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CN109224219B - Aerosol drug delivery device triggered by respiration - Google Patents

Aerosol drug delivery device triggered by respiration Download PDF

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Publication number
CN109224219B
CN109224219B CN201811382182.8A CN201811382182A CN109224219B CN 109224219 B CN109224219 B CN 109224219B CN 201811382182 A CN201811382182 A CN 201811382182A CN 109224219 B CN109224219 B CN 109224219B
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China
Prior art keywords
medicine
main body
nozzle
rod
assembly
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Active
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CN201811382182.8A
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Chinese (zh)
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CN109224219A (en
Inventor
张凯
崔畅
王扬成
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Suzhou Omni Pharmaceutical Co ltd
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Suzhou Omni Pharmaceutical Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

The novel aerosol administration device triggered by respiration comprises a main body A and a main body B, wherein a medicine pushing rod assembly is arranged in the main body A and the main body B; the spray medicine tank is inserted into the medicine spraying nozzle assembly; the suction nozzle cover is connected with the main body D, a suction nozzle channel is arranged in the suction nozzle cover and the main body D, and the medicine spraying nozzle component is arranged in the suction nozzle channel. The novel aerosol administration device triggered by respiration has reasonable structure, ingenious design, safety and reliability, can meet the use requirement of a user, and is beneficial to medicine storage and taking; the air suction channel has reasonable pressure air flow rate and the medicine has reasonable dispersivity during medicine suction.

Description

Aerosol drug delivery device triggered by respiration
Technical Field
The invention belongs to the technical field of medical equipment, and particularly relates to a novel aerosol administration device triggered by breathing and a working method thereof.
Background
Currently, effective treatment of asthma may use inhaled aerosols, but many patients use aerosols in a clinical course of use with incorrect methods. There are many documents at home and abroad that more than half of patients are unable to deliver effective doses of drug to the lungs when in use. Conventional delivery devices require a patient to breath the inhaler, do slow and deep inhalation and breath over several seconds while pressing the inhaler once to deliver the drug. This fit takes a long time and multiple exercises to achieve a good fit. When the coordination is inconsistent, the medicine can be delivered to the oral cavity or the throat by mistake, and the effect of treating and maintaining asthma is not achieved. Clinically, the patient's mishandling makes his confidence in the use process greatly discounted, even refuses to use the medicines again, which affects the patient's maintenance treatment in the stationary phase.
Therefore, the above-described problems are to be solved.
Disclosure of Invention
The invention aims to: in order to overcome the deficiencies of the prior art, it is an object of the present invention to provide a novel breath-triggered aerosol delivery device and method of operating the same.
The technical scheme is as follows: the present invention provides a novel breath-triggered aerosol delivery device comprising
The medicine pushing device comprises a main body A and a main body B, wherein medicine pushing rod assemblies are arranged in the main body A and the main body B;
The spray medicine tank is inserted into the medicine spraying nozzle assembly;
the suction nozzle cover is connected with the main body D, a suction nozzle channel is arranged in the suction nozzle cover and the main body D, and the medicine spraying nozzle component is arranged in the suction nozzle channel.
The novel aerosol administration device triggered by respiration has reasonable structure, ingenious design, safety and reliability, can meet the use requirement of a user, and is beneficial to medicine storage and taking; the air suction channel has reasonable pressure air flow rate and the medicine has reasonable dispersivity during medicine suction. Because the problem of patient compliance of aerosol products is ubiquitous throughout the world, the breath-triggered aerosol administration device of the invention employs a breath-activated drive structure that is triggered by active inhalation by the patient, thereby causing the drive structure to actively depress the aerosol canister itself to deliver the drug, achieving a consistent match of patient inhalation and depressing delivery of the drug, and solving the problem of delivering an effective dose of the drug to the lungs. And when the patient uses the aerosol correctly, the accuracy can be increased more remarkably due to the breathing active driving structure, and the dosage delivered to the lung does not exceed the marked dosage. The novel drug delivery device can better help patients to use drugs, improve compliance, and can also help medical staff to clearly educate the patients to use complex system drugs such as respiratory tract preparations when in clinical use. By improving the correct use of the drug by the patient, the drug is accurately delivered to achieve better clinical efficacy.
Furthermore, the novel aerosol drug delivery device triggered by respiration comprises a drug pushing rod assembly, a drug pushing rod assembly and a drug delivery device, wherein the drug pushing rod assembly comprises a drug pushing rod base, a rotary push rod, a spring seat and a self-tapping screw, inclined planes with the shapes being suitable for each other are respectively arranged on the drug pushing rod base and the rotary push rod, and the drug pushing rod base is sleeved on the rotary push rod; the spring is arranged on the spring seat, and the spring seat is fixed on the rotary push rod through a self-tapping screw. The medicine pushing rod assembly is reasonable in structure, and can realize loading and unloading of potential energy of the spring, so that the movement of the spraying medicine tank is driven.
Further, the novel aerosol drug delivery device triggered by respiration, wherein the drug spraying nozzle assembly comprises a rotating trigger rod, a reset rod, a drug nozzle cover and a drug spraying nozzle main body, the rotating trigger rod penetrates through the drug spraying nozzle main body, the reset rod is hinged to the rotating trigger rod, and the drug nozzle cover is hinged to the reset rod. The spray nozzle component has reasonable structure, and can control the work of the spray medicine tank through the rotation of the spray nozzle component, thereby realizing the spray of medicine.
Further, in the novel breath-triggered aerosol administration device, the nozzle of the spray medicine tank is arranged in the spray nozzle assembly, and the rotary trigger rod is contacted with the nozzle of the spray medicine tank; the medicine nozzle cover is positioned in the suction nozzle channel. A spray canister is a pressurized canister containing a drug for containing the drug and a propellant. Wherein the drug is dissolved in the propellant or the drug is suspended in the propellant.
Wherein the drug may be selected from the group consisting of: anti-inflammatory agents, anticholinergic agents, beta 2 -adrenoreceptor agonists, anti-infective agents, antihistamines, and combinations thereof.
In addition, the drug may also be selected from the group consisting of: salbutamol, formoterol, salmeterol, fluticasone, budesonide, mometasone, beclomethasone, tiotropium bromide, ipratropium bromide, and combinations thereof.
Further, the novel aerosol administration device triggered by respiration further comprises a counting assembly, and the counting assembly is sleeved on the medicine pushing rod assembly.
Further, the novel breath-triggered aerosol administration device comprises a counter pressing part, a cover, a gear rotating shaft, an elastic sheet, a single-digit rotating wheel, a gear, a ten-digit rotating wheel and a counter main body, wherein the ten-digit rotating wheel is arranged in the counter main body, and the ten-digit rotating wheel and the single-digit rotating wheel are respectively meshed with the gear; the counter pressing device is characterized in that a counter pressing device and a gear rotating shaft are arranged on the upper portion and the lower portion of the cover respectively, the gear rotating shaft is meshed with the unit number rotating wheel, and a spring piece is arranged between the gear rotating shaft and the unit number rotating wheel. The counting assembly is reasonable in structure, can display the residual medicine spraying amount in the medicine-containing pressurized tank containing medicines and propellant, and is convenient for a user to know the residual amount of medicines in time, so that the convenience of use is improved, and medicine supplement can be performed in time.
Furthermore, in the novel aerosol administration device triggered by breathing, the main body A is provided with a counter window, and the counter window is positioned at the position of the single-digit rotating wheel and the ten-digit rotating wheel. The counter window is convenient to view and, in addition, acts as an air inlet, cooperating with the mouthpiece channel as a medication delivery port, both together defining an air flow path in which the delivered medication is dispensed.
Furthermore, in the novel aerosol administration device triggered by breathing, the suction nozzle channel is also provided with a push button. The push button can be used for manually releasing the medicine, and is convenient to use.
The invention also provides a working method of the novel breath-triggered aerosol administration device, which comprises the following steps:
The main body A is rotated clockwise, the main body A drives the medicine pushing rod assembly to rotate, the medicine pushing rod base rotates together with the main body A, the rotary push rod rotates together with the main body B, and the rotary push rod moves downwards through matching with the inclined plane of the medicine pushing rod base to compress the spring;
The medicine nozzle cover is opened by sucking or pushing the push button through the suction nozzle channel, the reset rod is rotationally disconnected, the rotary trigger rod is turned over, the spraying medicine tank is disconnected with the rotary trigger rod, the spraying medicine tank is enabled to move downwards under the action of spring force, the spray nozzle of the spraying medicine tank is pressed into the medicine tank, the medicine is ejected, and the medicine is discharged through the medicine nozzle main body and the suction nozzle channel.
The working method of the aerosol administration device triggered by respiration is reasonable, convenient to use and has extremely high market application prospect.
Further, the above-described novel breath-triggered aerosol delivery device method of operation,
The main body A is rotated clockwise, and the rotary push rod drives the counter to be pressed downwards;
The main body A is rotated anticlockwise, the medicine pushing rod assembly is rotated reversely, the rotary push rod is reset and moves upwards through the spring, the counter is reset and released upwards according to the pressing, and the number displayed in the counter window on the main body A is reduced by 1. The working method is reasonable and the application is convenient.
Further, the working method of the novel breath-triggered aerosol administration device comprises the following steps when the counting assembly works: the counter is pressed down the time gear shaft rotates half check according to the system, drives the gear shaft through the shell fragment reset and rotates half check again when unclamping, and the gear shaft drives the rotation of unit runner one check simultaneously, and when the rotation of unit runner ten check, it rotates one check to drive ten digits runner through the gear. The counting assembly has reasonable working method and accurate counting.
The technical scheme can be seen that the invention has the following beneficial effects: the novel aerosol drug delivery device triggered by respiration has reasonable structure and convenient application, utilizes the spring potential energy loading structure and the respiration triggering structure, and the structure unloads the spring potential energy under the triggering of respiratory airflow to push the check valve of the spraying drug tank and release the drug, thereby achieving the purpose of quantitatively releasing the respiration control drug, recording the use times and having great market application prospect.
Drawings
FIG. 1 is a schematic perspective view of a novel breath-triggered aerosol delivery device in accordance with the present invention;
FIG. 2 is an exploded view of the novel breath-triggered aerosol delivery device of the present invention;
FIG. 3 is a schematic cross-sectional view of a novel breath-triggered aerosol delivery device in accordance with the present invention;
In the figure: 1 main body A, 2 counting components, 2-1 counter press, 2-2 cover, 2-3 gear rotating shaft, 2-4 shrapnel, 2-5 digit rotating wheel, 2-6 gear, 2-7 ten digit rotating wheel, 2-8 counter main body, 3 medicine pushing rod components, 3-1 medicine pushing rod base, 3-2 rotating push rod, 3-3 spring, 3-4 spring seat, 3-5 self-tapping screw, 4 main body B, 5 main body C, 6 spraying medicine tank, 7 medicine spraying nozzle components, 7-1 rotating trigger rod, 7-2 reset rod, 7-3 medicine nozzle cover, 7-4 medicine spraying nozzle main body, 8 main body D, 9 suction nozzle channel, 10 suction nozzle cover and 11 push button.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative and intended to explain the present invention and should not be construed as limiting the invention.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "clockwise", "counterclockwise", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include one or more such feature. In the description of the present invention, unless otherwise specified, the meaning of "a plurality" is two or more, unless otherwise clearly defined.
In the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present invention, unless expressly stated or limited otherwise, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, as well as the first and second features not being in direct contact but being in contact with each other through additional features therebetween. Moreover, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicating that the first feature is higher in level than the second feature. The first feature being "under", "below" and "beneath" the second feature includes the first feature being directly under and obliquely below the second feature, or simply means that the first feature is less level than the second feature.
Examples
The novel aerosol administration device triggered by breathing, as shown in fig. 1, comprises a main body A1 and a main body B4, wherein a counting assembly 2 and a medicine pushing rod assembly 3 are arranged in the main body A1 and the main body B4, and the counting assembly 2 is sleeved on the medicine pushing rod assembly 3. The counting assembly 2 comprises a counter pressing part 2-1, a cover 2-2, a gear rotating shaft 2-3, a spring piece 2-4, a single-digit rotating wheel 2-5, a gear 2-6, a ten-digit rotating wheel 2-7 and a counter main body 2-8, wherein the ten-digit rotating wheel 2-7 is arranged in the counter main body 2-8, and the ten-digit rotating wheel 2-7 and the single-digit rotating wheel 2-5 are respectively meshed with the gear 2-6; the counter pressing device is characterized in that a counter pressing device 2-1 and a gear rotating shaft 2-3 are arranged on the upper portion and the lower portion of the cover 2-2 respectively, the gear rotating shaft 2-3 is meshed with the unit rotating wheel 2-5, and a spring piece 2-4 is arranged between the gear rotating shaft 2-3 and the unit rotating wheel 2-5. In addition, the medicine pushing rod assembly 3 comprises a medicine pushing rod base 3-1, a rotary push rod 3-2, a spring 3-3, a spring seat 3-4 and a self-tapping screw 3-5, wherein inclined planes with the corresponding shapes are respectively arranged on the medicine pushing rod base 3-1 and the rotary push rod 3-2, and the medicine pushing rod base 3-1 is sleeved on the rotary push rod 3-2; the spring 3-3 is arranged on the spring seat 3-4, and the spring seat 3-4 is fixed on the rotary push rod 3-2 through a self-tapping screw 3-5.
In addition, the novel aerosol administration device triggered by respiration further comprises a main body C5 and a main body D8, wherein the main body C5 is connected with the main body B4, a spraying medicine tank 6 and a medicine spraying nozzle assembly 7 are arranged in the main body C5 and the main body D8, and the spraying medicine tank 6 is inserted into the medicine spraying nozzle assembly 7. The medicine spraying nozzle assembly 7 comprises a rotating trigger rod 7-1, a reset rod 7-2, a medicine nozzle cover 7-3 and a medicine spraying nozzle main body 7-4, wherein the rotating trigger rod 7-1 penetrates through the medicine spraying nozzle main body 7-4, the reset rod 7-2 is hinged to the rotating trigger rod 7-1, and the medicine nozzle cover 7-3 is hinged to the reset rod 7-2. The nozzle of the spraying medicine tank 6 is arranged in the medicine spraying nozzle assembly 7, and the rotating trigger rod 7-1 is contacted with the nozzle of the spraying medicine tank 6; the medicine nozzle cover 7-3 is positioned in the suction nozzle channel 9. The aerosol canister 6 is a pressurized canister containing medicament for containing medicament and propellant. Wherein the drug is dissolved in the propellant or the drug is suspended in the propellant. Wherein the drug may be selected from the group consisting of: anti-inflammatory agents, anticholinergic agents, beta 2 -adrenoreceptor agonists, anti-infective agents, antihistamines, and combinations thereof. In addition, the drug may also be selected from the group consisting of: salbutamol, formoterol, salmeterol, fluticasone, budesonide, mometasone, beclomethasone, tiotropium bromide, ipratropium bromide, and combinations thereof.
In addition, the novel aerosol administration device triggered by respiration further comprises a suction nozzle cover 10, the suction nozzle cover 10 is connected with the main body D8, a suction nozzle channel 9 is arranged in the suction nozzle cover 10 and the main body D8, and the medicine spraying nozzle assembly 7 is arranged in the suction nozzle channel 9. In addition, a push button 11 is further provided on the suction nozzle channel 9.
Furthermore, in the novel aerosol administration device triggered by breathing, the main body A1 is provided with a counter window, and the counter window is positioned at the position of the single-digit rotating wheel 2-5 and the position of the ten-digit rotating wheel 2-7. The counter window is convenient to view and furthermore, acts as an air inlet, cooperating with the mouthpiece channel 9 as a drug delivery port, both together defining an air flow path in which the delivered drug is dispensed.
When the novel breath-triggered aerosol administration device works, the novel breath-triggered aerosol administration device comprises the following steps based on the structural foundation:
the main body A1 is rotated clockwise, the main body A1 drives the medicine pushing rod assembly 3 to rotate, the medicine pushing rod base 3-1 rotates together with the main body A1, the rotary push rod 3-2 rotates together with the main body B4, and the rotary push rod 3-2 moves downwards through matching with the inclined plane of the medicine pushing rod base 3-1 to compress the spring 3-3; simultaneously, the main body A1 is rotated clockwise, and the rotary push rod 3-2 drives the counter to be pressed downwards according to the button 2-1;
The medicine nozzle cover 10 is opened by sucking or pushing the push button 11 through the suction nozzle channel 9, the reset rod 7-2 is rotated and separated, the rotating trigger rod 7-1 is turned over, the spraying medicine tank 6 is separated from the rotating trigger rod 7-1, the spraying medicine tank 6 moves downwards under the action of the force of the spring 3-3, the nozzle of the spraying medicine tank 6 is pressed into the medicine tank, the medicine is sprayed out, and the medicine is discharged through the medicine nozzle main body 7-4 and the suction nozzle channel 9.
The main body A1 is rotated anticlockwise, the medicine pushing rod assembly 3 is rotated reversely, the rotary push rod 3-2 is reset and moves upwards through the spring 3-3, the counter is reset upwards and released according to the pressing 2-1, and the number displayed in the counter window on the main body A1 is reduced by 1.
The counting assembly 2 comprises the following steps when in operation: when the counter is pressed by the pressing system 2-1, the gear rotating shaft 2-3 rotates half a lattice, when the counter is loosened, the elastic sheet 2-4 resets to drive the gear rotating shaft 2-3 to rotate half a lattice, meanwhile, the gear rotating shaft 2-3 drives the single digit rotating wheel 2-5 to rotate one lattice, and when the single digit rotating wheel 2-5 rotates ten lattices, the gear 2-6 drives the ten digit rotating wheel 2-7 to rotate one lattice.
The foregoing is merely a preferred embodiment of the invention, and it should be noted that modifications could be made by those skilled in the art without departing from the principles of the invention, which modifications would also be considered to be within the scope of the invention.

Claims (4)

1. A breath-triggered aerosol delivery device, characterized by: comprising
The medicine pushing device comprises a main body A (1) and a main body B (4), wherein medicine pushing rod assemblies (3) are arranged in the main body A (1) and the main body B (4);
the medicine spraying device comprises a main body C (5) and a main body D (8), wherein the main body C (5) is connected with a main body B (4), a spraying medicine tank (6) and a medicine spraying nozzle assembly (7) are arranged in the main body C (5) and the main body D (8), and the spraying medicine tank (6) is inserted into the medicine spraying nozzle assembly (7);
The medicine spraying device comprises a medicine spraying nozzle assembly (7), a main body D (8) and a nozzle cover (10), wherein the main body D (8) is connected with the medicine spraying nozzle assembly (7), and a nozzle channel (9) is arranged in the main body D (8) and the nozzle cover (10);
The medicine pushing rod assembly (3) comprises a medicine pushing rod base (3-1), a rotary push rod (3-2), a spring (3-3), a spring seat (3-4) and a self-tapping screw (3-5), wherein inclined planes with the shapes being matched with each other are respectively arranged on the medicine pushing rod base (3-1) and the rotary push rod (3-2), and the medicine pushing rod base (3-1) is sleeved on the rotary push rod (3-2); the spring (3-3) is arranged on the spring seat (3-4), and the spring seat (3-4) is fixed on the rotary push rod (3-2) through a self-tapping screw (3-5);
The spray nozzle of the spray medicine tank (6) is arranged in the spray nozzle assembly (7), and the rotary trigger rod (7-1) is contacted with the spray nozzle of the spray medicine tank (6); the medicine nozzle cover (7-3) is positioned in the suction nozzle channel (9);
The medicine spraying nozzle assembly (7) comprises a rotating trigger rod (7-1), a reset rod (7-2), a medicine nozzle cover (7-3) and a medicine spraying nozzle main body (7-4), wherein the rotating trigger rod (7-1) penetrates through the medicine spraying nozzle main body (7-4), the reset rod (7-2) is hinged to the rotating trigger rod (7-1), and the medicine nozzle cover (7-3) is hinged to the reset rod (7-2).
2. The breath-triggered aerosol delivery device of claim 1, wherein: the medicine pushing device further comprises a counting assembly (2), and the counting assembly (2) is sleeved on the medicine pushing rod assembly (3).
3. The breath-triggered aerosol delivery device of claim 2, wherein: the counting assembly (2) comprises a counter pressing part (2-1), a cover (2-2), a gear rotating shaft (2-3), an elastic sheet (2-4), a single-digit rotating wheel (2-5), a gear (2-6), a ten-digit rotating wheel (2-7) and a counter main body (2-8), wherein the ten-digit rotating wheel (2-7) is arranged in the counter main body (2-8), and the ten-digit rotating wheel (2-7) and the single-digit rotating wheel (2-5) are respectively meshed with the gear (2-6); the counter pressing device is characterized in that a counter pressing device (2-1) and a gear rotating shaft (2-3) are arranged on the cover (2-2) and the cover is arranged on the cover, the gear rotating shaft (2-3) is meshed with the unit rotating wheel (2-5), and an elastic piece (2-4) is arranged between the gear rotating shaft (2-3) and the unit rotating wheel (2-5).
4. The breath-triggered aerosol delivery device of claim 1, wherein: the suction nozzle channel (9) is also provided with a push button (11).
CN201811382182.8A 2018-11-20 2018-11-20 Aerosol drug delivery device triggered by respiration Active CN109224219B (en)

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CN113230503B (en) * 2021-05-26 2024-08-30 上海蕊思生物科技有限公司 Purely mechanical inhalation-triggered aerosol drug delivery device
CN113521456A (en) * 2021-08-27 2021-10-22 上海朔茂网络科技有限公司 Automatic detection trigger device of quantitative compression dosing aerosol
CN115025341B (en) * 2022-05-28 2023-12-05 山东京卫制药有限公司 Automatic aerosol pressing actuator, monitoring method and application

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US9452274B2 (en) * 2011-01-20 2016-09-27 Pneumoflex Systems, Llc Metered dose atomizer
CN207562183U (en) * 2017-05-16 2018-07-03 詹枝华 Inspiration trigger formula chemical spraying device

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