CN106178072A - Alginate fibre, bamboo fibre and collagen protein prepare medical dressing and method - Google Patents
Alginate fibre, bamboo fibre and collagen protein prepare medical dressing and method Download PDFInfo
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- CN106178072A CN106178072A CN201610602923.3A CN201610602923A CN106178072A CN 106178072 A CN106178072 A CN 106178072A CN 201610602923 A CN201610602923 A CN 201610602923A CN 106178072 A CN106178072 A CN 106178072A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
- A61L15/325—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F1/00—General methods for the manufacture of artificial filaments or the like
- D01F1/02—Addition of substances to the spinning solution or to the melt
- D01F1/10—Other agents for modifying properties
- D01F1/103—Agents inhibiting growth of microorganisms
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- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/02—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from cellulose, cellulose derivatives, or proteins
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01F—CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS; APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBON FILAMENTS
- D01F8/00—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof
- D01F8/18—Conjugated, i.e. bi- or multicomponent, artificial filaments or the like; Manufacture thereof from other substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention discloses medical dressing and method thereof that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the percentage by weight of each several part raw material is: alginate fibre bamboo fibre collagen protein=2 1 ~ 34 ~ 8, this medical dressing has part degradability, good hemostasis, moisture sorption effect, and natural antibacterial, deodorant.Its preparation method is, first prepares the calcium alginate fibre mixture of necessity, collagen solution, and bamboo fibre serosity, by a series of process such as stirring, heating after mixing, uses fixing spinning head to be finally made required mixing medical fibre dressing.
Description
Technical field
Medical dressing that the present invention relates to bio-based and preparation method thereof, belongs to medical devices field.
Background technology
Bamboo fibre, alginate fibre are applied the most extensive in terms of medical dressing.
The advantage of bamboo fibre is a lot, and it is natural antibacterial, antibacterial material, uvioresistant, deodorant, good breathability and
Water absorption makes it be widely used in other textile fabric, but, pure bamboo fibre is the most crisp, it is impossible to firmly twists and rubs, the most easily
Breakage, and the conventional bamboo cotton easy adhesive hair of mixed textile product, if for medical dressing, be easily sticked to wound, when opening dressing
Easily cause secondary injury.
Collagen protein has the physicochemical property of uniqueness, good biocompatibility so that alginate fibre and bamboo fibre can
Non-interference, and self can biodegradation.
The development of alginate fibre is very swift and violent, and good haemostatic effect, moisture absorption, moisturizing, biodegradability allow it win
The favor of numerous scientific research personnel, but its shortcoming is the most clearly, elastic and insufficient strength.And bamboo fibre wearability is strong, have
Unique resilience, the intensity of stronger portraitlandscape, the shortcoming that compensate for alginate fibre.Therefore, bamboo fibre and alginate fibre
Commingled yarn fabric will be that a kind of of medical dressing well selects.
Therefore, those skilled in the art is devoted to develop a kind of medical dressing that can merge three kinds of material advantages.
Summary of the invention
Because the drawbacks described above of prior art, the technical problem to be solved is to merge alginate fibre, bamboo fibre
The advantage of peacekeeping collagen protein prepares a kind of antibacterial, deodorant, ventilative, moisture absorption, moisturizing, good biocompatibility, degradable, hemostasis effect
The best, the medical dressing of good springiness.
For achieving the above object, the invention provides the Medical coating that a kind of alginate fibre, bamboo fibre and collagen protein prepare
Material, the percentage by weight of each several part raw material is:
Alginate fibre bamboo fibre collagen protein=2 1 ~ 34 ~ 8.
In the better embodiment of the present invention, the percentage by weight of each several part raw material is:
Alginate fibre bamboo fibre collagen protein=2 26.
Present invention also offers the preparation method of the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare,
Comprise the following steps:
Shuttle methyl chitosan fiber, ibuprofen, and collargol, silver ion or Nanocrystalline silver dressing is added in calcium alginate fibre
Obtain mixture；
Collagen protein powder is added in acetum, stir at a certain temperature to being completely dissolved；
Selected high-quality QINGZHU, by high temperature steaming and stirring, makes bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs a period of time so that it is mix homogeneously is consistent, then filters, bleaches；
Coagulating bath is made, under the temperature conditions of 20 ~ 80 DEG C, by the pressure of 0.1 ~ 0.6MPa nitrogen by saturated metabisulfite solution
Power, carries out spinning process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods are blended；
The fiber made is immersed in 30 ~ 70min in the ethanol solution of 25 ~ 75%, after shaking 6 ~ 10h under room temperature, takes out, then use
The warm water washing of 20 ~ 30 DEG C, is finally dried, obtains blended fiber.
Further, in spinning process, spinning head aperture 0.05, hole count 500 hole.
As the better embodiment of the present invention, comprise the following steps:
Calcium alginate fibre toward 700 ~ 1000 weight portions adds shuttle methyl chitosan fiber 2 ~ 4 weight portion of 50 ~ 100 weight portions
Ibuprofen, and the collargol of 3 ~ 4 weight portions, silver ion or Nanocrystalline silver dressing obtain mixture；
By the collagen protein powder of 1200 ~ 2000 weight portions, add the acetum of the 0.4mol/L of 10000 ~ 15000 weight portions,
Stir to being completely dissolved at a temperature of 10 DEG C；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 10 ~ 20 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 60 ~ 90min so that it is mix homogeneously is consistent, then filters, bleaching；
Coagulating bath is made, under the temperature conditions of 40 ~ 60 DEG C, by the pressure of 0.3 ~ 0.4MPa nitrogen by saturated metabisulfite solution
Power, carries out spinning process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods are blended；
The fiber made is immersed in 40 ~ 60min in the ethanol solution of 40 ~ 60%, after shaking 8h under room temperature, takes out, then with 25 DEG C
Warm water washing, be finally dried, obtain blended fiber.
Technique effect:The medical dressing of the present invention has a part degradability, good hemostasis, moisture sorption effect, and sky
The most antibacterial, deodorant.Its process characteristic is, first prepares the calcium alginate fibre mixture of necessity, collagen solution, and bamboo fibre
Serosity, by a series of process such as stirring, heating after mixing, uses fixing spinning head to be finally made required mixing medical
Fiber dressing.
Detailed description of the invention
Embodiment 1: the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the weight of each several part raw material
Percentage ratio is: alginate fibre bamboo fibre collagen protein=2 14, uses this percentage by weight, and the resilience of medical dressing is with strong
Spending on the weak side, the compatibility is slightly worse, somewhat ixoderm skin, and structure is the loosest, but has good haemostatic effect, can inhale
Wet, moisturizing, more soft.
Embodiment 2: the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the weight of each several part raw material
Percentage ratio is: alginate fibre bamboo fibre collagen protein=2 38, uses the medical dressing of this percentage by weight, good springiness, by force
Degree height, has good antibiotic property, biocidal property, uviolresistance, deodorant, breathability and water absorption, but material is partially hard partially
Crisp, may be used for special medical occasion.
Embodiment 3: the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the weight of each several part raw material
Percentage ratio is: alginate fibre bamboo fibre collagen protein=2 26, and the dressing resultant effect that this embodiment prepares is best, each group
The advantage brought is divided all to find full expression.Its stability is preferable, performance balance, in storing 6 months product do not occur outward appearance,
Loss on drying changes and keeps aseptic condition.The skin of the present invention glues stickiness test and shows that product can contact with wound face uniformly,
And not gluing glutinous skin, the wounded is without sense of discomfort.Owing to the cell adhesion of dressing is ten that medical dressing design needs to consider
Divide important problem.Dressing that is incorrect due to material and that cause adheres to granulation tissue, thus causes dressing to bring when removing
Secondary damage, including the adhesion to granulation, to the epithelial cell migrated, fibroblastic infringement of hypertrophy, even ratio does not makes
More serious with dressing.The superficial cell adhesion value of the test group of the present embodiment is the lowest, is substantially less than other three groups of matched groups, explanation
The hydrophilic of dressing of the present invention is high, water absorbing capacity is strong, thus is unfavorable for the adhesion of cell, and such dressing will not cause tissue to glue
Even.
Embodiment 4: the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the weight of each several part raw material
Percentage ratio is: alginate fibre bamboo fibre collagen protein=2 34,.Use the medical dressing of this percentage by weight, good springiness, by force
Degree height, has good antibiotic property, biocidal property, uviolresistance, deodorant, breathability and water absorption, but material is partially hard partially
Crisp, the compatibility is slightly worse, somewhat ixoderm skin, and structure is the loosest, may be used for special medical occasion.
Embodiment 5: the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, the weight of each several part raw material
Percentage ratio is: alginate fibre bamboo fibre collagen protein=2 18, uses this percentage by weight, and the resilience of medical dressing is with strong
Spending on the weak side, the compatibility is preferable, and toughness and other physical properties are slightly worse.But there is good haemostatic effect, can be with moisture absorption, guarantor
Wet, more soft.
Embodiment 6: the preparation method of the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, toward 700 weights
The calcium alginate fibre of amount part adds the ibuprofen of shuttle methyl chitosan fiber 4 weight portion of 100 weight portions, and 4 weight portions
Collargol obtain mixture；
By the collagen protein powder of 2000 weight portions, add the acetum of the 0.4mol/L of 15000 weight portions, the temperature of 10 DEG C
Lower stirring is to being completely dissolved；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 10 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 90min so that it is mix homogeneously is consistent, then filters, bleaching；
Make coagulating bath by saturated metabisulfite solution, under the temperature conditions of 40 DEG C, by the pressure of 0.3MPa nitrogen, spray
Silk process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods, spinning head aperture 0.05, hole count 500 hole is blended；
The fiber made is immersed in 60min in the ethanol solution of 40%, after shaking 8h under room temperature, takes out, then the warm water with 25 DEG C
Washing, is finally dried, obtains blended fiber.
Embodiment 7: the preparation method of the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, toward 1000
The calcium alginate fibre of weight portion adds the ibuprofen of shuttle methyl chitosan fiber 2 weight portion of 50 weight portions, and 3 weight portions
Nanocrystalline silver dressing obtain mixture；
By the collagen protein powder of 1200 weight portions, add the acetum of the 0.4mol/L of 10000 weight portions, the temperature of 10 DEG C
Lower stirring is to being completely dissolved；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 20 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 60min so that it is mix homogeneously is consistent, then filters, bleaching；
Make coagulating bath by saturated metabisulfite solution, under the temperature conditions of 60 DEG C, by the pressure of 0.4MPa nitrogen, spray
Silk process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods, spinning head aperture 0.05, hole count 500 hole is blended；
The fiber made is immersed in 40min in the ethanol solution of 60%, after shaking 8h under room temperature, takes out, then the warm water with 25 DEG C
Washing, is finally dried, obtains blended fiber.
Calcium alginate is a kind of Organic substance, powder, and white is light yellow the most indefinite, and odorless, tasteless is water insoluble, alginic acid
Containing substantial amounts of hydroxyl and carboxyl on the strand of sodium, with calcium chloride solution as cross-linking agent, the calcium alginate of crosslinking can be formed
Polymer, moisture content is high, and the good biological degradability having had and biocompatibility can be used for food processing, pharmacy.Carboxylic first
Base enclosure polysaccharide has important meaning in terms of medicine, chemical industry, environmental protection, health product, and it has stable character and antibacterial anti-sense
Dye, blood fat reducing and prevent and treat the pharmacological actions such as arteriosclerosis.Ibuprofen has antiinflammatory, analgesia, refrigeration function.Nanometer silver is exactly by particle diameter
Accomplishing nano level argent simple substance, nanometer silver particle diameter is mostly at 25 ran, former to escherichia coli, gonococcus, trachoma clothing
The tens of kinds of pathogenic microorganism such as body have strong suppression and killing action, and will not produce drug resistance.With nanometer silver and cotton
The fiber product that fiber is made, possesses the effect of good antibacterial deodourizing.
Embodiment 8: the preparation method of the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, toward 800 weights
The calcium alginate fibre of amount part adds the ibuprofen of shuttle methyl chitosan fiber 3 weight portion of 60 weight portions, and 3.5 weight portions
Silver ion obtain mixture；
By the collagen protein powder of 1500 weight portions, add the acetum of the 0.4mol/L of 12000 weight portions, the temperature of 10 DEG C
Lower stirring is to being completely dissolved；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 15 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 70min so that it is mix homogeneously is consistent, then filters, bleaching；
Make coagulating bath by saturated metabisulfite solution, under the temperature conditions of 20 DEG C, by the pressure of 0.1MPa nitrogen, spray
Silk process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods, spinning head aperture 0.05, hole count 500 hole is blended；
The fiber made is immersed in 70min in the ethanol solution of 25%, after shaking 6h under room temperature, takes out, then the warm water with 20 DEG C
Washing, is finally dried, obtains blended fiber.
The dressing fibre diameter prepared is 56.34 μm, and fiber number is 563dtex, is 72.2/cm through density, and weft density is
17.4/cm.Finer and close, good water absorption, anti, each performance reaches optimal.
Embodiment 9: the preparation method of the medical dressing that a kind of alginate fibre, bamboo fibre and collagen protein prepare, toward 900 weights
The calcium alginate fibre of amount part adds the ibuprofen of shuttle methyl chitosan fiber 3.5 weight portion of 90 weight portions, and 3.2 weight
The Nanocrystalline silver dressing of part obtains mixture；
By the collagen protein powder of 1700 weight portions, add the acetum of the 0.4mol/L of 13000 weight portions, the temperature of 10 DEG C
Lower stirring is to being completely dissolved；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 18 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 80min so that it is mix homogeneously is consistent, then filters, bleaching；
Make coagulating bath by saturated metabisulfite solution, under the temperature conditions of 80 DEG C, by the pressure of 0.6MPa nitrogen, spray
Silk process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods, spinning head aperture 0.05, hole count 500 hole is blended；
The fiber made is immersed in 30min in the ethanol solution of 75%, after shaking 10h under room temperature, takes out, then the temperature with 30 DEG C
Water washs, and is finally dried, obtains blended fiber.
The medical dressing that embodiment 6-9 prepares is detected its anti-microbial property, moisture pick-up properties and life in vivo and in vitro thereof respectively
The thing compatibility.
Take film applicator coating detection medical dressing to staphylococcus aureus and the anti-microbial property of Pseudomonas aeruginosa, and will doctor
Make comparisons with the anti-microbial property of dressing with the calcium alginate dressing adding silver ion and simple calcium alginate dressing.By reference culture
Staphylococcus aureus, Pseudomonas aeruginosa Secondary Culture, be suspended in TSB culture fluid, uses Maxwell turbidimetry to be configured to dense
Degree is the bacterium solution of 1.5 × 108 CFU/mL, and takes turns doing 2 10 times of incremental dilutions.Draw 200 μ L bacterium solution respectively and be seeded in each group
Antibacterial surface of test piece (every kind of dressing does five parallel specimen), covers sterilization PE film, cultivates 24 h.The sample of cultivation is taken out after 24h
Product, are separately added into eluent 20mL, repeatedly wash the coverlay (picking up thin film with tweezers to rinse) of each group of given the test agent, and vortex vibrates
After 1min fully shakes up, take 200 μ l and be inoculated in nutrient agar (NA), after cultivating 24h at (37 scholar 1) DEG C, count bacterium
Fall several CFU.More than experiment is repeated twice, results averaged.
The detection of the external moisture pick-up properties of medical dressing: weigh sodium chloride and the anhydrous calcium chloride of 0.277 g of 8.3 g, molten
The solution A that British Pharmacopoeia specifies it is configured in the distilled water of 1L.When testing the pick up of dressing, three kinds of dressing are cut out respectively
Place 24 h after becoming 5 cm × 5 cm sizes, make the regain of fiber reach balance.At this moment the initial mass measuring dressing is W.
Weigh the solution A than dressing weight 40 times, respectively solution and dressing are correspondingly placed in the culture dish of 2 a diameter of 9 cm,
After placing 30 min at 37 DEG C with tweezers clamp one jiao of dressing aloft, hang the wet quality (W1) weighing dressing after 30s.Unit
The pick up of quality dressing=(W1-W)/W (g/g), pick up=4 (W1-W) the g/100 cm2 of unit are.Repeat above-mentioned experiment
3 times, seek its meansigma methods.
During test liquid distribution in fiber and between fiber, the dressing (quality is W1) after imbibition with gauze respectively
Packing together after being placed in dewaterer dehydration 15min, measuring the quality of dressing after being dehydrated is W2, and this quality is fiber itself
Dry mass and be absorbed into the summation of liquid quality of fibrous inside.Then the dressing after centrifuge dehydration in 105 DEG C of dry 4h, examination
The dry mass W3 of fiber is recorded after the most permanent quality of sample.W1-W2 is to absorb liquid between the fibers, and W2-W3 is to be absorbed into fibre
Liquid within Wei.(W1-W2)/W3 and (w2-w3)/w3 can calculate the dressing of every gram of dry mass respectively and absorb between fiber
Liquid with fibrous inside.
By the series of standards requirement in country GB/T16886-2008 and IS010993.12-2009, medical to prepare
Dressing carry out cytotoxicity experiment, Acute systemic toxicity experiment, hemolytic experiment, with its biocompatibility of overall merit, and with add
The biocompatibility of the calcium alginate dressing and simple calcium alginate dressing that add silver ion is made comparisons.
Cytotoxicity experiment: by experimental group ((medical dressing lixiviating solution), negative control group (2% calf serum
RPMI1640) ((dimethyl sulfoxide of 5%) each 3ml, is respectively placed in the Tissue Culture Dish in 6 holes, adds with positive controls
4x104/ml L-929 cell suspension 3ml, 37 DEG C, cultivate 72h under the incubator environment of volume fraction 5%C02 after, observe thin
Born of the same parents' form and growing state.By L-929 cell suspension inoculation that 200ul concentration is 4 × 104/mL in 3 piece of 96 well culture plate,
Cultivating 24 h in same incubator, cell attachment grows, and is separately added into experimental group and (medical dressing lixiviating solution, adds after abandoning stock solution
Add the calcium alginate dressing lixiviating solution of silver ion and simple calcium alginate dressing lixiviating solution), negative control group (2% calf serum
RPMI1640) with each 200 μ l of positive controls (dimethyl sulfoxide of 5%), every kind of extracting solution repeats 4 holes/plate, and incubator is cultivated
After 72h, observation of cell form and growing state.And use MTT colorimetric method for determining L-929 cell to cultivate the relative rate of increase of 72h
(RGR) cytotoxicity of material, is evaluated.
By three kinds of lixiviating solution of experimental group respectively with RPMI1640 culture fluid by volume mark 75% of 2% calf serum,
50%, 25%, 10%, 1% gradient dilution, take the dilution of the respective various concentration of experimental group lixiviating solution of 200 μ L the most respectively
Liquid repeats above experiment, same use 2% calf serum RPMI1640 be negative control group with 5% dimethyl sulfoxide be the positive
Matched group, uses MTT colorimetric method for determining L-929 cell to cultivate the relative rate of increase (RGR) of 72h, after evaluation material is diluted
Cytotoxicity changes.
Acute systemic toxicity is tested: by 50ml/kg Dose standard, by medical dressing lixiviating solution injection testing under aseptic condition
In group mouse peritoneal, negative control group saline injection, positive controls injects phenol.Within after administration continuous 7 days, observe mice,
Record mouse breathing, take food, ordinary circumstance, toxic reaction, body weight change or the death such as motion.
Hemolytic experiment: take 10ml given the test agent lixiviating solution (medical dressing lixiviating solution), 10ml normal saline (negative control
Group), 10ml distilled water (positive controls), be separately added into 0.2ml fresh anticoagulant dilution Sanguis Leporis seu oryctolagi, it is bright whether perusal occurs
Aobvious haemolysis;Microplate reader detects the absorbance of each sample supernatant, evaluates the extracorporeal blood compatibility of subject material.
By scanning electron microscope, observe the microstructure of medical dressing by sterilized medical dressing and the sea adding silver ion
Calcium alginate dressings and simple calcium alginate dressing are cut into 1cm × 1cm size square respectively, use glutaraldehyde after autoclaving
And the double fixed preparation of osmic acid, cover after platinum being evaporated with metal-plated embrane method and at sample surfaces, sample specimen is placed under scanning electron microscope
Observe respective microstructure, predominantly detect dressing silver ion and the form of nanometer silver and distribution situation under Electronic Speculum.
The laboratory sample being cut into 1cm × 1cm size is put into respectively instilled 0.2 mL concentration be 1.5 ×
In the pancreas peptone soybean broth culture medium (TSB) of staphylococcus aureus (ATCC29213) bacterium solution of 106cfu/mL, then
Sterilizing culture test tube is placed on (37 scholar 1) DEG C, relative humidity more than 90% under the conditions of cultivate 24h.Take with aseptic nipper after 24h
Go out sample dressing, detect antibacterial distribution situation in each dressing.
Result: 1, medical dressing in-vitro antibacterial performance evaluation: medical dressing is to staphylococcus aureus and P. aeruginosa
Bacterium bacteriostasis rate averagely gets off respectively 99.4% and 99.6%, the calcium alginate dressing of silver ion to staphylococcus aureus and
Pseudomonas aeruginosa bacteriostasis rate is respectively 97.5% and 97.3%, and calcium alginate dressing is to staphylococcus aureus and Aerugo vacation list
Born of the same parents' bacterium bacteriostasis rate is respectively 84.9% and 84.4%.Antimicrobial test 3 kinds of equal staphylococcus aureuses of dressing of prompting and Aerugo
Pseudomonas all has certain bacteriostasis, and medical dressing is in suppression and kills in staphylococcus aureus and Pseudomonas aeruginosa
There is obvious advantage.Comparing between group and have obvious difference, staphylococcus aureus and Pseudomonas aeruginosa are had by medical dressing
Significantly antibacterial efficacy.
2, the evaluation of the external moisture pick-up properties of medical dressing: medical dressing is being centrifuged dehydration and is finding after drying, applying
Material itself has good water absorption, and in the moisture absorbed, most can be retained in fibrous inside, is difficult to by centrifugal
Dehydration is removed.
3, the evaluation of its biocompatibility of medical dressing: cytotoxicity experiment: medical dressing and the leaching of simple calcium alginate dressing
The cell attachment growth of extract, refractivity is relatively strong, and cell presents fusiformis, the cytopathy feelings such as cell detachment, cracking does not occur
Condition, after 72h, RGR is respectively 92.5%, and 94.7%, two group of cell-cytotoxic reaction is I grade;The calcium alginate adding silver ion applies
After material lixiviating solution effects Mice fibroblast 72h, RGR is 36.1%, and cell-cytotoxic reaction is III grade.Prompting calcium alginate
Dressing and medical dressing all have good cell compatibility, no cytotoxicity: the calcium alginate dressing adding silver ion has
Certain cytotoxicity, and point out and only work as silver ion calcium alginate dressing lixiviating solution and be diluted to 1/4th of original solution
Time, after 72h, RGR is 78.1%, just demonstrates relatively low cytotoxicity.
Acute systemic toxicity is tested: the mice of experimental group, after injection lixiviating solution, is taken food, breathes, movable, excretion is not all sent out
Now abnormal, in the observation period of seven days, Mouse Weight, in the trend increased, does not finds that convulsions, instability of gait, the toxicity such as manic are anti-
Should, death does not the most occur.
Hemolytic experiment: the lixiviating solution of subject material does not cause hemolysis in vitro to react, the hemolysis rate average out to of medical dressing
1.39%.
4, by scanning electron microscope, the microstructure of medical dressing, collargol, silver ion or the nanometer in medical dressing are observed
Crystal silver is in relatively regular spherical, and mean diameter is less, is evenly distributed in the hole between fiber.Medical dressing only have few
Antibacterial is sporadically distributed on fiber amount.
Conclusion: 1, the medical dressing that the technical program prepares.And confirm that this new pattern compress possesses relatively by experiment in vivo and vitro
Strong anti-microbial property, highly hygroscopic gelation and the biocompatibility of excellence.
2, according to QB/T2591-2003 prescribed material, the bacteriostasis rate ＞ 90% of microorganism just can be referred to as anti-biotic material,
Confirm that this medical dressing shows stronger anti-microbial property by plate count experiment, and by scanning electron microscopic observation, this doctor
Being evenly distributed on fiber with the collargol of dressing, silver ion or Nanocrystalline silver dressing, anti-microbial property is than calcium alginate fibre and adds
The calcium alginate fibre adding silver ion is strong.
3, experiment confirms that this medical dressing possesses stronger wettability power, with calcium alginate fibre quite (P ＞ 0.05).
4, according to the series standard of GB/T16886-2008 and IS010993-2009, biomaterial biocompatibility is wanted
Asking and detection method, experimental result more fully hereinafter shows the standby medical dressing no cytotoxicity of this project team system, acute without whole body
Toxicity, does not the most cause hemolytic reaction, compares with calcium alginate fibre, biocompatibility no significant difference.This medical dressing has
Good biocompatibility, is applied to clinic provides strong experimental basis for being further used as antiseptic dressing.
The preferred embodiment of the present invention described in detail above.Should be appreciated that those of ordinary skill in the art without
Need creative work just can make many modifications and variations according to the design of the present invention.Therefore, all technology in the art
Personnel are available by logical analysis, reasoning, or a limited experiment the most on the basis of existing technology
Technical scheme, all should be in the protection domain being defined in the patent claims.
Claims (5)
1. the medical dressing that an alginate fibre, bamboo fibre and collagen protein prepare, it is characterised in that the weight of each several part raw material
Percentage ratio is:
Alginate fibre bamboo fibre collagen protein=2 1 ~ 34 ~ 8.
The medical dressing that a kind of alginate fibre the most as claimed in claim 1, bamboo fibre and collagen protein prepare, its feature exists
In, the percentage by weight of each several part raw material is:
Alginate fibre bamboo fibre collagen protein=2 26.
3. the preparation method of the medical dressing that alginate fibre as claimed in claim 1 or 2, bamboo fibre and collagen protein prepare,
It is characterized in that, comprise the following steps:
Shuttle methyl chitosan fiber, ibuprofen, and collargol, silver ion or Nanocrystalline silver dressing is added in calcium alginate fibre
Obtain mixture；
Collagen protein powder is added in acetum, stir at a certain temperature to being completely dissolved；
Selected high-quality QINGZHU, by high temperature steaming and stirring, makes bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs a period of time so that it is mix homogeneously is consistent, then filters, bleaches；
Coagulating bath is made, under the temperature conditions of 20 ~ 80 DEG C, by the pressure of 0.1 ~ 0.6MPa nitrogen by saturated metabisulfite solution
Power, carries out spinning process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods are blended；
The fiber made is immersed in 30 ~ 70min in the ethanol solution of 25 ~ 75%, after shaking 6 ~ 10h under room temperature, takes out, then use
The warm water washing of 20 ~ 30 DEG C, is finally dried, obtains blended fiber.
4. the preparation method of the medical dressing that alginate fibre as claimed in claim 3, bamboo fibre and collagen protein prepare, it is special
Levy and be, in spinning process, spinning head aperture 0.05, hole count 500 hole.
5. the preparation method of the medical dressing that alginate fibre as claimed in claim 3, bamboo fibre and collagen protein prepare, it is special
Levy and be, comprise the following steps:
Calcium alginate fibre toward 700 ~ 1000 weight portions adds shuttle methyl chitosan fiber 2 ~ 4 weight portion of 50 ~ 100 weight portions
Ibuprofen, and the collargol of 3 ~ 4 weight portions, silver ion or Nanocrystalline silver dressing obtain mixture；
By the collagen protein powder of 1200 ~ 2000 weight portions, add the acetum of the 0.4mol/L of 10000 ~ 15000 weight portions,
Stir to being completely dissolved at a temperature of 10 DEG C；
Selected 3 ~ 4 years raw healthy and strong tall and straight high-quality QINGZHU 10 ~ 20 weight portions, by high temperature steaming and stirring, until making bamboo pulp；
The solution of above-mentioned preparation is mixed, stirs 60 ~ 90min so that it is mix homogeneously is consistent, then filters, bleaching；
Coagulating bath is made, under the temperature conditions of 40 ~ 60 DEG C, by the pressure of 0.3 ~ 0.4MPa nitrogen by saturated metabisulfite solution
Power, carries out spinning process, obtains alginate fibre, collagen protein and bamboo fibre and crude fibre goods are blended；
The fiber made is immersed in 40 ~ 60min in the ethanol solution of 40 ~ 60%, after shaking 8h under room temperature, takes out, then with 25 DEG C
Warm water washing, be finally dried, obtain blended fiber.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106806933A (en) * | 2017-01-14 | 2017-06-09 | 成都医学院 | Polyamide gauze as Wound dressing purposes |
| CN108744011A (en) * | 2018-07-09 | 2018-11-06 | 苏州市贝克生物科技有限公司 | Ventilative wound dressing and preparation method thereof |
| CN109045346A (en) * | 2018-09-17 | 2018-12-21 | 佛山市森昂生物科技有限公司 | A kind of preparation method of medical collagen sponge |
| CN116019965A (en) * | 2023-03-27 | 2023-04-28 | 江苏亨瑞生物医药科技有限公司 | Collagen film dressing and preparation method thereof |
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| CN103550818A (en) * | 2013-11-07 | 2014-02-05 | 海安县美佳卫生用品有限公司 | Preparation method of medical sterile gauze |
| CN104096260A (en) * | 2014-07-23 | 2014-10-15 | 江苏天麟生物医药科技有限公司 | Preparation of novel antibacterial repair dressing |
| CN104623716A (en) * | 2013-11-15 | 2015-05-20 | 王静 | Preparation method of medical calcium alginate fiber compound dressing |
| CN105797203A (en) * | 2016-04-01 | 2016-07-27 | 厦门迅朗生物技术有限公司 | Alginate fiber based collagen sponge dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550818A (en) * | 2013-11-07 | 2014-02-05 | 海安县美佳卫生用品有限公司 | Preparation method of medical sterile gauze |
| CN104623716A (en) * | 2013-11-15 | 2015-05-20 | 王静 | Preparation method of medical calcium alginate fiber compound dressing |
| CN104096260A (en) * | 2014-07-23 | 2014-10-15 | 江苏天麟生物医药科技有限公司 | Preparation of novel antibacterial repair dressing |
| CN105797203A (en) * | 2016-04-01 | 2016-07-27 | 厦门迅朗生物技术有限公司 | Alginate fiber based collagen sponge dressing and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806933A (en) * | 2017-01-14 | 2017-06-09 | 成都医学院 | Polyamide gauze as Wound dressing purposes |
| CN106806933B (en) * | 2017-01-14 | 2020-04-21 | 成都医学院 | Use of polyamide gauze as wound dressing |
| CN108744011A (en) * | 2018-07-09 | 2018-11-06 | 苏州市贝克生物科技有限公司 | Ventilative wound dressing and preparation method thereof |
| CN109045346A (en) * | 2018-09-17 | 2018-12-21 | 佛山市森昂生物科技有限公司 | A kind of preparation method of medical collagen sponge |
| CN116019965A (en) * | 2023-03-27 | 2023-04-28 | 江苏亨瑞生物医药科技有限公司 | Collagen film dressing and preparation method thereof |
| CN116019965B (en) * | 2023-03-27 | 2023-05-30 | 江苏亨瑞生物医药科技有限公司 | Collagen film dressing and preparation method thereof |
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