CN106806933B - Use of polyamide gauze as wound dressing - Google Patents
Use of polyamide gauze as wound dressing Download PDFInfo
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- CN106806933B CN106806933B CN201710029823.0A CN201710029823A CN106806933B CN 106806933 B CN106806933 B CN 106806933B CN 201710029823 A CN201710029823 A CN 201710029823A CN 106806933 B CN106806933 B CN 106806933B
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- 239000004952 Polyamide Substances 0.000 title claims abstract description 56
- 229920002647 polyamide Polymers 0.000 title claims abstract description 56
- 206010053615 Thermal burn Diseases 0.000 claims abstract description 13
- 208000008960 Diabetic foot Diseases 0.000 claims abstract description 11
- 239000011148 porous material Substances 0.000 claims abstract description 6
- 208000027418 Wounds and injury Diseases 0.000 abstract description 116
- 206010052428 Wound Diseases 0.000 abstract description 114
- 230000008859 change Effects 0.000 abstract description 11
- 230000000694 effects Effects 0.000 abstract description 10
- 230000035876 healing Effects 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 4
- 208000015181 infectious disease Diseases 0.000 abstract description 3
- 239000000463 material Substances 0.000 abstract description 3
- 206010014568 Empyema Diseases 0.000 abstract description 2
- 206010018833 Haematocoele Diseases 0.000 abstract description 2
- 208000005873 Hematocele Diseases 0.000 abstract description 2
- 241000521257 Hydrops Species 0.000 abstract description 2
- 206010030113 Oedema Diseases 0.000 abstract description 2
- 208000033809 Suppuration Diseases 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- 201000004920 hematocele of tunica vaginalis testis Diseases 0.000 abstract description 2
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 9
- 229940099259 vaseline Drugs 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 208000014674 injury Diseases 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000002329 infrared spectrum Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010000269 abscess Diseases 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000013480 data collection Methods 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035778 pathophysiological process Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000002759 woven fabric Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses application of polyamide gauze as wound dressing. The polyamide gauze is used as wound dressing, and due to the characteristics of the material, the thickness and the mesh pore size are combined, so that the polyamide gauze can be tightly attached to a wound, blood, pus and the like exuded from the wound can be smoothly discharged, hydrops, hematocele or empyema can be avoided, the moisturizing effect of the wound can be taken into consideration, and the wound can be prevented from being dried; therefore, the invention is suitable for dressing change treatment of various wound wounds, wound surfaces, operation incisions and the like, has the effect of promoting tissue healing, and particularly has remarkable advantages for treatment of refractory wound surfaces such as burn wound surfaces, infection wound surfaces, diabetic foot wound surfaces and the like. When the polyamide gauze is used for treating II-degree burn (scald) wound surfaces and diabetic foot wound surfaces, pain caused by dressing change is light, and the dressing change adaptability of patients can be improved.
Description
Technical Field
The invention relates to application of polyamide gauze as wound dressing, belonging to new application of medical materials.
Background
Wound healing is a complex pathophysiological process of an organism to external injury, and a large amount of clinical data show that the wound can be kept moist by applying sterile dressing to cover the wound to play a role in promoting wound healing, but the mechanism of promoting wound healing by different dressings is not clear yet.
After deep burn, a large area of wound surface is usually left on the body surface of a patient, and the healing of the wound surface is a complex physiological process of the body to the external injury and is also a precondition for the body to recover the normal function. The dressing covering of the wound surface caused by burn after the skin grafting operation can reduce the exposure of the skin piece gap and is beneficial to the storage of water electrolyte, protein and heat in the body. However, the effect of the dressings made of different materials on the healing effect of the wound surface is not very clear, and the different healing effects of the dressings in different microenvironments of the wound surface also attract the attention of a plurality of clinicians. In recent years, polyamide gauze has achieved better treatment effects clinically as a carrier of a Meek skin sheet, a transplant support and a wound covering, but reports on whether polyamide gauze can promote wound healing are few. The literature reports the use of polyamide gauze (manufactured by the netherlands Humeca BV company) for healing after skin grafting of deep burn wounds (caochengcheng, et al, comparison of the effects of different dressings on healing after skin grafting of deep burn wounds, volume 22, 11, 6 months in 2013, cosmetic medicine in china), the use of polyamide gauze for other wounds and less further research on polyamide.
Disclosure of Invention
The invention aims to provide application of polyamide gauze as wound dressing.
The polyamide gauze provided by the invention is used as wound dressing.
The polyamide gauze has a warp density of 230-250 pieces/10 cm, a weft density of 200-230 pieces/10 cm and a yarn diameter of 20-25 microns. The pore size of the polyamide gauze is 20 multiplied by 104～35×104Square micron.
Further, the wound surface is a burn wound surface.
Further, the burn and scald wound surface is a II-degree burn and scald wound surface.
Further, the wound surface is a diabetic foot wound surface.
Furthermore, the wound surface is a skin supply area wound surface of a medium-thickness fault skin sheet.
Further, the wound surface is a superficial wound surface.
Furthermore, the superficial wound surface comprises wound surfaces of limb trauma, operation incision, abscess or sinus tract formation.
The polyamide gauze is used as wound dressing, and due to the characteristics of the material, the thickness and the mesh pore size are combined, so that the polyamide gauze can be tightly attached to a wound, blood, pus and the like exuded from the wound can be smoothly discharged, hydrops, hematocele or empyema can be avoided, the moisturizing effect of the wound can be taken into consideration, and the wound can be prevented from being dried; therefore, the invention is suitable for dressing change treatment of various wound wounds, wound surfaces, operation incisions and the like, has the effect of promoting tissue healing, and particularly has remarkable advantages for treatment of refractory wound surfaces such as burn wound surfaces, infection wound surfaces, diabetic foot wound surfaces and the like. When the polyamide gauze is used for treating II-degree burn (scald) wound surfaces and diabetic foot wound surfaces, pain caused by dressing change is light, and the dressing change adaptability of patients can be improved.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Drawings
FIG. 1 is an infrared spectrum of a polyamide gauze of the present invention.
Figure 2 is a diagram of a product of polyamide gauze of the present invention.
Fig. 3 is an enlarged view of a portion of the polyamide gauze of the present invention.
Fig. 4 is a product diagram of vaseline gauze of a control group.
Fig. 5 is a partially enlarged view of vaseline gauze of the control group.
Fig. 6 is a graph comparing the clinical application effects of polyamide gauze of the present invention and vaseline gauze of a control group as wound dressing for suturing wound.
Fig. 7 is a graph showing the clinical application effect of the polyamide gauze of the present invention as a chronic sinus wound dressing.
Fig. 8 is a diagram of the clinical application effect of the polyamide gauze of the present invention as a wound dressing.
FIG. 9 is a clinical comparison of the polyamide gauze dressing of the present invention with a polyamide gauze dressing of cymeca, the Netherlands
Detailed Description
The raw materials and equipment used in the embodiment of the present invention are known products and obtained by purchasing commercially available products.
Test example 1 clinical test of the polyamide gauze of the present invention as a wound dressing
1. Selection of wound dressing
The polyamide gauze of the invention: the polyamide gauze is purchased from Mingdu medical materials Co., Ltd, detected according to the methods of FZ/T64015-2009 woven filter cloth and GB/T4668-1995 determination of woven fabric density, and then the properties and parameters of the polyamide gauze are identified by infrared spectrum analysis.
The infrared spectrum is shown in figure 1, 3307cm-1、1650cm-1、1200cm-1The characteristic peak of amide appears nearby, which indicates that the gauze is polyamide gauze.
The invention selects polyamide gauze (as shown in figure 2): the warp density was 237.5 threads/10 cm, the weft density was 215 threads/10 cm, the yarn diameter was 20.4 microns, and the pore size is shown in FIG. 3.
Control group: the size of the pores of the medical vaseline gauze (shown in fig. 4) is shown in fig. 5.
2. Inclusion and exclusion criteria for wound surface
The inclusion standards include ⑴, 45 people with II-degree burn (scald) wound surface, ⑵ people with 12 diabetic foot wound surfaces, ⑶, 30 people with middle-thickness fault skin-supplying zone wound surfaces (wound surfaces formed by skin with the thickness of about 0.5-0.6 mm and including epidermis and partial dermis), ⑷ and 50 other superficial wound surfaces (wound surfaces formed by limb trauma, various surgical incisions, abscess, sinus and the like).
The exclusion standard is ⑴ for pregnant women, ⑵ for clear infected wounds, ⑶ for other reasons unsuitable for clinical observation and study.
3. Test grouping and control
The polyamide gauze and the Vaseline gauze of the control group are respectively used as wound dressing, are pasted on the selected acute and chronic wounds, and are bound according to the wounds, and the specific grouping and control conditions are as follows:
the random grouping is that ① the same wound surface is divided by a long axis of a limb and is respectively brought into an experimental group and a control group (namely, the difference between the proximal end and the distal end is avoided), ② two independent wound surfaces are provided, the depth and the size of the two wound surfaces are compared, ③ wound surfaces are debrided and disinfected by the same method, an experimental group (E) and a control group (C) are marked by a marker pen and then are photographed, the experimental group (E) uses the polyamide gauze, and the control group (C) uses Vaseline gauze.
The acquisition time of the photos and the data is ① before treatment, namely before wound debridement treatment, ② when changing the drug, namely 3-7 days after the treatment for the first time, ③ when the wound is completely healed, ④ other clinicians think that the photos (such as infection, allergy and the like) need to be acquired, and the acquisition time of the photos is noted.
Standard for photograph and data collection ① photograph area is clean, preferably with blue or white background, to ensure the mark of experimental group (E) and control group (C) is clear, ② wound surface is not marked with color disinfectant (such as iodophor), or washed with normal saline after use until the color of wound surface base is shown.
4. Evaluation criteria and results
① wound exudation, see Table 1.
TABLE 1 comparison of wound exudation
The results show that the polyamide gauze provided by the invention is used as wound dressing, the exudation of the wound is light, and particularly, the polyamide gauze is used for burn wounds and diabetic foot wounds.
② feeling pain, itching or other discomfort;
visual analog Scale/Score (VAS for short): the method is sensitive and comparable.
A 10cm transverse line is drawn on the paper, and one end of the transverse line is 0, so that no pain is caused; the other end is 10, which indicates severe pain; the middle part indicates different degrees of pain. The patient can mark a mark on the horizontal line according to self-sensation to indicate the pain degree. The mean value of mild pain is 2.57 +/-1.04; mean moderate pain of 5.18 ± 1.41; mean value of severe pain 8.41 ± 1.35.
The polyamide gauze of the invention is used as the dressing for II-degree burn (scald) wound surfaces, and the scoring result is shown in table 2.
TABLE 2 VAS score of the polyamide gauze of the invention as a dressing for II degree burn (scald) wounds (P <0.05, statistical significance)
The results show that the polyamide gauze as the wound dressing for II-degree burn (scald) causes less pain to patients, and the pain of the patients is aggravated along with the increase of dressing change times.
The polyamide gauze of the invention is used as the dressing for the wound surface of the diabetic foot, and the scoring result is shown in table 3.
Table 3 VAS scores of polyamide gauze of the invention as a diabetic foot wound dressing (P <0.05, with significant differences)
The results show that the polyamide gauze provided by the invention is used as the wound dressing for the diabetic foot, the pain of the patient is light, and the pain of the patient is relieved along with the increase of the dressing change times, which is quite opposite to the change trend of the pain of the wound patient with II-degree burn (scald).
The polyamide gauze of the invention is used as other superficial wound dressings, and the scoring result is shown in table 4.
Table 4 VAS scores (P <0.05, statistically significant) of polyamide gauze of the invention as dressings for other superficial wounds (various surgical suture wounds)
The results show that the polyamide gauze of the invention is used as other superficial wound dressings, the pain of patients is light, and the pain of patients is relieved along with the increase of dressing change times, which is quite opposite to the change trend of the pain of patients with II-degree burn (scald) wound dressings.
③ wound healing time, recording the day after wound, see Table 5;
TABLE 5 comparison of wound healing time (P <0.05, statistical significance)
The results show that the polyamide gauze provided by the invention can be used as wound dressing, so that the wound can be quickly healed in a short time, and the time for patients to suffer from pain is greatly reduced.
⑤ the clinical application effect chart of the polyamide gauze as the wound dressing is shown in figures 6-8.
Experimental example 2 clinical comparison of polyamide gauze dressing of the present invention with polyamide gauze dressing of cymeca in the netherlands:
the mesh aperture of the polyamide gauze dressing of the invention is as follows: (500. + -. 50). mu. mx (500. + -. 50) μm; the mesh aperture of the polyamide gauze dressing (shown by the official gay of the company) of the Holland humeca is far larger than that of the gauze of the invention in both 1:3 and 1:1.5 varieties from the wound surface picture of a patient, and is more than 3000 micrometers multiplied by 3000 micrometers. Therefore, the invention is different from the Dutch product, the small mesh aperture of the invention can keep the wound surface moist to a certain extent to promote the growth of granulation tissue and the regeneration of epithelium, and on the other hand, the invention still keeps good permeability, for example, in figure 9, tendon exposes the wound surface, exudate can completely pass through dressing, and the invention has good treatment effect on the infected wound surface, and fresh granulation growth can be seen; the large mesh of the Dutch product can dry the wound surface quickly, which is not beneficial to wound surface repair and regeneration.
The invention is not only used for burn wounds, but also used for treating various wounds, including wounds difficult to heal by diabetes, wound suture wounds, conventional operation incisions and the like, and Dutch products are suitable for skin grafting of burn MEEK and are not used in other situations.
Claims (3)
1. The polyamide gauze is used as a wound dressing, the wound is a burn wound and a scald wound and a diabetic foot wound, the warp density of the polyamide gauze is 230-250 pieces/10 cm, the weft density of the polyamide gauze is 200-230 pieces/10 cm, and the yarn diameter is 20-25 microns.
2. Use according to claim 1, characterized in that: the pore size of the polyamide gauze is 20 multiplied by 104～35×104Square micron.
3. Use according to claim 2, characterized in that: the burn and scald wound surface is a II-degree burn and scald wound surface.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710029823.0A CN106806933B (en) | 2017-01-14 | 2017-01-14 | Use of polyamide gauze as wound dressing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710029823.0A CN106806933B (en) | 2017-01-14 | 2017-01-14 | Use of polyamide gauze as wound dressing |
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| Publication Number | Publication Date |
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| CN106806933A CN106806933A (en) | 2017-06-09 |
| CN106806933B true CN106806933B (en) | 2020-04-21 |
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| CN201710029823.0A Expired - Fee Related CN106806933B (en) | 2017-01-14 | 2017-01-14 | Use of polyamide gauze as wound dressing |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108434505A (en) * | 2018-03-20 | 2018-08-24 | 广州华生物科技有限公司 | A kind of nylon fiber medical dressing |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1743013A (en) * | 2005-09-28 | 2006-03-08 | 河南飘安高科股份有限公司 | Vaseline non-woven fabric dressing |
| CN103668617A (en) * | 2012-08-31 | 2014-03-26 | 康力得生技股份有限公司 | Natural polymer yarn, manufacturing method thereof, mesh fabric and application of the mesh fabric |
| CN106075592A (en) * | 2015-05-29 | 2016-11-09 | 杭州弘复医疗科技有限公司 | Multi-functional skin or wound surface combine dressing as reproducibility Graftskin |
| CN106178072A (en) * | 2016-07-28 | 2016-12-07 | 湖南帝星智能科技有限公司 | Alginate fibre, bamboo fibre and collagen protein prepare medical dressing and method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1743013A (en) * | 2005-09-28 | 2006-03-08 | 河南飘安高科股份有限公司 | Vaseline non-woven fabric dressing |
| CN103668617A (en) * | 2012-08-31 | 2014-03-26 | 康力得生技股份有限公司 | Natural polymer yarn, manufacturing method thereof, mesh fabric and application of the mesh fabric |
| CN106075592A (en) * | 2015-05-29 | 2016-11-09 | 杭州弘复医疗科技有限公司 | Multi-functional skin or wound surface combine dressing as reproducibility Graftskin |
| CN106178072A (en) * | 2016-07-28 | 2016-12-07 | 湖南帝星智能科技有限公司 | Alginate fibre, bamboo fibre and collagen protein prepare medical dressing and method |
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