contracting stress, when friction pulley short axle is close to reaction cup, the restoring force driving a reaction cup of spring is tilted to wheel side is mixed, such as
This is reciprocal, and liquid is easy to splash in blending process, causes to pollute instrument while cross contamination;It is squeezed using eccentric friction pulley
The blending manner of reaction cup is unable to adjust mixing intensity.
Summary of the invention
It is an object of that present invention to provide a kind of compact layout, consumptive materials to replace simply, convenient for memory and with emergency treatment and promptly
The chemical illumination immunity analysis instrument of stopping function.
To achieve the above object, the present invention takes following technical proposals:
Chemical illumination immunity analysis instrument of the present invention, including shell, the shell are L-shaped structure, the work of housing horizontal portion
Make to be disposed with sample storage unit, discarded reaction cup recovery unit, reaction cup feed unit on platform from left to right and have
The reaction reagent storage unit of flip lid is replaced, the sample storage unit upper cover is equipped with the first flip lid, and the discarded reaction cup is returned
It receives and is covered with the second flip lid above unit and reaction cup feed unit;The sample storage unit and the discarded reaction cup recycling
Unit interval setting, is provided with signal reagent storage rack on the longitudinal vertical plate on the right side of sample storage unit, is located at the reaction
It is provided with warm bath cleaning unit in the shell of reagent storage unit rear side and warm bath surveys light unit, is cleaned in the warm bath single
Reaction reagent sample-adding unit is provided between member and reaction reagent storage unit;It is arranged in the overhauls window of the shell vertical portion
There is protection to renovate, the lateral vertical plate being laterally extended is provided in shell vertical portion, slides and sets from left to right on the transverse direction vertical plate
It is equipped with dilution sample-adding unit, the first handgrip unit and the second handgrip unit, the shell below the dilution sample-adding unit
It is provided with Sample Dilution position on body, is provided in the shell on the left of the Sample Dilution position for cleaning dilution sample-adding unit
Cleaning station;The first handgrip unit transverse is supplied in the Sample Dilution position, discarded reaction cup recovery unit, reaction cup back and forth
To between unit and warm bath cleaning unit, the second handgrip unit transverse surveys light in the warm bath cleaning unit and warm bath back and forth
Between unit;It is provided with scram button on the shell, cleaning solution, waste liquid connectivity port are provided on the right side plate of shell.
The sample storage unit include be connected on the workbench, in the carrier of box structure, be vertically set on
Demarcation plate in the middle part of the carrier bottom plate, which is separated, channel and sets out channel in being loaded into, be provided on the loading channel into
Sample pushing handle mechanisms, the input end for setting out channel are provided with return pushing handle mechanisms;The loading channel outlet and set out it is logical
The input end in road is mutually connected by sample line mechanism, and the Sample Dilution position is arranged above the sample line mechanism, and sample is dilute
It releases and is provided with sample pick-and-place window above the sample line mechanism on the right side of position;The sample line mechanism includes the first lateral vertical plate,
The leading flank of first vertical plate is provided with synchronous belt driven by stepper motors, on the left of the loading channel described in
Synchronous belt constitutes emergency treatment sample and is loaded into area, and the emergency treatment sample is loaded into area and is being arranged at intervals with emergency treatment sensors in place and sample rack just
Anti-pass sensor is provided with limit barrier structure on the first vertical plate being loaded at channel;With the loading channel corresponding position
The emergency treatment pushing hands component of longitudinal back and forth movement, the first vertical plate on the right side of the emergency treatment pushing hands component are provided on first vertical plate
On be provided with sample line pushing hands component.
The second vertical plate of structure in shaped door is provided at the top of first vertical plate, with the loading channel corresponding position
Sample sensors in place and static bruss are arranged at intervals on second vertical plate;It is set in the middle part of the bottom plate of the synchronous belt
It is equipped with code reader, the second vertical plate on front side of the code reader is arranged at intervals with high cup sensor and low cup sensor up and down;
It sets out to be provided on the demarcation plate of channel exit described in and sets out sensor of buying securities with all one's capital.
The sample line pushing hands component includes the first sliding rail being horizontally installed on the first vertical plate, is slided on first sliding rail
It is dynamic to be provided with the first slide block assembly driven by synchronous belt drive mechanism, it is provided with blocking pushing hands on first slide block assembly,
The horizontal part for stopping pushing hands extends forwardly into the synchronous belt top and in left-right direction back and forth movement;The blocking pushing hands
The corner at top is provided with sample line sensor;The emergency treatment pushing hands of the emergency treatment pushing hands component passes through first vertical plate along vertical
To travelling to and fro between the loading channel and the first vertical plate.
The pushing handle mechanisms that return include the pedestal of structure of being in U-shape, and are provided with longitudinal extension on the side plate of the pedestal
The second sliding rail, sliding is provided with the second slide block assembly driven by synchronous belt drive mechanism on second sliding rail, described the
Return pushing hands is provided on two slide block assemblies, the vertical portion for returning to pushing hands is upwardly extended from the carrier right vertical,
The horizontal part for returning to pushing hands is horizontally set on described set out above channel;It is offered on first vertical plate and returns to pushing hands
The notch that horizontal part matches returns to pushing hands and travels to and fro between the synchronous belt along longitudinal direction and set out between channel.
The hair washing component of the warm bath cleaning unit includes that the mounting plate being connected on shell is arranged in, on the mounting plate
It is provided with toilet seat jaggy, is respectively arranged with sleeve needle and substrate needle, position on the toilet seat of the notch two sides
The identical injection needle of quantity and aspirating needle are staggeredly placed on toilet seat between the sleeve needle and substrate needle;The installation
Floating structure is provided in the middle part of plate, the floating structure includes the vertical locating shaft being connected on a mounting board, and the positioning is axial
On extend linear bearing in the middle part of the toilet seat, top is connected by screw to the locking cap that Open Side Down, toilet seat
Upper surface offers the annular groove matched with the locking cap bottom opening, and is set on the locating shaft in locking cap
One floating elastic part;The photoelectric sensor for detecting the floating structure signal is provided on the toilet seat.
The sleeve needle includes the first connector and the second connector being connected with needle tubing, above the first needle stand
Be provided with the guide pressing plate of L-shaped structure on first connector, the guide pressing plate pass through the connecting plate that is vertically arranged with
First needle stand is fixedly connected with, and is set with the second floating elastic part on the first connector between guide pressing plate and the first needle stand;
It is set with guiding briquetting at the top of second needle stand of the aspirating needle, is provided on second needle stand of the guiding briquetting
Annular convex platform is set with third floating elastic part on the annular convex platform and the second needle stand being oriented between briquetting.
The leakproof evenly mixing device of the warm bath cleaning unit includes the bottom deck assembly being arranged in below the hair washing component,
Leakage-proof socket is provided on the bottom deck assembly, the top edge of the leakage-proof socket expands outwardly to form collection port, setting in leakage-proof socket
There is the first eccentric mixing head by power mechanism driving, the described first eccentric head that mixes includes the locating slot for clamping reaction cup
With the shielding cap that Open Side Down, fluid hole is offered in the positioning groove groove wall;The first rotation being connected on the shielding cap
The driving gear of the through-hole and power mechanism that are pierced by leakproof groove bottom wall under axial direction is sequentially connected, and the edge of the through-hole hangs down upwards
It directly is bent to form the leakproof boss for being cylindrical in shape structure, is extended upwardly in the shielding cap at the top of the leakproof boss;It is described
The eccentric spacing d of locating slot central axes and first rotary shaft central axes is 0.5-3.0mm.
The power mechanism includes the motor vertical plate being vertically arranged on the mounting plate component, is set on the motor vertical plate
It is equipped with third sliding rail and lifting motor, the lifting motor drives rotary components to glide along the third sliding rail by transmission
Dynamic, the rotary components include the mounting rack being slidably arranged on third sliding rail, and the mounting rack bottom is provided with rotating electric machine,
In the pinion stand that the driving gear being sleeved on the rotating electric machine output shaft is rotatably arranged at the top of mounting rack, the tooth
The first driven gear engaged with driving gear is provided in wheel seat, the bottom of first rotary shaft, which is worn, is connected in described
In one driven gear.
The second driven gear being meshed with driving gear, institute are provided in the pinion stand on the right side of the driving gear
State the second rotary shaft for being fixed with and upwardly extending in the second driven gear, the top in second rotary shaft be fixed with it is described
First eccentric identical second bias of header structure that mixes mixes head.
It is provided with L-shaped frame on the mounting plate component, is arranged at intervals on the cross bar of the L shape frame and first rotation
First reaction cup limit hole of shaft coaxial line and the second reaction cup limit hole with the second concentric rotation axis line, described
One reaction cup limit hole is correspondingly arranged with the described first eccentric head or more that mixes, the second reaction cup limit hole and described second
Bias mixes head and is correspondingly arranged up and down.
The discarded reaction cup recovery unit includes longitudinally disposed vibrating bottom plate on the workbench, the vibration bottom
It is provided with longitudinally disposed collecting box on plate, dropping channel is provided with by bracket in the back upper place of the collecting box, under described
The inlet for falling channel is provided with the reaction cup guide plate tilted down, and the reaction cup guide plate is put by two spaced take
Wing plate composition, it is described take put between wing plate formed reaction cup card put slot;Vibration between the collecting box and the bracket
Vibrating motor is provided on bottom plate;Reaction cup position sensor is provided at the dropping channel above the collecting box.
The invention has the advantages that unified benchmark can guarantee that the front and back between each unit is closed using one-line layout
System;Handgrip element number is reduced simultaneously, shortens dilution sample-adding unit and handgrip unit motion stroke, convenient for memory, consumptive material replacement
Simply, easy to operate, also there is emergency treatment and emergency shutdown effect.It is embodied in the following:
(1), this chemical illumination immunity analysis instrument complete machine is one-line layout, is followed successively by sample storage unit, signal from left to right
Reagent storage frame, discarded reaction cup recovery unit, reaction cup feed unit and the reaction reagent storage unit with replacement flip lid,
Unified benchmark can guarantee the context between each unit;Dilution sample-adding unit and handgrip unit can be integrated in shell
Vertical portion, not only reduce handgrip unit quantity, save space, be also convenient for operator memory, in order to pick and place consumptive material, behaviour
Make simple and convenient;Scram button is provided on machine, when being in an emergency can quick shutdown, protect machine.
(2), emergency treatment sample is loaded into area independently of being loaded into channel and setting out channel, and emergency treatment sample is loaded into area and sampling area is integrated
On synchronous belt, when there is emergency treatment sample, emergency treatment sample, which is directly placed into emergency treatment sample loading area, can be realized emergency treatment sample
It jumps a queue detection, it is easy to operate, without standby, realize the random emergency treatment of emergency treatment sample;The positive and negative sensor of sample rack can judge emergency treatment
Sample whether be put into direction correct, it is ensured that emergency treatment sample accurately in place, reduces error rate, further increases the inspection of emergency treatment sample
Survey efficiency;Emergency treatment pushing hands component can push back sample rack to its arrival end from channel outlet is loaded into, and prevent conventional sample and emergency treatment
Sample interferes and influences normally to detect, it is ensured that machine operation is smooth;Synchronous belt with have push back, the sample line of barrier functionality
Pushing hands component collective effect is in detection sample, and synchronous belt drives sample rack mobile, and sample line pushing hands component realizes the essence of sample rack
It determines position, not only can guarantee that the first handgrip unit can accurately grab sample.
(3), hair washing component of the invention integrates signal reagent addition and cleaning function, and cleaning effect is good, and floating structure is true
It protects all aspirating needles all to bottom out, guarantees raffinate amount, reduce machine-spoiled rate.Second floating elastic part and third floating elastic
Part ensures that aspirating needle and sleeve needle all bottom out when hair washing component is fallen into place, and reduce the influence of rigging error, guarantees while inciting somebody to action
Waste liquid in reaction cup is all sucked out, and cleaning effect is good;When reaction cup position is there are when deviation, aspirating needle, injection needle, substrate needle
And/or any one in sleeve needle, when touching reaction cup wall of cup or transmission device, the first floating elastic part stress drives pedestal
It integrally floats with bottom plate, photoelectric sensor passes to controller after detecting pedestal floating sign, and controller issues whole shut down
Defencive function is opened in instruction, and protection hair washing component reduces machine-spoiled rate;It substrate needle and is made of injection needle, aspirating needle clear
The common cleaning magnetic bead of needle combination is washed, sleeve needle has self-cleaning function, by the waste liquid of the preparatory pumping high-concentration of sleeve needle, then
Target body is cleaned by one or two or more sets of cleaning needle combinations again, cleaning effect is good, moreover it is possible to avoid cross contamination;Bottom
Object needle can add signal reagent into reaction cup, and substrate needle is integrated on toilet seat, save space.
(4), evenly mixing device of the invention has liquid-leakage preventing effect, and the liquid that when mixing sputters from reaction cup is along reaction cup
Wall of cup flows into locating slot, is then flowed out and is fallen on shielding cap by the fluid hole on locating slot again, and from truncated cone structure
Shielding cap slide to leakproof trench bottom, prevent liquid from flowing out out of leakage-proof socket;Simultaneously fluid hole can guarantee liquid in time from
Outflow, avoids liquid crystalization in locating slot and influences mixed effect in locating slot;First partially when mixing state or non-mixing state
The shielding cap that the heart mixes head all exists with leakage-proof socket is overlapped overlap joint, prevents liquid from flowing out out of leakage-proof socket;Lifting motor is adjustable
First it is eccentric mix grease head highness adjustment, the revolving speed speed of rotating electric machine determines liquid blending intensity in reaction cup, by adjusting the
One eccentric mixing grease head highness and revolving speed guarantee liquid blending effect, simultaneously because locating slot and the setting of the first rotating shaft eccentric, the
One eccentric mixes while head revolves with the first rotary shaft shakes, so that the liquid in reaction cup mixes well, Jin Erbao
Demonstrate,prove magnetic bead cleaning effect;The second eccentric head that mixes for mixing the small reaction cup of reaction reagent additive amount, due to mixing amount is small can
Liquid splash is avoided completely;The second eccentric head that mixes is worked at the same time with the first eccentric head that mixes, and improves blending efficiency.
(5), the structure of the discarded reaction cup recovery unit of the present invention is simple, easy to use, reaction cup can be effectively prevent to exist
Liquid splash phenomenon occurs when into dropping channel, workbench environment is made to keep clean and tidy, clean, pollution-free;Meanwhile at vibration bottom
Under the action of plate, the reaction cup of lower backwardness can carry out tiling setting in collecting box, to effectively play the receiving of collecting box
Space, makes the productive temp of narrow discard unit and a whole set of instrument mutually be suitable for.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention (protection flip lid is in the open state).
Fig. 2 is structural schematic diagram of the invention (the first flip lid, the second flip lid are in the open state).
Fig. 3 is the structural schematic diagram of sample storage unit in Fig. 1.
Fig. 4 is the overlooking structure diagram of Fig. 3.
Fig. 5 is the explosive view of sample storage unit of the present invention.
Fig. 6 is the structural schematic diagram of Tu5Zhong sample line mechanism.
Fig. 7 is the structural schematic diagram of warm bath cleaning unit hair washing component of the present invention.
Fig. 8 is the broken section structural schematic diagram of Fig. 7.
Fig. 9 is the structural schematic diagram of sleeve needle described in Fig. 7.
Figure 10 is the structural schematic diagram of aspirating needle described in Fig. 1.
Figure 11 is the structural schematic diagram of warm bath cleaning unit leakproof evenly mixing device of the present invention.
Figure 12 is the schematic cross-sectional view of warm bath cleaning unit leakproof evenly mixing device of the present invention.
Figure 13 is that the structural schematic diagram of warm bath cleaning unit leakproof evenly mixing device of the present invention (conceals leakage-proof socket and bottom plate group
Part).
Figure 14 is the structural schematic diagram of discarded reaction cup recovery unit of the present invention.
Figure 15 is the enlarged structure schematic diagram in the portion M in Figure 14.
Specific embodiment
As shown in Figure 1, 2, chemical illumination immunity analysis instrument of the present invention, including shell A01, the shell A01 are L
Shape structure is disposed with sample storage unit B on the workbench A02 of shell A01 horizontal part from left to right, discarded reaction cup is returned
Receive unit C, reaction cup feed unit D and reaction reagent storage unit E, the sample storage unit B with replacement flip lid A03
Upper cover is equipped with the first flip lid A04, the discarded reaction cup recovery unit C and the top reaction cup feed unit D is covered with second and turns over
Cover A05;The sample storage unit B and the discarded interval the reaction cup recovery unit C setting, it is right to be located at sample storage unit B
Signal reagent storage rack F is provided on the longitudinal vertical plate A06 of side, the shell on rear side of the reaction reagent storage unit E
It is provided with warm bath cleaning unit G in A01 and warm bath surveys light unit H, in the warm bath cleaning unit G and reaction reagent storage unit
Reaction reagent sample-adding unit I is provided between E;Protection flip lid A07 is provided in the overhauls window of the vertical portion the shell A01,
The lateral vertical plate A08 being laterally extended, sliding setting from left to right on the transverse direction vertical plate A08 are provided in the vertical portion shell A01
Have dilution sample-adding unit J, the first handgrip unit K and the second handgrip unit L, be loaded below unit J positioned at the dilution described in
It is provided with Sample Dilution position A09 on shell A01, is provided in the shell A01 on the left of the Sample Dilution position A09 for clear
The cleaning station for washing dilution sample-adding unit J, the specimen needle of sample-adding unit J is diluted convenient for cleaning;The first handgrip unit K is laterally past
It returns between the Sample Dilution position A09, reaction cup feed unit D and warm bath cleaning unit G, the second handgrip unit L is horizontal
To being surveyed between light unit H in the warm bath cleaning unit G and warm bath back and forth;It is provided with scram button A10 on the shell A01,
When being in an emergency can quick shutdown, protect machine;Cleaning solution, waste liquid connectivity port are provided on the right side plate of shell A01
A11.Using one-line layout, unified benchmark can guarantee the context between each unit;Handgrip unit is reduced simultaneously
Quantity, simple to operate convenient for memory, consumptive material replacement is simple.
As seen in figures 3-6, the sample storage unit B include be connected on the workbench A02, holding in box structure
Carrier B01 is vertically set on the demarcation plate B02 in the middle part of the carrier B01 bottom plate and is separated in loading channel and set out logical
Road is provided with sample introduction pushing handle mechanisms B03 on the loading channel, and the input end for setting out channel, which is provided with, returns to pushing hands machine
Structure;The loading channel outlet is mutually connected with the input end for setting out channel by sample line mechanism, the Sample Dilution position A09
It is arranged above the sample line mechanism, sample is provided with above the sample line mechanism on the right side of the A09 of Sample Dilution position and picks and places window
B04;The sample line mechanism includes the first longitudinal vertical plate B05, is provided in the leading flank of the first vertical plate B05 by stepping
Motor-driven synchronous belt B06, the synchronous belt B06 on the left of the loading channel constitute emergency treatment sample and are loaded into area, institute
It states emergency treatment sample loading area and is arranged at intervals with emergency treatment sensors in place B07 and the positive and negative sensor B08 of sample rack, close to loading channel
Limit barrier structure B09 is provided on the first vertical plate B05 at place, limit barrier structure B09 is to extend to above synchronous belt B06
Electromagnet, electromagnet retract after being powered, and can smoothly enter into the sampling area of sample line mechanism convenient for emergency treatment sample;With the loading channel
Emergency treatment pushing hands the component B10, the emergency treatment pushing hands component B10 of longitudinal back and forth movement are provided on first vertical plate B05 of corresponding position
Emergency treatment pushing hands B21 across the first vertical plate B05 along longitudinal direction back and forth the loading channel and the first vertical plate B05, when
When having emergency treatment sample, the conventional sample that emergency treatment pushing hands B21 is loaded onto channel exit, which is pushed back into, to be loaded into channel, in order to emergency treatment
The smooth channel of sample prevents emergency treatment sample from interfering with conventional sample, it is ensured that the normal detection of emergency treatment sample;Positioned at the urgency
It examines and is provided with sample line pushing hands component on the first vertical plate B05 on the right side of pushing hands component B10, the sample line pushing hands component includes cross
It slides and is provided with by toothed belt transmission machine on the first sliding rail B18, the first sliding rail B18 being arranged on the first vertical plate B05
First slide block assembly of structure driving is provided on first slide block assembly and stops pushing hands B19, the water for stopping pushing hands B19
Flat portion extends forwardly into the synchronous belt top and in left-right direction back and forth movement;The corner stopped at the top of pushing hands B19
It is provided with sample line sensor B20, for detecting sample signal, sample line sensor B20, which is detected, to be stopped to push away when sample signal
Hand B19 starts to work, and stops pushing hands B19 to have and pushes back and barrier effect, carries out jointly to sample rack with synchronous belt B06 accurate
Positioning, convenient for accurate crawl sample.
As shown in Figure 3,4, the second vertical plate B11 of structure in shaped door is provided at the top of the first vertical plate B05, with institute
It states and is arranged at intervals with sample sensors in place B12 and static bruss B13 on the second vertical plate B11 for being loaded into channel corresponding position, it is quiet
Brush B13 is used to eliminate the residual static electricity in sample rack in reaction cup;The setting in the middle part of the bottom plate of the synchronous belt B06
There is a code reader B14, read sample rack and sample information, the second vertical plate B11 on front side of the code reader B14 is between the upper and lower every setting
It is equipped with high cup sensor B15 and low cup sensor B16, determines reaction cup height, in order to accurately control dilution sample-adding unit J sample
The falling head of this needle;It is provided on the demarcation plate B02 for setting out channel exit and sets out the sensor B17 that buys securities with all one's capital, mentioned
Discarded sample after the staff that wakes up will detect takes out.
It as in Figure 3-5, is protection emergency treatment component, sample sensors in place B12, high cup sensor B15, low cup sensor
B16, emergency treatment sensors in place B07 and the positive and negative sensor B08 of sample rack, the left part of the first vertical plate B05 are provided with upper cover plate B25
With lower cover plate B26.
As shown in Fig. 3,5, the pushing handle mechanisms that return include the pedestal B22 of structure of being in U-shape, the side of the pedestal B22
It is provided with to slide to be provided on the second the sliding rail B23, the second sliding rail B23 longitudinally extended on plate and be driven by synchronous belt drive mechanism
The second dynamic slide block assembly is provided on second slide block assembly and returns to pushing hands B24, the vertical portion for returning to pushing hands B24
It is upwardly extended from the carrier B01 right vertical, the horizontal part for returning to pushing hands B24, which is horizontally set on, described sets out channel
Top;The notch matched with return pushing hands B24 horizontal part is offered on the first vertical plate B05, returns to pushing hands B24 along longitudinal direction
Travel to and fro between the synchronous belt B06 and set out between channel, will dilution sample-adding unit sampling after discarded sample push to set out it is logical
It is recycled in road.
As shown in Figure 7,8, the hair washing component of the warm bath cleaning unit G includes that the peace being connected on shell A01 is arranged in
The toilet seat G02 with toilet seat G02 jaggy, positioned at the notch two sides is provided on loading board G01, the mounting plate G01
On be respectively arranged with sleeve needle G03 and substrate needle G04, the toilet seat G02 between the sleeve needle G03 and substrate needle G04
It is upper to be staggeredly placed with the identical injection needle G05 of quantity and aspirating needle G06, an injection needle G05 and aspirating needle G06 adjacent thereto
The combination of one group of cleaning needle is constituted, realizes that a note one of target body is inhaled and completes once to clean, aspirating needle G063 and note when actual installation
Liquid needle G054 is five, that is, constitutes five groups of cleaning needle combinations, be also possible to one group or two groups or three groups or more when installation certainly
Cleaning needle combination;Sleeve needle G03 has self-cleaning function, avoids cross contamination, sleeve needle G03 and cleaning needle combination accessory make
With, it is ensured that cleaning effect, then the waste liquid of the preparatory pumping high-concentration of sleeve needle G03 when cleaning is inhaled by a note one or two notes again
Target body is cleaned in two suctions, and cleaning effect is good and can be avoided cross contamination;Floating junction is provided in the middle part of the mounting plate G01
Structure, the floating structure include that the locating shaft G07, the locating shaft G07 being vertically connected on mounting plate G01 extend upward institute
The linear bearing G08 in the middle part of toilet seat G02 is stated, top is connected with the locking cap G09 that Open Side Down by screw G42, cleans
The upper surface seat G02 offers the annular groove matched with the locking cap G09 bottom opening, the positioning in locking cap G09
The first floating elastic part G10 is set on axis G07;The detection floating structure signal is provided on the toilet seat G02
Photoelectric sensor G11.When reaction cup position is there are when deviation, aspirating needle G06, injection needle G05, substrate needle G04 and/or sleeve needle
When any one in G03 touches reaction cup wall of cup or transmission device, the first floating elastic part G10 stress drive pedestal B22 and
Bottom plate integrally floats, and photoelectric sensor G11 passes to controller after detecting pedestal B22 floating sign, and controller issues whole
Halt instruction opens defencive function, and protection hair washing component reduces machine-spoiled rate.As shown in figure 9, the sleeve needle G03 includes
The the first connector G13 and the second connector G14 being connected with needle tubing G12, described first above the first needle stand G15 connects
It is provided with the guide pressing plate G16 of L-shaped structure on connector G13, the guide pressing plate G16 passes through the connecting plate being vertically arranged and the
One needle stand G15 is fixedly connected with, and it is floating that second is set on the first connector G13 between guide pressing plate G16 and the first needle stand G15
Dynamic elasticity part G17;As shown in Figure 10, it is set with guiding briquetting G19 at the top of the second needle stand G18 of the aspirating needle G06, close to institute
It states and is provided with annular convex platform on the second needle stand G18 of guiding briquetting G19, be located at the annular convex platform and guiding briquetting G19
Between the second needle stand G18 on be set with third floating elastic part G20.Wherein the first floating elastic part G10, the second floating elastic
Part G17 and third floating elastic part G20 is compressed spring, naturally it is also possible to be the spring leaf or elastic material of zigzag structure
Manufactured resilient sleeve.Sleeve needle G03 and aspirating needle G06 has floating action, it is ensured that hair washing falls into place rear imbibition when imbibition
Needle G06 and sleeve needle G03 are all bottomed out, it is ensured that cleaning effect.
The process of hair washing component of the present invention is as follows: driving unit drives hair washing component entire lowering, third when cleaning
Floating elastic part G20 and the second floating elastic part G17 ensures that aspirating needle G06 and sleeve needle G03 is full when hair washing component is fallen into place
Portion bottoms out, it is ensured that waste liquid in reaction cup is all sucked out, guarantees target body purification purity;As aspirating needle G06, sleeve needle G03, fluid injection
When any one or more in needle G05, sleeve needle G03 touch reaction cup wall of cup or transmission device, mounting plate G01 and toilet seat
G02 is squeezed the first floating elastic part G10 by resistance, and the first floating elastic part G10 stress drives hair washing component integrally to float, light
Electric transducer G11 detects floatation element floating sign and is sent to controller, and controller issues halt instruction to power mechanism,
Component of washing hair stops continuing lowering action, and protection hair washing slip casting reduces machine-spoiled rate.It, will be anti-by sleeve needle G03 when cleaning
It answers the high-concentration waste liquid in cup to be sucked out, then completes one by one or two or more sets of cleaning needle combined type cleaning target bodys again
Signal reagent is added in order to subsequent detection in the cleaning operation of sample after the completion of cleaning.
As figs 11-13, the leakproof evenly mixing device of the warm bath cleaning unit G includes being arranged under the hair washing component
The bottom deck assembly G21 of side, is provided with leakage-proof socket G22, the top edge of the leakage-proof socket G22 is outside on the bottom deck assembly G21
Expansion forms collection port, the first eccentric mixing head by power mechanism driving is provided in leakage-proof socket G22, described first is eccentric mixed
Even head includes the shielding cap G24 for clamping the locating slot G23 of reaction cup He Open Side Down, is opened on the locating slot G23 cell wall
Equipped with fluid hole G25, it is ensured that liquid is drained into time in leakage-proof socket G22 in locating slot G23, prevents liquid crystalization in locating slot G23
And influence mixed effect;The first rotary shaft G26 being connected on the shielding cap G24 is pierced by downwards on leakage-proof socket G22 bottom wall
The driving gear G27 of through-hole and power mechanism transmission connection, the edge of the through-hole is vertically bent to form upwards is cylindrical in shape structure
Leakproof boss G28, the leakproof boss G28 at the top of extend upwardly in the shielding cap G24, it is ensured that mix state or non-
Shielding cap G24 exists with leakage-proof socket G22 when mixing state is overlapped overlap joint, prevents liquid from flowing out out of leakage-proof socket G22;It is described fixed
The eccentric spacing d of the position central axes slot G23 and the central axes the first rotary shaft G26 is 0.5-3.0mm, it is ensured that reaction cup is with the
Shaking is generated while one rotary shaft G26 is rotated, and guarantees mixed effect.
As shown in figure 12, the power mechanism includes the motor vertical plate being vertically arranged on the mounting plate G01 component
It is provided with third sliding rail G30 on G29, the motor vertical plate G29 and lifting motor G31, the lifting motor G31 pass through transmission
Driving rotary components are slided up and down along the third sliding rail G30, and the rotary components include being slidably arranged on motor vertical plate G30
The bottom mounting rack G32, the mounting rack G32 be provided with rotating electric machine G33, be sleeved on the rotating electric machine G33 output shaft
The driving gear G27 be rotatably arranged in the pinion stand G34 at the top of mounting rack G32, be provided in the pinion stand G34 with
Driving gear G27 engagement the first driven gear G35, the bottom of the first rotary shaft G26 wear be connected in described first from
In moving gear G35;To be meshed with driving gear G27 is provided in the pinion stand G34 on the right side of the driving gear G27
The the second rotary shaft G37 upwardly extended, second rotation are fixed in two driven gear G36, the second driven gear G36
Top on axis G37 is fixed with second eccentric mixing head G38 identical with the first bias mixing header structure.To reduce first
Rotary shaft G26 and the second rotary shaft G37 rotation friction are set with first on the first rotary shaft G26 in pinion stand G34
Second bearing set G44 is set on bearing holder (housing, cover) G43, the second rotary shaft G37 in pinion stand G34.
As shown in Figure 11,12, L shape frame G39 is provided on the mounting plate G01 component, on the cross bar of the L shape frame G39
Be arranged at intervals with the first reaction cup limit hole G40 of the first rotary shaft G26 coaxial line and with the second rotary shaft G37
Second reaction cup limit hole G41, the first reaction cup limit hole G40 of coaxial line with described first eccentric to mix head or more right
It should be arranged, the second reaction cup limit hole G41 is correspondingly arranged with the described second eccentric head G38 or more that mixes, the first reaction cup
Limit hole G40 and the second reaction cup limit hole G41 is located above reaction cup rotating disk, has position-limiting action, limited reactions cup
Oscillation Amplitude reduces the probability of liquid spluttering.
The first of evenly mixing device of the present invention is eccentric to mix head and the second eccentric reaction for mixing head and being located at reaction cup rotating disk
Below cup aperture, the rotation of reaction cup rotating disk will need the reaction cup mixed to take to mix position, and the bottom of reaction cup is installed on the
The one eccentric head (or the second bias mixes head G38) that mixes is interior, partially by the eccentric mixing head of lifting motor G31 adjustment first and second
The heart mixes the height of head G38, and rotating electric machine G33 drives the first driven gear G35 and the second driven gear by driving gear G27
G36 is rotated simultaneously, and then the first eccentric mixing head and the second eccentric mixing head G38 is driven to rotate realize liquid in reaction cup simultaneously
Mixing.The second eccentric head G38 reaction cup less to reaction reagent additive amount that mix mixes;First eccentric mixing is right
The reaction cup for doing over cleaning is mixed, and is hung drop by sleeve needle G03, injection needle G05 and is fallen on the liquid in reaction cup rotating disk
The bottom leakage-proof socket G22 is entered directly by collection port with the liquid come is sputtered in reaction cup, or is flow to along reaction cup cup body
In locating slot G23, then fallen on the shielding cap G24 in truncated cone structure through fluid hole G25, by shielding cap G24 slide to
It in leakage-proof socket G22, prevents liquid from flowing on machine, protects machine environment.
As shown in Figure 14,15, the discarded reaction cup recovery unit C includes being disposed longitudinally on the workbench A02
Be provided with longitudinally disposed collecting box C02 on vibrating bottom plate C01, the vibrating bottom plate C01, the collecting box C02 it is rear on
Side is provided with dropping channel C03 by bracket, and the inlet of the dropping channel C03 is provided with the reaction cup guiding tilted down
Plate, the reaction cup guide plate are put wing plate C04 and are formed by two spaced take, it is described take to put reaction is formed between wing plate C04
Cup card puts slot C05, takes and puts the width that the distance between the dropping channel C03 inner wall of the end wing plate C04 corresponding thereto is greater than reaction cup
Degree;Vibrating motor C06 is provided on vibrating bottom plate C01 between the collecting box C02 and the bracket;The collecting box
Reaction cup position sensor C07 is provided at the dropping channel C03 above C02.
The course of work that the present invention discards reaction cup recovery unit C is as follows: anti-after surveying light by the second handgrip unit L
Answer cup to be placed in the reaction cup rotating disk in warm bath cleaning unit G, reaction cup rotating disk drive detection after reaction cup rotate to
Under first handgrip unit K, transfers the discarded reaction cup after detection by the first handgrip unit K relay and place it in reaction cup and lead
On plate, the ears of reaction cup are made to take to be placed on two and take and put on wing plate C04, while so that the cup body of reaction cup is located at reaction cup card and putting slot
In C05;After first handgrip unit K unclamps, reaction cup slides downwards along reaction cup guide plate.The end wing plate C04 position is put due to taking
In in dropping channel C03, and takes and put the distance between the dropping channel C03 inner wall of the end wing plate C04 corresponding thereto and be greater than reaction
The width of cup, thus reaction cup leave take put wing plate C04 after when continuing to fall in dropping channel C03, will not occur residual night splashes
Phenomenon outside dropping channel C03 out.When reaction cup is fallen into collecting box C02, due to the effect of vibrating motor C06, bottom is vibrated
Plate C01 and collecting box C02 constantly vibrate, and therefore, reaction cup can be along collecting box C02 bottom gradually to far from dropping channel
The direction of C03 is mobile.With the increase of reaction cup quantity, collecting box C02 is filled and reaches certain height, at this point, reaction
Cup position sensor C07 issues signal, and vibrating motor C06 is made to stop working.Staff inclines the reaction cup in collecting box C02
Down to centralized recovery point.
Detection process of the present invention is as follows:
Conventional pattern detection process: being first turned on the first flip lid A04, and multiple sample racks are pushed away simultaneously from the arrival end for being loaded into channel
Enter to be loaded into channel, i.e., sample to be detected is all put into and is loaded into channel, sample introduction pushing handle mechanisms B03 pushes sample rack to loading
Channel outlet is mobile, sample rack is pushed on synchronous belt B06, sample sensors in place B12 will test sample rack in place
Signal, control system control synchronous belt B06 rotation drive sample rack to move right, sample rack successively destatics through static bruss B13,
Reading code while code reader B14 reads sample rack information, high cup sensor B15 and low cup sensor B16 detection sample tube height
Device B14 reads sample information;First handgrip unit K is dilute to sample from two clean reaction cups of reaction cup feed unit D crawl
An A09 is released, dilution is added thereto in a reaction cup by the specimen needle of dilution sample-adding unit J, and specimen needle extracts a certain amount of
Sample to be examined injection lashes mixing in the reaction cup added with dilution, and (the discarded sample after sampling is pushed to by return pushing hands B24
Set out in channel and recycle), a certain amount of diluted sample is extracted with specimen needle after mixing again in another clean reaction cup, the
One handgrip unit K grabs dilution to recycling in collecting box C02 with reaction cup, and will turn equipped with the reaction cup of a certain amount of diluted sample
It moves in the reaction cup rotating disk outer ring reaction cup aperture of warm bath cleaning unit G, it is mixed that reaction cup rotating disk drives reaction cup to turn to
Even position and reaction reagent addition position addition reaction reagent are simultaneously mixed;When reaction cup rotating disk turns to the second handgrip unit L
When corresponding position, the handgrip of the second handgrip unit L, which grabs reaction cup to warm bath, surveys light unit H warm bath certain time, then again
The inner ring of the reaction cup pick-and-place after warm bath to reaction cup rotating disk is reacted in cup aperture by the second handgrip unit L, passes through hair washing
Component cleans reaction cup, adds one or more reaction reagents, signal reagent and mix (wash number and reaction examination
Agent addition type becomes because of detection project), reaction cup is turned to the second handgrip unit L by reaction cup rotating disk after the completion of mixing
Place is set, warm bath survey light unit H warm bath is transferred to by the reaction cup that its handgrip adds signal reagent and carries out survey light after a certain period of time.
It surveying after the completion of light, the second handgrip unit L grabs the discarded reaction cup after surveying light to the outer ring reaction cup aperture of reaction cup rotating disk,
Discarded reaction cup is turned to below the first handgrip unit K by rotational response cup rotating disk, the first handgrip unit K refile
To collecting box C02, pattern detection operation is completed.
Emergency treatment pattern detection process: when there is emergency treatment sample to need emergent management, emergency treatment sample is placed in emergency treatment sample and is carried
Enter area, when there is conventional sample to be tested on synchronous belt B06, electromagnet is extended to when powering off above synchronous belt B06, for stopping
Emergency treatment sample enters;When on synchronous belt B06 without sample to be tested, electromagnet retracts after being powered, and emergency treatment sample can smoothly enter into sampling
The detection zone of line mechanism;For the smooth detection for further ensuring that emergency treatment sample, when control system judgement has emergency treatment sample rack needs
When emergency treatment, emergency treatment pushing hands B21 is run to the outlet end certain time for being loaded into channel, stops conventional sample to enter sample line transmission single
Member avoids conventional sample and emergency treatment sample that interference phenomenon occurs when detecting, guarantees that machine operates normally, and repeats conventional sample
Detect operating process.
Claims (12)
1. a kind of chemical illumination immunity analysis instrument, including shell (A01), it is characterised in that: the shell (A01) is L-shaped structure,
Sample storage unit (B) is disposed on the workbench (A02) of shell (A01) horizontal part from left to right, discarded reaction cup is returned
Receive unit (C), reaction cup feed unit (D) and the reaction reagent storage unit (E) with replacement flip lid (A03), the sample
Storage unit (B) upper cover is equipped with the first flip lid (A04), the discarded reaction cup recovery unit (C) and reaction cup feed unit (D)
Top is covered with the second flip lid (A05);The sample storage unit (B) and discarded reaction cup recovery unit (C) interval are set
It sets, is located on the longitudinal vertical plate (A06) on the right side of sample storage unit (B) and is provided with signal reagent storage rack (F), be located at the reaction
It is provided with warm bath cleaning unit (G) in the shell (A01) on rear side of reagent storage unit (E) and warm bath surveys light unit (H),
Reaction reagent sample-adding unit (I) is provided between the warm bath cleaning unit (G) and reaction reagent storage unit (E);The shell
It is provided with protection flip lid (A07) in the overhauls window of the vertical portion body (A01), is provided with and is laterally extended in the vertical portion shell (A01)
Lateral vertical plate (A08), sliding is provided with dilution sample-adding unit (J), the first handgrip from left to right on transverse direction vertical plate (A08)
Unit (K) and the second handgrip unit (L) are located on the shell (A01) below dilution sample-adding unit (J) and are provided with sample
This dilution position (A09) is located in the shell (A01) on the left of the Sample Dilution position (A09) and is provided with for cleaning dilution sample-adding
The cleaning station of unit (J);First handgrip unit (K) lateral shuttle is returned in the Sample Dilution position (A09), discarded reaction cup
Between receipts unit (C), reaction cup feed unit (D) and warm bath cleaning unit (G), the second handgrip unit (L) lateral shuttle
It is surveyed between light unit (H) in the warm bath cleaning unit (G) and warm bath;Scram button is provided on the shell (A01)
(A10), cleaning solution, waste liquid connectivity port (A11) are provided on the right side plate of shell (A01).
2. chemical illumination immunity analysis instrument according to claim 1, it is characterised in that: sample storage unit (B) packet
It includes and is connected on the workbench (A02), in the carrier (B01) of box structure, be vertically set on the bottom the carrier (B01)
Demarcation plate (B02) in the middle part of plate is separated in being loaded into channel and setting out channel, is provided with sample introduction pushing hands on the loading channel
Mechanism (B03), the input end for setting out channel are provided with return pushing handle mechanisms;The loading channel outlet and set out channel
Input end be mutually connected by sample line mechanism, the Sample Dilution position (A09) is arranged above the sample line mechanism, sample
It is provided with sample above sample line mechanism on the right side of dilution position (A09) and picks and places window (B04);The sample line mechanism includes laterally
The first vertical plate (B05), the leading flank of first vertical plate (B05) is provided with synchronous belt driven by stepper motors (B06),
The synchronous belt (B06) on the left of the loading channel constitutes emergency treatment sample and is loaded into area, and the emergency treatment sample is loaded into section
Every being provided with emergency treatment sensors in place (B07) and the positive and negative sensor of sample rack (B08), close to the first vertical plate being loaded at channel
(B05) limit barrier structure (B09) is provided on;It is vertical with being provided on first vertical plate (B05) for being loaded into channel corresponding position
To the emergency treatment pushing hands component (B10) of back and forth movement, it is located on the first vertical plate (B05) on the right side of the emergency treatment pushing hands component (B10)
It is provided with sample line pushing hands component.
3. chemiluminescent analyzer according to claim 2, it is characterised in that: at the top of first vertical plate (B05)
Be provided with the second vertical plate (B11) of structure in shaped door, with it is described be loaded into channel corresponding position second vertical plate (B11) on be spaced
It is provided with sample sensors in place (B12) and static bruss (B13);The setting in the middle part of the bottom plate of the synchronous belt (B06)
There is code reader (B14), is located at the second vertical plate (B11) on front side of the code reader (B14) and is arranged at intervals with high cup sensor up and down
(B15) and low cup sensor (B16);It is provided on the demarcation plate (B02) for setting out channel exit and sets out biography of buying securities with all one's capital
Sensor (B17).
4. chemical illumination immunity analysis instrument according to claim 2, it is characterised in that: the sample line pushing hands component includes
The first sliding rail (B18) being horizontally installed on the first vertical plate (B05) is slided on first sliding rail (B18) and is provided with by synchronizing
First slide block assembly of tape handler driving, is provided on first slide block assembly and stops pushing hands (B19), and the blocking pushes away
The horizontal part of hand (B19) extends forwardly into the synchronous belt (B06) top and in left-right direction back and forth movement;The blocking pushing hands
(B19) corner at the top of is provided with sample line sensor (B20);The emergency treatment pushing hands (B21) of the emergency treatment pushing hands component (B10)
It is travelled to and fro between the loading channel and the first vertical plate (B05) along longitudinal direction across first vertical plate (B05).
5. chemical illumination immunity analysis instrument according to claim 2, it is characterised in that: the return pushing handle mechanisms include being in
The pedestal (B22) of U-shaped structure is provided with the second sliding rail (B23) longitudinally extended on the side plate of the pedestal (B22), described
Sliding is provided with the second slide block assembly driven by synchronous belt drive mechanism, second slide block assembly on second sliding rail (B23)
On be provided with return pushing hands (B24), it is described return pushing hands (B24) vertical portion it is upward from the carrier (B01) right vertical
Extend, the horizontal part for returning to pushing hands (B24) is horizontally set on described set out above channel;On first vertical plate (B05)
The notch matched with return pushing hands (B24) horizontal part is offered, pushing hands (B24) is returned and travels to and fro between the synchronous belt along longitudinal direction
(B06) it and sets out between channel.
6. chemical illumination immunity analysis instrument according to claim 1, it is characterised in that: the warm bath cleaning unit (G)
Hair washing component includes being arranged to be provided on the mounting plate (G01) being connected on shell (A01), the mounting plate (G01) to have
The toilet seat (G02) of notch is respectively arranged with sleeve needle (G03) and substrate on the toilet seat (G02) of the notch two sides
It is identical to be staggeredly placed with quantity on the toilet seat (G02) between the sleeve needle (G03) and substrate needle (G04) for needle (G04)
Injection needle (G05) and aspirating needle (G06);It is provided with floating structure in the middle part of the mounting plate (G01), the floating structure includes
The locating shaft (G07) being vertically connected on mounting plate (G01), the locating shaft (G07) extend upward the toilet seat (G02)
The linear bearing (G08) at middle part, top are connected by screw to the locking cap (G09) that Open Side Down, table on toilet seat (G02)
Face offers the annular groove matched with the locking cap (G09) bottom opening, the locating shaft being located in locking cap (G09)
(G07) the first floating elastic part (G10) is set on;The detection floating structure letter is provided on the toilet seat (G02)
Number photoelectric sensor (G11).
7. chemical illumination immunity analysis instrument according to claim 6, it is characterised in that: the sleeve needle (G03) include with
The first connector (G13) and the second connector (G14) that needle tubing (G12) is connected are located at described above the first needle stand (G15)
The guide pressing plate (G16) of L-shaped structure is provided on first connector (G13), the guide pressing plate (G16) is by being vertically arranged
Connecting plate be fixedly connected with the first needle stand (G15), first between guide pressing plate (G16) and the first needle stand (G15) connect
The second floating elastic part (G17) is set on head (G13);It is set with and leads at the top of the second needle stand (G18) of the aspirating needle (G06)
To briquetting (G19), it is provided with annular convex platform on second needle stand (G18) of guiding briquetting (G19), is located at described
Third floating elastic part (G20) is set on the second needle stand (G18) between annular convex platform and guiding briquetting (G19).
8. chemical illumination immunity analysis instrument according to claim 6, it is characterised in that: the warm bath cleaning unit (G)
Leakproof evenly mixing device includes the bottom deck assembly (G21) being arranged in below the hair washing component, is set on the bottom deck assembly (G21)
It is equipped with leakage-proof socket (G22), the top edge of the leakage-proof socket (G22) expands outwardly to form collection port, is provided in leakage-proof socket (G22)
By the first eccentric mixing head of power mechanism driving, the described first eccentric head that mixes includes the locating slot for clamping reaction cup
(G23) and the shielding cap (G24) that Open Side Down, fluid hole (G25) is offered on locating slot (G23) cell wall;It is connected in institute
State the master of through-hole and power mechanism that the first rotary shaft (G26) on shielding cap (G24) is pierced by downwards on leakage-proof socket (G22) bottom wall
Moving gear (G27) transmission connection, the edge of the through-hole are vertically bent to form the leakproof boss (G28) for being cylindrical in shape structure upwards,
It is extended upwardly at the top of the leakproof boss (G28) in the shielding cap (G24);The locating slot central axes (G23) and institute
The eccentric spacing d for stating the central axes the first rotary shaft (G26) is 0.5-3.0mm.
9. chemical illumination immunity analysis instrument according to claim 8, it is characterised in that: the power mechanism includes setting vertically
The motor vertical plate (G29) on the mounting plate (G01) component is set, is provided with third sliding rail on the motor vertical plate (G29)
(G30) and lifting motor (G31), the lifting motor (G31) drive rotary components along the third sliding rail by transmission
(G30) it slides up and down, the rotary components include the mounting rack (G32) being slidably arranged on motor vertical plate (G30), the installation
The bottom frame (G32) is provided with rotating electric machine (G33), the driving gear being sleeved on the rotating electric machine (G33) output shaft
(G27) it is rotatably arranged on the pinion stand (G34) at the top of mounting rack (G32) Nei, is provided in the pinion stand (G34) and driving tooth
Take turns (G27) engagement the first driven gear (G35), the bottom of first rotary shaft (G26) wear be connected in described first from
In moving gear (G35).
10. chemical illumination immunity analysis instrument according to claim 9, it is characterised in that: be located at the driving gear (G27)
Be provided with the second driven gear (G36) being meshed with driving gear (G27) in the pinion stand (G34) on right side, described second from
It is fixed with the second rotary shaft (G37) upwardly extended in moving gear (G36), the top on second rotary shaft (G37) is connected
There is the second eccentric mixing head (G38) identical with the first bias mixing header structure.
11. chemical illumination immunity analysis instrument according to claim 10, it is characterised in that: mounting plate (G01) component
On be provided with L-shaped frame (G39), be arranged at intervals on the cross bar of the L shape frame (G39) same with first rotary shaft (G26)
First reaction cup limit hole (G40) of axis and the second reaction cup limit hole with the second rotary shaft (G37) coaxial line
(G41), the first reaction cup limit hole (G40) is correspondingly arranged with the described first eccentric head or more that mixes, second reaction
Cup limit hole (G41) is correspondingly arranged with the described second eccentric mix head (G38) or more.
12. chemical illumination immunity analysis instrument according to claim 1, it is characterised in that: the discarded reaction cup recycling is single
First (C) includes the vibrating bottom plate (C01) being disposed longitudinally on the workbench (A02), is provided on the vibrating bottom plate (C01)
Longitudinally disposed collecting box (C02) is provided with dropping channel (C03), institute by bracket in the back upper place of the collecting box (C02)
The inlet for stating dropping channel (C03) is provided with the reaction cup guide plate tilted down, and the reaction cup guide plate is by two intervals
Taking of being arranged puts wing plate (C04) composition, it is described take to put form reaction cup card between wing plate (C04) and put slot (C05);Positioned at the receipts
Vibrating motor (C06) is provided on vibrating bottom plate (C01) between header (C02) and the bracket;On the collecting box (C02)
Side is provided with reaction cup position sensor (C07) at the dropping channel (C03).
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CN110376392A (en) * | 2019-07-09 | 2019-10-25 | 迈克医疗电子有限公司 | Discarded reaction cup dispatching method and device, analysis instrument and storage medium |
CN113092797A (en) * | 2021-04-08 | 2021-07-09 | 安徽养和医疗器械设备有限公司 | Automatic sample introduction device |
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WO2022262726A1 (en) * | 2021-06-15 | 2022-12-22 | 中元汇吉生物技术股份有限公司 | Recovery device for reaction container |
CN118549670A (en) * | 2024-07-26 | 2024-08-27 | 东软威特曼生物科技(沈阳)有限公司 | Positioning and unloading device for reaction cup of immunity analyzer and using method of positioning and unloading device |
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CN114236129A (en) * | 2021-12-20 | 2022-03-25 | 江苏集萃纳米应用技术研究所有限公司 | In-vitro immunodiagnosis reagent background luminescence processing system |
CN118549670A (en) * | 2024-07-26 | 2024-08-27 | 东软威特曼生物科技(沈阳)有限公司 | Positioning and unloading device for reaction cup of immunity analyzer and using method of positioning and unloading device |
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