CN107020009A - A kind of digestion procedure of space hydrogen peroxide - Google Patents
A kind of digestion procedure of space hydrogen peroxide Download PDFInfo
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- CN107020009A CN107020009A CN201611269038.4A CN201611269038A CN107020009A CN 107020009 A CN107020009 A CN 107020009A CN 201611269038 A CN201611269038 A CN 201611269038A CN 107020009 A CN107020009 A CN 107020009A
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- hydrogen peroxide
- space
- digesting enzyme
- enzyme preparation
- digestion procedure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/74—General processes for purification of waste gases; Apparatus or devices specially adapted therefor
- B01D53/84—Biological processes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/46—Removing components of defined structure
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D53/00—Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases, aerosols
- B01D53/34—Chemical or biological purification of waste gases
- B01D53/74—General processes for purification of waste gases; Apparatus or devices specially adapted therefor
- B01D53/76—Gas phase processes, e.g. by using aerosols
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
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- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Environmental & Geological Engineering (AREA)
- Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
Abstract
The invention discloses a kind of digestion procedure of space hydrogen peroxide, biologically digesting enzyme preparation is produced into aerosol in the way of spraying, the aerosol of atomization with particulate form disperse be suspended in needed for clear up in space or sealing space, the gaseous state or dry fog state hydrogen peroxide in closed environment are cleared up in Brownian movement mode.The present invention is by digestion instrument to the biologically digesting enzyme preparation that atomization is sprayed in space to be cleared up or sealing space, the biologically digesting enzyme preparation of atomization can reduce the concentration of hydrogen peroxide remained in closed environment rapidly, without nuisance generation, recover environment utilization ratio, reduce the harm to personnel health and environment, electricity, gas are saved, energy consumption is reduced.The inventive method is practical simple, clears up hydrogen peroxide effective.Apparatus of the present invention are simple in construction, are easy to quick connection.
Description
Technical field
The present invention relates to a kind of rapid-digestion method of space environment disinfectant, gaseous state and dry fog peroxidating are based especially on
After hydrogen sterilization in rapid-digestion air residual hydrogen dioxide method.
Background technology
Hydrogen peroxide is a kind of disinfectant efficiently, environmentally friendly.Environment is carried out using the hydrogen peroxide of vaporization or spray pattern
Fumigation, space especially closed to one carries out high level disinfection processing, it has also become one kind is by more and more widely used life
Thing decontamination measure.Generally with vaporized hydrogen peroxide (VHP), hydrogen peroxide steam (HPV) and hydrogen peroxide dry fog (HP~FOG) shape
Formula, by the field extensive use such as pharmaceuticals industry, bio-safety and hospital infection control, the sterilization of such as high-level clean room, part
Low temperature sterilizing and the terminal disinfection in the place such as ICU, ward online of pharmaceutical equipment, Biohazard Safety Equipment.It is this based on gaseous state or dry
The hydrogen peroxide of mist has stronger diffusivity and osmosis, therefore also has stronger fungicidal effectiveness.After treatment, disappeared
The hydrogen peroxide of higher concentration can be remained in poison ring border in longer time, health hazard can be produced to personnel, also can be to one
A little production activities and product quality have a negative impact, so as to influence to be sterilized the use of environment；On the other hand, when for biology
When the environment for learning experiment uses disinfectant with hydrogen peroxide, cytotoxicity, microorganism can be produced because of the presence of residual peroxide thing
Growth inhibition etc. influences the unfavorable factor of result of the test.Therefore, the quick hydrogen peroxide removed in environment is needed after sterilization, to drop
The adverse effect of low residual peroxide thing.
In existing removal air in the mode of residual hydrogen peroxide disinfectant, what is be widely used is carried out using air
Ventilation displacement or natural degradation method.Both modes, which exist, clears up that time-consuming, inefficiency and the problem of be difficult to cleared, this
Have a strong impact on the follow-up application for using, also therefore limiting this kind of disinfectant with hydrogen peroxide technology in processed region.
Also some similar researchs are directed to solving this problem, such as Chinese patent CN201310159540.X discloses one
Plant hydrogen peroxide steam and decompose filtering material, be that filling is golden using divalence is based between layer glass fiber air filtering material
Belong to ionic compound, such as manganese dioxide particulate filter is decomposed as catalyst, handled in the form of circulating filtration,
Root is it was found that partially long, the problem of energy consumption is big and less efficient that similarly there is digestion time.
The content of the invention
The present invention is that deficiency present in solution prior art is cleared up in hydrogen peroxide disappears there is provided a kind of residual peroxide
Solution thoroughly digestion procedure.
The present invention solve existing issue technical scheme method be：A kind of digestion procedure of space hydrogen peroxide, by biology
Clear up enzyme preparation and produce aerosol in the way of spraying, the aerosol of atomization be suspended in particulate form disperse needed for clear up sky
Between or sealing space in, the gaseous state or dry fog state hydrogen peroxide in closed environment are cleared up in Brownian movement mode.
As a further improvement, described every cubic metre of space spraying usage amount of biologically digesting enzyme preparation is 1~5ml.
As a further improvement, the aerosol particle particle diameter of described atomization is less than 10 μm.
As a further improvement, described aerosol is sterile aerosol；Described spraying is sterile spraying.
As a further improvement, described biologically digesting enzyme preparation includes 100mg~200mg peroxidating per 100ml components
Methanol that hydrogen enzyme dry powder, volume ratio are 1%~10%, the phosphate buffer that surplus is pH6.0~8.0, described biology disappear
Enzyme preparation copper ion concentration is solved for 1mmol/L~10mmol/L, activity of catalase is 2000U/ in biologically digesting enzyme preparation
Ml~3000U/ml.
As a further improvement, described methanol volume ratio is 2%；Described copper ion concentration is 2mmol/L；Described
Catalase dry powder is 200mg, and described phosphate buffer is pH 7.0.Peroxidating in described biologically digesting enzyme preparation
Hydrogen enzyme activity is 3000U/ml.
As a further improvement, the packing material of biologically digesting enzyme preparation can be positioned in space to be cleared up in advance.
As a further improvement, described condensation aerosol is divulged information while clearing up space hydrogen peroxide.
Compared with prior art, its advantage is to give space to be cleared up or sealing by digestion instrument to the present invention
The biologically digesting enzyme preparation of sprinkling atomization in space, the biologically digesting enzyme preparation of atomization can reduce what is remained in closed environment rapidly
Concentration of hydrogen peroxide, no nuisance generation, recovery environment utilization ratio, harm of the reduction to personnel health and environment, saving electricity,
Gas, reduces energy consumption.The inventive method is practical simple, clears up hydrogen peroxide effective.Apparatus of the present invention are simple in construction, are easy to quickly connect
Connect.
Brief description of the drawings
Fig. 1 is the structural representation of the device of the present invention.
Fig. 2-13 is concentration of hydrogen peroxide change curve in case study on implementation of the present invention.
Embodiment
The digestion procedure of the implementation case space such as hydrogen peroxide of isolator nacelle, by biologically digesting enzyme preparation to spray
Mode produce aerosol, the aerosol of atomization be suspended in particulate form disperse needed for clear up in space or sealing space,
The gaseous state or dry fog state hydrogen peroxide in closed environment are cleared up in Brownian movement mode.
Wherein, every cubic metre of space spraying usage amount of biologically digesting enzyme preparation is 1~5ml.The aerosol particle grain of atomization
Footpath is less than 10 μm, in order to which aerosol particle suspends, can uniformly be mixed with residual peroxide thing.Aerosol is that sterile gas is molten
Glue, sprays as sterile spraying.
Biologically digesting enzyme preparation include per 100ml components 100mg~200mg catalases dry powder, volume ratio be 1%~
10% methanol, surplus are the phosphate buffer of pH6.0~8.0, biologically digesting enzyme preparation copper ion concentration be 1mmol/L~
Activity of catalase is 2000U/ml~3000U/ml in 10mmol/L, biologically digesting enzyme preparation.
Preferably, methanol volume ratio is 2%；Catalase dry powder is 200mg；Copper ion concentration is 2mmol/L；Phosphorus
Phthalate buffer is pH 7.0, and the vigor of hydrogen peroxide enzyme preparation is 3000U/ml.
In order to reach aseptic result, the packing material of biologically digesting enzyme preparation can be positioned in space to be cleared up in advance.
Referring to Fig. 1, fog-spray nozzle 1 that digestion instrument includes being arranged in space to be cleared up, it is arranged at outside space and connects spraying
First 1 biologically digesting enzyme preparation pipeline 11 produces pipeline 12 with negative pressure, and biologically digesting enzyme preparation pipeline 11 is connected with biologically digesting
The storage tank 8 of enzyme preparation, negative pressure produce pipeline 12 from the one end of fog-spray nozzle 1 be connected with turn filter 2, flowmeter 3, pressure regulator valve 4,
Magnetic valve 5, air compressor machine 7, air compressor machine 7 and magnetic valve 5 are provided with controller 6.
Biologically digesting enzyme preparation is sprayed by digestion instrument, can be by biologically digesting enzyme preparation with less than specified particle diameter, sterile
The quick disperse of aerosol shape in confined space, the concentration of hydrogen peroxide remained in closed environment can be reduced rapidly, without harmful
Thing is generated, and recovers environment utilization ratio, reduces the harm to personnel health and environment, saves electricity, gas, reduces energy consumption.
On bulkhead 13 of the fog-spray nozzle 1 by the fixed in space dividing plate of nipple or isolator, fog-spray nozzle 1 can pass through spiral shell
Line joint or snap joint produce pipeline 12 with biologically digesting enzyme preparation pipeline 11 and negative pressure and are connected.
The tunnel of biologically digesting enzyme preparation pipe 11, which is located at, is additionally provided with sterilizing filter 9 between storage tank 8 and fog-spray nozzle 1.
Below in conjunction with specific embodiment, the invention will be further described.
1st, the hydrogen peroxide in air is cleared up after the completion of the sterilization of infection ward hydrogen peroxide steam.
1) carry out arranging residual using the air-conditioning system of traditional rooms.
Using portable vaporized hydrogen peroxide generator to 80m3Ward is infected, portable vaporized hydrogen peroxide generator
Run background environment condition：20~25 DEG C of temperature, relative humidity 60% carries out terminal disinfection, work using hydrogen peroxide steam
Parameter is set to：
Disinfecting process concentration of hydrogen peroxide change curve such as Fig. 2,3,4.
After three experiments terminate, residual peroxide concentration is respectively 1.4mg/m inside infection ward3, 1.2mg/m3,
1.4mg/m3。
2) row of progress is residual by the way of ventilation is combined with biologically digesting enzyme, uses portable vaporized hydrogen peroxide generator
To 80m3Infecting ward, (equipment runs background environment condition：20~25 DEG C of temperature, relative humidity 60%) steamed using hydrogen peroxide
Vapour carries out terminal disinfection, and running parameter is set to：
The implementation case includes methanol volume ratio as 2% using every 100ml biologically digestings enzyme preparation, and copper ion concentration is
Exemplified by 2mmol/L, catalase 200mg, pH 7.0 phosphate buffered saline biologically digesting enzyme, and pass through degerming mistake
Filter.Sterilize and terminate and after the air-conditioning system ventilation of 30 minutes in room, be combined using ventilation with sprinkling biologically digesting enzyme
Mode, immixture 30 minutes, as a result such as following table：
Concentration of hydrogen peroxide change curve such as Fig. 5,6,7.
3) from the point of view of the result of two groups of experiments, divulged information the side being combined with sprinkling biologically digesting enzyme using room air conditioning system
Formula can the row's of greatly shortening residual time.
2. clear up residual hydrogen dioxide in Sterilized isolator.
1) carry out arranging residual using draft type.
Bio-decontaminated is carried out using vaporized hydrogen peroxide in Sterilized isolator, to the stearothermophilus gemma with typical drag
Bacillus (ATCC#7953) reaches 6 logarithm killing effects, and it is residual with arranging to carry out sterilization cycle using following parameter：
Concentration of hydrogen peroxide change curve such as Fig. 8,9,10.
After three experiments terminate, residual peroxide concentration is respectively 4.9mg/m inside Sterilized isolator nacelle3,
5.3mg/m3, 6.3mg/m3。
2) row of progress is residual by the way of ventilation is combined with biologically digesting enzyme.
Bio-decontaminated is carried out using vaporized hydrogen peroxide in Sterilized isolator, to the stearothermophilus gemma with typical drag
Bacillus (ATCC#7953) reaches the killing effect of 6 logarithms, and it is residual with arranging to carry out sterilization cycle using following parameter：
Methanol volume ratio is included as 2% using every 100ml biologically digestings enzyme preparation, copper ion concentration is 2mmol/L, peroxide
Exemplified by the phosphate buffered saline biologically digesting enzyme for changing hydrogen enzyme 200mg, pH 7.0, above-mentioned enzyme preparation is diluted to 10 times of dilutions
Liquid prepares biologically digesting enzyme preparation, and passes through aseptic filtration.Sterilizing is completed in isolator and after the ventilation of 30 minutes, is used
Ventilation is with spraying the mode that is combined of biologically digesting enzyme, in immixture after 10 minutes, nacelle internal residual concentration such as following table：
Concentration of hydrogen peroxide change curve such as Figure 11,12,13.
1) from the point of view of the result of two groups of experiments, it can be contracted significantly by the way of sprinkling biologically digesting enzyme is combined using ventilation
Short row's residual time, and row residual effect fruit is more thorough.
Certainly, it is 1% that biologically digesting enzyme preparation, which includes 100mg~200mg catalases, volume ratio per 100ml components,
~10% methanol, surplus are the phosphate buffer of pH6.0~8.0, and described biologically digesting enzyme preparation copper ion concentration is
Activity of catalase is 2000U/ml~3000U/ml in 1mmol/L~10mmol/L, biologically digesting enzyme preparation, takes above-mentioned
Interval any ratio can also clear up the hydrogen peroxide of residual.
Claims (10)
1. a kind of digestion procedure of space hydrogen peroxide, it is characterised in that：Biologically digesting enzyme preparation is produced in the way of spraying
Aerosol, the aerosol of atomization be suspended in particulate form disperse needed for clear up in space or sealing space, with Brownian movement
Mode clears up gaseous state or dry fog state hydrogen peroxide in closed environment.
2. the digestion procedure of space hydrogen peroxide as claimed in claim 1, it is characterised in that：Described biologically digesting enzyme preparation
Every cubic metre of space spraying usage amount is 1 ~ 5ml.
3. the digestion procedure of space hydrogen peroxide as claimed in claim 1, it is characterised in that：The aerosol of described atomization
Grain particle diameter is less than 10 μm.
4. the digestion procedure of the space hydrogen peroxide as described in claim 1 or 3, it is characterised in that：Described aerosol is nothing
Bacterium aerosol；Described spraying is sterile spraying.
5. the digestion procedure of space hydrogen peroxide as claimed in claim 1 or 2, it is characterised in that：Described biologically digesting enzyme
Preparation includes 100mg~200mg catalases dry powder, the methanol that volume ratio is 1%~10%, surplus per 100ml components
The phosphate buffer of pH6.0~8.0, described biologically digesting enzyme preparation copper ion concentration is the mmol/L of 1mmol/L~10,
Activity of catalase is the U/ml of 2000 U/ml~3000 in biologically digesting enzyme preparation.
6. the digestion procedure of space hydrogen peroxide as claimed in claim 5, it is characterised in that：Described methanol volume ratio is
2%；Described copper ion concentration is 2mmol/L；Described catalase dry powder is 200mg.
7. the digestion procedure of space hydrogen peroxide as claimed in claim 5, it is characterised in that：Described biologically digesting enzyme system
Activity of catalase is 3000 U/ml in agent.
8. the digestion procedure of space hydrogen peroxide as claimed in claim 5, it is characterised in that：Described phosphate buffer is
pH 7.0。
9. the digestion procedure of space hydrogen peroxide as claimed in claim 1, it is characterised in that：Can be in advance by biologically digesting enzyme system
The packing material of agent is positioned in space to be cleared up.
10. the digestion procedure of space hydrogen peroxide as claimed in claim 1, it is characterised in that：Described condensation aerosol disappears
Divulged information while solution space hydrogen peroxide.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611269038.4A CN107020009A (en) | 2016-12-31 | 2016-12-31 | A kind of digestion procedure of space hydrogen peroxide |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201611269038.4A CN107020009A (en) | 2016-12-31 | 2016-12-31 | A kind of digestion procedure of space hydrogen peroxide |
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| CN107020009A true CN107020009A (en) | 2017-08-08 |
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| CN201611269038.4A Pending CN107020009A (en) | 2016-12-31 | 2016-12-31 | A kind of digestion procedure of space hydrogen peroxide |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116602314A (en) * | 2023-05-26 | 2023-08-18 | 浙江国药景岳气雾剂有限公司 | Spatial disinfectant capable of being suspended permanently and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103418002A (en) * | 2013-08-20 | 2013-12-04 | 叶明� | Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device |
| CN104127904A (en) * | 2013-05-03 | 2014-11-05 | 威海威高海盛医用设备有限公司 | Hydrogen peroxide vapor decomposing device |
-
2016
- 2016-12-31 CN CN201611269038.4A patent/CN107020009A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127904A (en) * | 2013-05-03 | 2014-11-05 | 威海威高海盛医用设备有限公司 | Hydrogen peroxide vapor decomposing device |
| CN103418002A (en) * | 2013-08-20 | 2013-12-04 | 叶明� | Tunnel-type hydrogen peroxide sterilization method and tunnel-type hydrogen peroxide sterilization device |
Non-Patent Citations (1)
| Title |
|---|
| 曹健等: "《食品酶学》", 28 February 2011, 郑州大学出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116602314A (en) * | 2023-05-26 | 2023-08-18 | 浙江国药景岳气雾剂有限公司 | Spatial disinfectant capable of being suspended permanently and preparation method thereof |
| CN116602314B (en) * | 2023-05-26 | 2024-03-12 | 浙江国药景岳气雾剂有限公司 | Spatial disinfectant capable of being suspended permanently and preparation method thereof |
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Application publication date: 20170808 |
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