CN105148252A - Compound blood glucose reducing preparation - Google Patents
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- CN105148252A CN105148252A CN201510511541.5A CN201510511541A CN105148252A CN 105148252 A CN105148252 A CN 105148252A CN 201510511541 A CN201510511541 A CN 201510511541A CN 105148252 A CN105148252 A CN 105148252A
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Abstract
The invention provides a compound blood glucose reducing preparation. The compound blood glucose reducing preparation comprises raw materials in parts by weight as follows: 8-10 parts of a mulberry leaf extract, 0.5-1.5 parts of a solomonseal rhizome extract and 1-2 parts of wheat oligopeptides. Medicinal and edible Chinese herbal medicines, namely, the mulberry leaf extract and the solomonseal rhizome extract, and new resource food, namely, the wheat oligopeptides, are used as the raw materials, and a solid drink is prepared and can significantly reduce the blood glucose of patients suffering from Type II diabetes. Meanwhile, five-cereal pulp and whey protein powder are added, and the preparation aims to supplement nutrients to the patients while reducing the blood glucose after the preparation is taken by the patients.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of compound antihypelipidemic preparation.
Background technology
Diabetes are a kind of chronic diseases caused by interactions such as heredity, environmental factors, immunologic function disorders, be due to insulin secretion definitely or relative deficiency and target tissue cell insulin sensitivity is reduced, cause the metabolism endocrinopathy of a series of metabolism disorders such as sugar, albumen, fat, water and eletrolytes.Diabetes mainly comprise insulin dependent diabetes mellitus (IDDM) (I type) and non-insulin-dependent diabetes mellitus (II type), and wherein II type accounts for diabetics more than 90%.Diabetes are outstanding feature clinically with hyperglycemia, the metabolism such as sugar, fat, protein of interference human body, patient's body tissue repair ability and resistance are reduced, be in a bad way or stress time can there is the acute metablize confusion, prolonged illness can cause multiple system damage; In addition, polyuria, polydipsia, polyphagia can be there is in diabetes, the clinical symptoms of the performance such as become thin i.e. " three-many-one-little ", the severe complications such as cardiovascular and cerebrovascular disease, blind, acromelic gangrene occur all apparently higher than non-diabetic people in diabetic population.Along with social economy and growth in the living standard, the mortality rate of diabetes occupied tumor, cardiovascular diseases after the 3rd, what become serious threat people ' s health becomes global illness.
At present, the medicine of diabetes mainly comprises Drugs Promoting Insulin Secretion (sulphanylureas, meglitinide), euglycemic agent (biguanides, thiazolidinediones), alpha-glucosidase inhibitor and the new drug that in recent years finds are as GLP-1 receptor stimulating agent DPP-4 inhibitor etc.But the western medicine problem that ubiquity toxicity is large clinically: insulin and Sulphonylurea all can make weight in patients increase, and it is made to suffer from the rising of hypoglycemic risk; The hypoglycemic medicine such as alpha-glucosidase inhibitor and metformin then can cause the uncomfortable reactions such as digestive tract.Given this, domestic and international medical investigator starts to turn to find efficient, low toxicity, safe, inexpensive antihypelipidemic preparation from Chinese medicine.The Diet Therapy of diabetes is important contents for the treatment of diabetes, the Chinese medicine of some new resource foods, integration of edible and medicinal herbs can provide rational meals for diabetics, while adjuvant therapy of diabetes, can be that patient is balanced nutritious, maintain body weight, reduce the risk that some complication occur.
Folium Mori are the dried leaves of Moraceae (Moraceae) plant Mulberry (MorusalbaL), bitter in the mouth, sweet, cold in nature, return lung, Liver Channel, have clearing away lung-heat and moistening for dryness, disperse wind heat, the effect such as liver heat removing profit order.Folium Mori, as a kind of raw material of medicine-food two-purpose, are widely used.Document shows, main containing flavone and glycoside, alkaloids, polysaccharide and Amino acids in Folium Mori, has the pharmacological actions such as blood sugar lowering, blood pressure lowering, antibacterial, antiviral.Alkaloid 1-DNJ (DNJ) in Folium Mori and polysaccharides of Folium Mori are its main blood sugar lowering effective ingredient.The emulative Inhibiting α-glucosidase of DNJ energy is active, can not only suppress post-prandial glycemia, also can improve diabetes common complication.Polysaccharides of Folium Mori is also the active component of mulberry leaf blood sugar reduction, and it is by maintaining the complete therapeutical effect with regulating insulin secretion to play diabetes of Pancreas Islet Structure.
Rhizoma Polygonati is the dry tuber of liliaceous plant Rhizoma Polygonati (PolygonatumsibiricumRed), Polygonatum cyrtonema Hua (PolygonatumcyrtonemaHua) or P. kingianum (PolygonatumkingianumColl.etHemsl), is that " Chinese Pharmacopoeia " records kind.And the main active in Rhizoma Polygonati is polygonatum polysaccharide, document shows that it has good hypoglycemic activity, and the activity of the remarkable Inhibiting α-glucosidase of polygonatum polysaccharide energy, improves insulin expression and insulin level.
Semen Tritici aestivi oligopeptide is from wholefood---the protein extracted wheat protein powder, then through the micromolecule polypeptide material that directed enzyme action and specific little peptide isolation technics obtain, be the new resource food through Ministry of Public Health approval in 2012.Semen Tritici aestivi oligopeptide itself can not cause blood glucose to raise, be applicable to as diabetes patient accesary foods, can balanced patient's nutrition.Oxidative stress and diabetes closely related, be the key factor causing diabetes, as oxidative stress can cause beta Cell of islet damage and apoptosis, cause diabetic cardiovascular disease become and diabetic nephropathy occur.Research show Semen Tritici aestivi oligopeptide have remarkable antioxidant inhibited oxidation stress effect, this illustrate its diabetes treatment and prevention related complication appearance significant; In addition, Semen Tritici aestivi oligopeptide also by inhibited oxidation stress, protection diabetes patient gastrointestinal function.Therefore, Semen Tritici aestivi oligopeptide possesses good application prospect in control diabetes and complication thereof.
Mixed grain rice, be beneficial to man healthy and harmless health, be free from side effects, and it also possesses some property of medicine, high dietary-fiber as contained in Semen Tritici aestivi has preventive and therapeutic effect to diabetes, high fat etc., brown rice energy prevention of arterial is atherosis and diabetes etc., and therefore appropriate edible mixed grain rice are useful to diabetics.
The present invention is blood-sugar lowering tcm drug, integration of edible and medicinal herbs Chinese medicine and new resource food and " mixed grain rice perfect adaptation; organically combined by the diet of the treatment of diabetes and patient; while reducing patient blood glucose safely and effectively; for patient provides the meals of safe and reasonable, thus be better applied to the treatment of diabetes patient.
Summary of the invention
The each component used in the present invention is medicinal and edible plant and new resource food, and side effect is little, is intended to the deficiency overcoming existing hypoglycemic medicine, provides the compound antihypelipidemic preparation that a kind of hypoglycemic effect is remarkable, side effect is little.
In order to achieve the above object, technical scheme provided by the invention is:
Described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8-10, Rhizoma Polygonati extract 0.5-1.5, Semen Tritici aestivi oligopeptide 1-2.
Preferably, described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8-10, Rhizoma Polygonati extract 0.5-1, Semen Tritici aestivi oligopeptide 1-1.5.
Preferably, described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8, Rhizoma Polygonati extract 1, Semen Tritici aestivi oligopeptide 1.5.
Above-mentioned antihypelipidemic preparation can be prepared into existing any dosage form.
Preferably, the adjuvant of following weight portion is also comprised in described compound antihypelipidemic preparation: corn starch 3-5, xylitol 1-1.5, mannitol 1-1.5, citric acid 0.6-1, sodium bicarbonate 0.2-0.6.Make effervescent tablet.
More preferably, in described compound antihypelipidemic preparation, also comprise the adjuvant of following weight portion: corn starch 4, xylitol 1, mannitol 1.5, citric acid 0.8, sodium bicarbonate 0.4.Make effervescent tablet.
Preferably, the adjuvant of following weight portion is also comprised in described compound antihypelipidemic preparation: grain rice homogenate 25-35, lactalbumin powder 35-40, xylitol 10-15, mannitol 7.5-8.Make electuary.
More preferably, in described compound antihypelipidemic preparation, also comprise the adjuvant of following weight portion: grain rice homogenate 30, lactalbumin powder 40, xylitol 10, mannitol 7.5.Make electuary.
Folium Mori extract of the present invention, Rhizoma Polygonati extract, Semen Tritici aestivi oligopeptide and other raw materials are commercially available.
Folium Mori are recorded in Compendium of Material Medica: " also, the title article of Cicadae food, the old man of people's food is little Tong to the spirit of Mulberry dustpan star, and Folium Mori have another name called: " Radix Rhodiolae ", and Japanese people claims Folium Mori tea to be life-prolonging tea.Folium Mori are kings of plant, there is the good reputation of " Radix Ginseng is vulcanized; Folium Mori are mended clearly ", be rich in human body 17 seed amino acid, crude protein, crude fat is that health ministry confirms " integration of edible and medicinal herbs " plant, listed in " mankind's 21 century ten is one of health food greatly " by international food health organization, become the green new food source of the mankind.Containing N-sugar compounds (N-containing-sugars) in Folium Mori, there is the pharmacological action suppressing blood glucose to rise, can be used for control and treatment diabetes.
Rhizoma Polygonati, belongs to liliaceous plant, has another name called and rescue poor grass, sweet in the mouth, and property is put down, and enters spleen, lung two warp, has spleen reinforcing lung moistening, YIN nourishing and the production of body fluid promoting, the effects such as strong muscles and bones.Be regarded as the treasure that lengthens one's life since ancient times.Can be used for deficiency of spleen-QI and stomach-QI, fatigue and weakness, pulmonary tuberculosis hemoptysis, weak after being ill, muscles and bones is weak, rheumatalgia, wind favus disease etc.This product begins to be loaded in " Mingyi Bielu ", have " invigorating the spleen and replenishing QI, except rheumatism, settling five organs.Clothes of a specified duration make light of one's life by commiting suicide prolong life not hungry " record.Effect that Ming Dynasty's Li Shizhen (1518-1593 A.D.) is supplemented with again " mending all void, only heat, replenishing essence marrow, lower three corpse worms ", therefore enjoys the laudatory title of " king of vim and vigour giving young employees remedial-courses in general knowledge and vocational skills ".That health ministry confirms " integration of edible and medicinal herbs " plant.Polygonatum polysaccharide for raw material, has the effect suppressing blood glucose to rise with the Rhizoma Polygonati of integration of edible and medicinal herbs.
Semen Tritici aestivi oligopeptide is from wholefood---the protein extracted wheat protein powder, then through micromolecule polypeptide material that directed enzyme action and specific little peptide isolation technics obtain.2012, Ministry of Public Health approval Semen Tritici aestivi oligopeptide was as new resource food (Ministry of Public Health announces 2012 No. 16).The oligomeric Toplink of Semen Tritici aestivi promotes the secretion of insulin, and its functional mass is oligomeric methionine, can be used for the blood glucose of mediator, improves diabetic symptom.
Grain rice homogenate is for Raw material processing forms with high quality white rice powder, soy peptide powder, ovalbumin peptide, Fructus Hordei Germinatus extract, soybean protein isolate, purple sweet potato powder, Rhizoma Dioscoreae powder, egg powder, wheat germ powder, Radix Dauci Sativae powder, compound vitamin and composite mineral matter etc.Product comprehensive nutrition is balanced, be easy to digest and assimilate, can be used as diet succedaneum or nutriment, be suitable for gastrointestinal function better but independently can not drink trencherman (tube feed crowd), rehabilitation phase person and need the various Diseases of enteral nutrition in the family by per os.Product prescription and feature: soy peptide powder, ovalbumin peptide: the catabolite of protein, can be absorbed by the body utilization fast, has the function recovering immuning tissue's function and Promote immunity cell proliferation, the crowd that especially appropriate digested function is poor.Rhizoma Dioscoreae: there is strengthening the spleen and tonifying the lung, stomach reinforcing the kidney invigorating, the effect of life lengthening.Rhizoma Steudnerae Henryanae: be rich in anthocyanidin and dietary fiber, has the effect of resisting oxidation and delaying senility.Wheat germ powder: containing rich in protein and whole essential amino acids.Containing abundant vitamin E, vitamin B complex, octacosanol, unsaturated fatty acid, dietary fiber and abundant mineral: calcium, ferrum, zinc, selenium etc.Radix Dauci Sativae powder: carrot nutritional enriches, and have the title of ' Radix Codonopsis Cardiophyllae ', is rich in saccharide, carotene, dietary fiber, the nutritions such as anthocyanidin, calcium, ferrum.Fructus Hordei Germinatus extract: be a kind of wholefood being derived from corn completely, it contains the necessary aminoacid of abundant maltose, fructose, glucose, protein, small-molecular peptides, human body and multivitamin, mineral, also containing beta glucan and the tocopherol with health care.
In the present invention, Folium Mori extract is mainly α glucosidase inhibitor, and the oligomeric Toplink of Semen Tritici aestivi promotes insulin secretion, and Rhizoma Polygonati extract has assisting in reducing blood sugar and improves the effect of immunity.3 components of the present invention can be supplemented mutually, Folium Mori extract can reduce post-prandial glycemia, Semen Tritici aestivi oligopeptide and Rhizoma Polygonati extract can reduce preprandial glucose, material base of the present invention embodies as follows: (1) Folium Mori extract is the mulberry leaf blood sugar reduction active component obtained through complicated preparation technology, main containing compositions such as polysaccharide, flavonoid (as: Quercetin), alkaloids (as: 1-DNJ) and amino acidses (as: γ-aminobutyric acid), wherein alkaloids composition is greater than 30%, and Amino acids is greater than 20%; (2) Rhizoma Polygonati extract is the composition such as polysaccharide and steroid oside (as: furan steroid enol form Saponin and spirostene alcohol type Saponin) obtained through complicated preparation technology, and wherein polysaccharide component content is greater than 50%; (3) in compound recipe, add the medicative new resource food of tool (Semen Tritici aestivi oligopeptide), the content of oligopeptide is greater than 70%; (4) 3 kinds of components in the present invention, through scientific matching, drug effect compares, and determines optimal proportion.
In a word, the present invention adopts the Chinese herbal medicine Folium Mori extract of integration of edible and medicinal herbs, Rhizoma Polygonati extract and new resource food Semen Tritici aestivi oligopeptide to be raw material, is prepared into solid beverage, significantly can reduces the blood glucose of type ii diabetes people.Add grain rice homogenate and lactalbumin powder simultaneously, after patient takes, the while of being intended to fall hypoglycemic, supplement the nutrients to patient.
Detailed description of the invention
Embodiment 1
Compound antihypelipidemic preparation is made up of the component of following weight (g): Folium Mori extract (8.0g), Rhizoma Polygonati extract (1.0g), Semen Tritici aestivi oligopeptide (1.5g); Said components is mixed into 10.5g/ bag.
Embodiment 2
The effervescent tablet preparation of compound antihypelipidemic preparation:
The weight (g) of constitutive material is: Folium Mori extract (10.0g), Rhizoma Polygonati extract (1.0g), Semen Tritici aestivi oligopeptide (1.5g) and adjuvant corn starch (4.0g), xylitol (1.0g), mannitol (1.5g), citric acid (0.8g) and sodium bicarbonate (0.4); Take each raw material according to the weight of above-mentioned raw materials, mix homogeneously, granulate, 60 DEG C of dryings, tabletting, makes about 1g/ sheet.
Embodiment 3
The electuary preparation of compound antihypelipidemic preparation:
The weight (g) of constitutive material is: Folium Mori extract (10.0g), Rhizoma Polygonati extract (1.0g), Semen Tritici aestivi oligopeptide (1.5g) and grain rice homogenate (30.0g), lactalbumin powder (40.0g), xylitol (10.0g), mannitol (7.5g); Take each raw material according to the weight of above-mentioned raw materials, mix homogeneously, make about 15g/ and wrap.
Embodiment 4 pharmacodynamic study result
Compound antihypelipidemic preparation and each folk prescription component hypoglycemic effect result of the test
In compound antihypelipidemic preparation (embodiment 1,2 or 3) composition, Folium Mori extract, Rhizoma Polygonati extract, Semen Tritici aestivi oligopeptide etc. all have effect of lowering blood sugar, and compare the effect of single component and mixed composition blood sugar lowering, result is as following table 1:
As shown in table 1, diabetic mice blood glucose obviously raises and gives compound antihypelipidemic preparation, Folium Mori extract, Semen Tritici aestivi oligopeptide, Rhizoma Polygonati extract (described Folium Mori extract, Semen Tritici aestivi oligopeptide, Rhizoma Polygonati extract are commercially available) respectively, successive administration 28 days, all can reduce diabetic mice blood glucose (P<0.01) by significance, good than single component of the successful of compound antihypelipidemic preparation.
Table 1 compound antihypelipidemic preparation and each folk prescription component hypoglycemic effect result of the test
Note: compare with blank group
*p<0.05,
*p<0.01, compares with model control group
+p<0.05,
++p<0.01
Get combination of two in compound antihypelipidemic preparation and compositions respectively, compare the effect of component and mixed composition blood sugar lowering between two, result is as following table 2:
Table 2 compound antihypelipidemic preparation and each component hypoglycemic effect result of the test between two
Note: compare with blank group
*p<0.05,
*p<0.01, compares with model control group
+p<0.05,
++p<0.01
Compositions and the hypoglycemic medicine acarbose test of pesticide effectiveness
Get compound antihypelipidemic preparation and acarbose respectively, compare the hypoglycemic effect of compound antihypelipidemic preparation and acarbose, the hypoglycemic effect of antihypelipidemic preparation is suitable with acarbose, and result is as following table 3:
Table 3 compound antihypelipidemic preparation and acarbose hypoglycemic effect result of the test
Note: compare with blank group
*p<0.05,
*p<0.01, compares with model control group
+p<0.05,
++p<0.01
Case 1: Tang *, man, 46 years old, Enterprise Staff, onset diabetes 2 years, fasting glucose 13.1mmol/L, two hours blood glucoses are 19.6mmol/L after the meal, clothes for patients compound antihypelipidemic preparation Mulberry of the present invention essence peptide effervescent tablet, and every day takes before the meal, each 2, after taking 3 days continuously, recording fasting glucose is 5.6mmol/L, and two hours blood glucoses are 9.3mmol/L after the meal, allow it continue to take compound antihypelipidemic preparation of the present invention 3 months, blood sugar content remains stable always.
Case 2: Lee *, man, 63 years old, retired employees of public institution, suffer from diabetes for many years, lean body mass, appetite is poor, fasting glucose 14.5mmol/L, two hours blood glucoses are 21.4mmol/L after the meal, clothes for patients compound antihypelipidemic preparation Mulberry of the present invention essence peptide electuary, every day takes before the meal, each 1 bag, after taking 7 days continuously, recording fasting glucose is 4.7mmol/L, two hours blood glucoses are 8.5mmol/L after the meal, allow it continue to take compound antihypelipidemic preparation of the present invention 6 months, physical recovery is normal, and blood sugar content remains stable always.
Case 3: Jiang *, female, 56 years old, public institution worker, suffers from diabetes for many years, lean body mass, appetite is poor, fasting glucose 9.5mmol/L, two hours blood glucoses are 16.4mmol/L after the meal, clothes for patients compound antihypelipidemic preparation Mulberry of the present invention essence peptide electuary, every day takes before the meal, each 1 bag, after taking 7 days continuously, recording fasting glucose is 5.8mmol/L, two hours blood glucoses are 9.2mmol/L after the meal, allow it continue to take compound antihypelipidemic preparation of the present invention 6 months, physical recovery is normal, and blood sugar content remains stable always.
Claims (7)
1. a compound antihypelipidemic preparation, is characterized in that, described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8-10, Rhizoma Polygonati extract 0.5-1.5, Semen Tritici aestivi oligopeptide 1-2.
2. compound antihypelipidemic preparation as claimed in claim 1, it is characterized in that, described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8-10, Rhizoma Polygonati extract 0.5-1, Semen Tritici aestivi oligopeptide 1-1.5.
3. compound antihypelipidemic preparation as claimed in claim 2, it is characterized in that, described compound antihypelipidemic preparation comprises the crude drug of following weight portion:
Folium Mori extract 8, Rhizoma Polygonati extract 1, Semen Tritici aestivi oligopeptide 1.5.
4. the compound antihypelipidemic preparation as described in any one of claims 1 to 3, is characterized in that, also comprises the adjuvant of following weight portion: corn starch 3-5 in described compound antihypelipidemic preparation, xylitol 1-1.5, mannitol 1-1.5, citric acid 0.6-1, sodium bicarbonate 0.2-0.6.
5. compound antihypelipidemic preparation as claimed in claim 4, is characterized in that, also comprise the adjuvant of following weight portion in described compound antihypelipidemic preparation: corn starch 4, xylitol 1, mannitol 1.5, citric acid 0.8, sodium bicarbonate 0.4.
6. the compound antihypelipidemic preparation as described in any one of claims 1 to 3, is characterized in that, also comprises the adjuvant of following weight portion in described compound antihypelipidemic preparation: grain rice homogenate 25-35, lactalbumin powder 35-40, xylitol 10-15, mannitol 7.5-8.
7. compound antihypelipidemic preparation as claimed in claim 6, is characterized in that, also comprise the adjuvant of following weight portion in described compound antihypelipidemic preparation: grain rice homogenate 30, lactalbumin powder 40, xylitol 10, mannitol 7.5.
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| CN111771988A (en) * | 2020-07-23 | 2020-10-16 | 江西人之初乳品营养有限公司 | Nutritional food suitable for diabetic patients and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108567900A (en) * | 2017-03-07 | 2018-09-25 | 湖南新能量健康产业有限公司 | A kind of compound antihypelipidemic preparation and preparation method |
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| CN110327456A (en) * | 2019-06-21 | 2019-10-15 | 中食都庆（山东）生物技术有限公司 | A kind of composition containing the glad family peptides in soybean Agra and its application |
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| CN111771988A (en) * | 2020-07-23 | 2020-10-16 | 江西人之初乳品营养有限公司 | Nutritional food suitable for diabetic patients and preparation method thereof |
| CN113712206A (en) * | 2021-09-16 | 2021-11-30 | 湖南希尔天然药业有限公司 | A composition containing folium Mori DNJ and folium Mori peptide and its preparation method |
| CN114042150A (en) * | 2021-12-06 | 2022-02-15 | 陕西中鸿科瑞再生医学研究院有限公司 | Oral stem cell factor compound and application thereof |
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Application publication date: 20151216 |
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| RJ01 | Rejection of invention patent application after publication |