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WO2014039787A3 - Germanium-containing camptothecin analogues - Google Patents

Germanium-containing camptothecin analogues Download PDF

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Publication number
WO2014039787A3
WO2014039787A3 PCT/US2013/058456 US2013058456W WO2014039787A3 WO 2014039787 A3 WO2014039787 A3 WO 2014039787A3 US 2013058456 W US2013058456 W US 2013058456W WO 2014039787 A3 WO2014039787 A3 WO 2014039787A3
Authority
WO
WIPO (PCT)
Prior art keywords
camptothecin
germanium
pharmaceutically
ethyl
acceptable salts
Prior art date
Application number
PCT/US2013/058456
Other languages
French (fr)
Other versions
WO2014039787A2 (en
Inventor
Xinghai Chen
Harry Kochat
Pavankumar N.V. Petluru
Aulma Parker
Frederick Hausheer
Original Assignee
Bionumerik Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionumerik Pharmaceuticals, Inc. filed Critical Bionumerik Pharmaceuticals, Inc.
Priority to EP13835149.9A priority Critical patent/EP2892906A2/en
Publication of WO2014039787A2 publication Critical patent/WO2014039787A2/en
Publication of WO2014039787A3 publication Critical patent/WO2014039787A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/30—Germanium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present invention discloses: (i) the novel germanium-containing camptothecin compound, 7-[2'-trimethylgermany1] ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; (ii) methods of synthesis of said novel germanium-containing camptothecin compound, 7-[2'-trimethylgermanyl] ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts; (iii) pharmaceutically-acceptable formulations comprising said novel germanium-containing camptothecin compound, 7-[2'-trimethylgermanyl] ethyl-20(S) camptothecin, and pharmaceutically-acceptable salts thereof; and (iv) methods of administration of said novel germanium-containing camptothecin compound, 7-[2'-trimethyIgermanyl] ethyl-20(S) camptothecin, and pharmaceuticafly-acceptable salts thereof to subjects in need thereof, including subjects with cancer.
PCT/US2013/058456 2012-09-07 2013-09-06 Germanium-containing camptothecin analogues WO2014039787A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP13835149.9A EP2892906A2 (en) 2012-09-07 2013-09-06 Germanium-containing camptothecin analogues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13/573,294 2012-09-07
US13/573,294 US20140073793A1 (en) 2012-09-07 2012-09-07 Germanium-containing camptothecin analogues

Publications (2)

Publication Number Publication Date
WO2014039787A2 WO2014039787A2 (en) 2014-03-13
WO2014039787A3 true WO2014039787A3 (en) 2015-09-03

Family

ID=50233906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/058456 WO2014039787A2 (en) 2012-09-07 2013-09-06 Germanium-containing camptothecin analogues

Country Status (3)

Country Link
US (1) US20140073793A1 (en)
EP (1) EP2892906A2 (en)
WO (1) WO2014039787A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108484623B (en) * 2018-05-17 2020-04-24 浙江工业大学 Camptothecin derivative and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080261919A1 (en) * 2007-04-19 2008-10-23 Bionumerik Pharmaceuticals, Inc. Camptothecin-analog with a novel, "flipped" lactone-stable, E-ring and methods for making and using same
US20090099166A1 (en) * 2007-10-16 2009-04-16 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US20090099224A1 (en) * 2007-10-16 2009-04-16 Bionumerik Pharmaceuticals, Inc. C7- substituted camptothecin analogs
US20120165522A1 (en) * 2009-06-17 2012-06-28 Threshold Pharmaceuticals, Inc. Camptothecin derivatives
US20120282261A1 (en) * 2011-05-06 2012-11-08 Bionumerik Pharmaceuticals, Inc. Deuterated analogs of (4S)-4-Ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3', 4':6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE261974T1 (en) * 1996-08-19 2004-04-15 Bionumerik Pharmaceuticals Inc HIGH-LIPOPHILIC CAMPOTHECIN DERIVATIVES
US7030243B1 (en) * 2004-10-28 2006-04-18 Bionumerik Pharmaceuticals, Inc. Process for making camptothecin derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080261919A1 (en) * 2007-04-19 2008-10-23 Bionumerik Pharmaceuticals, Inc. Camptothecin-analog with a novel, "flipped" lactone-stable, E-ring and methods for making and using same
US20090099166A1 (en) * 2007-10-16 2009-04-16 Bionumerik Pharmaceuticals, Inc. C10-substituted camptothecin analogs
US20090099224A1 (en) * 2007-10-16 2009-04-16 Bionumerik Pharmaceuticals, Inc. C7- substituted camptothecin analogs
US20120165522A1 (en) * 2009-06-17 2012-06-28 Threshold Pharmaceuticals, Inc. Camptothecin derivatives
US20120282261A1 (en) * 2011-05-06 2012-11-08 Bionumerik Pharmaceuticals, Inc. Deuterated analogs of (4S)-4-Ethyl-4-hydroxy-11-[2- (trimethylsilyl)ethyl]-1H-pyrano[3', 4':6,7] indolizino [1,2-b]quinoline-3,14(4H, 12H)-dione and methods of use thereof

Also Published As

Publication number Publication date
US20140073793A1 (en) 2014-03-13
EP2892906A2 (en) 2015-07-15
WO2014039787A2 (en) 2014-03-13

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