CN104825821A - Medicine for treating diabetes and preparation method thereof - Google Patents
Medicine for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating diabetes and a preparation method thereof. The medicine is mainly prepared from prepared gymnadnia conopsear broyn, largeflower triplostegia root, rhizoma polygonati (prepared), radix polygonati officinalis, Chinese yam, lance asiabell root, attenuate St. Johnwort herb, lily, Chinese ladiestresses root or herb, polygonum multiflorum (prepared), auriculate swallowwort root and auxiliary materials. According to the medicine, the blood sugar and blood fat can be obviously reduced, the diabetes is treated, and the complications of patients suffering from diabetes are improved. Moreover, the medicine is exact in curative effect, low in price, low in cost, small in side effects and low in dependence.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of diabetes and preparation method thereof, belong to the field of medicine technology.
Technical background
Diabetes (diabetes mellitus, DM) are a kind of incretion metabolism diseases of serious harm human health, and its complication has become the third-largest cause of death of the mankind after cardiovascular and cerebrovascular disease and tumor.Onset diabetes reason is a lot, and think in interior warp, spleen trauma, lung stomach kidney is scorching, is to lead diabetogenic reason.After modern medicine thinks that human body eats food, food is through the dissolving of partes corporis humani and digestion, by residual for slag excretion, part nutrition becomes blood glucose after dissolving, blood glucose, by the control of spleen institute, stores time many, can lower or stop time few, diabetics is polyphagia, polydipsia, polyuria, Light-headedness, lip and nail color green grass or young crops often, myasthenia of limbs.Diabetes also also have substantial connection with nervous system, uneasy, and indignation and agitation damage lung stomach, and cause lung spleen and stomach function disorderly, spleen disease is increasing.
In recent years, diabetes develop into common chronic disease from " affluenza ", and the medicine of various treatment diabetes and method also increase along with increasing of sickness rate and increase, and diabetes have become serious social problem.In order to treat diabetes, be necessary to develop the pharmaceuticals of organism high safety, food or the utility being equal to food.Current, some patients just starts the medicine taking a large amount of blood sugar lowering, Most patients commonly uses western medicine, advocate that long term injections islets of langerhans usually treats diabetes, result causes the toleration occurring the state of an illness, and the antidiabetic drug only taking a large amount of dosage just could have hypoglycemic effect, and use insulin also can produce dependency to medicine, blood glucose is caused to be difficult to control, and price, side effect is large.
Summary of the invention:
The object of the invention is to, a kind of medicine for the treatment of diabetes and preparation method thereof is provided.Described medicine can significantly reduce blood glucose and blood fat, treatment diabetes, and improves the complication of hyperglycemia patient.And determined curative effect, low price, cost is low, and side effect is little, and dependency is little.
For solving the problems of the technologies described above, the present invention realizes by the following technical solutions: a kind of medicine for the treatment of diabetes, calculate by weight, primarily of Rhizoma Gymnadeniae 1-80 part processed, Radix Triplostegiae Grandiflorae 1-80 part, Rhizoma Polygonati (processed) 1-85 part, Rhizoma Polygonati Odorati 1-30 part, Rhizoma Dioscoreae 5-90 part, Radix Codonopsis lanceolatae 1-60 part, Herba hyperici attenuati 10-100 part, Bulbus Lilii 1-30 part, Radix seu Herba Spiranthis Lanceae 1-80 part, Radix Polygoni Multiflori Preparata 1-50 part, Corii Bovis seu Bubali freezes 1-40 part and adjuvant is prepared from.
The medicine of aforesaid treatment diabetes, according to listed as parts by weight, primarily of Rhizoma Gymnadeniae 5-45 part processed, Radix Triplostegiae Grandiflorae 5-45 part, Rhizoma Polygonati (processed) 5-50 part, Rhizoma Polygonati Odorati 1-20 part, Rhizoma Dioscoreae 5-65 part, Radix Codonopsis lanceolatae 1-40 part, Herba hyperici attenuati 30-70 part, Bulbus Lilii 1-20 part, Radix seu Herba Spiranthis Lanceae 5-45 part, Radix Polygoni Multiflori Preparata 5-25 part, Corii Bovis seu Bubali freezes 1-20 part and adjuvant is prepared from.
The medicine of aforesaid treatment diabetes, according to listed as parts by weight, freeze 10 parts primarily of Rhizoma Gymnadeniae processed 20 parts, Radix Triplostegiae Grandiflorae 20 parts, Rhizoma Polygonati (processed) 25 parts, Rhizoma Polygonati Odorati 10 parts, Rhizoma Dioscoreae 30 parts, Radix Codonopsis lanceolatae 20 parts, Herba hyperici attenuati 50 parts, Bulbus Lilii 10 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Radix Polygoni Multiflori Preparata 15 parts and Corii Bovis seu Bubali and be prepared from.
The medicine of aforesaid treatment diabetes, described Rhizoma Polygonati (processed) and Radix Polygoni Multiflori Preparata are concocted like this: get Rhizoma Polygonati and Radix Polygoni Multiflori respectively, and with the Semen sojae atricolor of 10%, two kinds independent nine are steamed nine and shine nine dew, obtain Rhizoma Polygonati (processed) and Radix Polygoni Multiflori Preparata.
A preparation method for the medicine of aforesaid treatment diabetes, gets said medicine, conventionally extracts, combine with conventional pharmaceutical adjuvants, also can not add adjuvant, make traditional drug formulations.
In the preparation method of the medicine of aforesaid treatment diabetes, described pharmaceutical preparation is oral formulations.
In the preparation method of the medicine of aforesaid treatment diabetes, described oral formulations is decoction, tablet, pill, granule or capsule.
In the preparation method of the medicine of aforesaid treatment diabetes, the preparation method of described decoction is: get said medicine, decocts with water 2 times, first time adds 8 times amount soak by water 3 hours, and second time adds 6 times amount soak by water 2 hours, filters, decoction liquor merges, and is condensed into concentrated solution, obtains decoction.
In the preparation method of the medicine of aforesaid treatment diabetes, the preparation method of described tablet is: get said medicine, with the alcohol reflux 2 times of 6 times amount 70%, each 1 hour, extracting liquid filtering, filtrate recycling ethanol and when being condensed into 50-60 DEG C relative density be the extractum of 1.20-1.25, separately get the starch of extractum amount 20% and the microcrystalline Cellulose of 10% and extractum to mix, tabletting, film coating, to obtain final product.
In the preparation method of the medicine of aforesaid treatment diabetes, the preparation method of described pill is: get said medicine, decocts with water 3 times, and first time adds 12 times amount soak by water 3 hours, second time adds 10 times amount soak by water 2 hours, third time adds 8 times amount soak by water 1 hour, merges decoction liquor, and when being condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, extractum mixes general ball with the starch of extractum amount 15%, drying, coating, to obtain final product.
Medicine of the present invention freezes primarily of Rhizoma Gymnadeniae (system), Radix Triplostegiae Grandiflorae, Rhizoma Polygonati (system), Rhizoma Polygonati Odorati, Rhizoma Dioscoreae, Radix Codonopsis lanceolatae, Herba hyperici attenuati, Bulbus Lilii, Radix seu Herba Spiranthis Lanceae, Radix Polygoni Multiflori (system) and Corii Bovis seu Bubali to be made.Wherein, Rhizoma Gymnadeniae (Gymnadenia conopsea (L.) R.Br.) is a kind of herbaceos perennial, is mainly used in medicine.This medical material is mainly distributed in the northeast of China, North China, the ground such as northwest and Sichuan.Rhizoma Gymnadeniae removes stem and leaf and fibrous root, clean, dry, or with boiled water scalded dry again rear as medical material.Rhizoma Gymnadeniae nature and flavor are sweet, flat.There is benefiting vital QI and blood, effect of promoting the production of body fluid to quench thirst.Be usually used in treating cough and asthma due to lung deficiency, asthenia is become thin, neurasthenia, and chronic diarrhea is lost blood, leukorrhagia, and breast is few, chronic hepatitis etc.Radix Triplostegiae Grandiflorae, Classification system Triplostegia glanduliferaWall.ex DC, sweet in the mouth, micro-hardship, property is put down, and has tonifying speen and tonifying kidney, promoting blood flow to regulate menstruation, only metrorrhagia, effect of removing toxic substances.Be usually used in lumbago due to renal deficiency, anemia, cough, seminal emission, sexual impotence, rheumatic arthritis, menoxenia, vicarious menstruation, metrorrhagia, leukorrhagia, infertility and external hemostasis etc.Rhizoma Polygonati, Classification system Polygonatum sibiricum is HUANGJING ZANYU CAPSULE, rhizome horizontal walk, cylindric, tuberosity expands.Impeller is raw, stockless.Medicinal plants, has spleen reinforcing, the effect of the lung moistening and production of body fluid promoting.Effectively can treat anemicus, orthostatic, infectivity and agnogenio property hypotension, lack of lung-YIN, leukopenia, gastric heat is thirsty, improving eyesight, and Ying Qi is unclear, and because forming leprosy, nose bad dark and lustreless complexion, skin is itched routed, weakness of the spleen and stomach, the diseases such as fatigue and lack of strength.Rhizoma Polygonati Odorati is Liliaceae herbaceos perennial.Rhizome horizontal walk, meat yellow-white, the most fibrous root of close life.Blade face is green, below Lycoperdon polymorphum Vitt." stem is tetanic, like bamboo arrow shaft, has joint for Collective Notes to the Canon of Materia medica cloud." therefore have the name of Rhizoma Polygonati Odorati.The rhizome of plant can hyoscine, and Chinese medicine name is also Rhizoma Polygonati Odorati, and autumn excavates, and cleans, shines to softness, repeatedly rub, and dry in the sun, to without hard-core, is dried, or steams thoroughly, rubs to translucent, dries, and cuts sheet or section use.Rhizoma Polygonati Odorati extraction flavonoid substances is combined with Folium Mori extract deoxynojirimycin and forms a kind of novel substance---and wash clear sugar element (cics) of pancreas, there is the effects such as blood sugar lowering, blood fat, blood pressure.Rhizoma Polygonati Odorati also has yin nourishing, moisturizes, heat clearing away, promote the production of body fluid, the effect such as cough-relieving.As tonic, cure mainly the diseases such as consumption of YIN caused by febrile disease, deficiency-heat cough caused by dryness, heart disease, diabetes, tuberculosis, and high-grade nourishing food, delicacies and beverage can be made, with health role.Rhizoma Dioscoreae is the medical herbs that " China's book on Chinese herbal medicine " records, and medicinal source is Dioscoreaceae plant Rhizoma Dioscoreae dry rhizome.Winter, stem and leaf was excavated after withering, and cut root head, cleaned, removing crust and fibrous root, drying after smoked with sulfur, also have and select loose straight dry Rhizoma Dioscoreae, put in clear water, be dipped into without the dry heart, vexed, after smoked with sulfur, trim two ends, be twisted into plank cylindric, dry, polishing, claim " light yam ".Have spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission, nourishes strong, aid digestion, holds back sweating due to debility, effect of antidiarrheal, cure mainly insufficiency of the spleen diarrhoea, cough due to deficiency of the lung, diabetes quenched one's thirst, oliguria frequently, seminal emission, women's leukorrhagia and dyspeptic chronic enteritis.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.Radix Codonopsis lanceolatae, Classification system Lance Asiabell Root, Root of Lance Asiabell is herbaceous plant, there is high medical value, there is supplementing QI and nourishing YIN, removing toxic substances and promoting subsidence of swelling, evacuation of pus, lactogenesis, benefiting qi and nourishing blood, effect of detumescence and apocenosis, is used for the treatment of main spiritlessness and weakness, dizziness headache, lung abscess, acute mastitis,, furuncle toxic swelling, throat moth, scrofula, puerperal, breast was few, venom etc.Herba hyperici attenuati, Classification system Hypericum attenuatum Choisy, herbaceos perennial, medicinal have hemostasis, analgesia, the effects such as lactogenesis.Be usually used in treatment spitting of blood, spit blood, metrorrhagia, rheumatic arthritis, neuralgia, traumatic injury, agalactosis, mastitis; Wound hemorrhage is controlled in external, carbuncle furuncle and phyma poison.Bulbus Lilii, Classification system Lilium browniivar.Viridulum, belong to perennial herb bulbous plant, bulb is containing enriching starch, edible, also does medicinal.Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram is containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also containing some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also to dry in autumn and multiple Seasonal diseases that is that cause has certain preventive and therapeutic effect.The traditional Chinese medical science is said fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, weakling is after being ill highly profitable.Bulbus Lilii removing impurity is cleaned, and repeatedly adds water into pot after rinsing in clear water, with decocting in water to completely mashed, adds appropriate white sugar, and band soup eats in the lump, can make the dietetic therapy good merchantable brand of tuberculosis patient.Though slightly bitterness time edible, fine taste is then with in hardship sweet, makes us aftertaste; If putting into refrigerator deposits a little while, it is again fabulous ice drink.There is nourishing YIN and moistening the lung, effect of clearing away heart-fire for tranquillization.Be usually used in treatment deficiency of YIN chronic cough, sputum mixed with blood, the calentura later stage, waste heat is clear, or the unsuccessful caused fidgets due to deficiency palpitation with fear of feelings will, insomnia and dreamful sleep, absentminded, carbuncle, eczema etc.Radix seu Herba Spiranthis Lanceae belongs to the orchid family perennial herb.Rhizome is short, have cluster, slightly thick fibrous root.There is tonifying YIN heat clearing away, effect of nourishing the lung to arrest cough.Be usually used in treatment weak after being ill, yin asthenia generating intrinsic heat, cough is spitted blood, dizzy, the soreness of waist, seminal emission, stranguria with turbid discharge leukorrhagia, skin infection carbuncle.Radix Polygoni Multiflori, Classification system, Fallopiamultiflora (Thunb.) Harald is perennial plant, and tuber is plump, oblong, pitchy, sweet in the mouth, and temperature is nontoxic.There is nourishing the blood and yin, loosening bowel to relieve constipation, preventing the attack (or recurrence) of malaria, dispel the wind, effect of removing toxic substances.Be usually used in treatment blood deficiency Light-headedness, cardiopalmus, insomnia, the soreness of the waist and knees of the hepatic and renal YIN deficiency, early whitening of beard and hair, tinnitus, seminal emission, dryness of the intestine constipation, chronic malaria body is empty, rubella pruritus, carbuncle sore, scrofula, hemorrhoid etc.Compendium of Material Medica is said: this thing temperature bitter and puckery flavor, bitter the kidney invigorating, and temperature compensation liver, can restrain vital essence, so the liver benefiting that can nourish blood, controlling nocturnal emission with astringent drugs kidney tonifying, muscle reinforcing and bone strengthening, black hair is tonic medicine, and cold not dry, merit is on Radix Rehmanniae, all medicines of Radix Asparagi.QI and blood Taihe county, then wind void, carbuncle, all diseases of scrofula known (removing).Corii Bovis seu Bubali freezes, another name, Radix cynanchi wilfordii, thousand layers of skin, Semen phaseoli radiati ginseng, Herba Alii fistulosi skin Radix Ophiopogonis, formal name used at school, Lonicera ferdinandii is the plant of Caprifoliaceae Lonicera, be commonly called as Qinling Mountains Flos Lonicerae, be distributed in all parts of the country, production Qinling area, be grown on height above sea level 1, the area of 000 meter to 2,000 meter, sees in endroit woods with in border shrubbery, at present not yet by artificial introducing and planting, there is medicinal and ornamental value.Branch phloem fiber can rope making rope, gunnysack, also can make paper making raw material; There is heat-clearing and toxic substances removing, the merit that loose emaciation due to emotional upset is swollen, can be used as medicine, Shaanxi its alabastrum conventional among the people and all diseases of leaf treatment Common Cold; Set this form graceful, also can do ornamental plant.
Compared with prior art, the present invention adopts above-mentioned raw materials to make medicine, each component raw material has good synergistic function, there is reduction blood glucose and blood fat, improve glycosuria order feel symptom, regulate blood glucose, prevent diabetes, prevent sugared resistance to exception, improve sugared resistance to effect, improve effect of hyperglycemia patients symptomatic.Can effectively prevent or treat diabetes, evident in efficacy, low price, cost be low, side effect and little to the dependency of this medicine, reaches the object of invention.
Applicant carried out following experiments, provable the present invention has effective effect;
Experimental example 1 is treated diabetic experimental and is investigated
1. clinical data
Totally 62 examples, are divided into two groups at random.Treatment group 32 example, man 15 example, female 17 example; 18 ~ 66 years old age, average 41 years old; The course of disease 2 ~ 12 years, average 7 years; Type 1 diabetes 3 example, type 2 diabetes mellitus 29 example.Matched group 30 example, man 13 example, female 17 example; 18 ~ 68 years old age, average 43 years old; The course of disease 1 ~ 12 year, average 6.5 years; Type 1 diabetes 2 example, type 2 diabetes mellitus 28 example.Two groups of ages, sex, the state of an illness, course of disease statistical procedures there was no significant difference (P>O.05).
2. Therapeutic Method
Portion's case all meets the diabetes that WHO diabetologist committee formulates and to break standard.All through health education in diabetes, strictly implement diabetic diet for two groups, do not eat raw food, greasy food, suitable exercise therapy, oral antidiabetic drug or subcutaneous insulin injections by glycemic control within normal range.
The oral medicine of the present invention for the treatment of group (being prepared according to the mode of embodiment 1), each 1 dose, every day 3 times is oral.
Matched group oral antidiabetic drug 15 example, by insulin 15 example.Another vitamin B, 20mg, every day 3 times; Compound recipe benzene second croak pyridine 5mg, every day 3 times; Berberine .39, every day 3 times; Day takes.
Treat 1 month.
3. criterion of therapeutical effect
Recovery from illness: defecation every day 1 time, stool is shaped, abdominal part without sense of discomfort, without recurrence in 1 year.Effective: defecation every 13 is less than 2 times, stool is shaped, and abdominal discomfort disappears.Effective: defecation frequency reduces more than 50% before comparatively treating, and abdominal discomfort alleviates.Invalid: times of defecation minimizing does not reach above standard or abdominal discomfort is not alleviated.Recurrence: treatment has obtained effective, in 1 year, disease relapse is with before treatment.
4. therapeutic outcome
Treatment group recovery from illness 3 example, effective 14 examples, effective 13 examples, invalid 2 examples, total effective rate 93.8%; Matched group recovery from illness 0 example, effective 5 examples, effective 12 examples, invalid 13 examples, total effective rate 56.7%.
Treatment group has no adverse reaction and toxic and side effects over the course for the treatment of.Matched group has xerostomia, abdominal discomfort more, and wherein feeling sick appears in 10 examples, and vomiting appears in 4 examples, and after reducing compound recipe benzene second croak pyridine consumption, symptom alleviates or disappears.
Conclusion: the present invention effectively can treat diabetes.
Experimental example 2 reduces blood fat the effects
1 materials and methods
1.1 case selections: by cholesterolemia (CH) >5.95mmol/L and (or) triglyceride (TG) >I.81mmol/L person elects the object of observation as, totally 42 examples.Wherein man 47 example. female 47 example, 38 ~ 72 years old age, average 58 native SD8 year.In 36 routine hypercholesterolemia persons, belong to slight increased perosn (5.95 ~ 7.0mmoI/L) 8 example; In 28 routine hypertriglyceridemia persons. belong to slight increased perosn (1.8l ~ 2.53mmol/L) 9 example, moderate increased perosn (2.53 ~ 3.08mmol/L) 8 routine severe increased perosn (>3.08mmol/L) ll example.Whole 42 examples all look into high density lipoprotein tendon sterin (HDL-C).Quan Zuzhong is with hypertension 13 example, and coronary heart disease ll is routine.The course for the treatment of is 1 year 3 months ~ 11 years, and most of case was once taken inositol niacinate, beniol, SHANZHAJING JIANGZHI PIAN etc. and is blood fat ascensionist again after the not good enough or drug withdrawal of curative effect.
1.2 Therapeutic Method: at random hypercholesterolemia and high triglyceride patient are respectively divided into A, B two groups.The oral medicine of the present invention of A group (being prepared by embodiment 1) 0.2g, every day 3 times; The oral medicine of the present invention of B group (being prepared by embodiment 1) 0.4g, every day 3 times.Within 4 weeks, be a course for the treatment of, treatments period is stopped using other fat-reducing medicament.As usual, l weekend, 4 weekends check cholesterolemia, triglyceride, HDL-C and hepatic and renal function and routine blood test to diet before the treatment and after treatment.And observe its curative effect and untoward reaction.
1.3 efficacy evaluations: the efficacy evaluation of cholesterol reducing or Triglyceride values: effective: before treatment, blood CH or TG is in light, moderate increased perosn, is all down in normal range, or was severe increased perosn originally after treatment, are down to after treatment and slightly increase or in normal range; Improve: before treatment blood CH or TG value be in, severe increased perosn, to be down to respectively after treatment slightly or moderate increases in scope; Invalid: treatment before and after blood CH or TG value constant; Increase the weight of: after treatment, blood CH or TG value raise before comparatively treating.
2 results
2.1 pairs of effects of falling CH, TG and HDL-C increasing value: this medicine is to falling CH, TG and HDL-C increasing all has good effect, in table 1.
2.2 cholesterolemias and triglyceride increase the relation of degree and curative effect: this medicine to light, in, heavy blood CH or TG increased perosn all have certain curative effect, the former effective percentage is respectively 50%, 68.8% and 75%, and the latter is respectively 55.6%, 75% and 51.5%.
The change of the every lipid level average in front and back treated by table 1
The relation of 2.3 journeys and curative effect: in table 2.After table 2 represents treatment, l week blood CH and TG value reduces all not obvious (P>0.05); HDL-C (than decline 0.01g/L before treatment, no difference of science of statistics.After treatment, 4 weeks blood CH and TC values all have remarkable reduction, and HDL-C also obviously increases (P<0.05).
2.4 various dose curative effect of medication contrast of the present invention: in table 3,4.Table 3, table 4 show. every day 0.2g and 0.4g metronidazole to the effect of falling CH value, there were significant differences (P<0.05).And the effect no significant difference (P>0.05) to TG reducing value.
The relation that table 2 course for the treatment of and lipid level average change
Table 3 various dose is to the Comparison of therapeutic of serum cholesterol
Table 4 various dose is to the Comparison of therapeutic of serum triglycerides
2.5 side reactions: full group 42 examples have after the tablet has been ingested 6 example senses dizzy, feel sick, poor appetite, tired. but all can adhere to treatment.
Conclusion: medicine of the present invention has the effect of blood fat reducing.
Below in conjunction with embodiment, invention is further described, but not as the foundation limited the present invention.
Detailed description of the invention:
Embodiment 1.
Formula: Rhizoma Gymnadeniae (system) 20g, Radix Triplostegiae Grandiflorae 20g, Rhizoma Polygonati (system) 25g, Rhizoma Polygonati Odorati 10g, Rhizoma Dioscoreae 30g, Radix Codonopsis lanceolatae 20g, Herba hyperici attenuati 50g, Bulbus Lilii 10g, Radix seu Herba Spiranthis Lanceae 20g, Radix Polygoni Multiflori (system) 15g and Corii Bovis seu Bubali freeze 10g.
Technique: get Rhizoma Polygonati and Radix Polygoni Multiflori, every taste with 10% Semen sojae atricolor, two kinds independent nine steam nine shine nine dew, obtain the Rhizoma Polygonati after the process of preparing Chinese medicine and Radix Polygoni Multiflori, for subsequent use; Get all the other raw materials, get all the other medicines, decoct with water 2 times, first time adds 8 times amount soak by water 3 hours, and second time adds 6 times amount soak by water 2 hours, filters, and decoction liquor merges, and is condensed into concentrated solution, obtains decoction.
Usage and dosage: sooner or later respectively once, each 150 milliliters, oral.
Embodiment 2.
Formula: Rhizoma Gymnadeniae (system) 45g, Radix Triplostegiae Grandiflorae 45g, Rhizoma Polygonati (system) 50g, Rhizoma Polygonati Odorati 20g, Rhizoma Dioscoreae 65g, Radix Codonopsis lanceolatae 40g, Herba hyperici attenuati 70g, Bulbus Lilii 20g, Radix seu Herba Spiranthis Lanceae 45g, Radix Polygoni Multiflori (system) 25g and Corii Bovis seu Bubali freeze 20g.
Technique: get Rhizoma Polygonati and Radix Polygoni Multiflori, every taste with 10% Semen sojae atricolor, two kinds independent nine steam nine shine nine dew, obtain the Rhizoma Polygonati after the process of preparing Chinese medicine and Radix Polygoni Multiflori, for subsequent use; Get all the other medicines, with the alcohol reflux 2 times of 6 times amount 70%, each 1 hour, extracting liquid filtering, filtrate recycling ethanol and when being condensed into 50-60 DEG C relative density be the extractum of 1.20-1.25, separately get the starch of extractum amount 20% and the microcrystalline Cellulose of 10% and extractum and mix, tabletting, film coating, obtains tablet.
Specification: every sheet 0.5g.
Usage and dosage: every day 3 times, each 2, oral.
Embodiment 3.
Formula: Rhizoma Gymnadeniae (system) 5g, Radix Triplostegiae Grandiflorae 5g, Rhizoma Polygonati (system) 5g, Rhizoma Polygonati Odorati 1g, Rhizoma Dioscoreae 5g, Radix Codonopsis lanceolatae 1g, Herba hyperici attenuati 30g, Bulbus Lilii 1g, Radix seu Herba Spiranthis Lanceae 5g, Radix Polygoni Multiflori (system) 5g and Corii Bovis seu Bubali freeze 1g.
Technique: get Rhizoma Polygonati and Radix Polygoni Multiflori, every taste with 10% Semen sojae atricolor, two kinds independent nine steam nine shine nine dew, obtain the Rhizoma Polygonati after the process of preparing Chinese medicine and Radix Polygoni Multiflori, for subsequent use; Get all the other medicines, decoct with water 3 times, first time adds 12 times amount soak by water 3 hours, and second time adds 10 times amount soak by water 2 hours, and third time adds 8 times amount soak by water 1 hour, merge decoction liquor, when being condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, and extractum mixes general ball with the starch of extractum amount 15%, dry, coating, obtains pill.
Specification: every ball 0.5g.
Usage and dosage: every day 3 times, each 2 balls, oral.
Embodiment 4.
Formula: Rhizoma Gymnadeniae (system) 40g, Radix Triplostegiae Grandiflorae 40g, Rhizoma Polygonati 45g (system), Rhizoma Polygonati Odorati 18g, Rhizoma Dioscoreae 60g, Radix Codonopsis lanceolatae 35g, Herba hyperici attenuati 65g, Bulbus Lilii 18g, Radix seu Herba Spiranthis Lanceae 40g, Radix Polygoni Multiflori 20g (system), Corii Bovis seu Bubali freeze 18g.
Technique: get Rhizoma Polygonati and Radix Polygoni Multiflori, every taste with 10% Semen sojae atricolor, two kinds independent nine steam nine shine nine dew, obtain the Rhizoma Polygonati after the process of preparing Chinese medicine and Radix Polygoni Multiflori, for subsequent use; Get all the other medicines, with the alcohol reflux 2 times of 6 times amount 70%, each 1 hour, extracting liquid filtering, filtrate recycling ethanol and when being condensed into 50-60 DEG C relative density be the extractum of 1.20-1.25, separately get the starch of extractum amount 30% and the magnesium stearate of 0.7% and extractum to mix, with the alcohol granulation of 60%, dry, pulverize, filled capsules, obtains capsule.
Specification: every 0.5g.
Usage and dosage: every day 3 times, each 2, oral.
Embodiment 5
Formula: Rhizoma Gymnadeniae 9g (system), Radix Triplostegiae Grandiflorae 9g, Rhizoma Polygonati 10g (system), Rhizoma Polygonati Odorati 8g, Rhizoma Dioscoreae 12g, Radix Codonopsis lanceolatae 7g, Herba hyperici attenuati 35g, Bulbus Lilii 5g, Radix seu Herba Spiranthis Lanceae 15g, Radix Polygoni Multiflori 9g (system), Corii Bovis seu Bubali freeze 9g.
Technique: get said medicine, decoct with water 3 times, first time adds 12 times amount soak by water 3 hours, second time adds 10 times amount soak by water 2 hours, and third time adds 8 times amount soak by water 1 hour, merges decoction liquor, when being condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, the starch of extractum and extractum amount 20% and the dextrine powder mixing granulation of 20%, dry, obtain granule.
Specification: every 0.5g.
Usage and dosage: every day 3 times, each 2, oral.
Claims (10)
1. treat the medicine of diabetes for one kind, it is characterized in that: calculate by weight, primarily of Rhizoma Gymnadeniae 1-80 part processed, Radix Triplostegiae Grandiflorae 1-80 part, Rhizoma Polygonati (processed) 1-85 part, Rhizoma Polygonati Odorati 1-30 part, Rhizoma Dioscoreae 5-90 part, Radix Codonopsis lanceolatae 1-60 part, Herba hyperici attenuati 10-100 part, Bulbus Lilii 1-30 part, Radix seu Herba Spiranthis Lanceae 1-80 part, Radix Polygoni Multiflori Preparata 1-50 part, Corii Bovis seu Bubali freezes 1-40 part and adjuvant is prepared from.
2. the medicine for the treatment of diabetes as claimed in claim 1, it is characterized in that: according to listed as parts by weight, primarily of Rhizoma Gymnadeniae 5-45 part processed, Radix Triplostegiae Grandiflorae 5-45 part, Rhizoma Polygonati (processed) 5-50 part, Rhizoma Polygonati Odorati 1-20 part, Rhizoma Dioscoreae 5-65 part, Radix Codonopsis lanceolatae 1-40 part, Herba hyperici attenuati 30-70 part, Bulbus Lilii 1-20 part, Radix seu Herba Spiranthis Lanceae 5-45 part, Radix Polygoni Multiflori Preparata 5-25 part, Corii Bovis seu Bubali freezes 1-20 part and adjuvant is prepared from.
3. the medicine for the treatment of diabetes as claimed in claim 1, it is characterized in that: according to listed as parts by weight, freeze 10 parts primarily of Rhizoma Gymnadeniae processed 20 parts, Radix Triplostegiae Grandiflorae 20 parts, Rhizoma Polygonati (processed) 25 parts, Rhizoma Polygonati Odorati 10 parts, Rhizoma Dioscoreae 30 parts, Radix Codonopsis lanceolatae 20 parts, Herba hyperici attenuati 50 parts, Bulbus Lilii 10 parts, Radix seu Herba Spiranthis Lanceae 20 parts, Radix Polygoni Multiflori Preparata 15 parts and Corii Bovis seu Bubali and be prepared from.
4. the medicine of the treatment diabetes according to any one of claim 1-3, it is characterized in that: described Rhizoma Polygonati (processed) and Radix Polygoni Multiflori Preparata are concocted like this: get Rhizoma Polygonati and Radix Polygoni Multiflori respectively, with the Semen sojae atricolor of 10%, two kinds independent nine are steamed nine and shine nine dew, obtain Rhizoma Polygonati (processed) and Radix Polygoni Multiflori Preparata.
5. the preparation method of the medicine of the treatment diabetes according to any one of claim 1-3, it is characterized in that: get said medicine, conventionally extract, combine with conventional pharmaceutical adjuvants, also can not add adjuvant, make traditional drug formulations.
6. the preparation method of the medicine for the treatment of diabetes as claimed in claim 5, is characterized in that: described pharmaceutical preparation is oral formulations.
7. the preparation method of the medicine for the treatment of diabetes as claimed in claim 6, is characterized in that: described oral formulations is decoction, tablet, pill, granule or capsule.
8. the preparation method of the medicine for the treatment of diabetes as claimed in claim 7, it is characterized in that: the preparation method of described decoction is: get said medicine, decoct with water 2 times, first time adds 8 times amount soak by water 3 hours, second time adds 6 times amount soak by water 2 hours, filters, and decoction liquor merges, be condensed into concentrated solution, obtain decoction.
9. the preparation method of the medicine for the treatment of diabetes as claimed in claim 7, it is characterized in that: the preparation method of described tablet is: get said medicine, with the alcohol reflux 2 times of 6 times amount 70%, each 1 hour, extracting liquid filtering, filtrate recycling ethanol and when being condensed into 50-60 DEG C relative density be the extractum of 1.20-1.25, separately get the starch of extractum amount 20% and the microcrystalline Cellulose of 10% and extractum to mix, tabletting, film coating, to obtain final product.
10. the preparation method of the medicine for the treatment of diabetes as claimed in claim 7, it is characterized in that: the preparation method of described pill is: get said medicine, decocts with water 3 times, first time adds 12 times amount soak by water 3 hours, second time adds 10 times amount soak by water 2 hours, third time adds 8 times amount soak by water 1 hour, merges decoction liquor, and when being condensed into 50-60 DEG C, relative density is the extractum of 1.15-1.20, extractum mixes general ball with the starch of extractum amount 15%, drying, coating, to obtain final product.
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| CN201510262336.XA CN104825821A (en) | 2015-05-21 | 2015-05-21 | Medicine for treating diabetes and preparation method thereof |
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| CN109568489A (en) * | 2018-12-18 | 2019-04-05 | 漳州市吾梓贸易有限公司 | A kind of Chinese medicine composition and preparation method thereof for treating diabetes |
| CN110123827A (en) * | 2019-06-17 | 2019-08-16 | 中南民族大学 | A kind of pharmaceutical composition and its preparation method and application treated by metabolic disorder associated diseases |
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