CN105617095A

CN105617095A - Oral liquid for acute upper respiratory infection in children and preparation method

Info

Publication number: CN105617095A
Application number: CN201610056393.7A
Authority: CN
Inventors: 朱德密
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-27
Filing date: 2016-01-27
Publication date: 2016-06-01

Abstract

The invention discloses an oral liquid for acute upper respiratory infection in children and a preparation method, belonging to the field of traditional Chinese medicines. The oral liquid is prepared from the following raw materials: chrysoidine, honeysuckle, dried radix rehmanniae, schizonepeta, notopterygium, scutellaria baicalensis, fructus forsythia, gardenia, radix isatidis, rheum officinale, dandelion, liquorice, indigo naturalis, tabasheer, agastache rugosus, tetrapanax papyriferus, clean loquat leaves, pericarpium citri reticulatae, cercis chinensis and fructus viticis. The oral liquid has the efficacies of clearing away heat and toxic materials, expelling phlegm to arrest coughing as well as moistening the lung and depressing qi, and has significant curative effects on fever, head pain, cough, sticky phlegm, swollen sore throat and the like induced by common cold in children; the selected medicinal materials complement each other in compatibility; and the oral liquid is low in cost, free of toxic or side effect, suitable for children to take, and worthy of wide clinical popularization.

Description

A kind of oral liquid for infantile acute upper respiratory infection and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of oral liquid for infantile acute upper respiratory infection and preparation method.

Background technology

Acute upper respiratory tract infection is the modal disease of children's, mainly invade nose, nasopharynx and pharyngeal, therefore commonly use diagnosis nouns such as " acute nasopharyngitis " " flu " " acute pharyngitis " " acute tonsillitiss ", it is possible to be referred to as upper respiratory tract infection, be called for short " upper sense ". Nasopharynx infects and often may occur in which complication, relates to adjacent organs such as larynx, trachea, lung, oral cavity, nasal sinuses, middle ear, eye and lymphonodi cervicales etc. Sometimes the symptom of nasopharynx part protopathy has taken a turn for the better or has disappeared, and its complication can delay or increase the weight of, therefore must make the clinical characters of upper respiratory tract infection and complication thereof comprehensively to observe and analyze, so as early diagnosis, early treatment, improve curative effect, can't think daily minor illness and rashness is treated.

The flu of 80%��90% is caused by virus, and the virus of flu can be caused to have kind more than 200; Account for the flu of 10%��20% caused by antibacterial. Baby within 1 year old not yet reaches maturity due to immune system, so being easier to catch a cold. Child easily catches a cold, and the physiology first stopped with their machine, anatomical features, developing immune system is immature relevant. The rhinostenosis of child, mucosa is tender, and mucosa glandular secretion is not enough, and drier, environmental adaptation and resistivity are poor to external world, it is easy to be inflamed. Premature infant, having the child of birth defect or disease, such as pulmonary insufficiency, when particularly suffering from natural immunity disease, nursing is slightly slipped up and but can be caught a cold.

Infantile common cold also has relation with head of a family's feeding patterns is improper, and a result to 157 famous expert's progress row " investigation of child nutrition popularization of knowledge " shows, understands that the people of general child-bearing nutrient knowledge only accounts for 10.2%. Owing to child's growth promoter is fast, those take agalactous child because lacking breast milk, and excessively pamper, the child of monophagia, anorexia, malnutrition or unbalanced, it is possible to cause iron deficiency in various degree, calcium deficiency or vitamin and protein Deficiency of Intake. The nutritional labelings such as ferrum, zinc and protein are to the synthesis of immune various globulin and promote that immune cell maturation, differentiation all play an important role, and affect the resistivity of child's body. Health is deficient in vitamin A, causes airway epithelial cell cilium to reduce, disappears, and body of gland loses the immune antibody of normal function, lysozyme and secretion and significantly reduces, and barrier function goes down, and can cause infecting and occurs. And calcium Deficiency of Intake can cause rickets of child, causing lower for the resistance, susceptible viral, antibacterial infect. Low calcium may result in airway epithelial cell ciliary movement to be weakened, and makes respiratory secretions not easily discharge. These are all the reasons causing flu.

Infantile common cold is also possible to bad with surrounding relevant. Some child's family room conditions are poor, dark moist; Some indoor temperatures are excessive or too low; Some families like being closed by door and window all day, atmosphere draught-free; Some kinsfolks have a liking for smoking, add in main room and light a fire, and smoke contamination is serious. Environment is bad, stuffy, and respiratory tract harm is very big, is the major reason bringing out flu. Some heads of a family wear the clothes too much or very few to child, and result is not that perspiration is suffered from cold exactly, it is easy to bring out flu.

Finally, flu is also relevant with lacking outdoor exercise. Owing to objective condition limits, or paying attention to not, many children lack outdoor activities. Such as north of China and time cold season longer area, child stays in indoor the most of the time, seldom has an opportunity movable out of doors; Some heads of a family humour one's child, and child are closed in air-conditioned room all day long. These children, once it's just a slight cold, just cannot adapt to, very easily catch a cold.

For great majority flu, being mostly due to caused by virus, antibacterials are invalid, particularly early stage viral infection, not only antibiotic is invalid, and abuse of antibiotics can cause body dysbacteriosis, favourable germ reproduction on the contrary, increases the weight of the state of an illness.

The traditional Chinese medical science is thought, flu is mainly affected by the cold, wind heat or time row epidemic disease poison caused by, thus be classified as wind and cold, wind heat, time row type flu. Additionally also have experience the summer-wet type common cold that heat-damp in summer causes summer, and body void experiences several big types such as the weakness type cold that above-mentioned pathogenic factor causes. Its Therapeutic Principle is that Chinese medicine just has this feature for the above-mentioned different pathogeny determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs causing flu. Proving according to modern study, many Chinese medicines also have certain antiviral and improve the effect of body immunity. Compared with Western medicine, dialectical ask originally be treatment by Chinese herbs flu advantage, the flu course of disease can be shortened, and in preventing cold, also have positive role, and side effect is smaller.

Summary of the invention

The present invention in order to overcome above-mentioned technical disadvantages provide a kind of oral liquid for infantile acute upper respiratory infection, the present invention has effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, lung moistening sending down the abnormal ascending QI, the symptoms such as the heating that causes for infantile common cold, distending pain in the head, glutinous, the laryngopharynx swelling and pain of cough expectorant have significant curative effect, and technical scheme is implemented as follows:

Make described effective ingredient crude drug composition and parts by weight be:

Exocarpium Citri Rubrum 63��84 parts, Flos Lonicerae 59��79 parts, 58��78 parts of the Radix Rehmanniae, Herba Schizonepetae 54��75 parts, Rhizoma Et Radix Notopterygii 52��70 parts, Radix Scutellariae 49��68 parts, Fructus Forsythiae 46��65 parts, Gardenia 41��63 parts, Radix Isatidis 38��60 parts, Radix Et Rhizoma Rhei 35��57 parts, Herba Taraxaci 33��54 parts, 29��51 parts of Radix Glycyrrhizae, Indigo Naturalis 28��46 parts, Concretio Silicea Bambusae 24��43 parts, Herba Pogostemonis 22��42 parts, Medulla Tetrapanacis 18��39 parts, 16��35 parts of clean rake leaf, Pericarpium Citri Reticulatae 11��31 parts, Cortex cercis chinensis 8��28 parts, Fructus Viticis 5��26 parts.

Exocarpium Citri Rubrum 67��79 parts, Flos Lonicerae 65��74 parts, 61��71 parts of the Radix Rehmanniae, Herba Schizonepetae 58��70 parts, Rhizoma Et Radix Notopterygii 57��65 parts, Radix Scutellariae 54��64 parts, Fructus Forsythiae 51��60 parts, Gardenia 46��56 parts, Radix Isatidis 45��53 parts, Radix Et Rhizoma Rhei 40��50 parts, Herba Taraxaci 38��47 parts, 36��44 parts of Radix Glycyrrhizae, Indigo Naturalis 33��43 parts, Concretio Silicea Bambusae 28��39 parts, Herba Pogostemonis 27��36 parts, Medulla Tetrapanacis 24��33 parts, 19��30 parts of clean rake leaf, Pericarpium Citri Reticulatae 17��27 parts, Cortex cercis chinensis 13��25 parts, Fructus Viticis 11��20 parts.

Exocarpium Citri Rubrum 74 parts, Flos Lonicerae 71 parts, 67 parts of the Radix Rehmanniae, Herba Schizonepetae 64 parts,

Rhizoma Et Radix Notopterygii 62 parts, Radix Scutellariae 58 parts, Fructus Forsythiae 54 parts, Gardenia 51 parts,

Radix Isatidis 49 parts, Radix Et Rhizoma Rhei 47 parts, Herba Taraxaci 44 parts, 41 parts of Radix Glycyrrhizae,

Indigo Naturalis 37 parts, Concretio Silicea Bambusae 33 parts, Herba Pogostemonis 31 parts, Medulla Tetrapanacis 29 parts,

25 parts of clean rake leaf, Pericarpium Citri Reticulatae 23 parts, Cortex cercis chinensis 18 parts, Fructus Viticis 15 parts.

The preparation method making described medicine, comprises the following steps that:

1, by above-mentioned medical material mix homogeneously, it is ground into coarse powder, the soak with ethanol 3-5h of the 45% of addition medical material gross weight 5��8 times amount, with the percolation speed percolation of per kilogram medical material 4-20mL/min, collects percolate.

2, decompression filtrate recycling ethanol, and to be concentrated into relative density be 1.20 (50 DEG C), filters.

3, filtrate such as adds at the simple syrup of weight, regulates pH value to 7.0 with 10% sodium hydroxide solution, is blended into the water of triplication, embedding, and sterilizing obtains this oral liquid.

The property of medicine of Chinese medicine used by the present invention is as follows:

Exocarpium Citri Rubrum: bitter in the mouth; Pungent; Warm in nature. Enter spleen; Lung meridian. Drying dampness to eliminate phlegm; Regulate the flow of vital energy; Help digestion. Cure mainly cough due to wind and cold's abundant expectoration; Vomiting singultus; Accumulation of food in the stomach and intes tine due to indigestion; Abdominal distention. " Bencao Congxin " carries: " Huazhou Pericarpium Citri Reticulatae, expectorant ZHILING, so disappearing, it is too high to cut down, and should not gently use ". Classical ancient prescription has ERCHEN TANG, " drying dampness to eliminate phlegm, regulate the flow of vital energy and in, control cough due to damp-phlegm. ", Daotan Tang, " removing dampness and eliminating phlegm, activating QI to alleviate the depression, cure mainly accumulation and obstruction of sputum, chest and diaphragm painful abdominal mass plug, or cough feel sick, diet is thought less, and liver-wind holds expectorant under the arm, vomiting and unable to take food, even syncope due to accumulation of phlegm person. " modern medicine study confirmation, Exocarpium Citri Grandis has significant antiinflammatory, reduces platelet aggregation, speeds the effects such as blood flow, is effectively improved the permeability of blood capillary.

Flos Lonicerae: sweet in the mouth; Cold in nature. Enter lung; Stomach warp. Heat-clearing and toxic substances removing. Cure mainly epidemic febrile disease heating; Toxic-heat and blood stasis; Carbuncle row skin ulcer; Sore throat and multi-infection disease. " explaining abstruseness of the canon of materia medica " carries: " main distension dysentery, eliminating carbuncle dissipates poison, and qi-restoratives treats wind, common people but know the merit of its sterilization, hide the use of its swollen sharp wind void, with it in all diseases of minor, take effect repeatedly. " clinic study shows; Flos Lonicerae has antibacterial significantly and antivirus action; staphylococcus aureus, Hemolytic streptococcus, dysentery, typhoid fever, meningococcus, Diplococcus pneumoniae, bacillus pyocyaneus and influenza virus are had obvious inhibitory action; can strengthen function of immune system; promote lymphocyte transformation; strengthen the phagocytic function of leukocyte, promotes the release of adrenocortical hormone, inflammation has obvious inhibitory action.

The Radix Rehmanniae: sweet in the mouth; Bitter; Cold nature. GUIXIN; Liver; Kidney channel. Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood. Cure mainly calentura excessive thirst; Interior-heat is quenched one's thirst; Hectic fever due to YIN-deficiency consumptive fever; Epidemic febrile disease sends out speckle; Haematemesis caused by heat in blood; Metrorrhagia; Hematuria; Have blood in stool; Blood deficiency and yellow complexion; Dizziness cardiopalmus; Insufficiency of blood amenorrhea. " Japan hanako materia medica " carries: " controlling palpitation with fear labor bad, cardiopulmonary damage, and spit blood, epistaxis, and married woman's metrorrhagia bruise helps muscles and bones. " modern medicine study confirms, the Radix Rehmanniae is effective immunostimulant, comprises the beneficial many amino acids of human body, saccharide, and have heart tonifying, diuresis, blood pressure lowering, blood sugar lowering, protect the liver, the pharmacological action such as antibacterial, hemocytes increasing.

Herba Schizonepetae/mustard fringe: acrid in the mouth; Micro-hardship; Slightly warm in nature. Enter lung; Liver Channel. Dispel the wind; Induce sweat; Rash; Hemostasis. Cure mainly cold, fever; Headache; Eye itching; Cough; Laryngopharynx swelling and pain; Measles; Carbuncle; Skin ulcer scabies; Epistaxis; Spit blood; Have blood in stool; Metrorrhagia; Puerperal blood faints. " the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " control traumatic injury deposited skin infection. Control haematemesis. Herba Schizonepetae, all wind of upper refresh oneself, only headache, improving eyesight, solve lung, liver, throat burning pain, detumescence, except all poison, disperse carbuncle sore. Treating hematochezia, only woman's sudden onset of metrorrhagia, pathogenic wind expelling heat, logical lung qi nose key plug closes. " modern medicine study proves; Herba Schizonepetae has significant antipyretic-antalgic effect; staphylococcus aureus and diphtheria corynebacterium are had stronger antibacterial action; anthrax bacillus, group B streptococcus, Bacillus typhi, dysentery bacterium, bacillus pyocyaneus, Bacillus tuberculosis etc. are all showed certain inhibitory action; have anastalsis after parch to black, in addition with the effect of certain anticancer.

Rhizoma Et Radix Notopterygii: acrid in the mouth; Bitter; Warm in nature. Enter bladder; Kidney channel. Dissipate exterior cold; Wind-damp dispelling; Profit joint; Pain relieving. Cure mainly affection of exogenous wind-cold; Have a headache lossless; Mimeograph cold-damp numbness; Edema due to wind pathogen edema; Sore swollen toxin. " Thunder God concocts property of medicine solution " load: " controlling arthrodynia of extremities, brothers' sun herbal classic wind medicine also, adds Rhizoma Chuanxiong and controls the sufficient sun, SHAO YIN headache, thoroughly pass profit joint, dispelling the wind and dampness pathogens again. Gas belongs to clearly sun, benefaction edema caused by disorder of QI, relaxes and does not hold back, and rises and can sink, male and kind scattered, can deliver heresy, therefore sun small intestinal of starting with, sufficient sun bladder are to manage urticaria. "

Radix Scutellariae: bitter in the mouth; Cold in nature. Return lung; Gallbladder; Spleen; Stomach; Large intestine; Small intestine meridian. Heat clearing and damp drying; Eliminating fire and detoxication; Arresting bleeding and miscarriage prevention; Blood pressure lowering. Cure mainly hygropyrexia, heat-damp in summer vomiting and nausea uncomfortable in chest; Damp and hot feeling of fullness; Dysentery; Jaundice; Cough due to lung-heat; Heat in blood tells nosebleed; Carbuncle sore tumefacting virus; Frequent fetal movement. " herbal classic " carries: " main all hot jaundice, intestinal is out-of-the-way, lets out profit, relieves oedema or abdominal distension through diuresis or purgation, and hematochezia closes, malignant boil, and cellulitis is lost, acute scleritis. " modern medicine study confirms, Radix Scutellariae has the effect such as antibacterial, antifungal, antiviral, antiinflammatory, antiallergic action significantly, can reduce blood pressure, suppress platelet aggregation, anticoagulant, blood fat reducing, in addition with protecting the liver, function of gallbladder promoting, antioxidation, anticancer function.

Fructus Forsythiae: bitter in the mouth; Cold nature. Enter lung; The heart; Gallbladder meridian. Heat-clearing and toxic substances removing; Dispersing swelling and dissipating binds. Cure mainly anemopyretic cold; Epidemic febrile disease; Pyretic stranguria urine retention; Carbuncle; Toxic swelling; Scrofula; Goiter; Sore throat. Shennong's Herbal carries: " main cold and heat, scrofula, scrofula, carbuncle malignant boil, goiter, stagnation of pathogenic heat. " clinic study shows; Fructus Forsythiae has broad-spectrum antibacterial action; staphylococcus aureus, Hayes dysentery bacterium are had very strong inhibitory action; other pathogenic bacterium, influenza virus, fungus are had certain inhibitory action; contained oleanolic acid has heart tonifying, diuresis and hypotensive activity; Citrin can reduce vascular permeability and fragility, it is prevented that haemolysis, tells in addition with antiinflammatory, town, anti-liver injury effect.

Gardenia: bitter in the mouth; Cold in nature. Enter the heart; Liver; Lung; Stomach; Tri-jiao channel. Pathogenic fire purging relieving restlessness; Clearing away heat-damp and promoting diuresis; Removing pathogenic heat from blood and toxic substance from the body. Cure mainly calentura vexed; Liver-fire conjunctival congestion; Headache; Damp and hot yellow infantile malnutrition; Stranguria; Hematemesis and epistaxis; Dysentery hematuria; Aphtha of the mouth and tongue; Sore swollen toxin; Sprain and swell and ache. Materia Medica of Decoction carries: " Fructus Gardeniae diuresis, real non-diuresis, lung heat clearing also, normal lung-QI and change, bladder is the mansion of body fluid, and urine obtains this gasification and goes out also. " modern medicine study confirms; Fructus Gardeniae is containing flavonoid gardenin; bile secretion is had obvious potentiation by Aqueous extracts; gallbladder has obvious contraction; and can reduce in blood and bilirubin in tip lymph fluid; promoting that blood mesobilirubin is drained rapidly, geniposide has promotion pancreatic secretion and has the effect significantly reducing pancreatic amylase, and can increase pancreas gallbladder flow.

Radix Isatidis: bitter in the mouth; Cold in nature. Enter liver; Stomach warp. Heat clearing away; Removing toxic substances; Removing heat from blood; Sore-throat relieving. Cure mainly maculae caused by violent heat pathogen; High heat headache; Major part pestilence; Scarlet fever; Erysipelas; Mumps; Sore throat; Skin ulcer swells; Chickenpox; Measles; Hepatitis; Influenza. " book on Chinese herbal medicine is just read " carries: " entering liver stomach blood system, heat clearing away, removing toxic substances, ward off epidemic disease, parasite killing is also. " modern medicine study confirms, various bacteria is had inhibitory action by Radix Isatidis, can kill leptospira; solves Rhizoma et radix veratri (Radix Rhizoma Veratri) poison, strengthens antibody forming cell, improves body's immunity; in addition Radix Isatidis isatin jade can strengthen the phagocytic activity of mononuclear phagocyte, there is certain antitumaous effect.

Radix Et Rhizoma Rhei: bitter in the mouth; Cold in nature. Enter stomach; Large intestine; Liver; Spleen channel. Attack stagnant; Clearing away damp-heat; Pathogenic fire purging; Removing heat from blood; Blood stasis dispelling; Removing toxic substances. Cure mainly excess-heat constipation; The accumulation of heat feeling of stuffiness in chest; Damp-heat dysentery; Jaundice; Gonorrhea; Edema abdominal distention; Dysuria; Conjunctival congestion; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Gastropyretic vomiting; Spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Blood-retention; Amenorrhea; Puerperal the stagnant stomachache of the stasis of blood; Abdominal mass is gathered; Traumatic injury; Pyretic toxicity carbuncle and ulcer; Erysipelas; Scald. " Japan hanako materia medica " carries: " logical all gas of declaring, blood circulation regulating, profit joint are rushed down stagnant, the aqueous vapor of heap soil or fertilizer over and around the roots, extremity unbalanced cold and heat, temperature miasma heat-phlegm, profit defecation, and applied all furuncle carbuncle poison. " modern medicine study confirmation; Radix Et Rhizoma Rhei has broad-spectrum antiviral, antibacterial and antimycotic effect; can be used for the preventing and treating of various inflammation; the effective ingredient of Radix Et Rhizoma Rhei can eliminate oxygen-derived free radicals; anti-lipid peroxidation; has anti-aging effects, additionally has prominent adjustment immunologic function, diseases of urinary system has prevention clearly and therapeutical effect.

Herba Taraxaci: bitter in the mouth; Sweet; Cold in nature. Return liver; Stomach warp. Heat-clearing and toxic substances removing; Eliminating carbuncle eliminating stagnation. Cure mainly acute mastitis; Lung abscess; Intestinal carbuncle; Mumps; Furuncle carbuncle toxin; Conjunctival congestion and swelling pain; Cold, fever; Cough; Laryngopharynx swelling and pain; Stomach-fire; Intestinal is scorching; Dysentery; Hepatitis; Cholecystitis; Urinary tract infection; Snake bite and insect sting. " the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " control all pyogenic infections from tumour or sore, ruined tinea skin ulcer; Dispeling the wind, disappear all sores, dissipates scrofula tuberculosis; Stop little having blood in stool, control the five types of stranguria difficulty in urination, profit bladder. " clinic study shows, dandelion preparation can replace antibiotics to use to a certain extent, some disease shows effect of broad-spectrum antibiotic, has certain antiviral functions.

Radix Glycyrrhizae: sweet in the mouth; Property is put down. GUIXIN; Lung; Spleen; Stomach warp. Invigorating the spleen and replenishing QI; Heat-clearing and toxic substances removing; Expelling phlegm for arresting cough; Relieving spasm to stop pain; Coordinating the actions of various ingredients in a prescription. Cure mainly weakness of the spleen and stomach; Fatigue and weakness; Shortness of breath and palpitation; Cough with copious phlegm; Gastral cavity abdomen four muscle spasm of the leg and foot pain; Carbuncle sore tumefacting virus; Cushion toxicity. Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch. Controlling 72 kinds of mammary calculus poison, draft is malicious by every means to solve 1,002, is in harmonious proportion and gains merit from medicine. " modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; is widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, additionally has anti-gastric-ulcer, gastritis effect.

Indigo Naturalis: salty in the mouth; Cold in nature. Return liver; Lung; Stomach warp. Cure mainly heat-clearing and toxic substances removing; Cooling blood for hemostasis; Purging liver-fire. Main epidemic febrile disease maculopapulae due to toxic heat; Heat in blood is spitted blood; Epistaxis; Spitting of blood; Liver-heat infantile convulsion; Liver-fire invading the lung is coughed; Laryngopharynx swelling and pain; Erysipelas; Zha; Skin ulcer swells; Snake bite and insect sting. Modern medicine study confirms, Indigo Naturalis can strengthen the phagocytic activity of the Mononuclear phagocyte system of animal. Testing through antifungal, microsporum canis, disconnected tineatonsurans, microsporon gypseum, purple tinea bacterium, trichophyton gypseum, red mentagrophytes, acrothesium floccosum etc. are all had stronger inhibitory action by it, and its minimal inhibitory concentration is 5 �� g/ml.

Concretio Silicea Bambusae: sweet in the mouth; Cold in nature. Enter the heart; Liver; Gallbladder meridian. Removing heat-phlegm; The cool heart is calmed the frightened. Cure mainly infantile convulsion; Epilepsy; Middle wind-phlegm fan; Calentura coma; Expectorant heat syndrome cough is breathed heavily. " book on Chinese herbal medicine converge with speech " load: " Succus Bambusae speed, straight-through meridians and have the merit of cold cunning; Concretio silicea Bambusae seu schizostachyi delays, empty antipyretic and more have that arresting convulsion calms the nerves wonderful. " modern medicine study confirmation, blood vessel is had direct dilating effect by Concretio Silicea Bambusae, can significantly extend blood plasma recalcification time, zest pain is had good analgesic activity, can significantly reduce writhing response number of times caused by acetic acid, alleviates the sufficient sole of the foot caused by Ovum Gallus domesticus album and swells and ache.

Herba Pogostemonis: acrid in the mouth; Slightly warm in nature. Return lung; Spleen; Stomach warp. Dispelling summer-heat from superficies of the body; Removing dampness to restore normal function of the stomach. Cure mainly summertime flu; Cold and heat are had a headache; Breast gastral cavity painful abdominal mass is vexed; Vomiting is had loose bowels; Vomiting during pregnancy; Nasal sinusitis; Tinea manus and pedis. " book on Chinese herbal medicine is stated " carries: " cold expelling is wet, heat-damp in summer, hot and suffocating, damp and hot. It is in harmony diseases caused by exogenous pathogenic factor and trembles with fear that, internal injury diet, or diet hinders cold humidity hysteresis, and mountain breeze miasma, not FUSHUI scholar, cold and heat make the diseases such as malaria. " modern medicine study shows; fragrant contained GUANGXIANG ketone has good antifungal activity, staphylococcus aureus is had remarkable result, calcium ion is had antagonistic properties; be widely used in treatment dyspepsia, vomiting, diarrhoea and inappetence clinically, controls smooth muscle and is overexcited.

Medulla Tetrapanacis: sweet in the mouth, light; Cold nature. Enter lung; Stomach warp. Curing mainly dysuria, the puckery pain of all pouring, edema, jaundice, damp-warm diseases, puerperal, breast was few, agalactia, and blurred vision is deaf, and nose is trembled with fear aphonia, amenorrhea leukorrhagia. " Bencao Tujing ": " diuresis is held concurrently and solved all poison of drug. " modern medicine study confirms, Medulla Tetrapanacis has obvious diuretic effect, can substantially increase the discharge of potassium ion in urine, and urine sodium, urine chlorine are had no significant effect, therefore think that Medulla Tetrapanacis diuresis is relevant with row's potassium.

Pericarpium Citri Reticulatae: acrid in the mouth; Sweet; Cold in nature. Enter spleen; Stomach warp. The therapeutic method to keep the adverse QI flowing downwards; In tune; Reduce phlegm; Relieving alcoholic intoxication. Cure mainly drinking and eating irregularly; Upper gas stuffy sensation with restlessness; Get sick from drinking too much wine thirsty. " Japan hanako materia medica " carries: " skin is processed and is made soup, can alcoholic intoxication and wine thirsty, typhoid fever diet recurrence caused by overexertion person, dense pan-fried juice takes. " medicine clinical research shows; the Hesperidin contained by Pericarpium Citri Reticulatae can suppress gastric ulcer; reduces capillary permeability; has adjustment gastrointestinal function and antiinflammatory action; its volatile oil has eliminating the phlegm, relievings asthma, facilitating digestion liquid secretion and get rid of the effects such as enteral pneumatosis, in addition with coronary artery dilator, reduces blood pressure and the effect such as function of gallbladder promoting.

Cortex cercis chinensis: bitter in the mouth; Property is put down; Temperature; There is micro-poison. Enter liver; Spleen two warp. Promoting blood circulation to restore menstrual flow; Subduing swelling and detoxicating. Control anemofrigid-damp arthralgia; Vim and vigour pain; Sore throat; Drench disease; Carbuncle; Tinea scabies; Traumatic injury; Snake bite and insect sting. " classifying herbal " carries: " control all carbuncle, sore, the cold and hot not clear person of multiple abscess, all toxic swellings. " modern medicine study proves, capital section PR-1 virus is had inhibitory action by Cortex cercis chinensis, and Orphan virus can be delayed its pathological changes.

Fructus Viticis: bitter in the mouth, pungent; Cool in nature. Enter liver, stomach, bladder warp. Dispelling wind and heat pathogens, the clear profit head. Cure mainly anemopyretic cold, just, migraine, tooth disease, acute conjunctivitis, pain, dim many tears, arthralgia chiefly caused by damp pathogen contracture in order eyeball. Modern medicine study confirms, Fructus Viticis has significant sedation-analgesia and antipyretic effect. Fructus Viticis decocting liquid 1:10 concentration, has inhibitory action to virus ECHO11 strain. Staphylococcus aureus, Bacillus cereus, Bacillus megatherium are all had obvious inhibitory action by vitexicarpin. This product decocting liquid 1:10 concentrations on viral ECHO11 strain has inhibitory action.

The present invention compared with prior art, has the advantages that

The present invention has effect of heat-clearing and toxic substances removing, expelling phlegm for arresting cough, lung moistening sending down the abnormal ascending QI, the symptoms such as the heating that causes for infantile common cold, distending pain in the head, glutinous, the laryngopharynx swelling and pain of cough expectorant have significant curative effect, the medicinal raw material compatibility chosen brings out the best in each other, with low cost and without any side effects, it is suitable for child administration, clinic is widely popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated.

Embodiment 1

The crude drug of effective ingredient of the present invention forms and weight is:

Exocarpium Citri Rubrum 74g, Flos Lonicerae 71g, Radix Rehmanniae 67g, Herba Schizonepetae 64g,

Rhizoma Et Radix Notopterygii 62g, Radix Scutellariae 58g, Fructus Forsythiae 54g, Gardenia 51g,

Radix Isatidis 49g, Radix Et Rhizoma Rhei 47g, Herba Taraxaci 44g, Radix Glycyrrhizae 41g,

Indigo Naturalis 37g, Concretio Silicea Bambusae 33g, Herba Pogostemonis 31g, Medulla Tetrapanacis 29g,

Clean rake leaf 25g, Pericarpium Citri Reticulatae 23g, Cortex cercis chinensis 18g, Fructus Viticis 15g.

The processing step of process for preparing medicine of the present invention is:

1, by above-mentioned medical material mix homogeneously, it is ground into coarse powder, the soak with ethanol 4h of the 45% of addition medical material gross weight 5 times amount, with the percolation speed percolation of per kilogram medical material 15mL/min, collects percolate.

Usage and dosage: three times on the one, one time one, after meal half an hour clothes; It within 3 days, it is 1 course for the treatment of

Points for attention: during taking the present invention, avoid pungent food raw food food.

Embodiment 2

Exocarpium Citri Rubrum 72g, Flos Lonicerae 69g, Radix Rehmanniae 68g, Herba Schizonepetae 63g,

Rhizoma Et Radix Notopterygii 61g, Radix Scutellariae 58g, Fructus Forsythiae 54g, Gardenia 53g,

Radix Isatidis 50g, Radix Et Rhizoma Rhei 47g, Herba Taraxaci 44g, Radix Glycyrrhizae 39g,

Indigo Naturalis 38g, Concretio Silicea Bambusae 33g, Herba Pogostemonis 30g, Medulla Tetrapanacis 28g,

Clean rake leaf 26g, Pericarpium Citri Reticulatae 22g, Cortex cercis chinensis 19g, Fructus Viticis 15g.

The process for preparing medicine processing step of the present embodiment and usage and dosage and embodiment 1 are identical.

Embodiment 3

Exocarpium Citri Rubrum 74g, Flos Lonicerae 69g, Radix Rehmanniae 68g, Herba Schizonepetae 63g,

Rhizoma Et Radix Notopterygii 60g, Radix Scutellariae 59g, Fructus Forsythiae 54g, Gardenia 52g,

Radix Isatidis 50g, Radix Et Rhizoma Rhei 46g, Herba Taraxaci 44g, Radix Glycyrrhizae 41g,

Indigo Naturalis 37g, Concretio Silicea Bambusae 33g, Herba Pogostemonis 30g, Medulla Tetrapanacis 28g,

Clean rake leaf 26g, Pericarpium Citri Reticulatae 21g, Cortex cercis chinensis 19g, Fructus Viticis 16g.

The ultimate principle of the present invention, principal character and advantages of the present invention have more than been shown and described. Skilled person will appreciate that of the industry; the present invention is not restricted to the described embodiments; described in above-described embodiment and description is that principles of the invention is described; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements both fall within claimed wanting in the scope of the invention. Claimed scope is defined with its equivalent by appending claims.

Clinical data:

1, case selection

Selecting the infantile common cold patient 96 example clinical observation that my institute or outer court make a definite diagnosis, patient is randomly divided into two groups. Treatment group 48 example, 0��10 years old age, 5 years old mean age. Matched group 48 example, 0��10 years old age, 5 years old mean age. Two groups of qualifications and record of service are basically identical, without significant difference, have comparability.

2, treatment group patient takes Chinese medicine of the present invention, three times on the one, one time one, after meal half an hour clothes; Within 3 days, being 1 course for the treatment of, 1 course for the treatment of of the lighter, severe one can be fully recovered 2 one 3 courses for the treatment of. . Matched group takes QIANGLI YINQIAO PIAN, oral, one time 1,3 times flatly, 5 days be 1 course for the treatment of, 2 courses for the treatment of of the lighter, and severe one can be fully recovered 3 one 4 courses for the treatment of, and the person of being in a bad way is generally invalid.

3, efficacy determination:

(1) cure: after taking medicine, the clinical symptom disappearance such as high heat, creeping chill, headache, general weakness, appetite fall sharply, sleep disorder, passive protective physical fitness raising, healthy recovery.

(2) take a turn for the better: after taking medicine, above-mentioned symptom is alleviated to some extent.

(3) invalid: after taking medicine, symptom is without obvious change.

4, result

Curing 29 examples in treatment group, take a turn for the better 12 examples, invalid 7 examples, cure rate 60%, total effective rate 85%.

Curing 19 examples in matched group, take a turn for the better 9 examples, invalid 24 examples, cure rate 40%, total effective rate 58%.

Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.

Model case is illustrated:

1, the Qin, man, 3 years old. Infant is started the symptoms such as stream thin nasal discharge, gurgling with sputum, decreased food intake of receiving are few occur after wind, family's long band its be hospitalized for treatment, used multiple Drug therapy, poor effect, invalid. To our hospital afterwards, start to take oral liquid of the present invention, take transference cure after 1 course for the treatment of, the state of an illness is fully recovered.

2, poplar, female, 5 years old. Infant starts cough, nasal obstruction, the stream symptom such as thin nasal discharge, gurgling with sputum, few, the uneasy sleeping at night of decreased food intake of receiving occur after having a bath before 3 days, the head of a family feeds it and takes the medicine such as QIANGLI YINQIAO PIAN, cough syrup all to no effect. Recommending to take oral liquid of the present invention through doctor, after taking 1 course for the treatment of, symptom disappears substantially, and after taking the 2nd course for the treatment of, symptom is wholly absent, and the state of an illness is fully recovered.

3, Lee, man, 10 years old. Infants ' parents day finds that child has a fever cough with symptoms such as nasal obstruction, sneezes morning, to our hospital, diagnoses as seriousness flu. After taking 2 courses for the treatment of of oral liquid of the present invention, the symptom such as nasal obstruction, cough, sneeze, fever all disappears, and flu returns to one's perfect health.

4, Lee, female, 7 years old. Patient's high fever, going out the symptoms such as apogee sweating, agitation is thirsty, laryngopharynx swelling and pain, limb acid body are tired, used the equal inefficacy of many medicines, rear admission, after taking 1 course for the treatment of of oral liquid of the present invention, cold symptoms disappears substantially, takes recovery from illness after the 2nd course for the treatment of.

In the past few years, use the Children Treated with Chinese Traditional Drugs flu of the present invention, clinical practice shows that the symptoms such as heating that the present invention causes for infantile common cold, distending pain in the head, glutinous, the laryngopharynx swelling and pain of cough expectorant have significant curative effect, the present invention is with low cost and without any side effects, it is suitable for child administration, clinic is widely popularized.

Claims

1. the oral liquid for infantile acute upper respiratory infection, it is characterized in that, make described effective ingredient crude drug composition and parts by weight be: Exocarpium Citri Rubrum 63��84 parts, Flos Lonicerae 59��79 parts, 58��78 parts of the Radix Rehmanniae, Herba Schizonepetae 54��75 parts, Rhizoma Et Radix Notopterygii 52��70 parts, Radix Scutellariae 49��68 parts, Fructus Forsythiae 46��65 parts, Gardenia 41��63 parts, Radix Isatidis 38��60 parts, Radix Et Rhizoma Rhei 35��57 parts, Herba Taraxaci 33��54 parts, 29��51 parts of Radix Glycyrrhizae, Indigo Naturalis 28��46 parts, Concretio Silicea Bambusae 24��43 parts, Herba Pogostemonis 22��42 parts, Medulla Tetrapanacis 18��39 parts, 16��35 parts of clean rake leaf, Pericarpium Citri Reticulatae 11��31 parts, Cortex cercis chinensis 8��28 parts, Fructus Viticis 5��26 parts.

2. the oral liquid for infantile acute upper respiratory infection, it is characterized in that, make described effective ingredient crude drug composition and parts by weight be: Exocarpium Citri Rubrum 67��79 parts, Flos Lonicerae 65��74 parts, 61��71 parts of the Radix Rehmanniae, Herba Schizonepetae 58��70 parts, Rhizoma Et Radix Notopterygii 57��65 parts, Radix Scutellariae 54��64 parts, Fructus Forsythiae 51��60 parts, Gardenia 46��56 parts, Radix Isatidis 45��53 parts, Radix Et Rhizoma Rhei 40��50 parts, Herba Taraxaci 38��47 parts, 36��44 parts of Radix Glycyrrhizae, Indigo Naturalis 33��43 parts, Concretio Silicea Bambusae 28��39 parts, Herba Pogostemonis 27��36 parts, Medulla Tetrapanacis 24��33 parts, 19��30 parts of clean rake leaf, Pericarpium Citri Reticulatae 17��27 parts, Cortex cercis chinensis 13��25 parts, Fructus Viticis 11��20 parts.

3. the oral liquid for infantile acute upper respiratory infection, it is characterized in that, make described effective ingredient crude drug composition and parts by weight be: Exocarpium Citri Rubrum 74 parts, Flos Lonicerae 71 parts, 67 parts of the Radix Rehmanniae, Herba Schizonepetae 64 parts, Rhizoma Et Radix Notopterygii 62 parts, Radix Scutellariae 58 parts, Fructus Forsythiae 54 parts, Gardenia 51 parts, Radix Isatidis 49 parts, Radix Et Rhizoma Rhei 47 parts, Herba Taraxaci 44 parts, 41 parts of Radix Glycyrrhizae, Indigo Naturalis 37 parts, Concretio Silicea Bambusae 33 parts, Herba Pogostemonis 31 parts, Medulla Tetrapanacis 29 parts, 25 parts of clean rake leaf, Pericarpium Citri Reticulatae 23 parts, Cortex cercis chinensis 18 parts, Fructus Viticis 15 parts.

4. the preparation method of a kind of oral liquid for infantile acute upper respiratory infection according to claims 1 to 3, it is characterised in that comprise the following steps that:

(1) by above-mentioned medical material mix homogeneously, it is ground into coarse powder, the soak with ethanol 3-5h of the 45% of addition medical material gross weight 5��8 times amount, with the percolation speed percolation of per kilogram medical material 4-20mL/min, collects percolate.

(2) decompression filtrate recycling ethanol, and to be concentrated into relative density be 1.20 (50 DEG C), filters.

(3) filtrate such as adds at the simple syrup of weight, regulates pH value to 7.0 with 10% sodium hydroxide solution, is blended into the water of triplication, and sterilizing obtains this oral liquid.