CN104857404A - Traditional Chinese medicine preparation for treating pertussis by reducing phlegm and stopping coughing - Google Patents
Traditional Chinese medicine preparation for treating pertussis by reducing phlegm and stopping coughing Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine preparation for treating pertussis by reducing phlegm and stopping coughing and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine preparation is prepared from the following main raw materials in parts by weight: 9-15 parts of radix astragali, 11-16 parts of acalypha australis, 7-12 parts of herba andrographitis, 9-14 parts of morinda parvifolia, 11-15 parts of uncaria rhynchophylla, 8-13 parts of polytrichum commune, 9-15 parts of root of white flowered bitterness, 6-10 parts of root of orixa, 4-9 parts of radix stemonae, 9-12 parts of radix asteris, 11-17 parts of white orchid, 8-16 parts of faber bauhinia branchlet root, 12-15 parts of caulis bambusae in taeniam, 10-17 parts of centipeda minima, 8-14 parts of rhizoma phragmitis, 5-8 parts of garlic, 10-14 parts of aleuritopteris argentea and 8-12 parts of arisaema japonicum. The traditional Chinese medicine preparation is mild in medicine property, free of side effects, easily acceptable to infants with pertussis, free of adverse effects on growth and development of the infants with pertussis and applicable to treatment on the infants with pertussis.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to one and treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation and method for making thereof.
Background technology
Pertussis is the common Acute respiratory infectious disease of children's, and bordetella pertussis is the pathogenic bacterium of primary disease.It is characterized by paroxysmal spasmodic cough, cough end is with special air-breathing roar, and the course of disease is longer, can reach even about 3 months several weeks, therefore have the title of pertussis.Clinical manifestation: 1, general 7 ~ 10 days of incubation period, 21 days can be grown to.2, clinical disease course can be divided into for three phases.(1) catarrhal period.To there is paroxysmal spasmodic cough from morbidity, generally about 1 ~ 2 week.Start the similar flu of symptom, except cough, watery nasal discharge, sneeze, grade fever can be had, also can only have dry cough, not arouse attention.When other symptoms fade away, cough increases the weight of on the contrary, and day at light night is heavy, gradually in paroxysmal spasmodic cough shape.(2) stage of spasmodic cough.Be generally 2 ~ 6 weeks (from a couple of days to 2 wheat harvesting period).Paroxysmal, spasmodic cough are current period feature.Again and again during outbreak, continually shortly cough more than ten sound or tens of sound is expiration state, last profound air-breathing, because throat is at that time still in spasticity, therefore with in alt crow sample roar, and occur next time paroxysmal spasmodic cough, recurrent exerbation like this repeatedly, till bringing up sticky sputum.When coughing violent, stool, urine incontinence can be had, both hands clench fist elbow in the wrong, One's eyes nearly started from his head, flushed face with red ears, shed streams of tears and to snivel, head turns forward, dehisce to loll, color of the lip cyanosis etc., and expression is extremely painful, comes to an end in vomiting rear.For several times, severe one tens of times on the one, being night many for the lighter one day.When running, take food, suffer from cold, sootiness, cry and noisy etc. all can to bring out.Show effect last as without obvious omen.(3) intermission.Situation is without special.During paroxysmal spasmodic cough, superior vena cava pressure increases, and returns painstaking effort stream and is obstructed and has blood stasis phenomenon, common face and the puffiness of the eyes, when apasm of coughing is violent, can occurs nose Nv, spitting of blood and eye subconjunctival hemorrhage etc., even intracranial hemorrhage occur.The frequent person of paroxysmal spasmodic cough often affects sleep, cause infant tired, do not like activity, loss of appetite, add vomiting, secondary infection, can malnutrition be caused.As without secondary infection, the general body temperature of infant is normal, the no positive sign of pulmonary or have unfixed rale.3, neonate and young baby: normal without typical paroxysmal spasmodic cough, shows as paroxysmal and to hold one's breath cyanosis, easily causes to suffocate, faint from fear.Respiratory movement can stop at the expiration phase, and heart rate first speeds, and then slows down and even stops.If row artificial respiration, oxygen supply etc. are actively rescued not in time, can death by suffocation.
Treatment: 1. Therapeutic Principle: (1) general treatement.Press respiratory tract isolation, keep air fresh, avoid all can bring out the factor of paroxysmal spasmodic cough.Good nursing is with complication prevention.(2) antibiotic therapy.Be applied to catarrhal period or stage of spasmodic cough early stage, can reduce infectiousness, mitigation symptoms also shortens the course of disease.2. symptomatic treatment.Expelling phlegm for arresting cough agent is as ammonium chloride etc.Albuterol (salbutamol) 0.5mg/kg can alleviate cough symptom.Chlorpromazine etc. can reduce nocturnal cough, favourable sleep.Children baby should row artificial respiration at once when suffocating, and oxygen supply, gives relieving convulsion expectoration if desired.Available procaine intravenous instils, and every day 1 ~ 2 time, is used in conjunction 3 ~ 5 days, suffocates or faint from fear, need note HRV index simultaneously to reduce.Dehydrant can be used during pertussis encephalopathy.When having low calcium, hypoglycemia etc., give symptomatic treatment.3. the treatment of complication: by intercurrent disease kind, give corresponding treatment.4. 17-hydroxy-11-dehydrocorticosterone.Short application use in critical patient, as young baby or there is brain patient.Meticortelone is oral, or hydrocortisone intravenously administrable.5. outside, wipe therapy.With fresh ginger or Bulbus Allii section, sticky Limax liquid or Ovum Gallus domesticus album, from top to bottom embrocate at sternal part, 2 times on the 1st, every number of times minute.
Application publication number CN 103191354 A(application number 201310115143.2) Chinese patent literature disclose one and treat pertussal traditional Chinese medicine compound oral liquid, it is based on Cordyceps cicadae Shing, is equipped with India branch, shell, Radix Polygalae, Semen Armeniacae Amarum, Flos Inulae, Rhizoma Phragmitis, Radix Glycyrrhizae be prepared from by Radix Asteris, hundred steps, Bulbus Fritillariae Thunbergii, Herba Houttuyniae, sky.Application publication number CN 103768414(application number 201210399393.9) Chinese patent literature disclose one and treat pertussal Chinese medicine decoction, its formula is Radix Peucedani, Bulbus Fritillariae Cirrhosae, Mel, stir-baked FRUCTUS PERILLAE, Semen Raphani, Poria, Poria cum Radix Pini, Folium Nerviliae fordii, Semen Armeniacae Amarum, Radix Glycyrrhizae Preparata, Haematitum, Flos Inulae, Herba Ephedrae (processed), Rhizoma Phragmitis.Application publication number CN 103784828 A(application number 201210559640.7) Chinese patent literature disclose one and treat pertussal Chinese herbal medicine: Radix Platycodonis 10-20 part; Radix Stemonae 10-20 part; Rhizoma Cynanchi Stauntonii 10-20 part; Exocarpium Citri Rubrum 10-20 part; Radix Asteris 7-14 part; Flos Lonicerae 7-14 part; Bulbus Fritillariae Thunbergii 7-14 part; Radix Scutellariae 7-14 part; Semen Armeniacae Amarum 7-14 part; Radix Adenophorae (Radix Glehniae) 7-14 part; Radix Peucedani 7-14 part; Radix Isatidis 15-25 part.
At present, the antibiotic medicines such as western medical treatment pertussis many employings Roxithromycin, azithromycin, though there is certain curative effect, side effect is very big.The crowd suffering from this disease mainly concentrates in infant, and this type of crowd has certain inadaptable to medicine, takes medicine in a large number also to have bad impact to growth promoter from now on.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide one and treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation and method for making thereof.The property of medicine of the present invention is gentle, has no side effect, is easy to be accepted by infant, can not produce harmful effect to the growth promoter of infant, is applicable to the treatment of suffering from pertussal infant.
Technical scheme of the present invention is:
Treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 9-15, Herba seu Fructus Physalis Minimae 11-16, Herba Andrographis 7-12, Herba Morindae Parvifoliae 9-14, Ramulus Uncariae Cum Uncis 11-15, native Iuba Equi 8-13, Radix cardamines leucanthae 9-15, Radix orixae japonicae 6-10, Radix Stemonae 4-9, Radix Asteris 9-12, Flos micheliae Albae 11-17, Ramulus et Folium Bauhiniae Faberi 8-16, Caulis Bambusae In Taenia 12-15, Herba Centipedae 10-17, Rhizoma Phragmitis 8-14, Bulbus Allii 5-8, Aleuritopteris argentea (Gmel.) Fee 10-14, nine sons are not from female 8-12.
Treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, preferred scheme is, takes off the primary raw material medicine stating weight proportion and is prepared from: Radix Astragali 11-14, Herba seu Fructus Physalis Minimae 12-14, Herba Andrographis 8-10, Herba Morindae Parvifoliae 11-13, Ramulus Uncariae Cum Uncis 12-14, native Iuba Equi 9-12, Radix cardamines leucanthae 11-14, Radix orixae japonicae 7-9, Radix Stemonae 5-8, Radix Asteris 10-11, Flos micheliae Albae 12-14, Ramulus et Folium Bauhiniae Faberi 10-14, Caulis Bambusae In Taenia 13-14, Herba Centipedae 12-15, Rhizoma Phragmitis 10-13, Bulbus Allii 5.5-7, Aleuritopteris argentea (Gmel.) Fee 11-13, nine sons are not from female 9-11.
Treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the scheme be more preferably is, takes off the primary raw material medicine stating weight proportion and is prepared from: the Radix Astragali 12, Herba seu Fructus Physalis Minimae 13, Herba Andrographis 9, Herba Morindae Parvifoliae 12, Ramulus Uncariae Cum Uncis 13, native Iuba Equi 11, Radix cardamines leucanthae 12, Radix orixae japonicae 8, the Radix Stemonae 7, Radix Asteris 10.5, Flos micheliae Albae 13, Ramulus et Folium Bauhiniae Faberi 12, Caulis Bambusae In Taenia 13.5, Herba Centipedae 14, Rhizoma Phragmitis 12, Bulbus Allii 6, Aleuritopteris argentea (Gmel.) Fee 12, nine sons are not from female 10.
Present invention also offers the preparation method pertussal for aforementioned therapies preventing phlegm from forming and stopping coughing Chinese medicine preparation being made pharmaceutically acceptable thick paste agent, pill and decoction.
The preparation method of described thick paste agent is:
(1) Rhizoma Phragmitis is got, add rice vinegar to mix thoroughly, the weight of rice vinegar is the weight of the preferred rice vinegar of 1/4-1/2(of Rhizoma Phragmitis weight is 1/3 of Rhizoma Phragmitis weight), moistening 4-7 hour (preferred moistening 6 hours), puts and steams in container, steams 4-6 hour (preferably steaming 5 hours), take out, 55 DEG C of dry 8-12 hour (preferably 55 DEG C drying 10 hours), be ground into fine powder, cross No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter pot stewing out of water 50-75 minute (preferably entering pot stewing out of water 65 minutes), take out, 50 DEG C of dry 5-8 hour (preferably 50 DEG C drying 7 hours), be ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are decocted with water twice, each amount of water is the 3.7-5 of 16 taste crude drug gross weights doubly (preferably each amount of water is 4.5 times of 16 taste crude drug gross weights), and each decoction 1.2 hours, merges medicinal liquid, leave standstill 12 hours, obtain filtrate;
(4) in step (3) gained filtrate, Mel is added, the weight of Mel is the weight of the preferred Mel of 1/5-1/2(of step (3) gained filtrate weight is 1/3 of step (3) gained filtrate weight), be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, add step (1) and step (2) gained fine powder, stir evenly, to obtain final product.
The preparation method of described pill is:
(1) Rhizoma Phragmitis is got, add rice vinegar to mix thoroughly, the weight of rice vinegar is the weight of the preferred rice vinegar of 1/4-1/2(of Rhizoma Phragmitis weight is 1/3 of Rhizoma Phragmitis weight), moistening 4-7 hour (preferred moistening 6 hours), puts and steams in container, steams 4-6 hour (preferably steaming 5 hours), take out, 55 DEG C of dry 8-12 hour (preferably 55 DEG C drying 10 hours), be ground into fine powder, cross No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter pot stewing out of water 50-75 minute (preferably entering pot stewing out of water 65 minutes), take out, 50 DEG C of dry 5-8 hour (preferably 50 DEG C drying 7 hours), be ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are put into 55 DEG C of baking ovens, dry 12 hours, take out, grind to the powder altogether, cross No. six sieves; ;
(4) step (1), step (2) and step (3) gained fine powder are mixed;
(5) white sugar is got, the weight of white sugar is 6-9 times (weight of preferred white sugar is 8 times of step (4) gained fine powder weight) of step (4) gained fine powder weight, be heated to fusing, add step (4) gained fine powder again, slow fire is endured 2-5 minute (preferred slow fire endures 4 minutes), reduce internal heat slightly cold after make pill, the heavy 0.1g of every ball, to obtain final product.
The preparation method of described decoction is:
(1) 18 taste crude drug are put into marmite, add water and decoct altogether, amount of water is 6-8 times (preferred amount of water is 7.2 times of 18 taste crude drug gross weights) of 18 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 45-65 minute (preferably, a turn little fire decocts 58 minutes), leaches medicinal liquid;
(2) fill in the marmite of medicinal residues to step (1) and add water, amount of water is 3-5 times (preferred amount of water is 3.5 times of 18 taste crude drug gross weights) of 18 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 30-45 minute (preferably, a turn little fire decocts 40 minutes), leaches medicinal liquid;
(3) step (1) and step (2) gained medicinal liquid are merged, add crystal sugar, the weight of crystal sugar is the weight of the preferred crystal sugar of 1/8-1/5(of step (1) and step (2) gained medicinal liquid gross weight is 1/6 of step (1) and step (2) gained medicinal liquid gross weight), first boil to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 25 minutes), to obtain final product.
Chinese medicine preparation scientific formula provided by the invention.In addition, excellent results of the present invention also shows:
1, the property of medicine is gentle, has no side effect, is easy to be accepted by infant, can not produce harmful effect to the growth promoter of infant, is applicable to the treatment of suffering from pertussal infant;
2, there is effect of heat-clearing and toxic substances removing, antitussive and expectorant, nourishing the lung to arrest cough, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., removing heat from blood detumescence, evident in efficacy to treatment pertussis;
3, the preparation method of various dosage form is simple;
4, take natural Chinese medicinal herb as primary raw material, medicine source is easy to get and cheap.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 600g): the Radix Astragali 9 parts, Herba seu Fructus Physalis Minimae 11 parts, Herba Andrographis 7 parts, Herba Morindae Parvifoliae 9 parts, Ramulus Uncariae Cum Uncis 11 parts, 8 parts, native Iuba Equi, Radix cardamines leucanthae 9 parts, Radix orixae japonicae 6 parts, the Radix Stemonae 4 parts, Radix Asteris 9 parts, Flos micheliae Albae 11 parts, Ramulus et Folium Bauhiniae Faberi 8 parts, Caulis Bambusae In Taenia 12 parts, Herba Centipedae 10 parts, Rhizoma Phragmitis 8 parts, 5 parts, Bulbus Allii, Aleuritopteris argentea (Gmel.) Fee 10 parts, nine sons are not from female 8 parts.
The preparation method of above-mentioned treatment pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation decoction is:
(1) added water by 18 taste crude drug and decoct altogether, amount of water is 6 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 45 minutes afterwards, leaches medicinal liquid;
(2) fill in the marmite of medicinal residues to step (1) and add water, amount of water is 3 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 30 minutes afterwards, leaches medicinal liquid;
(3) step (1) and step (2) gained medicinal liquid are merged, add crystal sugar, the weight of crystal sugar is 1/8 of step (1) and step (2) gained medicinal liquid gross weight, first boils to boiling with big fire, and rear turn of little fire decocts 15 minutes, to obtain final product.
Gained of the present invention treats the instructions of taking of pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation decoction: oral, 2 years old with 5mL ~ 10mL, 2 ~ 5 years old one time 15mL ~ 25mL next time, 5 years old with last 30 ~ 50mL, 3 ~ 4 times on the one, warm.
embodiment 2treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 600g): the Radix Astragali 15 parts, Herba seu Fructus Physalis Minimae 16 parts, Herba Andrographis 12 parts, Herba Morindae Parvifoliae 14 parts, Ramulus Uncariae Cum Uncis 15 parts, 13 parts, native Iuba Equi, Radix cardamines leucanthae 15 parts, Radix orixae japonicae 10 parts, the Radix Stemonae 9 parts, Radix Asteris 12 parts, Flos micheliae Albae 17 parts, Ramulus et Folium Bauhiniae Faberi 16 parts, Caulis Bambusae In Taenia 15 parts, Herba Centipedae 17 parts, Rhizoma Phragmitis 14 parts, 8 parts, Bulbus Allii, Aleuritopteris argentea (Gmel.) Fee 14 parts, nine sons are not from female 12 parts.
The preparation method of above-mentioned treatment pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation decoction is:
(1) added water by 18 taste crude drug and decoct altogether, amount of water is 8 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 65 minutes afterwards, leaches medicinal liquid;
(2) fill in the marmite of medicinal residues to step (1) and add water, amount of water is 5 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 45 minutes afterwards, leaches medicinal liquid;
(3) step (1) and step (2) gained medicinal liquid are merged, add crystal sugar, the weight of crystal sugar is 1/5 of step (1) and step (2) gained medicinal liquid gross weight, first boils to boiling with big fire, and rear turn of little fire decocts 30 minutes, to obtain final product.
model case one:week XX, female, 5 years old.Infant occurs that the twin property of paroxysmal convulsion is coughed two weeks, once arrives the treatment of neighbouring clinic, unsatisfactory curative effect.On July 15th, 2009 examines.Examine and see infant paroxysm paroxysmal spasmodic cough, pause and cough again, with echo, the puffiness of the eyes, subconjunctival hemorrhage.Yellow and thin fur, slippery and rapid pulse.Be diagnosed as pertussis.Take the present embodiment gained and treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation decoction, three times on the one, each 25mL, warm.Take 3 days, cough obviously alleviates.Continue to take 3 days, recovery from illness.
embodiment 3treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 600g): the Radix Astragali 11 parts, Herba seu Fructus Physalis Minimae 12 parts, Herba Andrographis 8 parts, Herba Morindae Parvifoliae 11 parts, Ramulus Uncariae Cum Uncis 12 parts, 9 parts, native Iuba Equi, Radix cardamines leucanthae 11 parts, Radix orixae japonicae 7 parts, the Radix Stemonae 5 parts, Radix Asteris 10 parts, Flos micheliae Albae 12 parts, Ramulus et Folium Bauhiniae Faberi 10 parts, Caulis Bambusae In Taenia 13 parts, Herba Centipedae 12 parts, Rhizoma Phragmitis 10 parts, 5.5 parts, Bulbus Allii, Aleuritopteris argentea (Gmel.) Fee 11 parts, nine sons are not from female 9 parts.
The preparation method of above-mentioned treatment pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste agent is:
(1) get Rhizoma Phragmitis, add rice vinegar and mix thoroughly, the weight of rice vinegar is 1/3 of Rhizoma Phragmitis weight, and moistening 6 hours, puts and steam in container, steam 5 hours, takes out, and 55 DEG C of dryings 10 hours, are ground into fine powder, crosses No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter pot stewing out of water 65 minutes, take out, 50 DEG C of dryings 7 hours, are ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are decocted with water twice, each amount of water is 4.5 times of 16 taste crude drug gross weights, and each decoction 1.2 hours, merges medicinal liquid, leaves standstill 12 hours, obtains filtrate;
(4) in step (3) gained filtrate, add Mel, the weight of Mel is 1/3 of step (3) gained filtrate weight, is condensed into the thick paste that relative density is 1.34, adds step (1) and step (2) gained fine powder, stirs evenly, to obtain final product.
model case two:sieve XX, female, 3 years old.Infant is coughed 20 days, and once drug administration treatment, has no improvement.On November 10th, 2009 examines.Infant mother tells infant paroxysm of cough, increases the weight of gradually, and light night in daytime is heavy.Examine and see infant paroxysm of cough heavy cough, clear and thin sputum, pallor cold physique, pale tongue, Tai Bai and sliding, floating pulse.Be diagnosed as pertussis.Take the present embodiment gained and treat the agent of pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste, three times on the one, each 10g, drink-service washed open by boiled water.Take 3 days, only cough daytime, night, cough obviously alleviated.Continue to take 4 days, recovery from illness.
embodiment 4treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 600g): the Radix Astragali 14 parts, Herba seu Fructus Physalis Minimae 14 parts, Herba Andrographis 10 parts, Herba Morindae Parvifoliae 13 parts, Ramulus Uncariae Cum Uncis 14 parts, 12 parts, native Iuba Equi, Radix cardamines leucanthae 14 parts, Radix orixae japonicae 9 parts, the Radix Stemonae 8 parts, Radix Asteris 11 parts, Flos micheliae Albae 14 parts, Ramulus et Folium Bauhiniae Faberi 14 parts, Caulis Bambusae In Taenia 14 parts, Herba Centipedae 15 parts, Rhizoma Phragmitis 13 parts, 7 parts, Bulbus Allii, Aleuritopteris argentea (Gmel.) Fee 13 parts, nine sons are not from female 11 parts.
The preparation method of above-mentioned treatment pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation pill is:
(1) get Rhizoma Phragmitis, add rice vinegar and mix thoroughly, the weight of rice vinegar is 1/3 of Rhizoma Phragmitis weight, and moistening 6 hours, puts and steam in container, steam 5 hours, takes out, and 55 DEG C of dryings 10 hours, are ground into fine powder, crosses No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter pot stewing out of water 65 minutes, take out, 50 DEG C of dryings 7 hours, are ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are put into 55 DEG C of baking ovens, dry 12 hours, take out, grind to the powder altogether, cross No. six sieves; ;
(4) step (1), step (2) and step (3) gained fine powder are mixed;
(5) get white sugar, the weight of white sugar is 8 times of step (4) gained fine powder weight, and be heated to fusing, then add step (4) gained fine powder, slow fire endures 4 minutes, reduce internal heat slightly cold after make pill, the heavy 0.1g of every ball, to obtain final product.
model case three:guo XX, man, 2 years old.Paroxysmal cough three weeks.Repeatedly treat through Chinese medicine and western medicine, poor effect.On May 17th, 2010 examines.Examine and see the paroxysm of infant cough with asthma, in spasm shape, flushing conjunctival congestion, see when coughing play that its expression is painful, two hold fist, conjunctival congestion white of the eye is covered with the blood streak, have the blood streak and clot in nasal mucus, color and luster is scarlet, and high-pitched tone crow sample air-breathing roar is seen at apasm of coughing end, tears alternately, and the side of coughing stops temporarily after telling faint yellow mucus, colour of the tongue is red, yellow and thin fur, rapid pulse, fingerprint purple.Be diagnosed as pertussis.Take the present embodiment gained and treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation pill, each 10 balls, every day 3 times, the head of a family rubs pill broken, becomes soup to feed to infant by warm water molten in little spoon.Take 4 days, symptom is improved.Take 7 days, recovery from illness.
embodiment 5treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, the primary raw material medicine getting following weight parts is prepared from (every part is 600g): the Radix Astragali 12 parts, Herba seu Fructus Physalis Minimae 13 parts, Herba Andrographis 9 parts, Herba Morindae Parvifoliae 12 parts, Ramulus Uncariae Cum Uncis 13 parts, 11 parts, native Iuba Equi, Radix cardamines leucanthae 12 parts, Radix orixae japonicae 8 parts, the Radix Stemonae 7 parts, Radix Asteris 10.5 parts, Flos micheliae Albae 13 parts, Ramulus et Folium Bauhiniae Faberi 12 parts, Caulis Bambusae In Taenia 13.5 parts, Herba Centipedae 14 parts, Rhizoma Phragmitis 12 parts, 6 parts, Bulbus Allii, Aleuritopteris argentea (Gmel.) Fee 12 parts, nine sons are not from female 10 parts.
The preparation method of above-mentioned treatment pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation decoction is:
(1) added water by 18 taste crude drug and decoct altogether, amount of water is 7.2 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 58 minutes afterwards, leaches medicinal liquid;
(2) fill in the marmite of medicinal residues to step (1) and add water, amount of water is 3.5 times of 18 taste crude drug gross weights, first boils to boiling with big fire, turns little fire and decocts 40 minutes afterwards, leaches medicinal liquid;
(3) step (1) and step (2) gained medicinal liquid are merged, add crystal sugar, the weight of crystal sugar is 1/6 of step (1) and step (2) gained medicinal liquid gross weight, first boils to boiling with big fire, and rear turn of little fire decocts 25 minutes, to obtain final product.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
The Radix Astragali: base is former: be the dry root of leguminous plant Radix Astagali or Radix Astragali.The property of medicine: sweet, temperature.Return lung, spleen channel.Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, and burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst, chronic nephritis proteinuria, diabetes.
Herba seu Fructus Physalis Minimae: base is former: be herb or the fruit of the little Calyx seu fructus physalis of plant of Solanaceae.The property of medicine: bitter in the mouth; Cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Expelling phlegm for arresting cough, hard masses softening and resolving.Main jaundice due to damp-heat, dysuria, chronic cough and asthma, infantile malnutrition, scrofula, epidemic blisters, eczema, furuncle and phyma.
Herba Andrographis: base is former: be herb or the leaf of acanthaceous plant Herba Andrographis.The property of medicine: " Quanzhou book on Chinese herbal medicine ": " bitter in the mouth, cold in nature, nontoxic." " Quanzhou book on Chinese herbal medicine ": " enter the heart, lung two warp." function cures mainly: heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Control acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, oropharynx swells and ache, furuncle carbuncle, burn due to hot liquid or fire, venom.
Herba Morindae Parvifoliae: base is former: be the Herb of Rubiaceae Morinda plant spire Radix Morindae Officinalis.The property of medicine: " Guangxi book on Chinese herbal medicine a collection of selected materials ": " sweet, cool in nature." function cures mainly: clearing and antitussive, stomach function regulating removing dampness, eliminating stasis to stop pain.Cure mainly cold cough, pertussis, dyspepsia, eczema, traumatic injury, lumbar muscle strain.
Ramulus Uncariae Cum Uncis: base is former: be Maguireothamnus speciosus Ramulus Uncariae Cum Uncis or Uncaria sinensis (Oliv.) Havil. and the buckle branch belonging to various plants together thereof.Main component: containing an ancient unit of weight rattan alkali, isorhynchophylline, corynoxeine, different corynoxeine, corynantheine alkali, dihydrocorynantheine alkali, hirsutine, hirsuteine.Different Ramulus Uncariae Cum Uncis, corynoxein, different corynoxein, hair 9-methoxycorynantheidine., dehydrogenation hair 9-methoxycorynantheidine., pocket HUAMU alkali and dihydro pocket HUAMU alkali.The property of medicine: sweet, cool.Return liver, heart channel.Function cures mainly: heat clearing away suppressing the hyperactive liver, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Control pediatric epilepsy scared Chi Zong, adult's slight Hypertension, dizzy, dizzy, married woman's eclamposia.
Soil Iuba Equi: base is former: be the plant of pigeon-wheat section plant pigeon-wheat.The property of medicine: sweet; Cold; Acid; Salty; Bitter; Cool; Light; Flat; Nontoxic.Return lung, liver, large intestine channel.Function cures mainly: nourishing YIN and clearing away heat, cooling blood for hemostasis.Main deficiency of YIN hectic fever due to YIN-deficiency, hectic fever night sweat, pulmonary tuberculosis cough, heat in blood is spitted blood, epistaxis, and spitting of blood, has blood in stool, metrorrhagia, constipation and anuresis.
Radix cardamines leucanthae: base is former: be root stock or the herb of crucifer Cardamine leucantha.The property of medicine: pungent; Sweet; Flat.Return lung, Liver Channel.Function cures mainly: preventing phlegm from forming and stopping coughing, promoting blood circulation and stopping pain.Main pertussis, chronic bronchitis, menoxenia, traumatic injury.
Radix orixae japonicae: base is former: be the root of rutaceae orixa japonica.The property of medicine: bitter in the mouth; Pungent; Cool in nature.Return lung, stomach, kidney, large intestine channel.Function cures mainly: wind and heat dispersing, promoting flow of QI and blood, removing toxic substances dehumidifying, preventing the attack (or recurrence) of malaria.Main anemopyretic cold, cough, laryngalgia, abdominal distention, rheumatic arthritis, traumatic pain, hygropyretic dysentery, the scrotum is perspired, malaria.
The Radix Stemonae: base is former: be the root of Stemonaceae plant Radix Stemonae, Radix stemonae japonicae and radix stemonae tuberosae.The property of medicine: sweet; Bitter; Tepor.Return lung meridian.Function cures mainly: nourishing the lung to arrest cough, parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.
Radix Asteris: another name Radix Asteris, short braid, clamping plate dish, donkey ear dish, soft Radix Asteris.Base is former: be the root and rhizome of feverfew Radix Asteris.Chemical analysis: root, containing freidelin alcohol, freidelin, shionon, astersaponin, Quercetin, contains lachnophyllol, acetic acid hair leaf ester, methoxybenzene, hydrocarbon, fatty acid, aromatic acid etc. in volatile oil.The property of medicine: pungent, bitter, temperature.Return lung meridian.Function cures mainly: nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Breath with cough for abundant expectoration, new chronic cough is coughed, chronic cough hemoptysis.
Flos micheliae Albae: base is former: be the flower of Magnoliacea plant white orchid.The property of medicine: bitter, pungent, slightly warm in nature.Function cures mainly: removing dampness, circulation of qi promoting, cough-relieving.Main abdominal distention uncomfortable in chest, heatstroke, cough, prostatitis, leucorrhea.
Ramulus et Folium Bauhiniae Faberi: base is former: be branch and leaf or the root of leguminous plant saddle leaf Bauhinia purpurea.The property of medicine: bitter, puckery, flat.Function cures mainly: clearing heat and moistening lung, and yin fluid astringing is calmed the nerves, dehumidifying, parasite killing.Control pertussis, palpitation and insomnia, night sweat is passed out semen, and scrofula is stolen, eczema, scabies.
Caulis Bambusae In Taenia: base is former: the intermediate layer that the stem stalk for grass family Phyllostachys plant phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, the blue or green pole bamboo of Thorny Sinobambusa plant, Sinocalamus plant major part allusion quotation bamboo etc. goes crust to scrape.Composition: the Caulis Bambusae In Taenia of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle is containing phenolic constituent: 2,5-dimethoxy-1,4-benzoquinone, hydroxy benzaldehyde, syringic aldehyde, coniferyl aldehyde.Another containing p-phthalic acid 2 '-hydroxyethyl methyl ester.The property of medicine: sweet, is slightly cold.Return spleen, stomach, gallbladder meridian.Function cures mainly: removing heat-phlegm, relieves restlessness and prevents vomiting, antiabortive removing heat from blood.Cure mainly cough due to lung-heat, dysphoria with smothery sensation is palpitated with fear, and gastric heat is vomitted oh, pregnancy reactions, frequent fetal movement, spits blood, epistaxis, hematuria, metrorrhagia.
Herba Centipedae: base is former: be the wounded in the battle herb of feverfew Myriogyne minuta.Chemical analysis: still contain stigmasterol, sitosterol, flavonoid, volatile oil, organic acid etc. containing multiple Triterpenoid, taraxerol, taraxasterol, arnidiol and another kind of three unknown terpinums in herb.The property of medicine: pungent, temperature." must book on Chinese herbal medicine be joined ": " enter meridian of Hand-TAI YIN edema caused by disorder of QI." function cures mainly: dispel the wind, cold expelling, victory is wet, removing nebula, stuffy nose relieving plug.Cure cold, asthma of cold-type, sore throat, pertussis, eruptive disease is suffered from abdominal pain, and amebic dysentery, malaria, infantile malnutrition with diarrhea, nasal sinusitis, nasal polyp, corneal nebula is puckery itches, ecthyma, scabies, traumatic injury.
Rhizoma Phragmitis: base is former: be the rhizome of grass phragmites communis.The property of medicine: sweet; Cold.Return lung, stomach, urinary bladder channel.Function cures mainly: clearing away heat and promoting production of body fluid, relieves restlessness and prevents vomiting, diuresis, rash.Main calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, pyretic stranguria, measles, separates Fugu ocellatus ichthyotoxin.
Bulbus Allii: base is former: be the bulb of liliaceous plant Bulbus Allii.The property of medicine: acrid in the mouth; Warm in nature.Return spleen, stomach, lung, large intestine channel.Function cures mainly: warming middle-JIAO is capable stagnant, removing toxic substances, parasite killing.Main coldness and pain in the epigastrium, dysentery, has loose bowels, pulmonary tuberculosis, pertussis, flu, carbuncle furuncle and phyma poison, acute appendicitis, tinea skin ulcer, snake bite and insect sting, ancylostomiasis, enterobiasis, leukorrhagia pudendal pruritus, malaria, sore throat, edema.
Aleuritopteris argentea (Gmel.) Fee: base is former: the herb of Sinopteridaceae Aleuritopteris farinsa (Forsk.) Fee platymiscium Aleuritopteris argentea (Gmel.) Fee.The property of medicine: light, micro-puckery, temperature.Function cures mainly: promoting blood flow to regulate menstruation, tonify deficiency cough-relieving.For menoxenia, amenorrhea bellyache, pulmonary tuberculosis is coughed, spitting of blood.
Nine sons are not from mother: base is former: be the rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Hypoglaucae.The property of medicine: bitter; Micro-pungent; Be slightly cold.Function cures mainly: expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, heat-clearing and toxic substances removing.Main air pain of dampness syndrome, contracture is numb, peratodynia, jaundice due to damp-heat, nebulousurine, drenches pain, leucorrhea, traumatic pain, eczema toxic swelling, rubella, eczema, venom.
test example 1gained of the present invention treats the clinical practice of pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation (embodiment 5): in July ,-2011 in April, 2009, screens 320 routine pertussis infants in 5 hospitals, wherein man 170 example, female 150 example, eight months-7 years old age.Be divided into two groups at random, experimental group and matched group (often organizing 160 people).Experimental group man 85 example, female 75 example, eight months-7 years old age, 3.5 years old mean age, course of disease 8-70 days, average course of disease 30 days.Matched group man 85 example, female 75 example, eight months-7 years old age, 3.5 years old mean age, course of disease 8-70 days, average course of disease 30 days.Above two groups of patients are in age composition, sex composition, the course of disease, and the aspects such as the state of an illness compare there was no significant difference (P > 0.05), and case-data has comparability.
Therapeutic Method: experimental group uses gained of the present invention to treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, using method: oral, 2 years old with 5mL ~ 10mL next time, 2 ~ 5 years old 15mL ~ 25mL, 5 years old with last 30 ~ 50mL, 3 ~ 4 times on the one, warm, within 7 days, be a course for the treatment of.Matched group uses the Drug therapys such as Roxithromycin, pertussis capsule, 'Baikejing ' syrup, within 7 days, is a course for the treatment of.Comparison of therapeutic is carried out after two groups of patients all treat a course for the treatment of.
Curative effect situation criterion: cure: cough and simultaneous phenomenon thereof disappear completely; Effective: cough and simultaneous phenomenon alleviate; Invalid: above-mentioned symptom is without improvement or increase the weight of.Total effectively comprising cures and effective, and result is as shown in table 1.
Table 1: gained of the present invention treats pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation compliance test result
efficacy analysis:as can be seen from Table 1, the experimental group using gained of the present invention to treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation cures 130 examples, effective 28 examples, invalid 2 examples; And matched group cures 45 examples, effective 88 examples, invalid 27 examples.The total effective rate of experimental group reaches 98.75%, and the total effective rate of matched group is 83.12%.Experiment shows, experimental group total effective rate is obviously better than matched group, and its curative effect increases substantially, and cure rate significantly promotes, and inefficiency significantly reduces, and two groups of comparing differences have significance.
The present invention is primary raw material medicine with the Radix Astragali, Herba seu Fructus Physalis Minimae, Herba Andrographis and Herba Morindae Parvifoliae etc., makes the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of.Radix Astragali invigorating QI to consolidate the body surface resistance in side, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.Herba seu Fructus Physalis Minimae clearing away heat-damp and promoting diuresis, expelling phlegm for arresting cough, hard masses softening and resolving.Herba Andrographis heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling.Herba Morindae Parvifoliae clearing and antitussive, stomach function regulating removing dampness, eliminating stasis to stop pain.Ramulus Uncariae Cum Uncis heat clearing away suppressing the hyperactive liver, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion.Soil Iuba Equi nourishing YIN and clearing away heat, cooling blood for hemostasis.Radix cardamines leucanthae preventing phlegm from forming and stopping coughing, promoting blood circulation and stopping pain.Radix orixae japonicae wind and heat dispersing, promoting flow of QI and blood, removing toxic substances dehumidifying, preventing the attack (or recurrence) of malaria.Radix Stemonae nourishing the lung to arrest cough, parasite killing delousing.Radix Asteris nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm.Flos micheliae Albae removing dampness, circulation of qi promoting, cough-relieving.Ramulus et Folium Bauhiniae Faberi clearing heat and moistening lung, yin fluid astringing is calmed the nerves, dehumidifying, parasite killing.Caulis Bambusae In Taenia removing heat-phlegm, relieves restlessness and prevents vomiting, antiabortive removing heat from blood.Herba Centipedae is dispeled the wind, cold expelling, and victory is wet, removing nebula, stuffy nose relieving plug.Rhizoma Phragmitis clearing away heat and promoting production of body fluid, relieves restlessness and prevents vomiting, diuresis, rash.Bulbus Allii warming middle-JIAO is capable stagnant, removing toxic substances, parasite killing.Aleuritopteris argentea (Gmel.) Fee promoting blood flow to regulate menstruation, tonify deficiency cough-relieving.Nine sons not from female expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, heat-clearing and toxic substances removing.All medicines are harmonious, and have effect of heat-clearing and toxic substances removing, antitussive and expectorant, nourishing the lung to arrest cough, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., removing heat from blood detumescence, evident in efficacy to treatment pertussis.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. treat pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation, it is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 9-15, Herba seu Fructus Physalis Minimae 11-16, Herba Andrographis 7-12, Herba Morindae Parvifoliae 9-14, Ramulus Uncariae Cum Uncis 11-15, native Iuba Equi 8-13, Radix cardamines leucanthae 9-15, Radix orixae japonicae 6-10, Radix Stemonae 4-9, Radix Asteris 9-12, Flos micheliae Albae 11-17, Ramulus et Folium Bauhiniae Faberi 8-16, Caulis Bambusae In Taenia 12-15, Herba Centipedae 10-17, Rhizoma Phragmitis 8-14, Bulbus Allii 5-8, Aleuritopteris argentea (Gmel.) Fee 10-14, nine sons are not from female 8-12.
2. the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: Radix Astragali 11-14, Herba seu Fructus Physalis Minimae 12-14, Herba Andrographis 8-10, Herba Morindae Parvifoliae 11-13, Ramulus Uncariae Cum Uncis 12-14, native Iuba Equi 9-12, Radix cardamines leucanthae 11-14, Radix orixae japonicae 7-9, Radix Stemonae 5-8, Radix Asteris 10-11, Flos micheliae Albae 12-14, Ramulus et Folium Bauhiniae Faberi 10-14, Caulis Bambusae In Taenia 13-14, Herba Centipedae 12-15, Rhizoma Phragmitis 10-13, Bulbus Allii 5.5-7, Aleuritopteris argentea (Gmel.) Fee 11-13, nine sons are not from female 9-11.
3. the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of as claimed in claim 1, is characterized in that, take off the primary raw material medicine stating weight proportion and be prepared from: the Radix Astragali 12, Herba seu Fructus Physalis Minimae 13, Herba Andrographis 9, Herba Morindae Parvifoliae 12, Ramulus Uncariae Cum Uncis 13, native Iuba Equi 11, Radix cardamines leucanthae 12, Radix orixae japonicae 8, the Radix Stemonae 7, Radix Asteris 10.5, Flos micheliae Albae 13, Ramulus et Folium Bauhiniae Faberi 12, Caulis Bambusae In Taenia 13.5, Herba Centipedae 14, Rhizoma Phragmitis 12, Bulbus Allii 6, Aleuritopteris argentea (Gmel.) Fee 12, nine sons are not from female 10.
4. the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, pertussal for this treatment preventing phlegm from forming and stopping coughing Chinese medicine preparation is made pharmaceutically acceptable thick paste agent, and the preparation method of described thick paste agent is:
(1) get Rhizoma Phragmitis, add rice vinegar and mix thoroughly, the weight of rice vinegar is the 1/4-1/2 of Rhizoma Phragmitis weight, and moistening 4-7 hour, puts and steam in container, steam 4-6 hour, takes out, and 55 DEG C of dry 8-12 hour (preferably 55 DEG C drying 10 hours), is ground into fine powder, crosses No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter a pot stewing out of water 50-75 minute, take out, 50 DEG C of dry 5-8 hour (preferably 50 DEG C drying 7 hours), be ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are decocted with water twice, each amount of water is the 3.7-5 of 16 taste crude drug gross weights doubly (preferably each amount of water is 4.5 times of 16 taste crude drug gross weights), and each decoction 1.2 hours, merges medicinal liquid, leave standstill 12 hours, obtain filtrate;
(4) in step (3) gained filtrate, Mel is added, the weight of Mel is the weight of the preferred Mel of 1/5-1/2(of step (3) gained filtrate weight is 1/3 of step (3) gained filtrate weight), be condensed into the thick paste (being preferably condensed into the thick paste that relative density is 1.34) that relative density is 1.32-1.35, add step (1) and step (2) gained fine powder, stir evenly, to obtain final product.
5. the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, pertussal for this treatment preventing phlegm from forming and stopping coughing Chinese medicine preparation is made pharmaceutically acceptable pill, and the preparation method of described pill is:
(1) Rhizoma Phragmitis is got, add rice vinegar to mix thoroughly, the weight of rice vinegar is the weight of the preferred rice vinegar of 1/4-1/2(of Rhizoma Phragmitis weight is 1/3 of Rhizoma Phragmitis weight), moistening 4-7 hour (preferred moistening 6 hours), puts and steams in container, steams 4-6 hour (preferably steaming 5 hours), take out, 55 DEG C of dry 8-12 hour (preferably 55 DEG C drying 10 hours), be ground into fine powder, cross No. six sieves;
(2) get Bulbus Allii, peel off garlic skin, mash, enter pot stewing out of water 50-75 minute (preferably entering pot stewing out of water 65 minutes), take out, 50 DEG C of dry 5-8 hour (preferably 50 DEG C drying 7 hours), be ground into fine powder, cross No. six sieves;
(3) all the other the 16 taste crude drug except Rhizoma Phragmitis and Bulbus Allii are put into 55 DEG C of baking ovens, dry 12 hours, take out, grind to the powder altogether, cross No. six sieves; ;
(4) step (1), step (2) and step (3) gained fine powder are mixed;
(5) white sugar is got, the weight of white sugar is 6-9 times (weight of preferred white sugar is 8 times of step (4) gained fine powder weight) of step (4) gained fine powder weight, be heated to fusing, add step (4) gained fine powder again, slow fire is endured 2-5 minute (preferred slow fire endures 4 minutes), reduce internal heat slightly cold after make pill, the heavy 0.1g of every ball, to obtain final product.
6. the pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation for the treatment of as described in as arbitrary in claims 1 to 3, it is characterized in that, pertussal for this treatment preventing phlegm from forming and stopping coughing Chinese medicine preparation is made pharmaceutically acceptable decoction, and the preparation method of described decoction is:
(1) 18 taste crude drug are put into marmite, add water and decoct altogether, amount of water is 6-8 times (preferred amount of water is 7.2 times of 18 taste crude drug gross weights) of 18 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 45-65 minute (preferably, a turn little fire decocts 58 minutes), leaches medicinal liquid;
(2) fill in the marmite of medicinal residues to step (1) and add water, amount of water is 3-5 times (preferred amount of water is 3.5 times of 18 taste crude drug gross weights) of 18 taste crude drug gross weights, first boil to boiling with big fire, rear turn of little fire decocts 30-45 minute (preferably, a turn little fire decocts 40 minutes), leaches medicinal liquid;
(3) step (1) and step (2) gained medicinal liquid are merged, add crystal sugar, the weight of crystal sugar is the weight of the preferred crystal sugar of 1/8-1/5(of step (1) and step (2) gained medicinal liquid gross weight is 1/6 of step (1) and step (2) gained medicinal liquid gross weight), first boil to boiling with big fire, rear turn of little fire decocts 15-30 minute (preferably, a turn little fire decocts 25 minutes), to obtain final product.
7. the preparation method for the treatment of as claimed in claim 4 pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste agent, is characterized in that, in step (1), the weight of rice vinegar is 1/3 of Rhizoma Phragmitis weight.
8. the preparation method for the treatment of as claimed in claim 4 pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste agent, is characterized in that, moistening 6 hours in step (1).
9. the preparation method for the treatment of as claimed in claim 4 pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste agent, it is characterized in that, step steams 5 hours in (1).
10. the preparation method for the treatment of as claimed in claim 4 pertussal preventing phlegm from forming and stopping coughing Chinese medicine preparation thick paste agent, is characterized in that, enter pot stewing out of water 65 minutes in step (2).
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