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CN105143876B - 生物标志物用于评估用β7整联蛋白拮抗剂治疗胃肠炎性病症的用途 - Google Patents

生物标志物用于评估用β7整联蛋白拮抗剂治疗胃肠炎性病症的用途 Download PDF

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Publication number
CN105143876B
CN105143876B CN201480019012.7A CN201480019012A CN105143876B CN 105143876 B CN105143876 B CN 105143876B CN 201480019012 A CN201480019012 A CN 201480019012A CN 105143876 B CN105143876 B CN 105143876B
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antibody
patient
seq
amino acid
biomarker
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Chinese (zh)
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CN105143876A (zh
Inventor
L·迪尔
M·凯伊尔
M·T·唐
X·魏
M·B·威廉姆斯
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Chemical Kinetics & Catalysis (AREA)
CN201480019012.7A 2013-03-27 2014-03-26 生物标志物用于评估用β7整联蛋白拮抗剂治疗胃肠炎性病症的用途 Active CN105143876B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361805860P 2013-03-27 2013-03-27
US61/805,860 2013-03-27
US201361914619P 2013-12-11 2013-12-11
US61/914,619 2013-12-11
PCT/US2014/031825 WO2014160753A1 (fr) 2013-03-27 2014-03-26 Utilisation de biomarqueurs pour évaluer le traitement de troubles gastro-intestinaux inflammatoires par des antagonistes de l'intégrine bêta7

Publications (2)

Publication Number Publication Date
CN105143876A CN105143876A (zh) 2015-12-09
CN105143876B true CN105143876B (zh) 2018-04-20

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CN201480019012.7A Active CN105143876B (zh) 2013-03-27 2014-03-26 生物标志物用于评估用β7整联蛋白拮抗剂治疗胃肠炎性病症的用途

Country Status (14)

Country Link
US (3) US20160209426A1 (fr)
EP (3) EP2979087A4 (fr)
JP (4) JP6615745B2 (fr)
KR (1) KR102175688B1 (fr)
CN (1) CN105143876B (fr)
AU (3) AU2014241552B2 (fr)
BR (1) BR112015024856A2 (fr)
CA (1) CA2904095A1 (fr)
HK (1) HK1218442A1 (fr)
IL (2) IL241185B (fr)
MX (1) MX2015011765A (fr)
RU (1) RU2015145610A (fr)
SG (1) SG11201507974RA (fr)
WO (1) WO2014160753A1 (fr)

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CN116741409A (zh) * 2023-05-12 2023-09-12 中国医学科学院北京协和医院 基于外周血生物标志物构建的模型在预测上消化道肿瘤化疗疗效中的应用

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US20160209426A1 (en) 2016-07-21
EP3933401A2 (fr) 2022-01-05
IL241185A0 (en) 2015-11-30
IL241185B (en) 2020-05-31
BR112015024856A2 (pt) 2018-04-17
IL273930A (en) 2020-05-31
EP2979087A4 (fr) 2017-03-15
EP2979087A1 (fr) 2016-02-03
KR20150134414A (ko) 2015-12-01
EP3933401A3 (fr) 2022-04-13
JP2016515705A (ja) 2016-05-30
AU2018206728A1 (en) 2018-08-02
AU2021200422A1 (en) 2021-02-25
JP2019023637A (ja) 2019-02-14
JP2020191883A (ja) 2020-12-03
AU2014241552A1 (en) 2015-10-08
JP6740294B2 (ja) 2020-08-12
KR102175688B1 (ko) 2020-11-06
EP3495814A2 (fr) 2019-06-12
CA2904095A1 (fr) 2014-10-02
AU2018206728B2 (en) 2020-10-22
JP2022106732A (ja) 2022-07-20
AU2014241552B2 (en) 2018-08-16
MX2015011765A (es) 2016-01-15
JP6615745B2 (ja) 2019-12-04
EP3495814A3 (fr) 2019-07-17
SG11201507974RA (en) 2015-10-29
US20220357343A1 (en) 2022-11-10
HK1218442A1 (zh) 2017-02-17
RU2015145610A (ru) 2017-05-04
JP7055176B2 (ja) 2022-04-15
WO2014160753A1 (fr) 2014-10-02
CN105143876A (zh) 2015-12-09
US20200025775A1 (en) 2020-01-23

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