CN107375716A - A kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma and its preparation technology - Google Patents

Abstract

A kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma of the present invention and its preparation technology, by formulations of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma formula, materials procurement, raw material processing, raw material tcm and herbal slice extracts active ingredients, prepare it is canned, sterilize, the multiple working procedure such as pack and machine；Compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma formula is formulated：7 kinds of 20 grams of marine alga, 20 grams of radix paeoniae rubrathe etc., honey and distillation water consumption, by 5: 5 volume measurements, preservative dosage 0.1%, the buying ratio of 75% alcohol solvent and tcm and herbal slice total amount is 2: 1；Raw material tcm and herbal slice extracts active ingredients, the patent of invention (application number 201710572547.2) " medicinal herb componentses suit cylinder electric circulation automatic fitration percolating extractor " designed using the applicant, applied carries out seepage pressure effects, extract solution adds auxiliary material to be mixed evenly, with 200 milliliters of volume oral liquid bottles carry out it is canned, pack, it is oral 20 milliliters every time, twice a day.

Description

A kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma and its preparation technology

Technical field

It is prepared by a kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma of the present invention and its preparation technology category anti-tumor Chinese herbal preparation Field, more particularly to a kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma and its preparation technology.

Background technology

Nasopharyngeal carcinoma refers to betide the malignant tumour at the top of nasopharyngeal cavity with side wall.It is one of China's malignant tumour occurred frequently, hair Sick rate is first of ear,nose ＆ throat malignant tumour.Common symptoms are band blood, ear suffocation sense, Hearing, diplopia in nasal obstruction, tears And headache etc..Nasopharyngeal carcinoma radiotherapy multipair greatly has Medium sensitivity, and radiotherapy is the preferred treatment method of nasopharyngeal carcinoma.But It is that the course of disease is later and the case of recurrence after radiotherapy to compared with well-differentiated carcinoma, surgery excision and chemotherapy also belong to can not A kind of means lacked, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma of the present invention, select marine alga, the radix paeoniae rubrathe, the tuber of dwarf lilyturf, the root of straight ladybell, mother chrysanthemum 8 kinds of tcm and herbal slices such as flower, the stem of noble dendrobium, black nightshade, honey, are prepared into Compound Solanum Nigrum rhizoma imperatae oral liquids against nasopharyngeal carcinoma, it is desirable to suffering from Preventing and treating, the health care of person's disease play a role.

The content of the invention

The object of the present invention is to select 7 kinds of Chinese medicines such as marine alga, the radix paeoniae rubrathe, the tuber of dwarf lilyturf, the root of straight ladybell, chrysanthemum indicum, the stem of noble dendrobium, black nightshade, honey Material medicine materical crude slice compositing formula, a kind of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma is made, there is antitumor, antiviral, anti-inflammatory resistance State reaction, antibacterial, strengthen the multiple functions such as immune.8 kinds of tcm and herbal slice effects are complementary, and effect is extensive, is often drunk by the course for the treatment of, then add Upper necessary dietary adjustments and physical training, while psychological quality is adjusted, one surely makes liver tumour patient play treatment, health care work With, mitigation patient mental's burden, raising patients ' life quality.

To achieve these goals, the technical solution adopted by the present invention is：A kind of anti-nasopharyngeal carcinoma of the compound recipe seaweed radix paeoniae rubrathe is oral Liquid preparing process, formulated by oral liquid prescription, materials procurement, raw material processing, raw material extracts active ingredients, extraction medicine add Water stirring precipitation, oral liquid are prepared, oral liquid filling sterilizes, label is pasted and packaging multiple working procedure machines；Compound recipe seaweed Radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma formula is formulated, 20 grams of marine alga, 20 grams of the radix paeoniae rubrathe, 20 grams of the tuber of dwarf lilyturf, 20 grams of the root of straight ladybell, 10 grams of chrysanthemum indicum, stone 10 grams of dry measure used in former times, 10 grams of black nightshade, honey are equal with distillation water consumption, molten by 5: 5 volume measurements, preservative dosage 0.1%, 75% ethanol Agent is 2 times of tcm and herbal slice () total amount except honey similarly hereinafter；Materials procurement：First determine that the anti-nasopharyngeal carcinoma of the compound recipe seaweed radix paeoniae rubrathe is oral This batch of liquid always produce total bottle number, every bottle of capacity, production total capacity, every bottle take number of days, take total number of days, then by recipe calculation Go out 7 kinds of daily expenses of tcm and herbal slice, calculate 6 kinds of total expenses of tcm and herbal slice by total number of days is taken, total expense is pressed Formula rate calculates the expense of every kind of tcm and herbal slice, and graded kind is purchased, and the various tcm and herbal slices of buying are necessary Meet the quality index and specification standards of every kind of tcm and herbal slice, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% solvent It is 2: 1 that ethanol, which is purchased with tcm and herbal slice total amount buying ratio,；Raw material are processed：In addition to honey, distilled water, preservative, to every Kind of tcm and herbal slice is carried out selected and dried, and after being sufficiently mixed uniformly, is first crushed with 8 millimeters of particle diameter pulverizers, then with 4 millimeter particles Footpath pulverizer crushes standby；Raw material tcm and herbal slice extracts active ingredients, take ethanol extract from water precipitation to carry out, using the applicant Design, " medicinal herb componentses are set with cylinder electric circulation automatic fitration to the patent of invention (application number 201710572547.2) of application Percolating extractor " carries out seepage pressure effects；The device is circulated by percolating extractor support, suit cylinder percolating device, electric pump Percolating device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent evaporating separation device, The part of diacolation solvent condensate recycling device seven forms；The percolating extractor operation technological process is：1. close diacolation solution control Valve processed-→ opens the closure-→ meter feedstock that feeds and loads uniformly-→ the addition diacolation solvent leaching of inner cylinder-→ layering loading actual situation Enter to be slowly added to diacolation solvent-→ solvent in circular groove-→ circular groove and uniformly drench to push down circular groove into raw material-→ and not float-→ solvent Add to no longer to drench into 5 centimetres away from circular groove bottom and circular hole in the middle part of closure only-→ rotates to open diacolation into circular groove inner edge-→ molten to drenching Liquid circulating pump-→ regulation diacolation solution circulating valve do not make diacolation solution overflow stop-→ close diacolation solution circulation pump-→ close plus Material closure penetrates screw tightening-→ and stands 36 hours-→ passes of diacolation 36 hours-→ unlatching diacolation solution circulation pump circulatory displacement Closing diacolation solution circulation pump-→ opening diacolation solution control valve-→ diacolation solution ,-→ passes through through the screen pack automatic fitration of internal barrel bottom Diacolation solution control valve-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ filtered fluid and flows into the steaming of diacolation solution Open charging closure-→ and open diacolation solution circulation pump-→ and determine whether internal barrel bottom screen pack filters knot in hair cylinder bottom-→ Beam-→ 2. terminates filtering and closes diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle seepage pressure effects (behaviour Make flow with the-it is secondary identical) after the completion of-→ secondary cycle seepage pressure effects-→ to open diacolation solution control valve-→ secondary diacolation molten Liquid is through the screen pack automatic fitration of internal barrel bottom-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ secondary diacolation Solution flow into diacolation solution evaporative cylinder bottom-→ mix with first time diacolation solution-→ 3. taking-up inner cylinder pour out the dregs of a decoction clean-→ Inner cylinder is reentered into outer barrel-→ and closes diacolation solution control valve-→ meter feedstock loading inner cylinder-→ into next seepage pressure effects journey Sequence-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to boiler, hot water storgae, condensation Device adds water-→ unlatching electromagnetic stove to start to follow with hot water storgae hot water to boiler heating-→ unlatching hot water circulating pump-→ boiler 5. open automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90 DEG C, low temperature to 80 to ring-→ DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature is down to 80 DEG C of electromagnetic stoves and automatically turns on-→ and steam Send out cylinder diacolation solution solvent evaporation-→ solvent evaporate gas through gas delivery pipe-→ 6. gas be sent into the remittance of condenser solvent gas Collection room-→ solvent gas is condensed into liquid-→ liquid into condenser spiral condensing tube and collected into condenser condensing solvent Room-→ inflow condensing solvent recovery cylinder-→ is put into condensing solvent storage barrel-→ recycling or storage-→, and 7. unlatching diacolation is molten The total extraction medicine of liquid evaporative cylinder bottom valve-→, which is put into storage barrel-→ preparation water and sinks agitator-→ water, to sink agitator and adds and account for extraction The distilled water of medicine 60%-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into 0--5 DEG C of refrigerator Or freezer low-temperature precipitation-→ precipitation completion pours out supernatant-→ and obtains compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma and always extract medicine；It is multiple Fang Haizao radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma finished medicines are prepared：After total extraction medicine is measured by volume, subtracted from oral liquid total capacity, Residual volume amount, calculate honey in 5: 5 ratio and add capacity with distilled water, preservative is calculated by 0.1% dosage；It is standby with 300-400 rises stainless steel cylindrical vessel, and the total extraction medicine measured, honey, distilled water, preservative are added into stainless steel cylinder holds Device, mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until stirring.Compound recipe seaweed Radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma filling sterilizing is packed：The oral liquid finished product to stir is added into filling apparatus, with 200 milliliters of appearances Measuring bottle carries out oral liquid bottling capping, obtains compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma finished product；By bottled oral liquid finished product through height Temperature sterilizing, adhesive label, mounted box vanning, storage preserve sale.Compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma is taken：It is oral each 20 milliliters, 1 twice.

According to《Chinese book on Chinese herbal medicine》Record：Marine alga is the frond of Sargassaceae plant sargassum fusifome and Sargassum, contains alginic acid 15.32%-32.18%, mannitol 2.21%-7.87%, iodine 32.2%-84.2%, potassium oxide 3.23%-11.67%, total ash Point 19.72%-37.53%, Hijiki polysaccharide A (SFPP), Hijiki polysaccharide B (SFPPR), Hijiki polysaccharide C (SFPPRR) and Laminaran is laminarin.Sargassum contains alginic acid, mannitol, iodine, potassium, crude protein, ash content, sargassan, also contain with Phospholipids compounds based on cephalin, the sodium alginate and sargassum fusifome that its antineoplastic component obtains when being extracted for algae component are more Sugared B；The radix paeoniae rubrathe is the root of Paeoniaceae plant peony；Contain Paeoniflorin, oxidized paeoniflorin glycosides, benzoylpaeoniflorin, albiflorin, Paeoniflorin Without ketone, nutgall acyl Paeoniflorin, β-pinane -10- alkenyls-β-vicianin, lactiflorin, paeonilactone A, B, C, cupreol, Hu Glucoraphenin.Also get 1,2,3,6- tetra- galloyl glucoses from the tannin of root, galloyl glucoses of 6- five and corresponding Six galloyl glucoses and seven galloyl glucoses etc..Cachou extract containing dextrorotation and volatile oil again.Volatile oil is main Containing benzoic acid, paeonol and other alcohols and phenols component totally 33；Its main anti-tumor composition is radix paeoniae rubrathe n-butanol extract (radix paeoniae rubrathe D) and cupreol, the tuber of dwarf lilyturf are the root tuber of the liliaceous plant tuber of dwarf lilyturf or dwarf lilyturf.Contain a variety of glucosides：Glucoside member is sieve Scott sapogenin has ophiopogonin B, D；Glucoside member examines having for sapogenin for (22S, 24S, 25S) -23-24- dihydroxy Rosss (23S, 24S, 25S) -23,24- dihydroxy Rosss examine sapogenin -1-O- [rhamnopyranosyl (1 → 2)] [xylopyranosyl (1 → 3)]-arabopyranose glucoside -24-O- β-D- pyrans fucose glucosides.The root of straight ladybell is Campanulaceae the root of straight ladybell and belongs to several plants together Root.Containing cupreol, cupreol-β-D- glucopyanosides, taraxerone and 28 carbonic acid [1], its is main Anticancer component is cupreol, and chrysanthemum indicum is the flower of feverfew mother chrysanthemum and lavandulaleaf dendranthema herb, containing yejuhua lactone, chrysanthemol, Chrysanthetriol, chrysanthemum indicum ketone, chrysanthenone, cis- helicene alcohol ether, trans- helicene alcohol ether, Radix Angelicae Sinensis acyl ambrosin B, Radix Angelicae Sinensis acyl Asia chrysanthemum Element, Scotland artemisin, acaciin, cyanidenon, cyanidenon -7- β-D-Glucose glucoside, Quercetin-β-D-Glucose glucoside, arrow Car chrysanthemum glucoside, chrysanthemaxanthin, Daucosterol, ambrosin S, robinin, robinin -7-O- β-D- galactopyranosyl glucosides, the mono- behenic acids of 1- are sweet Oil, palmitic acid, ursolic acid, linoleic acid, cupreol, plumage room beans alcohol, n-octacosanol and volatile oil etc. [18]；Its is main Anticancer component is cupreol, and the stem of noble dendrobium is the stem of a variety of stems of noble dendrobium of orchid, separated to obtain containing alkaloid 0.3%：The stem of noble dendrobium Alkali, nobilonine, 6-hydroxydendrobine also known as dendramine, stem of noble dendrobium ether alkali, 6- hydroxyl stem of noble dendrobium ether alkali, 4- hydroxyl stem of noble dendrobium ether alkali, stone Dry measure used in former times ester alkali, 3- hydroxyls 2- oxygen-dendrobine etc..According to another report, also isolated (unclear location) 5 kinds of quartermary ammonium alkaloidses：N- methyl Stem of noble dendrobium quaternary ammonium base, N- isopentene group stem of noble dendrobium quaternary ammonium ether alkali, dendrobine N- oxides, N- isopentene group -6- hydroxyl stem of noble dendrobium ether quaternary ammoniums Alkali.The stem also element of HERBA DENDROBII containing methylene, HERBA DENDROBII phenanthrenequione, cupreol, carrot glucoside；Its main anti-tumor composition be β- Sitosterol；Black nightshade is the herb of plant of Solanaceae black nightshade.Contain solasonine, solamargine, β-solamargine.Orange fruit Contain alpha-carotene in reality, phytolectin, solasodine, N- methyl solasodines, 12 beta-hydroxy Australia eggplants are also contained in fruit Amine, tomato enamine, 12 beta-hydroxy solasodines, tomato enamine, solanocapsin, Tigogenin, i.e. 12 beta-hydroxies- 26- goes to first solasodine -26- hydroxy acid SN-e, i.e. Australia somnirol amine -3- β-solatriose glucoside, SN-f, i.e. 12 β, 27- dihydroxy Australia Continent solanamine -3- β-chacotriose glucoside.Still contain α-solamargine, α-solasonine, acetylcholine in fruit.In fruit The content of fat and alkaloid accounts for 5%-6% after maturation, contains cholesterine in seed oil.Get from rhizome black nightshade saponin A, B, black nightshade spiral shell glucoside.Contain Quercetin, Quercetin -3-O- α-rhamnopyranosyl (1 → 2)-beta galactoside, Quercetin -3- β-Portugal in leaf Grape glycosyl (1 → 6)-beta galactoside, Quercetin -3- gentiobiosides, Quercetin -3- galactosides, Quercetin -3- glucose Glucoside；The honey that honey is made by the close honeybee of Apidae animal China or apis mellifera.Containing the glucide led in honeycomb, Master contains glucose, fructose；Other also contain sucrose, dextrin, organic acid, protein, volatile oil, wax, pollen grain, vitamin B1, B2, B6, C, K, H, amylase, turn people's enzyme, peroxidase, esterase, growth stimulant, acetylcholine, nicotinic acid, pantothenic acid, carrotene, nothing Machine element calcium, sulphur, phosphorus, magnesium, potassium, sodium, iodine etc..

The beneficial effects of the invention are as follows：Above-mentioned 8 kinds of Chinese medicine prescriptions, marine alga have antitumor action, radiation resistance, resisted Endotoxin effect, enhancing immunization, the effect for reducing serum cholesterol, antibacterial action, softening hard masses, dissolving phlegm, Li Shui, detumescence are made With.Control scrofula, goiter and tumor, accumulation, oedema；There is the radix paeoniae rubrathe antitumor action, reducing blood lipid and anti arteriosclerosis effect, antiplatelet to gather Collection effect, anti-thrombosis function, function of resisting myocardial ischemia, hepatoprotective effect, calmness and certain analgesic activity, moreover it is possible to improve stomach The acidity of liquid, improves a poor appetite and digestive function, clearing heat and cooling blood, promoting blood circulation；Control febrile virulent maculae；Hematemesis and epistaxis；Discharging fresh blood stool；Mesh Red swelling and pain；Carbuncle swells sore；Hernia lump in the abdomen is gathered；The tuber of dwarf lilyturf have invigorating the spleen disappear cancer, enriching yin body-building, resist myocardial ischemia, anti-arrhythmia, enhancing The effect such as immune, antibacterial, hypoglycemic；The root of straight ladybell has antitumor action, regulation immunization, phlegm-dispelling functions, cardiotonic, anti-true Bacterium effect, replenishing the vital essence and removing heat, moistening lung for removing phlegm, reinforcing stomach reg fluid effect.Control yin chronic cough, consumptive disease cough few phlegm blood, cough caused by dryness phlegm, abnormal heat larynx numbness, Injury thirst etc. acts on；Chrysanthemum indicum has antitumor, promotion phagocytic activity of leukocytes, resisting pathogenic microbes effect, antiplatelet Aggtegation, antihypertensive effect, function of resisting myocardial ischemia, the effect of clearing heat and detoxicating, dispelling wind soothing the liver, treatment sore, ulcer, erysipelas, eczema, Dermatitis, anemopyretic cold, abscess of throat, high blood pressure etc.；The stem of noble dendrobium has antitumor action, nourishing Yin and clearing heat, the beneficial stomach that promotes the production of body fluid, moistening lung benefit Kidney, the strong waist effect of improving eyesight；Control consumption of body fluid caused by febrile disease, dry polydipsia, deficiency of stomach-Yin, stomachache retch, dryness of the lung dry cough, abnormal heat are not moved back, impairment of yin Mesh is dark, waist and knee is weak etc.；Black nightshade has clearing heat and detoxicating；Activating blood circulation and reducing swelling, anti-inflammatory, antibechic, phlegm-dispelling functions.Treat sore；Carbuncle swells；It is red Poison；Bruises and sprains；Chronic bronchitis；Nephritic dropsy etc.；Honey has lipotropy, can improve the composition of blood, promotes Heart and brain and vascular function；There is protective effect to liver, liver cell regeneration can be promoted；It can regain one's strength of body rapidly, dispelling fatigue, enhancing To the resistance of disease；The also effect of sterilizing；The skin damage of moderate can be treated, is particularly scalded；Sleep can be improved； It can also relax bowel.8 kinds of tcm and herbal slices of the above have the effect such as anticancer, anti-aging, antivirus action, antibacterial action； Effect is complementary, and effect is extensive, is often drunk by the course for the treatment of, along with necessary physical training, adjusts psychological quality, one surely play it is anti- Cancer, health-care effect, mitigate patient mental's burden, improve patients ' life quality.

Embodiment

Specific embodiment

1st, formulating compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma formula is：20 grams of marine alga, 20 grams of the radix paeoniae rubrathe, 20 grams of the tuber of dwarf lilyturf, sand 20 grams of ginseng, 10 grams of chrysanthemum indicum, 10 grams of the stem of noble dendrobium, 10 grams of black nightshade, honey are equal with distillation water consumption, by 5: 5 volume measurements, preservative Dosage 0.1%.

2nd, it is 1000 bottles to determine this batch compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma output, per bottled 200 milliliters, altogether Oral liquid total amount need to be prepared as 200 liters.

3rd, the tcm and herbal slice as needed for this batch compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma output and recipe calculation is total Measure as 550 kilograms, calculating 5 kinds of tcm and herbal slice amount of purchases by formula rate is respectively：Marine alga double centner, the radix paeoniae rubrathe 100,000 Gram, tuber of dwarf lilyturf double centner, the root of straight ladybell double centner, 50 kilograms of chrysanthemum indicum, 50 kilograms of the stem of noble dendrobium, 50 kilograms of black nightshade, honey and distilled water Ratio is 5: 5, waits active ingredients from traditional Chinese medicinal to measure buying by volume after the completion of extracting；Preservative dosage is 0.1%, 75% ethanol Solvent purchases 1200 liters, recycles.

4th, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma tcm and herbal slice is processed：To every kind of tcm and herbal slice carry out it is selected and Dry, after being sufficiently mixed uniformly, first crushed with 6 millimeters of particle diameter pulverizers, then it is standby with 3 millimeters of particle diameter pulverizers crushing.

5th, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma tcm and herbal slice extracts active ingredients：Ethanol extract from water precipitation is taken to enter OK, patent of invention (application number 201710572547.2) " the medicinal herb componentses suit cylinder electricity designed using the applicant, applied Dynamic circulation automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder diacolation Device, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation solvent Evaporating separation device, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is：1. close Close diacolation solution control valve-→ open charging closure-→ meter feedstock load inner cylinder-→ layering load actual situation uniform-→ plus Enter diacolation solvent and drench in circular groove-→ circular groove to be slowly added to diacolation solvent-→ solvent and uniformly drench into raw material-→ that pushing down circular groove should not Float-→ solvent add to no longer drench into 5 centimetres away from circular groove bottom only-→ by circular hole in the middle part of closure rotate to drench into circular groove inner edge- → unlatching diacolation solution circulation pump-→ regulation diacolation solution circulating valve does not make diacolation solution spilling, and only-→ closing diacolation solution follows Ring pump-→, which closes charging closure and penetrates screw tightening-→ and stand diacolation 36 hours-→ and open diacolation solution circulation pump and circulate, to be oozed - → closing diacolation solution circulation pump-→ of filtering 36 hours opens diacolation solution control valve-→ diacolation solution through internal barrel bottom screen pack Automatic fitration-→ through diacolation solution control valve ,-→ flows into diacolation solution evaporative cylinder top screen pack natural filtration-→ filtering liquid stream Enter diacolation solution evaporative cylinder bottom-→ opening charging closure-→ unlatching diacolation solution circulation pump-→ and determine that internal barrel bottom is filtered Whether net, which filters, which is terminated ,-→ 2. terminates filtering closing diacolation solution control valve-→ addition new diacolation solvent-→ progress secondary cycle After the completion of seepage pressure effects (operating process is identical with first time)-→ secondary cycle seepage pressure effects-→ open diacolation solution control valve- Through the screen pack automatic fitration of internal barrel bottom ,-→ flows into diacolation solution evaporative cylinder top screen pack nature mistake to → secondary diacolation solution Filter-→ secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution 3. taking-up inner cylinder falls Go out dregs of a decoction cleaning-→ inner cylinder and be reentered into outer barrel-→ closing diacolation solution control valve-→ meter feedstock loading inner cylinder-→ entrance Next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to hot water Case, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and hot water Groove hot water starts the cycle over-→, and 5. opening automatic temperature control instrument-→ to diacolation solution evaporative cylinder heating-→ adjusts temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature be down to 80 DEG C of electromagnetic stoves from Dynamic unlatchings-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporation gas through gas delivery pipe-→ 6. gas feeding condenser Solvent gas merging chamber-→ solvent gas into condenser spiral condensing tube be condensed into liquid-→ liquid into condenser it is cold Solidifying solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7. Open diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine and be put into storage barrel-→ heavy agitator of the heavy agitator-→ water of preparation water Add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ be put into 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pour out supernatant-→ and obtain compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma Total extraction medicine.

6th, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma finished medicines are prepared：After total extraction medicine is measured by volume, from oral liquid Subtracted in 200 liters of total capacity, residual volume amount, calculate honey in 5: 5 ratio adds capacity with distilled water, and preservative is pressed 0.1% dosage calculates；It is standby that stainless steel cylindrical vessel, thick finished medicines, honey, distilled water, the anti-corrosion that will be measured are risen with 300-400 Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling Divide and stir.

7th, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma filling sterilizing is packed：The oral liquid finished product to stir is added and filled Assembling device, the bottling capping of compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma is carried out with 200 milliliters of volumetric flasks；The compound recipe seaweed radix paeoniae rubrathe is obtained to resist Nasopharynx cancer treating oral liquid finished product；By bottled compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma finished product through high-temperature sterilization, adhesive label, mounted box Vanning, storage preserve sale.

8th, compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma is taken：Oral 20 milliliters every time, 1 twice.

Claims (7)

1. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma formula is formulated, it is characterized in that：20 grams of marine alga, 20 grams of the radix paeoniae rubrathe, 20 grams of the tuber of dwarf lilyturf, 20 grams of the root of straight ladybell, 10 grams of chrysanthemum indicum, 10 grams of the stem of noble dendrobium, 10 grams of black nightshade, honey and distillation water consumption, by 5: 5 volume measurements, preservative is used Amount 0.1%.

2. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma materials procurement, it is characterized in that：First determine the anti-nasopharynx of the compound recipe seaweed radix paeoniae rubrathe This batch of cancer treating oral liquid always produce total bottle number, every bottle of capacity, production total capacity, every bottle take number of days, take total number of days, by formula And take total number of days and calculate the total expense of every kind of tcm and herbal slice, graded kind is purchased, the various tcm and herbal slices of buying Have to comply with the quality index and specification standards of every kind of tcm and herbal slice, without go mouldy, it is no disease and pests harm, free from admixture, pollution-free；75% It is 2: 1 that etoh solvent, which is purchased with tcm and herbal slice total amount buying ratio,.

3. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma raw material are processed, it is characterized in that：It is right in addition to honey, distilled water, preservative Every kind of tcm and herbal slice is carried out selected and dried, and after being sufficiently mixed uniformly, is first crushed with 8 millimeters of particle diameter pulverizers, then with 4 millimeters Particle diameter pulverizer crushes standby.

4. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma tcm and herbal slice extracts active ingredients, it is characterized in that：Take alcohol extracting-water precipitating Method is carried out, patent of invention (application number 201710572547.2) " the medicinal herb componentses suit circle designed using the applicant, applied Cylinder electric circulation automatic fitration percolating extractor " carries out seepage pressure effects；The device is by percolating extractor support, suit cylinder Percolating device, electric pump circulatory displacement device, diacolation solution automatic filtering unit, temperature automatically controlled hot water circulating heating device, diacolation Solvent evaporating separation device, the part of diacolation solvent condensate recycling device seven composition；The percolating extractor operation technological process is： 1. close diacolation solution control valve-→ open charging closure-→ meter feedstock load inner cylinder-→ layering load actual situation uniformly- → add diacolation solvent and drench in circular groove-→ circular groove and be slowly added to diacolation solvent-→ solvent and uniformly drench into raw material-→ push down circular groove Not float-→ solvent add to no longer drench 5 centimetres away from circular groove bottom only-→ circular hole in the middle part of closure is rotated to drenching in circular groove Diacolation solution circulation pump-→ regulation diacolation solution circulating valve is opened on side-→ does not make diacolation solution overflow only-→ closing diacolation solution Circulating pump-→ closes charging closure and penetrates-→ the unlatching diacolation solution circulation pump circulation in 36 hours of screw tightening-→ standing diacolation Diacolation 36 hours-→ closes diacolation solution circulation pump-→ and opens diacolation solution control valve-→ diacolation solution and filtered through internal barrel bottom Net automatic fitration-→ through diacolation solution control valve-→ diacolation solution inflow evaporative cylinder top screen pack natural filtration-→ filtered fluid Flow into diacolation solution evaporative cylinder bottom-→ opening charging closure-→ unlatching diacolation solution circulation pump-→ and determine internal barrel bottom mistake Whether filter screen, which filters, which is terminated ,-→ 2. terminates filtering and closes diacolation solution control valve-→ and add new diacolation solvent-→ to carry out secondary follow - → opens the control of diacolation solution after the completion of ring seepage pressure effects (operating process is identical with first time)-→ secondary cycle seepage pressure effects Valve-→ secondary diacolation solution through the screen pack automatic fitration of internal barrel bottom-→ to flow into diacolation solution evaporative cylinder top screen pack natural Filtering-→ secondary diacolation solution flows into diacolation solution evaporative cylinder bottom-→ and-→ is mixed with first time diacolation solution and 3. takes out inner cylinder Pour out dregs of a decoction cleaning-→ inner cylinder and be reentered into outer barrel-→ and close diacolation solution control valve-→ meter feedstock and load inner cylinder-→ Enter next seepage pressure effects program-→ secondary diacolation solution evaporative cylinder self-filtering net filtration terminate-→ 4. connect water source-→ to heat Water tank, hot water storgae, condenser add water-→ to open electromagnetic stove to boiler heating-→ unlatching hot water circulating pump-→ boiler and heat Tank hot water starts the cycle over-→ to diacolation solution evaporative cylinder heat-→ 5. open automatic temperature control instrument-→ regulation temperature controller high temperature to 90 DEG C, low temperature to 80 DEG C-→ hot water storgae water temperature rise to 90 DEG C of electromagnetic stoves close automatically-→ hot water storgae water temperature is down to 80 DEG C of electromagnetic stoves Automatic opening-→ evaporative cylinder diacolation solution solvent evaporation-→ solvent evaporate gas through gas delivery pipe-→ 6. gas be sent into condensation Device solvent gas merging chamber-→ solvent gas is condensed into liquid-→ liquid into condenser spiral condensing tube and enters condenser Condensing solvent collecting chamber-→ flow into condensing solvent recovery cylinder-→ be put into condensing solvent storage barrel-→ recycle or storage-→ 7. opening diacolation solution evaporative cylinder bottom valve-→ coarse extraction medicine is put into storage barrel-→ heavy stirring of the heavy agitator-→ water of preparation water Device add account for extraction medicine 60% distilled water-→ be slowly added to extract medicine quickly stir-→ stir load precipitation cylinder-→ put Enter 0--5 DEG C of refrigerator or freezer low-temperature precipitation-→ precipitation completion pour out supernatant-→ the anti-nasopharyngeal carcinoma of the compound recipe seaweed radix paeoniae rubrathe is oral Liquid always extracts medicine.

5. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma finished medicines are prepared；It is characterized in that：After total extraction medicine is measured by volume, from mouth Take in 200 liters of liquid total measurement (volume) amount and subtract, residual volume amount, calculate honey and distillation water capacity in 5: 5 ratio, preservative is pressed 0.1% dosage calculates；It is standby that stainless steel cylindrical vessel is risen with 300-400, by the total extraction medicine measured, honey, distilled water, anti-corrosion Agent adds stainless steel cylindrical vessel, is mixed, elder generation's stirring at low speed, constantly regulate to high-speed stirred during stirring, until filling Divide and stir.

6. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma filling sterilizing is packed；It is characterized in that：The oral liquid finished product that will be stirred Filling apparatus is added, oral liquid bottling capping is carried out with 200 milliliters of volumetric flasks；Compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma into Product；Bottled oral liquid finished product is preserved into sale through high-temperature sterilization, adhesive label, mounted box vanning, storage.

7. compound recipe seaweed radix paeoniae rubrathe oral liquids against nasopharyngeal carcinoma is taken；It is characterized in that：Oral 20 milliliters every time, 1 twice.