CN105106523A - Spleen and stomach strengthening preparation for treating lung cancer and preparing method thereof - Google Patents
Spleen and stomach strengthening preparation for treating lung cancer and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a spleen and stomach strengthening preparation for treating lung cancer. The preparation is mainly prepared from, by mass, 10-16 parts of herb of pilose gerbera, 8-14 parts of oyster rhoeo, 9-15 parts of screwtree roots, 7-12 parts of lance asiabell roots, 9-13 parts of trikeraia hookeri, 8-12 parts of senecio scandens, 10-14 parts of gynostemma pentaphylla, 7-11 parts of sweet tea roots, 9-16 parts of large angiopteris, 8-15 parts of flos farfarae, 7-16 parts of incised spleenwort, 5-10 parts of solanum lyratum thumb, 10-17 parts of roots of arrowleaf abelmoschus, 8-13 parts of peperomia dindygulensis miq, 7-15 parts of melastoma affine D.Don, and 9-14 parts of monochoria vaginalis. The preparation is obtained based on years of clinical practice, can clear the lung and suppress cough and achieve detumescence by detoxification, and has a remarkable treatment effect.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to the invigorating the spleen and regulating the stomach preparation and method for making for the treatment of pulmonary carcinoma.
Background technology
Pulmonary carcinoma is a kind of common pulmonary malignant tumour, and most pulmonary carcinoma originates from bronchial mucosa epithelium.Refer to lung tissue's inner cell and grow out of control disease.This Growth of Cells may cause transfer, invades adjacent tissue exactly and penetrates into beyond pulmonary.Pulmonary carcinoma not what characteristic symptom in early days, is only the symptom that general respiratory system disease is common, as cough, expectorant blood, low grade fever, chest pain, unhappy etc., is easy to ignore.The concrete manifestation of the early stage common sympton of pulmonary carcinoma: 1, cough.Pulmonary carcinoma at broncho-pulmonary tissue because of long, usually can produce respiratory tract symptom and irritable cough occurs.2, low grade fever.Tumor often has the obstructive lobe of the lung to exist after blocking bronchus, degree varies, and the lighter only has low grade fever, and severe one then has high heat, temporarily can take a turn for the better, but can recur again very soon after medication.3, chest pain with distension sensation.The early stage chest pain of pulmonary carcinoma is comparatively light, main manifestations be vexed pain, dull pain, position not necessarily, also uncertain with the relation of breathing.As distending pain continues to occur, illustrate that cancer has the possibility of involving pleura.4, expectorant blood.Tumor inflammation causes necrosis, blood capillary has hemorrhage on a small quantity time damaged, often mixes with expectorant, in interval or intermittently occur.A lot of lung cancer patient is medical because of expectorant blood.Advanced lung cancer symptom is 1., cervical region edema.2. hoarseness is most common sympton.3. tachypnea, the patients with lung cancer of generation area property diffusion nearly all has tachypnea in various degree.
Publication No. CN104825899A(application number 201510285090.8) Chinese patent literature disclose a kind of Chinese medicine for the treatment of pulmonary carcinoma, its be following weight proportion raw material of Chinese medicine composition: Radix Achyranthis Bidentatae 5-8, Radix Astragali 3-5, Thallus Laminariae (Thallus Eckloniae) 4-6, Oletum Trogopterori 6-8, Rhizoma Corydalis 3-5, Radix Notoginseng 6-8, Herba Lophatheri 6-8, Herba Solani Nigri 3-5, Radix Codonopsis 7-9, Radix Rehmanniae Preparata 8-10, Rhizoma Cyperi 5-7, Flos Farfarae 4-6, Herba Agrimoniae 3-5, Herba Houttuyniae 4-6, Rhizoma Paridis 3-5.Publication No. CN104800538A(application number 201510251333.6) Chinese patent literature disclose a kind of Chinese medicine for the treatment of pulmonary carcinoma, be made up of the crude drug of following weight ratio: Rhizoma Paridis 10-20 part, Bulbus Fritillariae Cirrhosae 5-10 part, Rabdosia rubescens 5-15 part, dried Alumen 10-20 part, Radix Astragali 10-20 part, Borneolum Syntheticum 10-20 part, Flos Lonicerae 5-15 part, Radix Ginseng 5-10 part, Ganoderma 5-10 part, SHANZHIZI 5-15 part, Poria 15-30 part, Rhizoma Acori Calami 10-20 part, Herba Andrographis 5-10 part, Radix Glycyrrhizae 10-20 part, Rhizoma Polygoni Cuspidati 25-40 part, lobule buys numb Teng 15-25 part, Radix Tripterygii Wilfordii 5-10 part, Herba Scutellariae Barbatae 5-15 part, Hedyotidis Diffusae 5-10 part.Publication No. CN103800719A(application number 201410041332.4) Chinese patent literature disclose a kind of Chinese medicine for the treatment of pulmonary carcinoma, Fructus Ligustri Lucidi 4-9 gram, Herba Lophatheri 1-5 gram, Rhizoma Paridis 5-15 gram, Flos Carthami 10-20 gram, Radix Achyranthis Bidentatae 6-10 gram, Rhizoma Corydalis 4-15 gram, Radix Astragali 5-10 gram, Radix Notoginseng 3-8 gram.
Though operative treatment can remove lump fast, relapse rate is high, and treatment by Chinese herbs to have side effect little, the advantage that anti-recurrence rate is effective, can stablize the state of an illness, indiffusion, part Chinese medicine formula Clinical Practice, therapeutic effect is poor, therefore needs to work out Be very effective, formula that anti-relapse rate is high.
Summary of the invention
For the problem of prior art, the object of this invention is to provide a kind of Be very effective, take invigorating the spleen and regulating the stomach preparation and the method for making of the wide treatment pulmonary carcinoma of safe and applicable.
Technical scheme of the present invention is:
The invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from primarily of following bulk drugs, is mass parts: Herba Gerberae Piloselloidis 10-16; Flos Rhoeo discolorae 8-14; Radix Helicteris 9-15; Radix Codonopsis lanceolatae 7-12; Herba Kylligac coloratae 9-13; Herba Senecionis Scandentis 8-12; Herb Gynostemmae Pentaphylli 10-14; Radix Hydrangeae Strigosae 7-11; Angiopteris magna Ching (Angiopteris majuscula Ching) 9-16; Flos Farfarae 8-15; Iron Herba Selaginellae Moellendorfii 7-16; Herba Solani Lyrati 5-10; Radix Abelmoschi Sagittifolii 10-17; Herba Peperomiae Dindygulensis 8-13; Broken bowl palm foot tree 7-15; Herba monochoriae vaginalis 9-14.
Preferred version is, Herba Gerberae Piloselloidis 12-14; Flos Rhoeo discolorae 10-12; Radix Helicteris 11-13; Radix Codonopsis lanceolatae 9-10; Herba Kylligac coloratae 10-12; Herba Senecionis Scandentis 9-11; Herb Gynostemmae Pentaphylli 11-13; Radix Hydrangeae Strigosae 8-10; Angiopteris magna Ching (Angiopteris majuscula Ching) 11-14; Flos Farfarae 10-13; Iron Herba Selaginellae Moellendorfii 9-14; Herba Solani Lyrati 6-9; Radix Abelmoschi Sagittifolii 12-15; Herba Peperomiae Dindygulensis 9-12; Broken bowl palm foot tree 9-13; Herba monochoriae vaginalis 10-13.
Be more preferably, Herba Gerberae Piloselloidis 13; Flos Rhoeo discolorae 11; Radix Helicteris 12; Radix Codonopsis lanceolatae 9.5; Herba Kylligac coloratae 11; Herba Senecionis Scandentis 10; Herb Gynostemmae Pentaphylli 12; Radix Hydrangeae Strigosae 9; Angiopteris magna Ching (Angiopteris majuscula Ching) 12.5; Flos Farfarae 11.5; Iron Herba Selaginellae Moellendorfii 11.5; Herba Solani Lyrati 7.5; Radix Abelmoschi Sagittifolii 13.5; Herba Peperomiae Dindygulensis 10.5; Broken bowl palm foot tree 11; Herba monochoriae vaginalis 11.5.
The invigorating the spleen and regulating the stomach preparation of described treatment pulmonary carcinoma, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) blend step (3) (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
The preparation method of the invigorating the spleen and regulating the stomach preparation decoction of described treatment pulmonary carcinoma, the amount that step (3) adds alcoholic solution by 6 times of extraction crude drug quality.
The invigorating the spleen and regulating the stomach preparation of described treatment pulmonary carcinoma, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) spray drying step (3) (4) gained filtrate, pulverizes and sieves, then adds adjuvant, make granule, and dry, granulate, obtains granule.
The preparation method of the invigorating the spleen and regulating the stomach preparation granules agent of described treatment pulmonary carcinoma, it is (preferred: to pulverize 80-120 mesh sieve that step (5) pulverized 60-140 mesh sieve; Be more preferably: pulverized 100 mesh sieves).
The invigorating the spleen and regulating the stomach preparation of described treatment pulmonary carcinoma, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) step (3) (4) gained filtrate mixed, heating is concentrated into clear paste, adds refined honey mixing, obtains unguentum.
The preparation method of the invigorating the spleen and regulating the stomach preparation unguentum of described treatment pulmonary carcinoma, the amount that step (5) adds refined honey is the 0.3-0.5 of clear paste quality doubly (preferred: the amount adding refined honey is 0.4 times of clear paste quality).
The invigorating the spleen and regulating the stomach preparation of described treatment pulmonary carcinoma, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) concentration step (3) (4) gained filtrate, dries and pulverizes, be packed in capsule, obtain capsule.
The preparation method of the invigorating the spleen and regulating the stomach preparation capsule of described treatment pulmonary carcinoma, in the every capsules of step (5) step (5), contained medicated powder quality is that 0.3-0.4g(is preferred: in every capsules, contained medicated powder quality is 0.35g).
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Herba Gerberae Piloselloidis: base is former: be the herb of feverfew Herba Leibnitziae.Nature and flavor: bitter in the mouth; Pungent; Cool in nature.Function cures mainly: heat-clearing and toxic substances removing; Lung qi dispersing cough-relieving; Promoting flow of QI and blood.The main cough due to common cold; Epigastric distending pain; Have loose bowels; Dysentery; Edema; Stranguria with turbid discharge; Furuncle toxic swelling; Treating swelling and pain by traumatic injury; Venom.
Flos Rhoeo discolorae: base is former: be the flower of the purple Rohdea japonica Roth of Commelianaceae plant.Nature and flavor: sweet; Cool; Light.Function cures mainly: removing heat from the lung and dissipating phlegm; Cooling blood for hemostasis; Removing toxic substances dysentery relieving.Main lung-heat cough with asthma; Pertussis; Spitting of blood; Epistaxis; Dysentery; Have blood in stool; Scrofula.
Radix Helicteris: base is former: be root or the Herb of Sterculiaceae plant Radix Helicteris.Nature and flavor: bitter; Cool in nature; Mild toxicity.Gui Jing: stomach warp.Function cures mainly: heat-clearing and toxic substances removing.Main cold, fever; Cough due to lung-heat; Laryngopharynx swelling and pain; Measles; Mumps; Intestinal is scorching; Dysentery; Carbuncle; Scrofula skin ulcer; Venom.
Radix Codonopsis lanceolatae: base is former: be the root of Campanulaceae Lac caprae seu ovis.Nature and flavor: sweet in the mouth; Pungent; Property is put down.Gui Jing: return spleen; Lung meridian.Function cures mainly: supplementing QI and nourishing YIN; Removing toxic substances and promoting subsidence of swelling; Evacuation of pus; Lactogenesis.Main spiritlessness and weakness; Dizziness headache; Lung abscess; Acute mastitis; Intestinal future; Furuncle toxic swelling; Throat moth; Scrofula; Puerperal, breast was few; Leucorrhea; Venom.
Herba Kylligac coloratae: base is former: be the herb of sedge kyllinga monocephala.Nature and flavor: " Guangxi conventional medical herbs among the people ": " micro-sweet pungent, flat, nontoxic.Function cures mainly: dispelling wind, heat clearing away, cough-relieving, preventing the attack (or recurrence) of malaria, dissipating blood stasis, detumescence.Cure cold, cough, pertussis, laryngopharynx swelling and pain, dysentery, malaria, traumatic injury damages imitative, and skin sore swells.
Herba Senecionis Scandentis: base is former: be the herb of feverfew Herba Senecionis Scandentis.Nature and flavor: bitter in the mouth; Pungent; Cold in nature.Function cures mainly: heat-clearing and toxic substances removing; Improving acuity of vision and removing nebula; Killing parasites for relieving itching.Main flow sense; Upper respiratory tract infection; Pneumonia; Acute tonsillitis; Rib adenitis; Acute enteritis; Bacillary dysentery; Icterohepatitis; Gallbladder exudative dermatitis is scorching; Acute urinary tract infection; Conjunctival congestion and swelling pain cataracta; Carbuncle furuncle poison; Erysipelas; Eczema; Dry exudative dermatitis skin ulcer; Trichomonal vaginitis; Burn and scald.
Herb Gynostemmae Pentaphylli: base is former: be the herb of cucurbitaceous plant Herb Gynostemmae Pentaphylli.Nature and flavor: bitter in the mouth; Micro-sweet; Cool in nature.Gui Jing: return lung; Spleen; Kidney channel.Function cures mainly: heat clearing away; Tonify deficiency; Removing toxic substances.Main body void is weak; Nephrasthenia emission; Leukopenia; Hyperlipemia; Viral hepatitis; Chronic gastroenteritis; Chronic tracheitis.
Radix Hydrangeae Strigosae: base is former: be the root of the cured lotus silk ball of saxifragaceae plant and umbrella shape silk ball.Nature and flavor: pungent; Acid; Cool.Gui Jing: spleen channel.Function cures mainly: preventing the attack (or recurrence) of malaria; Help digestion; Heat-clearing and toxic substances removing; Expectorant powder junction.Main goiter; Dyspeptic abdominal distention; Laryngopharynx swelling and pain; Tinea leprosy; Furuncle toxic swelling; Malaria.
Angiopteris magna Ching (Angiopteris majuscula Ching): base is former: be the rhizome of the large Microsorium dilatatum (Bedd.) Sledge of Angiopteridaceae plant.Nature and flavor: bitter; Puckery; Cold.Gui Jing: the heart; Lung; Large intestine channel.Function cures mainly: heat-clearing and toxic substances removing; Diuresis damp eliminating; Promoting blood circulation and hemostasis; Stasis-dispelling and pain-killing.Master has loose bowels; Dysentery; Oedema due to nephritis; Gastralgia; Pulmonary tuberculosis; Hemoptysis; Metrorrhagia; Treating swelling and pain by traumatic injury; Rheumatalgia.
Flos Farfarae: base is former: be the alabastrum of feverfew coltsfoot.Nature and flavor: acrid in the mouth; Micro-sweet; Warm in nature.Gui Jing: return lung meridian.Function cures mainly: nourishing the lung to keep the adverse QI downward; Preventing phlegm from forming and stopping coughing.Main new chronic cough is coughed; Asthma; Chronic cough hemoptysis.
Iron Herba Selaginellae Moellendorfii: base is former: be the herb of Aspleniaceae spleen wort asplenium pekinense Hance.The property of medicine: sweet, micro-pungent, flat.Function cures mainly: preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing, hemostasis.Cure mainly cold cough, pulmonary tuberculosis, dysentery, diarrhoea, pyretic arthralgia, toxic swelling, carbuncle sore, traumatic injury, traumatic hemorrhage.
Herba Solani Lyrati: base is former: be the herb of plant of Solanaceae Herba Solani Lyrati.Nature and flavor: sweet in the mouth; Bitter; Cold in nature; Mild toxicity.Gui Jing: return liver; Gallbladder; Kidney channel.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing toxic substances and promoting subsidence of swelling.Main jaundice due to damp-heat; Cholecystitis; Cholelithiasis; Oedema due to nephritis; Rheumatic arthritis; Women's damp-heat vaginal discharge; Infantile hyperpyrexia is frightened jerks; Carbuncle scrofula; Eczema pruritus; Herpes zoster.
Radix Abelmoschi Sagittifolii: base is former: be the root of Malvaceae plant arrowleaf abelmoschus.Nature and flavor: sweet; Light; Flat.Gui Jing: kidney; Stomach warp.Function cures mainly: nourishing YIN and moistening the lung; Stomach function regulating.Main xeropulmonary cough; Pulmonary tuberculosis; Stomachache; Infantile malnutrition; Neurasthenia.
Herba Peperomiae Dindygulensis: base is former: be the herb of Piperaceae plant Herba Peperomiae Dindygulensis.Nature and flavor: pungent; Cool.Gui Jing: lung; Spleen; Liver; Kidney channel.Function cures mainly: heat-clearing and toxic substances removing; Blood stasis-eliminating and stagnation-dissipating; Inducing diuresis to remove edema.Main lung-heat cough with asthma; Measles; Sore; Cancerous protuberance; Burn and scald; Traumatic injury; Oedema due to nephritis.
Broken bowl palm foot tree: base is former: be the Herb of Melastomateae plants Herba Melastomatis polyanthi.Nature and flavor: bitter in the mouth, puckery, cool in nature.Function cures mainly: clearing away heat-damp and promoting diuresis; Removing stasis to stop bleeding; Removing toxic substances.Main intestinal is scorching; Dysentery; Hepatitis; Malaria; Migraine; Spitting of blood; Hemoptysis; Epistaxis; Have blood in stool; Hematuria; Menoxenia; Difficult labour; Cervical erosion; Cyclomastopathy; Carbuncle furuncle and phyma poison; Burn due to hot liquid or fire; Eczema; Traumatic injury wound is swollen.
Herba monochoriae vaginalis: base is former: be the herb of Pontederiaceae plant Herba monochoriae vaginalis.Nature and flavor: bitter; Cool.Function cures mainly: heat clearing away; Removing heat from blood; Diuresis; Removing toxic substances.The high heat of main flu; Lung-heat cough with asthma; Pertussis; Hemoptysis; Spit blood; Metrorrhagia; Hematuria; Pyretic stranguria; Dysentery; Intestinal is scorching; Intestinal carbuncle; Erysipelas; Skin ulcer swells; Laryngopharynx swelling and pain; Gingival swelling and pain; Wind-fire acute conjunctivitis; Venom; Poison mushroom is poisoning.
The invigorating the spleen and regulating the stomach pharmaceutical formulation science for the treatment of pulmonary carcinoma provided by the invention, preparation method is simple.In addition, its excellent part also shows:
1, products obtained therefrom of the present invention, therapeutic effect is good, and cure rate is high, effectively can prevent recurrence and diffusion;
2, this formula is summed up through clinical practice for many years and is formed, and has effect of clearing away lung-heat to relieve cough, removing toxic substances and promoting subsidence of swelling;
3, Chinese crude drug selected by the present invention, safety is high, and side effect is little, does not increase patient economy burden.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Gerberae Piloselloidis 10 parts, Flos Rhoeo discolorae 8 parts, Radix Helicteris 9 parts, Radix Codonopsis lanceolatae 7 parts, Herba Kylligac coloratae 9 parts, Herba Senecionis Scandentis 8 parts, Herb Gynostemmae Pentaphylli 10 parts, Radix Hydrangeae Strigosae 7 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 9 parts, Flos Farfarae 8 parts, iron Herba Selaginellae Moellendorfii 7 parts, Herba Solani Lyrati 5 parts, Radix Abelmoschi Sagittifolii 10 parts, Herba Peperomiae Dindygulensis 8 parts, broken bowl palm foot sets 7 parts, Herba monochoriae vaginalis 9 parts.The preparation method of the invigorating the spleen and regulating the stomach preparation decoction of above-mentioned treatment pulmonary carcinoma is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mixes with crude drug, put into steamer, Steam by water bath 25 minutes, takes out, and dries;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 120 mesh sieves, the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 2 hours, filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, marmite is put in taking-up, add the water of boiled crude drug quality 7.5 times, big fire is boiled to boiling, turns little fire and decocts 28 minutes, after filtration, collect filtrate;
(5) blend step (3) (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
embodiment 2the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Gerberae Piloselloidis 16 parts, Flos Rhoeo discolorae 14 parts, Radix Helicteris 15 parts, Radix Codonopsis lanceolatae 12 parts, Herba Kylligac coloratae 13 parts, Herba Senecionis Scandentis 12 parts, Herb Gynostemmae Pentaphylli 14 parts, Radix Hydrangeae Strigosae 11 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 16 parts, Flos Farfarae 15 parts, iron Herba Selaginellae Moellendorfii 16 parts, Herba Solani Lyrati 10 parts, Radix Abelmoschi Sagittifolii 17 parts, Herba Peperomiae Dindygulensis 13 parts, broken bowl palm foot sets 15 parts, Herba monochoriae vaginalis 14 parts.The preparation method of the invigorating the spleen and regulating the stomach preparation granules agent of above-mentioned treatment pulmonary carcinoma is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mixes with crude drug, put into steamer, Steam by water bath 25 minutes, takes out, and dries;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 120 mesh sieves, the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 2 hours, filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, marmite is put in taking-up, add the water of boiled crude drug quality 7.5 times, big fire is boiled to boiling, turns little fire and decocts 28 minutes, after filtration, collect filtrate;
(5) spray drying step (3) (4) gained filtrate, pulverized 100 mesh sieves, then added adjuvant, made granule, and dry, granulate, obtains granule.
Model case: xxx, male, 41 years old.Main suit: without uncomfortable in chest, the cough of obvious inducement, slight hemoptysis; To examination in hospital, show two lung diffusivity distributions through CT, close on pleural thickening, the vertical visible enlarged lymph node shadow of diaphragm, be diagnosed as pulmonary carcinoma, once chemotherapy three times, there is serious adverse reaction in patient, then stops chemotherapy, seeks additive method.
Take this example gained granule, each 3-4g, warm boiled water, one day twice, within 20 days, be a course for the treatment of, after patient takes a course for the treatment of, cough alleviates, feed obviously increases, after continuing to take two courses for the treatment of, patient mental's state takes a turn for the better, and check display pulmonary shadow disappears substantially, follow up a case by regular visits to after 1 year, do not recur.
embodiment 3the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Gerberae Piloselloidis 12 parts, Flos Rhoeo discolorae 10 parts, Radix Helicteris 11 parts, Radix Codonopsis lanceolatae 9 parts, Herba Kylligac coloratae 10 parts, Herba Senecionis Scandentis 9 parts, Herb Gynostemmae Pentaphylli 11 parts, Radix Hydrangeae Strigosae 8 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 11 parts, Flos Farfarae 10 parts, iron Herba Selaginellae Moellendorfii 9 parts, Herba Solani Lyrati 6 parts, Radix Abelmoschi Sagittifolii 12 parts, Herba Peperomiae Dindygulensis 9 parts, broken bowl palm foot sets 9 parts, Herba monochoriae vaginalis 10 parts.The preparation method of the invigorating the spleen and regulating the stomach preparation unguentum of above-mentioned treatment pulmonary carcinoma is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mixes with crude drug, put into steamer, Steam by water bath 25 minutes, takes out, and dries;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 120 mesh sieves, the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 2 hours, filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, marmite is put in taking-up, add the water of boiled crude drug quality 7.5 times, big fire is boiled to boiling, turns little fire and decocts 28 minutes, after filtration, collect filtrate;
(5) step (3) (4) gained filtrate mixed, heating is concentrated into clear paste, adds the refined honey mixing of clear paste quality 0.4 times, obtains unguentum.
Model case: xxx, male, 59 years old.Medical history: patient has serious smoking history, during health check-up last year, checks out pulmonary carcinoma, and existing symptom is dry cough, few expectorant, spitting of blood, and stature is become thin, and spirit is poor, because of economic cause, is reluctant to carry out chemicotherapy.
Recommend to take this example gained unguentum, each 6-10g, warm boiled water through people, one day twice, within 20 days, be a course for the treatment of, patient takes a course for the treatment of, and uncomfortable disease alleviates gradually, spirit is recovered to some extent, after adhering to taking four courses for the treatment of, patient is clearly better, and uncomfortable disease is eliminated substantially, quality of life improves, and follows up a case by regular visits to survival 3 years.
embodiment 4the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Gerberae Piloselloidis 14 parts, Flos Rhoeo discolorae 12 parts, Radix Helicteris 13 parts, Radix Codonopsis lanceolatae 10 parts, Herba Kylligac coloratae 12 parts, Herba Senecionis Scandentis 11 parts, Herb Gynostemmae Pentaphylli 13 parts, Radix Hydrangeae Strigosae 10 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 14 parts, Flos Farfarae 13 parts, iron Herba Selaginellae Moellendorfii 14 parts, Herba Solani Lyrati 9 parts, Radix Abelmoschi Sagittifolii 15 parts, Herba Peperomiae Dindygulensis 12 parts, broken bowl palm foot sets 13 parts, Herba monochoriae vaginalis 13 parts.The preparation method of the invigorating the spleen and regulating the stomach preparation capsule of above-mentioned treatment pulmonary carcinoma is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mixes with crude drug, put into steamer, Steam by water bath 25 minutes, takes out, and dries;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 120 mesh sieves, the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 2 hours, filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, marmite is put in taking-up, add the water of boiled crude drug quality 7.5 times, big fire is boiled to boiling, turns little fire and decocts 28 minutes, after filtration, collect filtrate;
(5) concentration step (3) (4) gained filtrate, dries and pulverizes, be packed in capsule, and in every capsules, contained medicated powder quality is 0.35g, obtains capsule.
Model case: xxx, male, 68 years old.Medical history: patient was because of uncomfortable in chest, hemoptysis three months, and to examination in hospital, CT shows the visible lump shadow of pulmonary, and pathological section is shown as central type carcinoma of lung, after a course for the treatment of of radiotherapy, exacerbation of symptoms worsens, and patient selects to go home expectant treatment.
Recommend to take this example gained capsule, each 3-4 grain, warm boiled water through people, one day twice, within 20 days, be a course for the treatment of, after patient takes two courses for the treatment of, the symptom such as uncomfortable in chest, hemoptysis alleviates, uncomfortable disease is reduced gradually, after adhering to taking four courses for the treatment of, patient body obviously recovers, and consolidates again a course for the treatment of, patient checks display shade and substantially disappears, and follows up a case by regular visits to survival so far.
embodiment 5the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma, is prepared from (every part of 10g) primarily of following bulk drugs: Herba Gerberae Piloselloidis 13 parts, Flos Rhoeo discolorae 11 parts, Radix Helicteris 12 parts, Radix Codonopsis lanceolatae 9.5 parts, Herba Kylligac coloratae 11 parts, Herba Senecionis Scandentis 10 parts, Herb Gynostemmae Pentaphylli 12 parts, Radix Hydrangeae Strigosae 9 parts, Angiopteris magna Ching (Angiopteris majuscula Ching) 12.5 parts, Flos Farfarae 11.5 parts, iron Herba Selaginellae Moellendorfii 11.5 parts, Herba Solani Lyrati 7.5 parts, Radix Abelmoschi Sagittifolii 13.5 parts, Herba Peperomiae Dindygulensis 10.5 parts, broken bowl palm foot sets 11 parts, Herba monochoriae vaginalis 11.5 parts.The preparation method of the invigorating the spleen and regulating the stomach preparation decoction of above-mentioned treatment pulmonary carcinoma is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mixes with crude drug, put into steamer, Steam by water bath 25 minutes, takes out, and dries;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 120 mesh sieves, the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 2 hours, filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, marmite is put in taking-up, add the water of boiled crude drug quality 7.5 times, big fire is boiled to boiling, turns little fire and decocts 28 minutes, after filtration, collect filtrate;
(5) blend step (3) (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
test example 1the clinical practice of the invigorating the spleen and regulating the stomach preparation (embodiment 5) of gained treatment pulmonary carcinoma of the present invention:
Choose crowd: in October, 2013 in December ,-2014, according to medical case history, be diagnosed as patient 268 example of pulmonary carcinoma six hospitals' screenings, age 39-72 year, 58.6 ± 2.4 years old mean age, the course of disease 10 months-3 years, wherein male patient 143 example, female patient 125 example.
Before test, patient is divided into two groups at random, experimental group 168 example and matched group 100 routine, two groups in sex, age, the course of disease, the state of an illness etc. without significant difference.Matched group adopts conventional therapy, and experimental group, on the basis of matched group, takes products obtained therefrom of the present invention, each 200-300ml, one day twice, warmly takes, and within 20 days, is a course for the treatment of.Treatments period carries out Continuous Observation to two groups of patients, record symptom and change.
Clinical effectiveness: after the taking medicine of five courses for the treatment of, the therapeutic outcome of two groups is as shown in table 1:
The untoward reaction number of cases of two groups of patients and Follow-up results as shown in table 2:
As shown in Table 1, the effective percentage of experimental group is 83.3%, and apparently higher than the therapeutic effect of matched group, illustrate that products obtained therefrom of the present invention is evident in efficacy, cure rate is high.And known by table 2, products obtained therefrom safety of the present invention, side effect is little, can improve life in patients.
The Chinese medicine used in the present invention, Herba Gerberae Piloselloidis can lung qi dispersing cough-relieving, Flos Rhoeo discolorae can removing heat from the lung and dissipating phlegm, Radix Helicteris, Herba Senecionis Scandentis can heat-clearing and toxic substances removing, Radix Codonopsis lanceolatae can supplementing QI and nourishing YIN, Herba Kylligac coloratae can clearing and antitussive, Herb Gynostemmae Pentaphylli can heat clearing away tonify deficiency, Radix Hydrangeae Strigosae can expectorant powder junction, Angiopteris magna Ching (Angiopteris majuscula Ching) can promoting blood circulation and hemostasis, Flos Farfarae can nourishing the lung to keep the adverse QI downward, iron Herba Selaginellae Moellendorfii can preventing phlegm from forming and stopping coughing, Herba Solani Lyrati can removing toxic substances and promoting subsidence of swelling, Radix Abelmoschi Sagittifolii can nourishing YIN and moistening the lung, Herba Peperomiae Dindygulensis can inducing diuresis to remove edema, broken bowl palm foot tree can removing stasis to stop bleeding, Herba monochoriae vaginalis can clearing away heat and cooling blood, multiple medical material synergism, play clearing away lung-heat to relieve cough altogether, effect of removing toxic substances and promoting subsidence of swelling, effective symptom management.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. treat the invigorating the spleen and regulating the stomach preparation of pulmonary carcinoma, it is characterized in that, be prepared from primarily of following bulk drugs, be mass parts: Herba Gerberae Piloselloidis 10-16; Flos Rhoeo discolorae 8-14; Radix Helicteris 9-15; Radix Codonopsis lanceolatae 7-12; Herba Kylligac coloratae 9-13; Herba Senecionis Scandentis 8-12; Herb Gynostemmae Pentaphylli 10-14; Radix Hydrangeae Strigosae 7-11; Angiopteris magna Ching (Angiopteris majuscula Ching) 9-16; Flos Farfarae 8-15; Iron Herba Selaginellae Moellendorfii 7-16; Herba Solani Lyrati 5-10; Radix Abelmoschi Sagittifolii 10-17; Herba Peperomiae Dindygulensis 8-13; Broken bowl palm foot tree 7-15; Herba monochoriae vaginalis 9-14.
2. the invigorating the spleen and regulating the stomach preparation for the treatment of pulmonary carcinoma as claimed in claim 1, is characterized in that, Herba Gerberae Piloselloidis 12-14; Flos Rhoeo discolorae 10-12; Radix Helicteris 11-13; Radix Codonopsis lanceolatae 9-10; Herba Kylligac coloratae 10-12; Herba Senecionis Scandentis 9-11; Herb Gynostemmae Pentaphylli 11-13; Radix Hydrangeae Strigosae 8-10; Angiopteris magna Ching (Angiopteris majuscula Ching) 11-14; Flos Farfarae 10-13; Iron Herba Selaginellae Moellendorfii 9-14; Herba Solani Lyrati 6-9; Radix Abelmoschi Sagittifolii 12-15; Herba Peperomiae Dindygulensis 9-12; Broken bowl palm foot tree 9-13; Herba monochoriae vaginalis 10-13(is preferably: Herba Gerberae Piloselloidis 13; Flos Rhoeo discolorae 11; Radix Helicteris 12; Radix Codonopsis lanceolatae 9.5; Herba Kylligac coloratae 11; Herba Senecionis Scandentis 10; Herb Gynostemmae Pentaphylli 12; Radix Hydrangeae Strigosae 9; Angiopteris magna Ching (Angiopteris majuscula Ching) 12.5; Flos Farfarae 11.5; Iron Herba Selaginellae Moellendorfii 11.5; Herba Solani Lyrati 7.5; Radix Abelmoschi Sagittifolii 13.5; Herba Peperomiae Dindygulensis 10.5; Broken bowl palm foot tree 11; Herba monochoriae vaginalis 11.5).
3. the invigorating the spleen and regulating the stomach preparation of the treatment pulmonary carcinoma as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable decoction, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) blend step (3) (4) gained filtrate, heating is concentrated into the half of original volume, obtains decoction.
4. the preparation method of the invigorating the spleen and regulating the stomach preparation decoction for the treatment of pulmonary carcinoma as claimed in claim 3, is characterized in that, the amount that step (3) adds alcoholic solution by 6 times of extraction crude drug quality.
5. the invigorating the spleen and regulating the stomach preparation of the treatment pulmonary carcinoma as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable granule, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) spray drying step (3) (4) gained filtrate, pulverizes and sieves, then adds adjuvant, make granule, and dry, granulate, obtains granule.
6. the preparation method of the invigorating the spleen and regulating the stomach preparation granules agent for the treatment of pulmonary carcinoma as claimed in claim 5, it is characterized in that, it is (preferred: to pulverize 80-120 mesh sieve that step (5) pulverized 60-140 mesh sieve; Be more preferably: pulverized 100 mesh sieves).
7. the invigorating the spleen and regulating the stomach preparation of the treatment pulmonary carcinoma as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable unguentum, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) step (3) (4) gained filtrate mixed, heating is concentrated into clear paste, adds refined honey mixing, obtains unguentum.
8. the preparation method of the invigorating the spleen and regulating the stomach preparation unguentum for the treatment of pulmonary carcinoma as claimed in claim 7, is characterized in that, the amount that step (5) adds refined honey is the 0.3-0.5 of clear paste quality doubly (preferred: the amount adding refined honey is 0.4 times of clear paste quality).
9. the invigorating the spleen and regulating the stomach preparation of the treatment pulmonary carcinoma as described in as arbitrary in claim 1-2, it is characterized in that, be made into pharmaceutically acceptable capsule, its preparation method is:
(1) get Herba Gerberae Piloselloidis, Herba Kylligac coloratae, Herba Senecionis Scandentis, Herb Gynostemmae Pentaphylli, iron Herba Selaginellae Moellendorfii, Herba Solani Lyrati, Herba Peperomiae Dindygulensis and Herba monochoriae vaginalis and clean remove impurity, refined honey is mixed with the ratio of rice wine according to 1:3, mix with crude drug, put into steamer, Steam by water bath 20-30 minute (preferred: Steam by water bath 22-28 minute; Be more preferably: Steam by water bath 25 minutes), take out, dry;
(2) get Flos Rhoeo discolorae and Flos Farfarae roguing, rinse is clean, and be placed in parch container, little fire stir-fries to surperficial zoom, and Guan Huo, pulverizes, and drenches into white vinegar, airtight vexed 5 minutes, takes out, cools;
(3) step (1) (2) made crude drug was pulverized 80-160 mesh sieve (preferred: to pulverize 100-140 mesh sieve; Be more preferably: pulverized 120 mesh sieves), the alcoholic solution adding 60% of extracted crude drug quality 6 times carries out reflux, extract, and extraction time is 1-3 hour (preferred: extraction time is 2 hours), filters and reclaims filtrate extremely without alcohol taste;
(4) Radix Helicteris, Radix Codonopsis lanceolatae, Radix Hydrangeae Strigosae, Angiopteris magna Ching (Angiopteris majuscula Ching), Radix Abelmoschi Sagittifolii and broken bowl palm foot tree is cleaned remove impurity, be cut into sheet, slow fire fries 8 minutes, takes out and puts into marmite, adds boiled crude drug quality 6-9 water doubly (preferably: add boiled crude drug quality 7-8 water doubly; Be more preferably: the water adding boiled crude drug quality 7.5 times), big fire is boiled to boiling, turns little fire and decocts 22-34 minute (preferably: turn little fire and decoct 26-30 minute; Be more preferably: turn little fire and decoct 28 minutes), after filtration, collect filtrate;
(5) concentration step (3) (4) gained filtrate, dries and pulverizes, be packed in capsule, obtain capsule.
10. the preparation method of the invigorating the spleen and regulating the stomach preparation capsule for the treatment of pulmonary carcinoma as claimed in claim 9, it is characterized in that, in the every capsules of step (5) step (5), contained medicated powder quality is that 0.3-0.4g(is preferred: in every capsules, contained medicated powder quality is 0.35g).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510572726.7A CN105106523A (en) | 2015-09-10 | 2015-09-10 | Spleen and stomach strengthening preparation for treating lung cancer and preparing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510572726.7A CN105106523A (en) | 2015-09-10 | 2015-09-10 | Spleen and stomach strengthening preparation for treating lung cancer and preparing method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241438A (en) * | 1999-06-23 | 2000-01-19 | 陈大明 | Lung cancer treating Chinese medicine preparation and its preparation |
| CN103071100A (en) * | 2013-01-05 | 2013-05-01 | 杨干波 | Traditional Chinese medicine for curing lung cancer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241438A (en) * | 1999-06-23 | 2000-01-19 | 陈大明 | Lung cancer treating Chinese medicine preparation and its preparation |
| CN103071100A (en) * | 2013-01-05 | 2013-05-01 | 杨干波 | Traditional Chinese medicine for curing lung cancer |
Non-Patent Citations (2)
| Title |
|---|
| 苏慧萍等: "《中医内科临证必备——呼吸科》", 30 September 2014, 人民军医出版社 * |
| 金国梁等: "《防癌抗癌中药》", 31 August 2001, 上海科学技术出版社 * |
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Address after: 336000, Jiangxi, Yuanzhou District, Xiu Xiu Jiang Road, No. 9, District, No. 2 building 3-501 Applicant after: Zhang Guangmin Address before: 250000 Ji'nan Province, Lixia District, Shandong by Road No. ten, No. 12372 Applicant before: Zhang Guangmin |
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Application publication date: 20151202 |