CN106561698A - Sterilization composition containing fenhexamid - Google Patents
Sterilization composition containing fenhexamid Download PDFInfo
- Publication number
- CN106561698A CN106561698A CN201610948486.0A CN201610948486A CN106561698A CN 106561698 A CN106561698 A CN 106561698A CN 201610948486 A CN201610948486 A CN 201610948486A CN 106561698 A CN106561698 A CN 106561698A
- Authority
- CN
- China
- Prior art keywords
- fenhexamid
- active component
- composition
- biguanides
- sterilization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
- A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a sterilization composition containing fenhexamid and an application thereof. The sterilization composition includes the effective active components of a first active component, fenhexamid, and a second active component, chlorothalonil, wherein the weight ratio of the first active component to the second active component is 1:50-50:1, preferably 1:30-30:1. The sum of the contents of the first active component and the second active component is 1-70% of the total weight of the composition, preferably 5-60%. The composition can be processed into wettable powders, water dispersible granules, suspension agents, emulsifiable oil, micro-emulsions, emulsion-in-water, dispersible oil suspension agents and granules, which are acceptable in agriculture. The sterilization composition has reasonable ingredients and good sterilization effect. The activity and sterilization effect of the sterilization composition are not simply adding the activities of the components. Compared with single preparations, the sterilization composition not only has significant sterilization effects but also has significant synergistic effect. The sterilization composition has good safety on crops and has significant prevention and treatment effects on gray mold diseases.
Description
The application is the divisional application of patent CN105123735A.
Patent name：A kind of bactericidal composition containing fenhexamid.
Number of patent application：201510553500.2.
Patent application day：On September 2nd, 2015.
Technical field
The present invention relates to a kind of bactericidal composition, pungent by the first active component fenhexamid and the second active component biguanides three
Alkylbenzenesulfonate or Bravo and auxiliary agent composition, belong to technical field of compounded pesticide.
Background technology
Fenhexamid, the product of Beyer Co., Ltd's research and development belongs to amide-type, Patent expiry in 2009, Bayer listing ring in 1999
Acyl bacterium amine, sells 0.4 hundred million dollars in 2009.Fenhexamid can suppress melanic synthesis and promote the product of plant antibiotic
It is raw, it is mainly used in sclerotiniose, black spot of rice field preventing and treating rice blast, various gray molds and correlation etc..There is special efficacy to gray mold.
The octyl benzene sulfonate of biguanides three is to tag and preventative bactericide, mainly acts on the cruel compound of class of pathogen
Synthesis and cell membrane function, suppress spore germination, germ tube elongation, attachment robe and mycelia formation.Fungicidal spectrum is wider, for preventing
Control the disease caused by sac fungus and Fungi Imperfecti.It is the fresh-keeping of different mechanism of action from imidazoles series bactericidal agent conventional at present
Agent, no interactions resistance.To gray mold effect is significant.
Bravo, can be combined with the protein of the cysteine in the glyceraldehyde 3-phosphate dehydro-genase in fungal cell, be broken
Bad cell metabolism and loss of life power.Its Main Function is prevention fungal infection, without Uptake and translocation effect, but is being planted
There is good adherence on thing surface, is difficult, by rain drop erosion, there is the longer drug effect phase.
Applicant Jing is retrieved, and be there is presently no fenhexamid and is prevented and treated with the octyl benzene sulfonate of biguanides three or Bravo mixture
The document report of gray mold, is further advanced by test and finds, by the different fenhexamid of the mechanism of action and the octyl of biguanides three
Benzene sulfonate or chlorothalonil compound, with obvious synergistic effect, can significantly improve the prevention effect to gray mold, reduce medication
Amount, reduces cost accounting, high to crop safety.
The content of the invention
It is an object of the invention to provide a kind of component is rationally, significantly, bactericidal effect is good, and drug cost is low for synergistic effect,
Agricultural bactericidal composition to crop safety.
Another object of the present invention is to provide killing containing fenhexamid and the octyl benzene sulfonate of biguanides three or Bravo
Bacteria composition preparation formulation.
It is still another object of the present invention to provide application of the above-mentioned composition on gray mold is prevented and treated.
In order to overcome the defect of existing unitary agent, such solution is the technical scheme is that：
A）First active component fenhexamid；
B）The octyl benzene sulfonate of second active component biguanides three or Bravo；
The weight ratio of the first active component and the second active component is 1：50～50：1, preferably 1：30～30：1.
The content sum of the first active component and the second active component is the 1%～70% of the composition total weight, preferably
For 5%～60%.
A kind of bactericidal composition containing fenhexamid and the octyl benzene sulfonate of biguanides three or Bravo of the present invention is according to this
The preparation formulation that method well known to technical field technical staff can be prepared be wettable powder, water dispersible granules, suspending agent,
Missible oil, microemulsion, aqueous emulsion, dispersible oil-suspending agent, granule.
To wettable powder, the auxiliary agent that can be used has：Dispersant such as polycarboxylate, lignosulfonates, polyoxyethylene gather
Oxypropylene group ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonates, alkylphenol-polyethenoxy base ether phosphate, poly alkyl alcohol
One or more in oxygen ethene ether phosphate, alkylphenol-polyethenoxy base ether sulfonate etc.；Wetting agent such as alkyl sulfate, alkane
One or more in base sulfonate, alkylnaphthalene sulfonate etc.；Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, height
One or more in ridge soil, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay etc..
To water dispersible granules, the auxiliary agent that can be used has：Dispersant such as polycarboxylate（TERSPERSE2700、T36、GY-D06
Deng）, lignosulfonates, polyoxyethylene polyoxypropylene base ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonates, alkyl phenol
One kind in polyoxyethylene groups ether phosphate, aliphatic alcohol polyoxyvinethene phosphate, alkylphenol-polyethenoxy base ether sulfonate etc.
Or it is various；One or more in wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Disintegrant such as ammonium sulfate,
One or more in sodium sulphate, urea, sodium acid carbonate, polyvinylpyrrolidone, starch and its derivative, bentonite etc.；It is viscous
One or more in knot agent such as starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, sucrose；Filler
One or more such as in diatomite, kaolin, white carbon, fine particle calcium carbonate, talcum powder, attapulgite, potter's clay.
To suspending agent, the auxiliary agent that can be used has：Dispersant such as polycarboxylate, lignosulfonates, alkyl naphthalene formaldehyde condensation
Thing sulfonate, alkylphenol-polyethenoxy base ether phosphate, alkylphenol-polyethenoxy base ether sulfonate, phenethyl phenol polyoxyethylene groups
Ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, pull open powder, dodecyl
One or more in polyoxyethylene ether phosphate etc.；Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate,
Phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, alkylnaphthalene sulfonate, alkylphenol-formaldehyde resin
One or more in APEO, in triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer etc.；Thickener is such as
In xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate, carboxymethylcellulose calcium, carboxyethyl cellulose, methylcellulose etc. one
Plant or various；One or more in preservative such as formaldehyde, benzoic acid, Sodium Benzoate, potassium sorbate, OIT；Disappear
Infusion such as silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 aliphatic alcohols, hexanol, butanol, octanol
One or more in；Antifreezing agent such as ethylene glycol, propane diols, glycerine, polyethylene glycol, sorbierite, urea, inorganic salts etc.
In one or more；Water is deionized water.
To missible oil, the auxiliary agent that can be used has：Emulsifying agent such as calcium dodecyl benzene sulfonate（Agriculture breast 500#）, Nongru-700 #, agriculture
Breast 2201, this disk -60#, emulsifying agent T-60（Common name：Anhydrous sorbitol single-hard ester acid ester APEO）、TX-10（It is general
Name：Octyl phenol polyoxyethylene（10）Ether）, agriculture breast 1601#, agriculture breast 600#, one or more in agriculture breast 400# etc.；Solvent such as two
Toluene, solvent naphtha（S-150、S-180、S-200）, toluene, biodiesel, methylated vegetable oil, in 1-METHYLPYRROLIDONE etc.
One or more；One kind in cosolvent such as ethyl acetate, methyl alcohol, dimethylformamide, cyclohexanone, acetone, MEK
Or it is various；One or more in stabilizer such as triphenyl phosphite, epoxychloropropane, aceticanhydride.
To microemulsion, the auxiliary agent that can be used has：Emulsifying agent such as calcium dodecyl benzene sulfonate（Agriculture breast 500#）, Nongru-700 #,
Agriculture breast 2201, this disk-60#, polysorbate60-#, TX-10, agriculture breast 1601（Common name：Phenethyl phenol polyoxyethylene polyoxypropylene
Ether）, agriculture breast 600#, one or more in agriculture breast 400# etc.；In assistant for emulsifying agent such as methyl alcohol, isopropanol, n-butanol, ethanol etc.
One or more；Solvent such as cyclohexanone, 1-METHYLPYRROLIDONE, dimethylbenzene, toluene, solvent naphtha（The trade mark：S-150、S-180、S-
200）One or more in；One or more in stabilizer such as triphenyl phosphite, epoxychloropropane；Water for go from
Sub- water.
To aqueous emulsion, the auxiliary agent that can be used has：Emulsifying agent such as Nonyl pheno（EO=10）Ether phosphate, triphen second
Base phenol polyoxyethylene phosphonate, Nongru-700 #（Common name：Alkyl phenol formaldehyde resin polyoxyethylene ether）, agriculture breast 2201#, this
Disk -60#（Common name：Span60）, Tween-60 #（Common name：Polyoxyethylene sorbitan stearic acid
Ester）、TX-10（Common name：Octyl phenol polyoxyethylene（10）Ether）, agriculture breast 1601（Common name：Triphenoethyl benzene phenol polyoxypropylene gathers
Oxygen ethylene block polymer）, agriculture breast 600#, one or more in agriculture breast 400# etc.；Solvent for example dimethylbenzene, toluene, cyclohexanone,
Solvent naphtha（The trade mark：S-150、S-180、S-200）One or more in；Stabilizer such as triphenyl phosphite, epoxy chloropropionate
One or more in alkane, epoxidized soybean oil etc.；Antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as chlorination
One or more in sodium etc.；One or more in thickener such as xanthans, polyvinyl alcohol, bentonite, aluminium-magnesium silicate；It is anti-
One or more in rotten agent such as formaldehyde, benzoic acid, Sodium Benzoate, water is deionized water.
To dispersibling oil-suspending agent, the auxiliary agent that can be used has：Dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene
Sulfonate（Dispersing agent NNO）、TERSPERSE 2020（Huntsman Corporation of U.S. HUNTSMAN produces, alkyl naphthalene sulfonic acid salt）Deng
In one or more；Emulsifying agent such as BY（Castor oil polyoxyethylene ether）Serial emulsifying agent（BY-110、BY-125、BY-140）、
Nongru-700 #（Common name：Alkyl phenol formaldehyde resin polyoxyethylene ether）, agriculture breast 2201, this disk -60#（Common name：Sorbitol anhydride list
Stearate）, Tween-60 #（Common name：Sorbitan monostearate APEO）, agriculture breast 1601#（Common name：Benzene
Ethyl -phenol polyoxyethylene poly-oxygen propylene aether）、TERSPERSE 4894（Huntsman Corporation of the U.S. produces）One kind or many in
Kind；Wetting agent such as alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, APES phosphate, phenethyl phenol
Polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, naphthalene sulfonate, TERSPERSE 2500（U.S.'s Hensel steps public affairs
Department produces）One or more in；One kind or many in thickener such as white carbon, polyvinyl alcohol, bentonite, aluminium-magnesium silicate
Kind；One or more in antifreezing agent such as ethylene glycol, propane diols, glycerine, urea, inorganic salts such as sodium chloride；Decentralized medium
Such as soybean oil, rapeseed oil, cottonseed oil, paddy rice oil, castor oil, palm oil, epoxidized soybean oil, methyl oleate and its methyl esters carburetion
One or more in class, diesel oil, machine oil, mineral oil etc., and esters solvent such as repefral, phthalic acid two
One or more in butyl ester, ethyl acetate, methyl benzoate etc..
To granule, the auxiliary agent that can be used has：Carrier such as clay, kaolin, talcum, calcium carbonate, cornstarch, alumina silicate
One or more in；One or more in dispersant such as polycarboxylate, lignosulfonates, alkylnaphthalene sulfonate；
One or more in wetting agent such as alkyl sulfate, alkylsulfonate, naphthalene sulfonate；Adhesive for example polyvinyl alcohol, dextrin,
One or more in polyvinylpyrrolidone etc..
Rationally, treatment adds protective effect to instant component, and bactericidal effect is good, and drug cost is low, and its activity and sterilized effect
Fruit is not the simple superposition of each component activity, but is had significant synergies, good to crop safety, meets pesticidal preparations
Security requirement.The present invention has preferable prevention effect to gray mold.
Specific embodiment
Illustrate fenhexamid with the octyl benzene sulfonate of biguanides three or Bravo mixture below by Toxicity Determination
Synergistic effect to gray mold.
In order to prevent and treat the gray mold in agricultural production, we are with fenhexamid and the octyl benzene sulfonate of biguanides three or hundred bacterium
Sorting has not carried out the synergy research of mutual compounding, and concrete grammar is：
Subjects are botrytis cinerea（Botrytis cinerea）.The test medicine that active compound is configured to need, test
Method is referred to《The part of farm-chemical indoor determination test rule bactericide the 6th：The synergy of mixture is determined》With《In agricultural chemicals room
The part of bioassay test criterion bactericide the 10th：Prevent and treat gray mold test pot-culture method》.
First single dose and each Mixed Pharmacy are arranged into 5 variable concentrations gradients（On the basis of pilot study, bacteriostasis rate exists
Set by geometric progression in the range of 5%～90%）.If blank, it is repeated 4 times.Using pot-culture method, liquid is uniformly sprayed in
Blade face, it is standby after liquid natural air drying.Spore suspension spray inoculation is used, incubator is then moved to（Relative humidity 95% with
On, 20～22 DEG C of temperature）24h is cultivated under dark condition, then temperature be 20～25 DEG C, 12h alternation of light and darkness, relative humidity
7d is cultivated under conditions of 80%～90%.When blank disease leaf rate reaches more than 50%, incidence is managed everywhere in classification investigation,
Often process at least 30 leaves of investigation.According to survey data, the disease index and prevention effect of each process are calculated.By preventive effect probability
Linear regression analysis between value and the logarithm value of series concentration, obtains the EC of each medicament50Value.
The co-toxicity coefficient of mixture is calculated with the abundant methods of Sun Yun（CTC）, activity of the reagent agent to germ is evaluated with this.Compounding
The co-toxicity coefficient of preparation（CTC）>=120 show as synergistic effect；CTC≤80 show as antagonism；80 ＜ CTC ＜ 120 are showed
For summation action.
The fenhexamid of table 1 is compounded to graw mold of tomato Toxicity Determination with the octyl benzene sulfonate of biguanides three
The fenhexamid of table 2 is with chlorothalonil compound to graw mold of tomato Toxicity Determination
Toxicity Determination result shows：Fenhexamid is with the octyl benzene sulfonate of biguanides three or Bravo with weight ratio as 1：50
～50：1 it is mixed have preferable virulence to gray mold of cucumber, especially weight ratio is 1：30～30：1 synergistic effect is notable.
In order to the present invention is better described, present invention is described further with reference to embodiment, in formula
Percentage is weight percentage.
Example of formulations 1
Weigh 30% fenhexamid, the octyl benzene sulfonate of 20% biguanides three, 4% alkyl naphthalene formaldehyde condensation product sodium sulfonate, 3% poly- carboxylic
Sour sodium, 3% lauryl sodium sulfate, fine particle calcium carbonate is filled up to 100% weight portion.Above-mentioned raw materials are blended, ultra micro air-flow crushing, mixing
Processing step is prepared into the octyl benzene sulfonate wettable powder of 50% fenhexamid biguanides three.
Example of formulations 2
Weigh 25% fenhexamid, the octyl benzene sulfonate of 20% biguanides three, 6% calcium lignosulfonate, the condensation of 5% alkyl naphthalene formaldehyde
Thing sodium sulfonate, 2% sodium alkyl sulfonate, kaolin is filled up to 100% weight portion.Above-mentioned raw materials are blended, ultra micro air-flow crushing, mixed
Close processing step and be prepared into the octyl benzene sulfonate wettable powder of 45% fenhexamid biguanides three.
Example of formulations 3
Weigh 20% fenhexamid, 50% Bravo, 5% alkylphenol-polyethenoxy base ether sulfonic acid calcium, 4% alkylnaphthalene sulfonate formaldehyde
Condensation product, 2% Negel, white carbon is filled up to 100% weight portion.Above-mentioned raw materials are blended, ultra micro air-flow crushing, mixed
Close processing step and be prepared into 70% fenhexamid Bravo wettable powder.
Example of formulations 4
Weigh 10% fenhexamid, 40% Bravo, 6% sodium lignin sulfonate, 2% alkylphenol-polyethenoxy base ether phosphate, 2%
Sodium alkyl sulfonate, diatomite is filled up to 100% weight portion.Above-mentioned raw materials are blended, ultra micro air-flow crushing, hybrid technique step
It is prepared into 50% fenhexamid Bravo wettable powder.
Example of formulations 5
Weigh 40% fenhexamid, the octyl benzene sulfonate of 30% biguanides three, 6% polycarboxylate GY-D06,3% Negel first
Aldehyde condensate）, 3% nekal, 2% sodium alkyl sulfonate, 2% polyethylene glycol, talcum powder adds to 100% weight portion.It is above-mentioned
Raw material Jing routinely produces that the method for water dispersible granules mixes, ultra micro air-flow crushing, mixing, granulation step produce 70% ring acyl bacterium
The octyl benzene sulfonate water dispersible granules of amine biguanides three.
Example of formulations 6
Weigh 20% fenhexamid, the octyl benzene sulfonate of 35% biguanides three, 2% polycarboxylate 5ERSPERSE2700,4% lignin
Sodium sulfonate, 1% nekal, 3% lauryl sodium sulfate, 1% ammonium sulfate, 1% glucose, kaolin adds to 100% weight
Part.Above-mentioned raw materials Jing routinely produces that the method for water dispersible granules mixes, ultra micro air-flow crushing, mixing, granulation step produce 60%
The octyl benzene sulfonate water dispersible granules of fenhexamid biguanides three.
Example of formulations 7
Weigh 25% fenhexamid, 35% Bravo, 5% polycarboxylate GY-D06,3% sodium lignin sulfonate, 5% dibutyl naphthalenesulfonic acid
Sodium, 2% neopelex, 1% polyvinylpyrrolidone, 2% starch, white carbon adds to 100% weight portion.Above-mentioned raw materials Jing
Routine produces that the method for water dispersible granules mixes, ultra micro air-flow crushing, mixing, granulation step produce 60% fenhexamid hundred
Bacterium clear water dispersible granule.
Example of formulations 8
Weigh 10% fenhexamid, 40% Bravo, 4% polycarboxylate T36,2% Negel formaldehyde condensation products, 3% dodecane
Base sodium sulphate, 4% sodium naphthalene sulfonate, 2% polyvinyl alcohol, fine particle calcium carbonate adds to 100% weight portion.Above-mentioned raw materials Jing routinely produces water-dispersible grain
The method of agent mixes, ultra micro air-flow crushing, mixing, granulation step produce 50% fenhexamid chlorothalonil water dispersible granule.
Example of formulations 9
Weigh 10% fenhexamid, the octyl benzene sulfonate of 5% biguanides three, 3% polycarboxylic acids sodium, 2% phenethyl phenol polyoxyethylene ether
Phosphate, 3% sodium alkyl sulfate, 0.5% carboxymethylcellulose calcium, 3% polyethylene glycol, 0.2% potassium sorbate, 01% octanol, deionized water
Add to 100% weight portion.Above-mentioned raw materials are blended, high speed shear dispersion 30min, with sand mill sand milling to particle diameter D90Less than 10 μm
The octyl benzene sulfonate suspending agent of 15% fenhexamid biguanides three is obtained afterwards.
Example of formulations 10
Weigh 5% fenhexamid, the octyl benzene sulfonate of 25% biguanides three, 7% alkyl polyoxyethylene ether sodium sulfonate, 2% alkyl phenol first
Urea formaldehyde APEO, 0.3% aluminium-magnesium silicate, 0.2% bentonite, 5% propane diols, 0.2% Sodium Benzoate, 1.5% silicone oil, go from
Sub- water adds to 100% weight portion.Above-mentioned raw materials are blended, high speed shear dispersion 30min, with sand mill sand milling to particle diameter D90It is less than
The octyl benzene sulfonate suspending agent of 30% fenhexamid biguanides three is obtained after 10 μm.
Example of formulations 11
Weigh 30% fenhexamid, 3% Bravo, 5% sodium lignin sulfonate, 2% sodium naphthalene sulfonate, 0.3% aluminium-magnesium silicate, 0.2% first
Base cellulose, 5% glycerine, 0.2% benzoic acid, 1% hexanol, deionized water adds to 100% weight portion.Above-mentioned raw materials are blended, high
Speed shearing dispersion 30min, with sand mill sand milling to particle diameter D9033% fenhexamid Bravo suspending agent is obtained after less than 10 μm.
Example of formulations 12
Weigh 5% fenhexamid, 25% Bravo, 6% alkylphenol-polyethenoxy base ether phosphate, 2% Negel, 0.3%
Aluminium-magnesium silicate, 0.2% aluminium-magnesium silicate, 5% ethylene glycol, 0.2% formaldehyde, 0.5% octanol, deionized water adds to 100% weight portion.It is above-mentioned
Raw material is blended, high speed shear dispersion 30min, with sand mill sand milling to particle diameter D9030% fenhexamid is obtained after less than 10 μm
Bravo suspending agent.
Example of formulations 13
Weigh 25% fenhexamid, the octyl benzene sulfonate of 10% biguanides three, 3% Nongru-700 #, this disk -60# of 3% agriculture breast 2201,5%,
2% cyclohexanone, 2% aceticanhydride, toluene adds to 100% weight portion.Above-mentioned raw materials are blended, and stirring and dissolving is obtained afterwards completely 35% ring acyl bacterium
The octyl benzene sulfonate missible oil of amine biguanides three.
Example of formulations 14
Weigh 20% fenhexamid, the octyl benzene sulfonate of 2% biguanides three, 3% agriculture breast 500#, 3% Nongru-700 #, 5% agriculture breast 1601#,
2% dimethylformamide, 2% epoxychloropropane, solvent naphtha S-150 adds to 100% weight portion.Above-mentioned raw materials are blended, stirring and dissolving
The prepared octyl benzene sulfonate missible oil of 22% fenhexamid biguanides three after completely.
Example of formulations 15
Weigh 25% fenhexamid, 10% Bravo, 3% Nongru-700 #, this disk -60# of 3% agriculture breast 2201,5%, 2% cyclohexanone, 2% ring
Oxygen chloropropane, toluene adds to 100% weight portion.Above-mentioned raw materials are blended, and stirring and dissolving is obtained afterwards completely 35% fenhexamid hundred
The clear missible oil of bacterium.
Example of formulations 16
Weigh 15% fenhexamid, 5% Bravo, 3% agriculture breast 500#, 3% Nongru-700 #, 5% agriculture breast 1601#, 2% ethyl acetate, 2%
Triphenyl phosphite, biodiesel adds to 100% weight portion.Above-mentioned raw materials are blended, and stirring and dissolving is obtained afterwards completely 20% ring acyl
Bacterium amine Bravo missible oil.
Example of formulations 17
Weigh 30% SYP-Zo48, the octyl benzene sulfonate of 5% biguanides three, 4% agriculture breast 500#, 6% agriculture breast 1601#, 5% isobutanol,
2.5% cyclohexanone, 5% dimethylbenzene, Jing dissolvings are complete and are well mixed, and deionized water adds to 100% weight portion, and 35% is obtained after stirring
The octyl benzene sulfonate microemulsion of fenhexamid biguanides three.
Example of formulations 18
Weigh 10% SYP-Zo48, the octyl benzene sulfonate of 20% biguanides three, 5% agriculture breast 400#, 6% agriculture breast 1601#, 5% isobutanol,
25% cyclohexanone, 5% solvent naphtha S-150, Jing dissolvings are complete and are well mixed, and deionized water adds to 100% weight portion, make after stirring
Obtain the octyl benzene sulfonate microemulsion of 30% fenhexamid biguanides three.
Example of formulations 19
20% SYP-Zo48,5% Bravo, 4% agriculture breast 500#, 6% Nongru-700 #, 5% isobutanol, 25% cyclohexanone, 5% toluene are weighed,
Jing dissolvings are complete and are well mixed, and deionized water adds to 100% weight portion, and 25% fenhexamid Bravo micro emulsion is obtained after stirring
Agent.
Example of formulations 20
Weigh 10% SYP-Zo48,20% Bravo, 5% agriculture breast 400#, 6% agriculture breast 1601#, 5% n-butanol, 25% cyclohexanone, 5% 2
Toluene, Jing dissolvings are complete and are well mixed, and deionized water adds to 100% weight portion, and the bacterium of 30% fenhexamid hundred is obtained after stirring
Clear microemulsion.
Example of formulations 21
Weigh 15% fenhexamid, the octyl benzene sulfonate of 10% biguanides three, 4% agriculture breast 2201#, 5% NPE
Phosphate, 5% cyclohexanone, 3% solvent naphtha S-180,1% epoxychloropropane, 5% sodium chloride, 0.2% polyvinyl alcohol, 0.5% benzoic acid,
Deionized water adds to 100% weight portion.Above-mentioned raw materials are blended, and high speed shearing emulsification is obtained the octane of 25% fenhexamid biguanides three
Base benzene sulfonate aqueous emulsion.
Example of formulations 22
Weigh 10% fenhexamid, the octyl benzene sulfonate of 25% biguanides three, 8% agriculture breast TX-10#, 2% Nonyl pheno
（EO=10）Ether phosphate, 4% triphenoethyl benzene phenol polyethenoxy ether phosphate, 2% this disk -60#, 5% dimethylbenzene, 1% phosphorous acid three
Phenyl ester, 2% ethylene glycol, 0.2% xanthans, 0.5% Sodium Benzoate, deionized water adds to 100% weight portion.Above-mentioned raw materials are blended,
High speed shearing emulsification is obtained the octyl benzene sulfonate aqueous emulsion of 35% fenhexamid biguanides three.
Example of formulations 23
Weigh 15% fenhexamid, 3% Bravo, 8% agriculture breast TX-10#, 2% Nonyl pheno（EO=10）Ether phosphate,
4% triphenoethyl benzene phenol polyethenoxy ether phosphate, 2% this disk -60#, 5% toluene, 1% epoxychloropropane, 2% urea, 0.2% poly- second
Enol, 0.5% formaldehyde, deionized water adds to 100% weight portion.Above-mentioned raw materials are blended, and high speed shearing emulsification is obtained 18% ring acyl bacterium
Amine Bravo aqueous emulsion.
Example of formulations 24
Weigh 5% fenhexamid, 15% Bravo, 6% agriculture breast TX-10#, 4% triphenoethyl benzene phenol polyethenoxy ether phosphate, 2%
This disk -60#, 5% solvent naphtha S-150,1% epoxidized soybean oil, 2% glycerine, 0.2% bentonite, 0.5% Sodium Benzoate, deionized water adds
To 100% weight portion.Above-mentioned raw materials are blended, and high speed shearing emulsification is obtained 20% fenhexamid Bravo aqueous emulsion.
Example of formulations 25
Weigh 20% fenhexamid, the octyl benzene sulfonate of 5% biguanides three, 2%T Negels, 4% this disk -60#, 5% agriculture breast
2201st, 1% sodium naphthalene sulfonate, 0.5% bentonite, 5% ethylene glycol, methyl oleate adds to 100% weight portion.Above-mentioned raw materials are blended, high
Speed shearing dispersion 30min, dispersibles oil outstanding with the prepared octyl benzene sulfonate of 25% fenhexamid biguanides three after sand mill sand milling
Floating agent.
Example of formulations 26
Weigh 15% fenhexamid, the octyl benzene sulfonate of 5% biguanides three, 2% dispersing agent NNO, 3% Nongru-700 #, 8%BY-110,1%
Sodium alkyl sulfonate, 1% aluminium-magnesium silicate, 3% glycerine, little wheat oil adds to 100% weight portion.Above-mentioned raw materials are blended, high speed shear dispersion
30min, with the octyl benzene sulfonate of 20% fenhexamid biguanides three is obtained after sand mill sand milling oil-suspending agent is dispersibled.
Example of formulations 27
Weigh 21% fenhexamid, 3% Bravo, 2%T Negels, 4% Emulsifier BY -110,5% agriculture breast 2201,1% naphthalene sulphur
Sour sodium, 0.5% white carbon, 5% ethylene glycol, rapeseed oil adds to 100% weight portion.Above-mentioned raw materials are blended, high speed shear dispersion
30min, with 24% fenhexamid Bravo is obtained after sand mill sand milling oil-suspending agent is dispersibled.
Example of formulations 28
Weigh 10% fenhexamid, 20% Bravo, 2% dispersing agent NNO, 3% Nongru-700 #, 8%BY-125,1% sodium alkyl sulfonate, 1%
Aluminium-magnesium silicate, 3% propane diols, mineral oil adds to 100% weight portion.Above-mentioned raw materials are blended, high speed shear dispersion 30min, use sand
30% fenhexamid Bravo is obtained after grinding machine sand milling and dispersibles oil-suspending agent.
Example of formulations 29
Weigh 0.5% fenhexamid, the octyl benzene sulfonate of 0.5% biguanides three, 5% Negel, 4% sodium alkyl sulfonate, 3%
Polyvinylpyrrolidone, talcum powder adds to 100% weight portion.Above-mentioned raw materials are well mixed in mixed cylinder, through extruding, making
Grain, drying, and screened step is obtained the octyl benzene sulfonate granule of 1% fenhexamid biguanides three.
Example of formulations 30
2% fenhexamid, the octyl benzene sulfonate of 3% biguanides three, 5% polycarboxylic acids sodium, 3% sodium naphthalene sulfonate, 4% polyvinyl alcohol are weighed,
Calcium carbonate adds to 100% weight portion.Above-mentioned raw materials are well mixed in mixed cylinder, through extruding, granulation, are dried, and screened
Step is obtained the octyl benzene sulfonate granule of 5% fenhexamid biguanides three.
Example of formulations 31
Weigh 1.7% fenhexamid, 0.3% Bravo, 5% Negel, 4% sodium alkyl sulfate, 3% dextrin, cornstarch
Add to 100% weight portion.Above-mentioned raw materials are well mixed in mixed cylinder, through extruding, granulation, are dried, and screened step system
Obtain 2% fenhexamid Bravo granule.
Example of formulations 32
1% fenhexamid, 2% Bravo, 5% polycarboxylic acids sodium, 3% sodium naphthalene sulfonate, 4% polyvinyl alcohol are weighed, kaolin adds to 100%
Weight portion.Above-mentioned raw materials are well mixed in mixed cylinder, through extruding, granulation, are dried, and screened step is obtained 3% ring acyl
Bacterium amine Bravo granule.
Biological Examples 1：Preventing and treating graw mold of tomato field test.
Example of formulations 1 has been carried out in Xianyang, Shanxi province city Jingyang County Yunyang town East Street village within 2015（50% ring acyl bacterium
The octyl benzene sulfonate wettable powder of amine biguanides three）, example of formulations 8（50% fenhexamid Bravo water-dispersible grain
Agent）, example of formulations 10（The octyl benzene sulfonate suspending agent of 30% fenhexamid biguanides three）, example of formulations 15（35%
Fenhexamid Bravo missible oil）, example of formulations 20（30% fenhexamid chlorothalonil microemulsion）, example of formulations 21
（The octyl benzene sulfonate aqueous emulsion of 25% fenhexamid biguanides three）, example of formulations 28（30% fenhexamid Bravo
Dispersible oil-suspending agent）, example of formulations 30（The octyl benzene sulfonate granule of 5% fenhexamid biguanides three）Preventing and treating tomato
Gray mold field test, demonstrates prevention effect of the medicament to graw mold of tomato and the security to tomato.
Trial crops are cucumber, and controlling object is graw mold of tomato（Botrytis cinerea）.Test is located at Jingyang County
Yunyang town, experimental plot physical features is flat, and soil is medium loam, middle fertility, pH value 7.9, and rich water quality management is medium during test.Test
Medicament and dosage refer to table 3.Blank is separately set, 4 repetitions is often processed, often the ㎡ of cell 30, totally 48 cells, random district's groups row
Row.Using conventional spray-on process or broadcast application, mu dispenser liquid 45kg during spraying is uniformly sprayed at leave dual sides.
Investigation and statistical method：State of an illness radix is investigated before dispenser, 10～14d is reinvestigated once after last time dispenser, altogether
Investigation 2 times.Per cell using 5 points of samplings, whole blades of per 2 plants of investigation, every leaf is recorded according to the classification of scab number.Point
Level method：
0 grade：Disease-free spot；
1 grade：Single blade has scab 3；
3 grades：Single blade has scab 4～6；
5 grades：Single blade has scab 7～10；
7 grades：Single blade has scab 11～20, and part is intensive in flakes；
9 grades：Single blade has that scab is intensive to be accounted for more than leaf area a quarter.
Disease index=[∑ (the sick numbers of sheets at different levels × relative value of series)/(investigation total leaf number × 9)] × 100
Prevention effect (%)=[1- (disease index after disease index × process dispenser before control dispenser)/（The state of an illness refers to after control dispenser
Number × process disease index before dispenser] × 100
Table 3 prevents and treats graw mold of tomato field test results
Table of field test results is bright, and 8 embodiments of the above have good prevention effect to graw mold of tomato, by 25ga.i./mu spray
Mist 2 times, reached more than 90%, hence it is evident that better than the preventive effect of each single dose to the preventive effect of 10 days after the 2nd medicine of graw mold of tomato.Pass through
To 10 days significance difference analysis after medicine, preventive effect difference reaches the pole level of signifiance（It is shown in Table 3）.
Security survey to tomato, observes for some days after the 1st day and medicine after spray, and each test process are to cucumber without poisoning
Phenomenon occurs.
Above example explanation, the first active component fenhexamid and the octyl benzene sulfonate of the second active component biguanides three
Or Bravo is by weight 1：50～50：1 compounding, can be made into wettable powder, water dispersible granules, suspending agent, missible oil, micro emulsion
Agent, aqueous emulsion, oil-suspending agent, granule formulation are dispersibled, there is significant prevention effect to graw mold of tomato, synergistic effect is bright
Aobvious, dosage is few, prevention effect is high and good to crop safety.
In sum, composition of the invention is that, using two kinds of active components compound scheme, its activity and bactericidal effect are not
It is the simple superposition of each component activity, compared with existing unitary agent, in addition to significant bactericidal effect, more has significantly
Synergistic effect, to making, security is good, meets the security requirement of pesticidal preparations.
Claims (6)
1. a kind of bactericidal composition containing fenhexamid, it is characterised in that：Active ingredient by the first active component fenhexamid with
The octyl benzene sulfonate of second active component biguanides three or Bravo are constituted, the weight of the first active component and the second active component
Than being 1：50～50：1.
2. the bactericidal composition of fenhexamid is contained according to claim 1, it is characterised in that the first active component and second is lived
The weight ratio of property composition is 1：30～30：1.
3. the bactericidal composition containing fenhexamid according to claim 1 or claim 2, it is characterised in that the first active component and
The content sum of two active components is the 1%～70% of the composition total weight.
4. the bactericidal composition of fenhexamid is contained according to claim 3, it is characterised in that the first active component and second is lived
The content sum of property composition is the 5%～60% of the composition total weight.
5. the bactericidal composition of fenhexamid is contained according to claim 4, it is characterised in that the combination dosage form is wettable
Property pulvis, water dispersible granules, suspending agent, missible oil, microemulsion, aqueous emulsion, dispersible oil-suspending agent, granule.
6. purposes of the bactericidal composition of fenhexamid in preventing and treating crops gray mold is contained according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610948486.0A CN106561698A (en) | 2015-09-02 | 2015-09-02 | Sterilization composition containing fenhexamid |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510553500.2A CN105123735A (en) | 2015-09-02 | 2015-09-02 | Sterilization composite containing fenhexamid |
| CN201610948486.0A CN106561698A (en) | 2015-09-02 | 2015-09-02 | Sterilization composition containing fenhexamid |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510553500.2A Division CN105123735A (en) | 2015-09-02 | 2015-09-02 | Sterilization composite containing fenhexamid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106561698A true CN106561698A (en) | 2017-04-19 |
Family
ID=54709626
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510553500.2A Pending CN105123735A (en) | 2015-09-02 | 2015-09-02 | Sterilization composite containing fenhexamid |
| CN201610948486.0A Pending CN106561698A (en) | 2015-09-02 | 2015-09-02 | Sterilization composition containing fenhexamid |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510553500.2A Pending CN105123735A (en) | 2015-09-02 | 2015-09-02 | Sterilization composite containing fenhexamid |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105123735A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108651447A (en) * | 2018-04-23 | 2018-10-16 | 江苏邦盛生物科技有限责任公司 | A kind of oil-suspending agent and preparation method thereof containing Tebuconazole and Bravo |
| CN109566642A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106689181B (en) * | 2016-12-07 | 2019-12-06 | 陕西上格之路生物科学有限公司 | Bactericidal composition containing fenpyrazamine |
| CN107027756A (en) * | 2017-03-10 | 2017-08-11 | 南京华洲药业有限公司 | A kind of bactericidal composition and its application containing Hexanaphthene flusulfamide and fenhexamid |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094221A (en) * | 1993-04-28 | 1994-11-02 | 拜尔公司 | Fungicidal combinations of active substances |
| CN1287473A (en) * | 1998-11-02 | 2001-03-14 | 大日本油墨化学工业株式会社 | Bacteriocide compositions for agricultural and horticultural use |
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103636655A (en) * | 2013-12-20 | 2014-03-19 | 北京燕化永乐生物科技股份有限公司 | Compound bactericide |
-
2015
- 2015-09-02 CN CN201510553500.2A patent/CN105123735A/en active Pending
- 2015-09-02 CN CN201610948486.0A patent/CN106561698A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1094221A (en) * | 1993-04-28 | 1994-11-02 | 拜尔公司 | Fungicidal combinations of active substances |
| CN1287473A (en) * | 1998-11-02 | 2001-03-14 | 大日本油墨化学工业株式会社 | Bacteriocide compositions for agricultural and horticultural use |
| WO2005104847A1 (en) * | 2004-04-30 | 2005-11-10 | Basf Aktiengesellschaft | Fungicidal mixtures |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109566642A (en) * | 2017-09-29 | 2019-04-05 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
| CN108651447A (en) * | 2018-04-23 | 2018-10-16 | 江苏邦盛生物科技有限责任公司 | A kind of oil-suspending agent and preparation method thereof containing Tebuconazole and Bravo |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105123735A (en) | 2015-12-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106561698A (en) | Sterilization composition containing fenhexamid | |
| CN106857514A (en) | A kind of composition of the amino acid of peptide containing benzene and flumetralim | |
| CN108077270A (en) | A kind of bactericidal composition containing fluopyram and fenhexamid | |
| CN107006500A (en) | Composition pesticide comprising folpet and pyrrole metsulfovax | |
| CN107568239A (en) | A kind of bactericidal composition containing rosickyite azoles and benziothiazolinone | |
| CN104082303B (en) | A kind of bactericidal composition containing cyflufenamid and acid amide fungicides | |
| CN103283770B (en) | Insecticidal composition containing cycolxylidin and metaflumizone | |
| CN104798790A (en) | Sterilizing composition containing SYP-Z048 and picoxystrobin | |
| CN105494417A (en) | Sterilization composition containing metalaxyl-M and phosethyl-al | |
| CN106172451A (en) | The application on preventing and treating gibberella zeaze petch of wheat and barley of the bactericidal composition containing captan and Tebuconazole | |
| CN105076212B (en) | A kind of bactericidal composition containing bacillus subtilis and 2-cyano-3-amino-3-phenylancryic acetate | |
| CN106879614A (en) | A kind of bactericidal composition and application thereof | |
| CN104041491B (en) | A kind of bactericidal composition containing cyflufenamid and nonylphenolsulfonate copper | |
| CN105165828B (en) | Bactericidal composition containing metrafenone and meptyldinocap | |
| CN107279162A (en) | A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium | |
| CN105409964A (en) | Germicidal composition containing fluopyram and proquinazid | |
| CN108064848A (en) | A kind of bactericidal composition containing fluopyram and amine benzene pyrrole bacterium ketone | |
| CN108770856A (en) | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and amine benzene pyrrole bacterium ketone | |
| CN105340888B (en) | A kind of bactericidal composition containing nitre benzene bacterium ester and cyflufenamid | |
| CN109169692A (en) | A kind of bactericidal composition containing fluorine azoles bacterium acyl azanol and Mancozeb | |
| CN104957158B (en) | A kind of Herbicidal combinations of Han oxaziclomefones and benthiocarb | |
| CN109452298A (en) | A kind of bactericidal composition containing isopropyl metsulfovax and captan | |
| CN106689181A (en) | Bactericidal composition containing fenpyrazamine | |
| CN107347900A (en) | A kind of bactericidal composition of the urethane of pyrrole containing tetrazolium | |
| CN107853309A (en) | A kind of composition pesticide comprising folpet and dimethomorph |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170419 |
|
| RJ01 | Rejection of invention patent application after publication |