CN105288274A - Urination promoting and swelling diminishing preparation for treating nephrotic syndrome and preparation method - Google Patents
Urination promoting and swelling diminishing preparation for treating nephrotic syndrome and preparation method Download PDFInfo
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Abstract
The invention discloses a urination promoting and swelling diminishing preparation for treating a nephrotic syndrome. The urination promoting and swelling diminishing preparation is mainly prepared from, by mass, 8-14 parts of radix ophiopogonis, 6-12 parts of arenaria brevipetala, 10-15 parts of corn stigma, 7-13 parts of uraria crinita roots, 6-10 parts of radix morindae officinalis, 9-14 parts of mangnolia, 7-12 parts of dioscorea pentaphylla, 8-13 parts of radix rubiae, 6-14 parts of flos hibisci mutabilis, 7-11 parts of wideleaf osbeckia roots, 9-12 parts of ixeris japonica, 6-11 parts of radix cynanchi paniculati, 8-15 parts of kerria japonica, 10-14 parts of rhizoma fagopyri dibotryis and 5-8 parts of cordyceps liangshanensis. The urination promoting and swelling diminishing preparation is obtained by summarizing multiple years of clinical practices, has the effects of clearing heat, promoting urination, tonifying the lung and benefiting the kidney and is significant in treatment effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the inducing diuresis to remove edema preparation and preparation method of curing nephrotic syndrome.
Background technology
Nephrotic syndrome (nephroticsyndrome, NS) shows as one group of clinical syndrome of High-grade Proteinuria, hypoproteinemia, treating serious edema caused, hyperlipemia, can be caused, be divided into constitutional, Secondary cases and heritability three major types by Different types of etiopathogenises.Nephrotic syndrome typical performance is " three high and one low ", i.e. High-grade Proteinuria, hypoalbuminemia, treating serious edema caused, hyperlipemia.High-grade Proteinuria refers to when particularly electrostatic barrier is impaired for the molecular barriers of glomerular filtration membrane and electrostatic barrier, glomerular filtration membrane increases the permeability of plasma protein, cause protein content in urine to increase, when exceeding Distal convoluted tubule and returning absorbtivity, form High-grade Proteinuria.Hypoalbuminemia refers to that a large amount of albumin is lost from urine, promote that albumin synthesizes at the compensatory of liver, hepatoalbumin synthesis increase is not enough to overcome loss, in addition, because of gastrointestinal tract mucous edema cause diet to go down, albumen Deficiency of Intake, malabsorption or to lose also be the reason of hypoalbuminemia.Treating serious edema causedly refer to that hypoalbuminemia makes plasma colloid osmotic pressure decline, moisture enters interstice from Endovascular.Hyperlipemia refers to that in hypercholesterolemia or hypertriglyceridemia, serum, LDL, VLDL and lipoprotein concentration increase, and normal and hypoalbuminemia is also deposited, its mechanism increases with liver synthetic fat albumen and lipoprotein decompose weaken relevant.
Publication No. CN104188992A(application number 201410494340.4) Chinese patent literature disclose the pharmaceutical composition kind being used for the treatment of nephrotic syndrome, be made up of the raw material of following weight proportion: glycyrrhizin 150 parts, paeonol 60 parts, puerarin 100 parts, osthole 120 parts.Publication No. CN103536795A(application number 201310528490.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of nephrotic syndrome, it is characterized in that, described Chinese medicine comprises following component: the components such as Fructus Ligustri Lucidi 5-15g, Semen Phaseoli 10-20g, Herba Houttuyniae 6-12g, Herba Plantaginis 10-20g, Radix Codonopsis 5-15g, Cortex Phellodendri 6-12g, Radix Astragali 5-15g, Cordyceps 5-15g.Publication No. CN103610990A(application number 201310668950.7) Chinese patent literature disclose a kind of Chinese medicine for the treatment of nephrotic syndrome, be prepared from by the medical material of following weight proportion: Radix seu Folium Gaultheriae Forrestii 10 parts, Viscum multinerve (Hayata) Hayata 14 parts, BAIMI 20 parts, Radix Parkinsoniae 16 parts, Begonia aptera Bl. 12 parts, Rhizoma Gymnadeniae 16 parts, Caulis et Folium Pulsatillae 18 parts, Fructus Trapae qudricaudatae 14 parts, tetramerous jasminorange leaf 14 parts, Senecio kaschkarovii 15 parts, Ergota 18 parts, large Herba Lobeliae Chinensis 12 parts, Hemerocallis citrina Baroni louse fiber crops 10 parts, Amaranthus mangostanus L. 20 parts, how luxuriant Herba phlomidis 15 parts.
The medicine for the treatment of nephrotic syndrome conventional is at present mainly the medicines such as hormone, cell toxicity medicament and ciclosporin, some drugs can only alleviate disease, side effect is obvious, the effect for the treatment of both the principal and secondary aspects of a disease can not be reached, for the Chinese medicine formula providing a kind of curative effect reliable, cheap, need strengthen research in this respect.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take inducing diuresis to remove edema preparation and the preparation method of the wide treatment nephrotic syndrome of safe and applicable.
Technical scheme of the present invention is:
Cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from primarily of following bulk drugs, be mass parts: Radix Ophiopogonis 8-14; Herba arenariae kansuensis 6-12; Stigma Maydis 10-15; Radix Urariae crinitae 7-13; Radix Morindae Officinalis 6-10; Flos Magnoliae Liliflorae 9-14; Five leaf potato 7-12; Radix Rubiae 8-13; Flos Hibisci Mutabilis 6-14; Look up to heaven clock 7-11; Herba ixeritis debilis 9-12; Radix Cynanchi Paniculati 6-11; Flos kerriae japonicae 8-15; Rhizoma Fagopyri Dibotryis 10-14; Cordyceps liangshanensis Zang Hu et Liu 5-8.
Preferred version is, Radix Ophiopogonis 10-12; Herba arenariae kansuensis 8-10; Stigma Maydis 11-14; Radix Urariae crinitae 9-11; Radix Morindae Officinalis 7-9; Flos Magnoliae Liliflorae 10-13; Five leaf potato 9-10; Radix Rubiae 10-11; Flos Hibisci Mutabilis 8-12; Look up to heaven clock 8-10; Herba ixeritis debilis 10-11; Radix Cynanchi Paniculati 7-10; Flos kerriae japonicae 10-13; Rhizoma Fagopyri Dibotryis 11-13; Cordyceps liangshanensis Zang Hu et Liu 6-7.
More preferably, Radix Ophiopogonis 11; Herba arenariae kansuensis 9; Stigma Maydis 12.5; Radix Urariae crinitae 10; Radix Morindae Officinalis 8; Flos Magnoliae Liliflorae 11.5; Five leaf potatos 9.5; Radix Rubiae 10.5; Flos Hibisci Mutabilis 10; To look up to heaven clock 9; Herba ixeritis debilis 10.5; Radix Cynanchi Paniculati 8.5; Flos kerriae japonicae 11.5; Rhizoma Fagopyri Dibotryis 12; Cordyceps liangshanensis Zang Hu et Liu 6.5.
The preparation method of described preparation decoction, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, decoct with water to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) blend step (1) (4) gained filtrate, heating is concentrated into the half of original volume, and agitation and filtration, obtains decoction.
The preparation method of described preparation decoction, the 6-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality is doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
The preparation method of described preparation electuary, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverizes and sieves dry thing, makes medicated powder, add auxiliary materials and mixing, obtain electuary.
The preparation method of described preparation electuary, it is (preferred: to pulverize 110-130 mesh sieve that step (5) pulverized 90-150 mesh sieve; Be more preferably: pulverized 120 mesh sieves).
The preparation method of described preparation soft extract, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) heat concentration step (1) (4) gained filtrate to thick paste, mix and add adjuvant refined honey and mix thoroughly, obtain soft extract.
The preparation method of described preparation soft extract, the amount that step (5) adds adjuvant refined honey is the 0.3-0.5 of thick paste quality doubly (preferred: the amount adding adjuvant refined honey is 0.4 times of thick paste quality).
The preparation method of described preparation capsule, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverized 60-120 mesh sieve (preferred: to pulverize 80-100 mesh sieve by dry thing; Be more preferably: pulverized 90 mesh sieves), make medicated powder, be packed in capsule, make capsule.
The preparation method of described preparation capsule, in the every capsules of step (5), contained medicated powder weight is that 0.2-0.4g(is preferred: in every capsules, contained medicated powder weight is 0.3g).
The inducing diuresis to remove edema pharmaceutical formulation science for the treatment of nephrotic syndrome provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, evident in efficacy, and cure rate is high, effectively can prevent disease relapse;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of clearing away heat and promoting diuresis, invigorating the lung and the kidney;
3, Chinese crude drug selected by the present invention, cheap, do not increase patient burden, is worthy to be popularized.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ophiopogonis 8 parts, Herba arenariae kansuensis 6 parts, Stigma Maydis 10 parts, Radix Urariae crinitae 7 parts, Radix Morindae Officinalis 6 parts, Flos Magnoliae Liliflorae 9 parts, five leaf potatos 7 parts, 8 parts, Radix Rubiae, Flos Hibisci Mutabilis 6 parts, 7 parts, clock of looking up to heaven, Herba ixeritis debilis 9 parts, Radix Cynanchi Paniculati 6 parts, Flos kerriae japonicae 8 parts, Rhizoma Fagopyri Dibotryis 10 parts, Cordyceps liangshanensis Zang Hu et Liu 5 parts.The preparation method of the inducing diuresis to remove edema preparation decoction of above-mentioned treatment nephrotic syndrome is:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, add yellow wine according to the mass ratio of 1:1, stir, big fire evaporate to dryness, add the water of boiled crude drug quality 4 times, big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening thoroughly 12 minutes, take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 20 minutes, take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, the soak by water adding boiled crude drug quality 7.5 times, to boiling, continues 5 minutes, add step (2) (3) gained crude drug, change little fire heating 21 minutes, close fire and filter, collect filtrate;
(5) blend step (1) (4) gained filtrate, heating is concentrated into the half of original volume, and agitation and filtration, obtains decoction.
embodiment 2cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ophiopogonis 14 parts, Herba arenariae kansuensis 12 parts, Stigma Maydis 15 parts, Radix Urariae crinitae 13 parts, Radix Morindae Officinalis 10 parts, Flos Magnoliae Liliflorae 14 parts, five leaf potatos 12 parts, 13 parts, Radix Rubiae, Flos Hibisci Mutabilis 14 parts, 11 parts, clock of looking up to heaven, Herba ixeritis debilis 12 parts, Radix Cynanchi Paniculati 11 parts, Flos kerriae japonicae 15 parts, Rhizoma Fagopyri Dibotryis 14 parts, Cordyceps liangshanensis Zang Hu et Liu 8 parts.The preparation method of the inducing diuresis to remove edema preparation electuary of above-mentioned treatment nephrotic syndrome is:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, add yellow wine according to the mass ratio of 1:1, stir, big fire evaporate to dryness, add the water of boiled crude drug quality 4 times, big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening thoroughly 12 minutes, take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 20 minutes, take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, the soak by water adding boiled crude drug quality 7 times, to boiling, continues 5 minutes, add step (2) (3) gained crude drug, change little fire heating 21 minutes, close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverized 120 mesh sieves by dry thing, made medicated powder, added auxiliary materials and mixing, obtained electuary.
Model case: xxx, male, 28 years old.Main suit: eyelid and edema of pair of lower extremities; Medical history: patient developed signs of a cold before one week, eyelid and two lower limb start edema, and clothes cure cold after medicine, and cold symptoms is eliminated, edema does not alleviate, and has and increase the weight of sign, and urine volume reduces gradually, and spirit is deteriorated, hypodynamia, removes examination in hospital then, through being diagnosed as nephrotic syndrome.
Take this example gained electuary, each 3-4g, warm boiled water, one day twice 20 days is a course for the treatment of, after patient takes a course for the treatment of, edema symptom alleviates to some extent, and urine volume increases, and adheres to taking three courses for the treatment of, the uncomfortable disease of patient is eliminated, muscle power and spirit are obviously improved, and each index of check routine urinalysis is normal, and patient fully recovers, follow up a case by regular visits in 1 year, the state of an illness is without recurrence.
embodiment 3cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ophiopogonis 10 parts, Herba arenariae kansuensis 8 parts, Stigma Maydis 11 parts, Radix Urariae crinitae 9 parts, Radix Morindae Officinalis 7 parts, Flos Magnoliae Liliflorae 10 parts, five leaf potatos 9 parts, 10 parts, Radix Rubiae, Flos Hibisci Mutabilis 8 parts, 8 parts, clock of looking up to heaven, Herba ixeritis debilis 10 parts, Radix Cynanchi Paniculati 7 parts, Flos kerriae japonicae 10 parts, Rhizoma Fagopyri Dibotryis 11 parts, Cordyceps liangshanensis Zang Hu et Liu 6 parts.The preparation method of the inducing diuresis to remove edema preparation soft extract of above-mentioned treatment nephrotic syndrome is:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, add yellow wine according to the mass ratio of 1:1, stir, big fire evaporate to dryness, add the water of boiled crude drug quality 4 times, big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening thoroughly 12 minutes, take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 20 minutes, take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, the soak by water adding boiled crude drug quality 7 times, to boiling, continues 5 minutes, add step (2) (3) gained crude drug, change little fire heating 21 minutes, close fire and filter, collect filtrate;
(5) heat concentration step (1) (4) gained filtrate to thick paste, to mix and the adjuvant refined honey adding thick paste quality 0.4 times is mixed thoroughly, obtain soft extract.
Model case: xxx, women, 43 years old.Medical history: existing 2 years of patient's edema of pair of lower extremities, heavy time light during the state of an illness, urine protein (+++) during examination in hospital, blood albumin 11.6g/L, inappetence, loses weight, lethargy, be diagnosed as nephrotic syndrome, take western medicine result very not remarkable, then find Chinese medicine formula.
Recommend to take this example gained soft extract, each 6-10g, warm boiled water through people, one day twice 20 days is a course for the treatment of, after patient takes a course for the treatment of, urine protein content declines gradually, blood albumin increases, and uncomfortable disease alleviates to some extent, adheres to taking three courses for the treatment of, patient's muscle power and spirit are clearly better, after consolidating again a course for the treatment of, indices all returns to normally, and patient fully recovers.
embodiment 4cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ophiopogonis 12 parts, Herba arenariae kansuensis 10 parts, Stigma Maydis 14 parts, Radix Urariae crinitae 11 parts, Radix Morindae Officinalis 9 parts, Flos Magnoliae Liliflorae 13 parts, five leaf potatos 10 parts, 11 parts, Radix Rubiae, Flos Hibisci Mutabilis 12 parts, 10 parts, clock of looking up to heaven, Herba ixeritis debilis 11 parts, Radix Cynanchi Paniculati 10 parts, Flos kerriae japonicae 13 parts, Rhizoma Fagopyri Dibotryis 13 parts, Cordyceps liangshanensis Zang Hu et Liu 7 parts.The preparation method of the inducing diuresis to remove edema preparation capsule of above-mentioned treatment nephrotic syndrome is:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, add yellow wine according to the mass ratio of 1:1, stir, big fire evaporate to dryness, add the water of boiled crude drug quality 4 times, big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening thoroughly 12 minutes, take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 20 minutes, take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, the soak by water adding boiled crude drug quality 7 times, to boiling, continues 5 minutes, add step (2) (3) gained crude drug, change little fire heating 21 minutes, close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverized 90 mesh sieves by dry thing, made medicated powder, be packed in capsule, and in every capsules, contained medicated powder weight is 0.3g, makes capsule.
Model case: xxx, male, 63 years old.Main suit: myasthenia of limbs, appetite declines, edema of lower limbs; Medical history: patient must have nephropathy the year before, for a long time by taking medicine mitigate the disease, prominent sense is uncomfortable in the recent period, checks to hospital, urine protein 3+, blood albumin content 18.6g/L, blood urea nitrogen 10.6mmol/L, serum creatinine is normal, be diagnosed as nephrotic syndrome, patient, because of older, refuses hormone therapy.
Learning the present invention through asking about, then taking this example gained capsule, each 2-3 grain, warm boiled water, one day twice 20 days is a course for the treatment of, after patient takes a course for the treatment of, appetite strengthens, and urine volume increases, uncomfortable disease is taken a turn for the better, and adheres to taking two courses for the treatment of, and urine protein reduces, blood albumin raises, and edema disappears, and patient fully recovers, follow up a case by regular visits in half a year, patient is not recurred.
embodiment 5cure the inducing diuresis to remove edema preparation of nephrotic syndrome, be prepared from (every part of 10g) primarily of following bulk drugs: Radix Ophiopogonis 11 parts, Herba arenariae kansuensis 9 parts, Stigma Maydis 12.5 parts, Radix Urariae crinitae 10 parts, Radix Morindae Officinalis 8 parts, Flos Magnoliae Liliflorae 11.5 parts, five leaf potatos 9.5 parts, 10.5 parts, Radix Rubiae, Flos Hibisci Mutabilis 10 parts, 9 parts, clock of looking up to heaven, Herba ixeritis debilis 10.5 parts, Radix Cynanchi Paniculati 8.5 parts, Flos kerriae japonicae 11.5 parts, Rhizoma Fagopyri Dibotryis 12 parts, Cordyceps liangshanensis Zang Hu et Liu 6.5 parts.The preparation method of the inducing diuresis to remove edema preparation decoction of above-mentioned treatment nephrotic syndrome is:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, add yellow wine according to the mass ratio of 1:1, stir, big fire evaporate to dryness, add the water of boiled crude drug quality 4 times, big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening thoroughly 12 minutes, take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 20 minutes, take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, the soak by water adding boiled crude drug quality 7.5 times, to boiling, continues 5 minutes, add step (2) (3) gained crude drug, change little fire heating 21 minutes, close fire and filter, collect filtrate;
(5) blend step (1) (4) gained filtrate, heating is concentrated into the half of original volume, and agitation and filtration, obtains decoction.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Radix Ophiopogonis: base is former: be the tuber of liliaceous plant Radix Ophiopogonis or dwarf lilyturf.Nature and flavor: sweet; Micro-hardship; Cold.Gui Jing: lung; Stomach; Heart channel.Function cures mainly: nourishing YIN and moistening the lung; Reinforcing stomach reg fluid; Clear away heart-fire relieving restlessness.Main dryness of the lung dry cough; Lung abscess; Deficiency of YIN chronic cough; Tianjin wound is thirsty; Quench one's thirst; Vexed insomnia; Have sore throat; Dryness of the intestine constipation; Heat in blood tells nosebleed.
Herba arenariae kansuensis: base is former: be the herb of pinkwort Gansu sandwort.Nature and flavor: sweet; Bitter; Cold in nature.Gui Jing: liver; Gallbladder; Kidney channel.Function cures mainly: clearing and antitussive; Dampness removing jaundice eliminating; Exempt from numbness pain relieving.Main fever caused by exogenous pathogens; Cough due to lung-heat; Jaundice; Stranguria with turbid discharge; Rheumatic arthralgia; Hypertension.
Stigma Maydis: base is former: be the zeistic style of grass and stigma.Nature and flavor: sweet in the mouth; Light; Property is put down.Gui Jing: kidney; Stomach; Liver; Gallbladder meridian.Function cures mainly: inducing diuresis to remove edema; Liver heat removing function of gallbladder promoting.Main edema; Dribbling urination; Jaundice; Cholecystitis; Cholelithiasis; Hypertension; Diabetes; Galactostasis.
Radix Urariae crinitae: base is former: the root penetrated for leguminous plant cat tail.Nature and flavor: sweet in the mouth; Warm in nature.Gui Jing: enter lung, stomach, kidney three warp.Function cures mainly: promoting the circulation of QI to relieve pain; Reduce phlegm by drink.Main heart peratodynia; Cough due to fluid-retention.
Radix Morindae Officinalis: base is former: be the dry root of Maguireothamnus speciosus Radix Morindae Officinalis.Nature and flavor with return through: sweet, pungent, tepor.Return kidney, Liver Channel.Function with cure mainly: kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.For impotence and seminal emission, cold womb is infertile, menoxenia, and few abdomen cold type of pain, rheumatic arthralgia, muscles and bones flaccidity is soft.
Flos Magnoliae Liliflorae: base is former: be the alabastrum of Magnoliacea plant Flos Magnoliae Amoenae, Magnolia sieboldii, Magnolia cylindrica.Nature and flavor: bitter; Cold in nature.Gui Jing: liver; Spleen channel.Function cures mainly: inducing diuresis to remove edema; Nourishing the lung to arrest cough.Main cough due to deficiency of the lung; Sputum mixed with blood; Alcoholic jaundice; Congenital deformity of the tongue; Carbuncle.
Five leaf potatos: base is former: be the tuber of Dioscoreaceae yam five leaf Rhizoma Dioscoreae.Function cures mainly: " Guangxi ethnic drug short course ": " be decocted in water for oral dose eliminate-poverty blood (strengthening), edema (Mulao).Decocting rushes rice vinegar clothes and controls dysentery (precious jade).Steam clothes with thin pork to manage property woman's skinny and wizened (strengthening).
Radix Rubiae: base is former: be the root of Maguireothamnus speciosus Radix Rubiae.Nature and flavor: bitter; Cold.Gui Jing: return Liver Channel.Function cures mainly: cooling blood for hemostasis; Blood circulation promoting and blood stasis dispelling.Main heat in blood spitting of blood; Spit blood; Epistaxis; Hematuria; Have blood in stool; Metrorrhagia; Amenorrhea; Postpartum stagnation is suffered from abdominal pain; Traumatic injury; Rheumatic arthralgia; Jaundice; Carbuncle sore; Hemorrhoid swell.
Flos Hibisci Mutabilis: base is former: be the flower of Malvaceae Hibisci Mutabilis platymiscium Hibisci Mutabilis.The property of medicine: pungent, micro-hardship, cool.Return lung, the heart, Liver Channel.Function cures mainly: heat-clearing and toxic substances removing, and removing heat from blood is subsided a swelling.Cure mainly cough due to lung-heat, spitting of blood, conjunctival congestion and swelling pain, metrorrhagia, leucorrhea, diarrhoea, stomachache, carbuncle, furuncle, venom, burn due to hot liquid or fire, traumatic injury.
To look up to heaven clock: base is former: be the herb of Melastomataceae Radix Osbeckiae Crinitae platymiscium Osbeckia crinita Benth. Ex Triana.The property of medicine: sweet, puckery, micro-hardship, flat.Return lung, kidney, Liver Channel.Function cures mainly: kidney tonifying of astringing the lung, promoting blood circulation and hemostasis.Cure mainly chronic cough dyspnea due to deficiency, body deadhead is swooned, rheumatic arthralgia, stranguria with turbid discharge, and dysentery, has blood in stool, metrorrhagia, menoxenia, leucorrhea, traumatic injury congestive edema, traumatic hemorrhage, scalds.
Herba ixeritis debilis: base is former: be the herb of feverfew Herba ixeritis debilis.Nature and flavor: bitter in the mouth; Cold in nature.Gui Jing: return stomach; Tripe; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Inducing diuresis to remove edema.Main lung abscess; Pharyngalgia; Conjunctival congestion; Mastitis; Ulcer sores; Edema; Dysuria.
Radix Cynanchi Paniculati: base is former: be the dry root welding technology of Luo Mo section plant Radix Cynanchi Paniculati.Nature and flavor with return through: pungent, temperature.Return liver, stomach warp.Function with cure mainly: dispel the wind, removing dampness, pain relieving, antipruritic.For rheumatic arthralgia, stomachache distension, toothache, lumbago, falls and flutters the pain of injury, rubella, eczema.
Flos kerriae japonicae: base is former: be flower or the branch and leaf of rosaceous plant kerria.Chemical analysis: flower, containing waxiness pigment, is the mixture of helenine, lutein dipalmitate, xanthophyll-oil acid esters.Leaf is containing vitamin C _ 100 ~ 200 milligram %.Separately there is meaning kerria containing linariin.Nature and flavor: bitter, puckery; Flat.Gui Jing: lung; Stomach; Spleen channel.Function cures mainly: preventing phlegm from forming and stopping coughing; Inducing diuresis to remove edema; Removing toxic substances.Main cough, rheumatic arthralgia, puerperal impairment caused by overstrain pain, edema, dysuria, dyspepsia, swollen ulcer drug, eczema, urticaria.
Rhizoma Fagopyri Dibotryis: base is former: be the rhizome of polygonaceae plant Radix Et Rhizoma Fagopyri Tatarici.Chemical analysis: containing Radix Et Rhizoma Fagopyri Tatarici glycoside.P-coumaric acid, ferulic acid and glucose is generated after this glycoside basic hydrolysis; Another containing dimercyanidin, be principle active component.Nature and flavor: cool in nature, puckery, micro-pungent.Function cures mainly: heat-clearing and toxic substances removing.Lung heat clearing expectoration, evacuation of pus is subsided a swelling, removing dampness of dispeling the wind.For lung abscess, laryngopharynx swelling and pain, dysentery, innominate toxic swelling, traumatic injury, rheumatic arthritis.
Cordyceps liangshanensis Zang Hu et Liu: base is former: be sclerotium and the Stroma of Clavicipitaceae Cordyceps sinensis fungus Cordyceps liangshanensis Zang Hu et Liu.Nature and flavor: sweet; Flat.Gui Jing: kidney; Lung meridian.Function cures mainly: invigorating the lung and the kidney.Cure mainly the cough with asthma of deficiency of both the lung and kidney.
test example 1gained of the present invention cures the clinical practice of the inducing diuresis to remove edema preparation (embodiment 5) of nephrotic syndrome:
Choosing crowd: in April ,-2015 in June, 2014, according to medical case history, is patient 296 example of nephrotic syndrome at four hospital's Screening Diagnosis, age 11-67 year, 34.8 ± 2.2 years old mean age, course of disease 0.5-3, wherein male patient 153 example, female patient 143 example.Diagnostic criteria: 1. urine protein content is greater than 3.5g/d; 2. plasma albumin is lower than 30g/L; 3. edema; 4. hyperlipemia, wherein 1. 2. two for diagnosis necessary.
Before test, patient is divided into two groups at random, experimental group 185 example and matched group 111 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Experimental group takes products obtained therefrom of the present invention, each 250-300ml, one day twice, warmly takes, and within 20 days, is a course for the treatment of; Matched group takes other conventional medicines (Huang Kui capsule, SHENSHUAINING granule, immunosuppressant etc.).Period in a medicine carries out Continuous Observation to two groups of patients, record symptom and change.
Curative effect determinate standard: reference literature criterion of therapeutical effect, (1) cures: the clinical symptoms such as edema all disappear, and repeatedly the qualitative feminine gender of urine protein or 24h urine protein quantitation are no more than 0.2g, and plasma protein and blood fat recover normal, and graft function is normal; (2) effective: clinical symptom disappearance is incomplete, and repeatedly 24h urine protein quantitation is all less than 1g, and blood plasma albumin level significantly improves but is not increased to normal level, renal function is close to normal; (3) effective: clinical symptoms does not disappear, repeatedly 24h urine protein quantitation measures and declines to some extent, and be all less than 3g, plasma albumin value increases, and renal function take a favorable turn but abnormal; (4) invalid: clinical symptoms does not disappear or increases the weight of, the 24h urine protein quantitation before and after patient treatment and blood albumin value are without significant change, and renal function is without improvement or worsen.Total effective rate=cure rate+obvious effective rate+effective percentage
Clinical effectiveness: after the taking medicine of three courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The healing patient of experimental group is 87 examples, and cure rate is 47.0%, and effective patient is 75 examples, and effective patient is 19 examples, and total effective rate is 97.8%; The patient that matched group is cured is 35 examples, and cure rate is 31.5%, and effective patient is 42 examples, and effective patient is 11 examples, and total effective rate 79.2%, is starkly lower than the therapeutic effect of experimental group, and illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.
The untoward reaction of two groups of patients is routine and recur such as shown in table 2:
As shown in Table 2, all there is the untoward reaction diseases such as nausea and vomiting, heart beating is excessive, stature is got fat in two groups of patients, but after drug withdrawal, untoward reaction is eliminated substantially, and each index of health is without exception; The relapse rate of experimental group patient is 4.3%, and the relapse rate of matched group is 16.2%, illustrates that products obtained therefrom of the present invention can effectively prevent the state of an illness from again recurring.
The Chinese medicine used in the present invention, Radix Ophiopogonis nourishing YIN and moistening the lung, Herba arenariae kansuensis dampness removing jaundice eliminating, Stigma Maydis, Flos Magnoliae Liliflorae, Flos kerriae japonicae inducing diuresis to remove edema, Radix Urariae crinitae promoting the circulation of QI to relieve pain, the strong muscle of Radix Morindae Officinalis the kidney invigorating, five leaf potatos are enriched blood detumescence, Radix Rubiae blood circulation promoting and blood stasis dispelling, Flos Hibisci Mutabilis heat-clearing and toxic substances removing, clock of looking up to heaven is astringed the lung kidney tonifying, Herba ixeritis debilis inducing diuresis to remove edema, Radix Cynanchi Paniculati dispels the wind removing dampness, and Rhizoma Fagopyri Dibotryis evacuation of pus is subsided a swelling, Cordyceps liangshanensis Zang Hu et Liu invigorating the lung and the kidney, multiple medical material synergism, play effect of clearing away heat and promoting diuresis, invigorating the lung and the kidney altogether, effectively eliminate uncomfortable disease, prevent disease relapse.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure the inducing diuresis to remove edema preparation of nephrotic syndrome, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Radix Ophiopogonis 8-14; Herba arenariae kansuensis 6-12; Stigma Maydis 10-15; Radix Urariae crinitae 7-13; Radix Morindae Officinalis 6-10; Flos Magnoliae Liliflorae 9-14; Five leaf potato 7-12; Radix Rubiae 8-13; Flos Hibisci Mutabilis 6-14; Look up to heaven clock 7-11; Herba ixeritis debilis 9-12; Radix Cynanchi Paniculati 6-11; Flos kerriae japonicae 8-15; Rhizoma Fagopyri Dibotryis 10-14; Cordyceps liangshanensis Zang Hu et Liu 5-8.
2. inducing diuresis to remove edema preparation of curing nephrotic syndrome as claimed in claim 1, is characterized in that, Radix Ophiopogonis 10-12; Herba arenariae kansuensis 8-10; Stigma Maydis 11-14; Radix Urariae crinitae 9-11; Radix Morindae Officinalis 7-9; Flos Magnoliae Liliflorae 10-13; Five leaf potato 9-10; Radix Rubiae 10-11; Flos Hibisci Mutabilis 8-12; Look up to heaven clock 8-10; Herba ixeritis debilis 10-11; Radix Cynanchi Paniculati 7-10; Flos kerriae japonicae 10-13; Rhizoma Fagopyri Dibotryis 11-13; Cordyceps liangshanensis Zang Hu et Liu 6-7(is preferably: Radix Ophiopogonis 11; Herba arenariae kansuensis 9; Stigma Maydis 12.5; Radix Urariae crinitae 10; Radix Morindae Officinalis 8; Flos Magnoliae Liliflorae 11.5; Five leaf potatos 9.5; Radix Rubiae 10.5; Flos Hibisci Mutabilis 10; To look up to heaven clock 9; Herba ixeritis debilis 10.5; Radix Cynanchi Paniculati 8.5; Flos kerriae japonicae 11.5; Rhizoma Fagopyri Dibotryis 12; Cordyceps liangshanensis Zang Hu et Liu 6.5).
3. the preparation method of the preparation decoction as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, decoct with water to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) blend step (1) (4) gained filtrate, heating is concentrated into the half of original volume, and agitation and filtration, obtains decoction.
4. the preparation method of preparation decoction as claimed in claim 3, is characterized in that, the 6-9 that step (4) amount of water is boiled crude drug quality is doubly (preferred: the 7-8 that amount of water is boiled crude drug quality doubly; Be more preferably: amount of water is 7.5 times of boiled crude drug quality).
5. the preparation method of the preparation electuary as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverizes and sieves dry thing, makes medicated powder, add auxiliary materials and mixing, obtain electuary.
6. the preparation method of preparation electuary as claimed in claim 5, is characterized in that, it is (preferred: to pulverize 110-130 mesh sieve that step (5) pulverized 90-150 mesh sieve; Be more preferably: pulverized 120 mesh sieves).
7. the preparation method of the preparation soft extract as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) heat concentration step (1) (4) gained filtrate to thick paste, mix and add adjuvant refined honey and mix thoroughly, obtain soft extract.
8. the preparation method of preparation soft extract as claimed in claim 7, is characterized in that, the amount that step (5) adds adjuvant refined honey is the 0.3-0.5 of thick paste quality doubly (preferred: the amount adding adjuvant refined honey is 0.4 times of thick paste quality).
9. the preparation method of the preparation capsule as described in as arbitrary in claim 1-2, it is characterized in that, step is as follows:
(1) get Stigma Maydis, Flos Magnoliae Liliflorae, Flos Hibisci Mutabilis and Flos kerriae japonicae and clean remove impurity, pulverize, yellow wine is added according to the mass ratio of 1:1, stir, big fire evaporate to dryness, adds boiled crude drug quality 3-5 water doubly (preferred: the water adding boiled crude drug quality 4 times), big fire is boiled to boiling, continue 10 minutes, filter after closing fire, collect filtrate;
(2) by Semen oryzae sativae remove impurity, add rice vinegar and mix moistening 8-16 minute thoroughly (preferably: moistening 10-14 minute; Be more preferably: moistening 12 minutes), take out and mix with the Herba arenariae kansuensis cleaned, look up to heaven clock and Herba ixeritis debilis, be placed in frying pan, slow fire heats, and fry to Semen oryzae sativae in time yellow, taking-up, sieves and remove Semen oryzae sativae, cool;
(3) get Cordyceps liangshanensis Zang Hu et Liu removing impurity, add alcoholic solution rinse 15 minutes, take out and be placed in steamer, Steam by water bath 13-27 minute (preferred: Steam by water bath 16-24 minute; Be more preferably: Steam by water bath 20 minutes), take out, cutting while hot, cools;
(4) Radix Ophiopogonis, Radix Urariae crinitae, Radix Morindae Officinalis, five leaf potatos, Radix Rubiae, Radix Cynanchi Paniculati and Rhizoma Fagopyri Dibotryis are picked up clean impurity, with rice washing water logging 8 minutes, take out section, put into non iron container, add the soak by water of boiled crude drug quality 7 times to boiling, continue 5 minutes, add step (2) (3) gained crude drug, change little fire heating 14-28 minute (preferred: little fire heating 18-24 minute; Be more preferably: little fire heating 21 minutes), close fire and filter, collect filtrate;
(5) spray drying step (1) (4) gained filtrate, pulverized 60-120 mesh sieve (preferred: to pulverize 80-100 mesh sieve by dry thing; Be more preferably: pulverized 90 mesh sieves), make medicated powder, be packed in capsule, make capsule.
10. the preparation method of preparation capsule as claimed in claim 9, is characterized in that, in the every capsules of step (5), contained medicated powder weight is that 0.2-0.4g(is preferred: in every capsules, contained medicated powder weight is 0.3g).
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Address after: 553000 Guizhou city in Liupanshui Province, Zhongshan Road No. 10 Pik Yee King District 2 building 1-301 Applicant after: Li Lianqing Address before: Huaiyin District Ji'nan city Shandong province 250000 Happy Street No. 11 Applicant before: Li Lianqing |
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Application publication date: 20160203 |