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CN107427516B8 - 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1h)-酮、其类似物、及其盐、以及它们用于治疗的方法 - Google Patents

7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1h)-酮、其类似物、及其盐、以及它们用于治疗的方法 Download PDF

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Publication number
CN107427516B8
CN107427516B8 CN201680008476.7A CN201680008476A CN107427516B8 CN 107427516 B8 CN107427516 B8 CN 107427516B8 CN 201680008476 A CN201680008476 A CN 201680008476A CN 107427516 B8 CN107427516 B8 CN 107427516B8
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methods
salts
analogs
hexahydroimidazo
pyrido
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CN107427516B (zh
CN107427516A (zh
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M·斯托格努
J·E·阿朗
R·S·波托夫
B·R·纳拉罕楚
G·L·奥尔森
Y·孙
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Oncoceutics Inc
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Oncoceutics Inc
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Abstract
CN201680008476.7A 2015-01-30 2016-01-29 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1h)-酮、其类似物、及其盐、以及它们用于治疗的方法 Active CN107427516B8 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202110266214.3A CN113149985A (zh) 2015-01-30 2016-01-29 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US62/109,737 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US62/148,844 2015-04-17
US201562233757P 2015-09-28 2015-09-28
US62/233,757 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Related Child Applications (1)

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CN202110266214.3A Division CN113149985A (zh) 2015-01-30 2016-01-29 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途

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CN107427516A CN107427516A (zh) 2017-12-01
CN107427516B CN107427516B (zh) 2021-02-26
CN107427516B8 true CN107427516B8 (zh) 2021-04-09

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CN201680008476.7A Active CN107427516B8 (zh) 2015-01-30 2016-01-29 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1h)-酮、其类似物、及其盐、以及它们用于治疗的方法
CN202110266214.3A Pending CN113149985A (zh) 2015-01-30 2016-01-29 六氢咪唑并吡啶并嘧啶酮、其类似物和盐、及其治疗用途

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EP (2) EP3250208B1 (zh)
JP (2) JP6802172B2 (zh)
KR (2) KR20240005186A (zh)
CN (2) CN107427516B8 (zh)
AU (4) AU2016211243B2 (zh)
BR (1) BR112017016487B1 (zh)
CA (3) CA3209519A1 (zh)
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IL (5) IL312936A (zh)
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MX (3) MX2017009841A (zh)
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MA55402A (fr) * 2015-01-30 2022-02-02 Oncoceutics Inc Dérivés de 7-benzyl-4-(2-méthylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, leurs sels et leur utilisation en thérapie
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
CA3013044A1 (en) * 2016-01-29 2017-08-03 Oncoceutics, Inc. G protein-coupled receptor (gpcr) modulation by imipridones
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
WO2018169994A1 (en) * 2017-03-13 2018-09-20 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
EP3589745A1 (en) * 2018-04-11 2020-01-08 Chemestmed Ltd. A method of modulating the rna methylation
CN113631192B (zh) 2019-03-26 2023-07-21 富士胶片株式会社 抑制乙型肝炎病毒蛋白产生的医药组合物、用于处置乙型肝炎的医药组合物及筛选方法
WO2021154750A1 (en) * 2020-01-29 2021-08-05 Corcept Therapeutics Incorporated TREATMENT OF ADRENOCORTICAL CARCINOMA WITH SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS (SGRMs) AND ANTIBODY CHECKPOINT INHIBITORS
JP2023536524A (ja) * 2020-08-06 2023-08-25 エトヴェシュ ロラーンド トゥドマニュジェテム 新規イミプリドン誘導体の合成とその抗癌活性の評価
CN116249538A (zh) 2020-09-30 2023-06-09 富士胶片株式会社 抑制乙型肝炎病毒蛋白质的产生的双链rna及药物组合物
CN113100233B (zh) * 2021-04-19 2022-02-08 中国农业科学院植物保护研究所 芳甲羟肟酸及其衍生物作为几丁质脱乙酰基酶抑制剂及植物抗真菌剂的应用
CN115448921B (zh) * 2021-06-08 2023-08-01 四川大学 一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途
WO2024218275A1 (en) * 2023-04-20 2024-10-24 Institut Gustave Roussy Liquid and solid compositions of imipridone derivatives
CN117599041B (zh) * 2024-01-22 2024-05-03 中国人民解放军军事科学院军事医学研究院 去氢雌马酚及其衍生物作为新型辐射防护剂和细胞保护剂的医药用途

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