CN104814901B - One kind prevention striae of pregnancy gel and preparation method thereof - Google Patents
One kind prevention striae of pregnancy gel and preparation method thereof Download PDFInfo
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Abstract
Prevent striae of pregnancy gel the invention discloses one kind, its composition includes purified water, preservative, gel, polyalcohol, sodium alginate, hydroxyethyl cellulose, deep-sea cod collagen, alkali lye, beta glucan, water-soluble ceramide, Gotu Kola P.E etc., the invention also discloses a kind of preparation method of prevention striae of pregnancy gel, inventive gel and the compatibility of skin surrounding tissue are good, the production of Neng Cu Walk-reverently skin fibroblast collagens and hyaluronic acid, repairing skin tissue, promote the metabolism of skin, and improve skin elasticity, so as to realize skin care, soften sclerderm, promote skin revitalization, slow down skin keratin, the purpose of careful pore.
Description
Technical field
The invention belongs to cosmetic technical field, more particularly to a kind of prevention striae of pregnancy gel and preparation method thereof.
Background technology
Now, with the continuous lifting of living standard, increasing female friend pays close attention to the appearance bearing of oneself, still
The problem of postpartum striae of pregnancy but becomes puzzlement many women.
Striae of pregnancy is a kind of striae distensae.In period of gestation, on the one hand, due to the acute variation of hormone secretion, cause skin
Flexibility decrease, elastomer under skin is produced Damage and Fracture；On the other hand, increase with the expansion in uterus, belly is grand
Rising causes muscle to elongate, and thinning of skin attenuates, and stomach wall occurs irregular purplish red color patterned.After childbirth terminates, these flowers
Line decorative pattern fades away, and leaves the scar line-transect line of white, is exactly striae of pregnancy.
The generation of striae of pregnancy is influenceed by many factors, and many factors can influence the generation and development of striae of pregnancy,
Some cosmetics for example used in terms of age factor, individual difference, diet and often.But it is existing for preventing striae of pregnancy
Or massage products are exactly the oily matters such as olive oil, there are inconvenience, easy pollution clothes during use；Contain
There are artificial color or essence etc. may material influential on baby；Price is sufficiently expensive, it is impossible to meet numerous women
The long-term needs of friend.It is, thus, sought for a kind of easy and effective, moderate product solves to perplex asking for many women
Topic.
The content of the invention
Problem to be solved by this invention is to provide a kind of safe and harmless, and Costco Wholesale is cheap, and manufacturing process is simply pre-
Gel of anti-striae of pregnancy and preparation method thereof.
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：45.00%-96.00%
Preservative：0.00%-3.00%
Gel：0.01%-3.00%
Polyalcohol：1.00%-20.00%
Sodium alginate：0.20%-10.00%
Hydroxyethyl cellulose：0.01%-15.00%
Deep-sea cod collagen：0.05%-15.00%
Alkali lye：0.10%-3.00%
Beta glucan：0.10%-20.00%
Water-soluble ceramide：0.10%-10.00%
Gotu Kola P.E：0.01%-10.00%
Allantoin：0.05%-5.00%
Dipotassium glycyrrhizinate：0.01%-8.00%
Sodium Hyaluronate：0.01%-5.00%
It is preferred that, described preservative is methyl hydroxybenzoate, propylben, methylisothiazolinone and diazonium imidazolidine
Mixture more than one or both of base urea.
It is preferred that, described gel is one kind in acrylate, carbomer and xanthans.
It is preferred that, described polyalcohol is one kind in 1,3-BDO, propane diols and glycerine.
It is preferred that, described alkali lye is one kind in triethanolamine and 5% sodium hydroxide solution.
A kind of preparation method of prevention striae of pregnancy gel, comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added in 40-50 DEG C of purified water, adds while stirring after dimension element, sodium alginate, polyalcohol, gel, preservative are well mixed
Hot to 75-80 DEG C is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）Be eventually adding alkali lye regulation pH, it is ensured that temperature stir at 35-40 DEG C to be made to be well mixed, produce described in it is pre-
Anti- striae of pregnancy gel.
It is preferred that, the hydroxyethyl cellulose is less than the hydroxyethyl cellulose powder of 40 mesh using particle diameter.
It is preferred that, the Gotu Kola P.E is using water-soluble Gotu Kola P.E.
It is preferred that, the purified water is made using water purification equipment, and water purification equipment uses ultraviolet sterilization and Pasteur
Sterilization carries out disinfection when the purified water is made.
Purified water is drinking water through supplying medicine made from the way of distillation, ion-exchange, hyperfiltration or other suitable methods
Water, without any additive.Water purification equipment is for meeting the equipment that every profession and trade demand produces purified water, being used for doctor
The industries such as medicine, biochemistry chemical industry, hospital, whole system is all combined by SUS304L or SUS316L all steel materials,
And whole system uses ultraviolet sterilization or pasteurization, bacterium when making purified water is eliminated, it is ensured that purifying
The sanitation degree of water.
Polyalcohol is the alcohols containing three or more than three hydroxyls in molecule.1,3 butylene glycol, third are used in the present invention
One kind in glycol and glycerine, it has, toxicity and the characteristic such as volatility small, with good strong to polar substances solvability
Hygroscopicity and bactericidal action, the mucous membrane and skin of human body are had no stimulation.
Sodium alginate is a kind of natural polysaccharide, with the stability needed for pharmaceutical preparation auxiliary material, dissolubility, viscosity and safety
Property, the present invention in be beneficial to various medicines suspension, and can effectively improve skin-nourishing, improve epithelial tissue healthy growth, prevent
Only dry skin, make skin rich in gloss, improve fat secretion, careful pore.
Hydroxyethyl cellulose is a kind of white or faint yellow, tasteless, nontoxic threadiness or pulverulent solids, by alkaline fine
Dimension element and oxirane（Or chlorethanol）Prepared by etherified reaction, belong to the plain ethers of non-ionic soluble fibre.It is in the present invention and many
First alcohol complements each other to form the atherosclerotic thing do not allowed, with good moisture retention and water imbibition, it is ensured that skin obtains sufficient
Moisture, it is ensured that the vigor of cell.
Collagen is extracted by Animal Skin, can be spread to the deep layer of skin, the junket in its tyrosine and skin that contain
Propylhomoserin is competed, and is combined with the catalytic center of tyrosinase, so as to suppress the generation of melanin, the collagen in skin is lived
Property enhancing, keep the integrality of cuticula moisture and fibre structure, improve the living environment of Skin Cell, promote skin histology
Metabolism, and there is certain enhancing effect for the circulation of blood, good moist moisturizing, wrinkle-chasing produced to skin beautiful
Appearance is acted on.Pollution in cod of the deep-sea cod collagen in deep-sea, the scope of activities of the principle mankind, its fish-skin into
Divide less, influence when being used as medicine to skin is smaller.
Beta glucan is a kind of new product with unique process exploitation, its from fresh food brewer's yeast,
Oat, edible fungi etc..It is a kind of polysaccharide, general chemical structure β -1,3 glucans and β -1,6 glucans, assists impaired group
Knit histocyte such as to accelerate to recover to produce cytokine, promote to include antibiotic, antimycotic, the other drugs including anti-parasitic medicine are more
Play effectiveness well, the performance of other compositions drug effect can be accelerated.
The water-soluble ceramide of water-soluble ceramide, also known as ceramide, are a kind of water-soluble lipid matters, it and structure
The structure of matter into keratoderma is close, and the water that can be penetrated into quickly in skin, and cuticula is combined, and forms a kind of netted knot
Structure, pins moisture, and the ability with active cell promotes the metabolism of cell, promotes the regular regeneration of keratoprotein.
Gotu Kola P.E centella can compact epidermis and corium coupling part, skin can be made to limber up, contribute to solution
Certainly cutis laxa phenomenon, makes skin smooth flexible；Help promotes collagen in skin corium to be formed, and regenerates fibrin,
Reconnect is got up, and is inherently eliminated striae of pregnancy, skin is reached smooth effect of compacting.Impaired tissue is also assisted in be cured
Close and consolidation skin.The close connection between epidermis and corium can be promoted, the increase of fat cell can be suppressed again, skin is prevented
Oedema, appearance are fat.Compact epidermis and corium coupling part, skin can be made to limber up, help promotes collagen in skin corium
Formed, there is the effect for making skin compact.The present invention is easy to it to be spread in gel uniformly using water-soluble Gotu Kola P.E, skin
The assimilation effect of skin is more preferable.
Allantoin is a kind of amphoteric compound, can combine many kinds of substance formation double salt, with lucifuge, sterilization and anticorrosion, analgesic,
Antioxidation, can make skin keep moisture content, moisten and soft.
Dipotassium glycyrrhizinate is white or off-white color fine powder, and purity has special sweet taste up to 98%, and water-soluble good, mouthfeel is pure.It is sweet
Oxalic acid dipotassium has the multiple efficacies such as antibacterial, anti-inflammatory, removing toxic substances, antiallergic, deodorization.Glycyrrhizic acid diformazan and other compositions in the present invention
Use cooperatively, the absorption of other compositions can be accelerated, and with the effect of regulation sebum, prevention and elimination for striae of pregnancy are very
It is effective.
Sodium Hyaluronate is white or off-white color particle or powder, odorless, is one of composition of human body skin, is human body
It is interior to be distributed the acid glutinous sugar of most wide one kind, it is present in the matrix of connective tissue, with good moisture-keeping function, skin can be kept
Moisten smooth, fine and smooth tender, high resilience, the effect with wrinkle resistant, crease-resistant, beauty and health care and recovery skin physiology function is prevented
The only generation of chapped skin and wrinkle.
Above-mentioned that explanation is made that to the pharmacology of each composition and the effect of performance, what each component of the invention was particular about is mutual
Synergy, has reached following effect：
1. the good , Neng Cu Walk-reverently skin fibroblast collagens of compatibility and the production of hyaluronic acid with skin surrounding tissue,
Repairing skin tissue, promotes the metabolism of skin, and improves skin elasticity, so as to realize skin care, softening sclerderm, promote
Skin revitalization, slow down skin keratin, the purpose of careful pore；
2. affinity is strong, it can be combined together with the sebum film of mankind itself, in skin surface one layer of natural screen of formation
Barrier, and promote the propagation of skin base cell, there is obvious physiologic effect to delay skin aging, careful pore；
3. can effectively improve skin-nourishing, improving epithelial tissue healthy growth, prevent dry skin, make skin rich in light
Pool, improves fat secretion, careful pore；
4. formula is reasonable, environmental protection, to no skin irritation, long-term use can supplement skin-nourishing, careful pore,
Make skin wet flexible.
What inventive gel played a part of for striae of pregnancy is prevention and treatment, the medicine with traditional treatment striae of pregnancy
Thing is different, and general medicine is that striae of pregnancy formation starts to smear medicine after pregnant woman produces, and then continuously smears a period of time
Striae of pregnancy starts slowly to eliminate afterwards, and the required time is longer, between generally 3 months to 12 months, although also can be to striae of pregnancy
Play a part for the treatment of, but want not accomplishing putting on refrigerant summer clothing within these few days after pregnant woman's production, gestation
The overlong time of line treatment has had a strong impact on the effect and meaning of its treatment.Inventive gel can be made in pregnant woman's period of gestation
With having no influence on fetus, can be used after pregnant woman is pregnant three months, pregnancy takes appropriate inventive gel to smear for 3 to 6 months
To belly, buttocks and huckle, and stroke 2 to 5 minutes so that inventive gel is uniformly applied on skin, to drug effect
Good absorption is played, frequency of use is once a day；Pregnancy 6 to October take appropriate inventive gel be applied to belly, buttocks and
Huckle, and stroke 2 to 5 minutes, frequency of use is twice daily；Appropriate inventive gel is taken to be applied to after pregnant woman's production
Belly, buttocks and huckle, and massage 5 to 10 minutes is carried out, frequency of use is three times a day.Prove to use this through multiple experiment
The rehabilitation probability that the probability of thorough treatment can reach in 85%, three months postpartum in inventive gel striae of pregnancy two weeks is 100%.This
Inventive gel for different age group pregnant woman all extremely effectively, rehabilitation probability is in the pregnant woman of 20 years old to 35 years old one month
100%, rehabilitation probability reaches 90%, the patient that striae of pregnancy was not fully recovered in one month in pregnant woman's striae of pregnancy of more than 35 years old one month
The present invention is continuing with, was all cured within three months postpartum.
The service condition of inventive gel is as follows：
| Pregnant woman age section | Two weeks in postpartum recovery from illness probability | One month postpartum recovery from illness probability | Three months postpartum recovery from illness probability |
| 20 to 35 years old | 90% | 100% | 100% |
| More than 35 years old | 70% | 90% | 100% |
Embodiment
Embodiment one
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：86.05%；Methyl hydroxybenzoate：0.1%；Carbomer：0.3%；Glycerine：10%；Sodium alginate：0.4%；Hydroxyl
Ethyl cellulose：0.5%；Deep-sea cod collagen：0.25%；Triethanolamine：0.3%；Beta glucan：0.4%；Water-soluble god
Through acid amides：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.4%；Sodium Hyaluronate：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, glycerine, carbomer, methyl hydroxybenzoate are well mixed in 40-50 DEG C of purified water, side stirring
While being heated to 75-80 DEG C is incubated 10-15 minutes, make each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment two
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：80%；Propylben：0.2%；Carbomer：0.2%；Propane diols：16.05%；Sodium alginate：0.3%；Hydroxyl
Ethyl cellulose：0.6%；Deep-sea cod collagen：0.25%；Triethanolamine：0.3%；Beta glucan：0.4%；Water-soluble god
Through acid amides：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.3%；Dipotassium glycyrrhizinate：0.3%；Sodium Hyaluronate：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, propane diols, carbomer, propylben are well mixed in 40-50 DEG C of purified water, side stirring
While being heated to 75-80 DEG C is incubated 10-15 minutes, make each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment three
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：86%；Methyl hydroxybenzoate：0.2%；Acrylate：0.35%；Glycerine：10%；Sodium alginate：0.4%；Hydroxyl
Ethyl cellulose：0.45%；Deep-sea cod collagen：0.25%；5% sodium hydroxide solution：0.3%；Beta glucan：0.4%；
Water-soluble ceramide：0.4%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.45%；Hyaluronic acid
Sodium：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, glycerine, acrylate, methyl hydroxybenzoate are well mixed in 40-50 DEG C of purified water, while stirring
Mix side be heated to 75-80 DEG C be incubated 10-15 minutes, make each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding 5% sodium hydroxide solution regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, i.e.,
Obtain described prevention striae of pregnancy gel.
Example IV
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：84%；Methyl hydroxybenzoate：0.15%；Xanthans：0.3%；1,3 butylene glycol：12%；Sodium alginate：0.4%；
Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.35%；Triethanolamine：0.2%；Beta glucan：0.4%；It is water-soluble
Ceramide：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.38%；Sodium Hyaluronate：
0.12%。
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, 1,3-BDO, xanthans, methyl hydroxybenzoate are well mixed in 40-50 DEG C of purified water, side
Stirring side is heated to 75-80 DEG C and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment five
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：87%；Propylben：0.1%；Carbomer：0.3%；1,3 butylene glycol：9.05%；Sodium alginate：
0.3%；Hydroxyethyl cellulose：0.6%；Deep-sea cod collagen：0.25%；Triethanolamine：0.3%；Beta glucan：0.4%；
Water-soluble ceramide：0.5%；Gotu Kola P.E：0.9%；Allantoin：0.3%；Dipotassium glycyrrhizinate：0.4%；Sodium Hyaluronate：
0.1%。
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, 1,3-BDO, carbomer, propylben are well mixed in 40-50 DEG C of purified water, side
Stirring side is heated to 75-80 DEG C and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment six
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：80%；Propylben：0.15%；Acrylate：0.3%；1,3 butylene glycol：16%；Sodium alginate：
0.4%；Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.2%；5% sodium hydroxide solution：0.35%；Beta glucan：
0.3%；Water-soluble ceramide：0.6%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.4%；Hyalomitome
Sour sodium：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, 1,3-BDO, acrylate, propylben are well mixed in 40-50 DEG C of purified water,
75-80 DEG C is heated to while stirring and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding 5% sodium hydroxide solution regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, i.e.,
Obtain described prevention striae of pregnancy gel.
Embodiment seven
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：82%；Methylisothiazolinone：0.1%；Carbomer：0.35%；Glycerine：14%；Sodium alginate：0.4%；
Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.25%；Triethanolamine：0.35%；Beta glucan：0.35%；It is water-soluble
Nerve acid amides：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.4%；Dipotassium glycyrrhizinate：0.2%；Sodium Hyaluronate：
0.1%。
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, glycerine, carbomer, methylisothiazolinone are well mixed in 40-50 DEG C of purified water, side
Stirring side is heated to 75-80 DEG C and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment eight
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：88%；Diazonium imidazolidinyl urea：0.1%；Carbomer：0.35%；Glycerine：8%；Sodium alginate：0.4%；
Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.25%；5% sodium hydroxide solution：0.4%；Beta glucan：
0.25%；Water-soluble ceramide：0.5%；Gotu Kola P.E：1.05%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.4%；It is transparent
Matter acid sodium：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, glycerine, carbomer, diazonium imidazolidinyl urea are well mixed in 40-50 DEG C of purified water, side
Stirring side is heated to 75-80 DEG C and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding 5% sodium hydroxide solution regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, i.e.,
Obtain described prevention striae of pregnancy gel.
Embodiment nine
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：86%；Methyl hydroxybenzoate：0.05%；Propylben：0.05%；Carbomer：0.3%；Glycerine：10%；
Sodium alginate：0.4%；Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.3%；Triethanolamine：0.3%；Gather β-Portugal
Sugar：0.4%；Water-soluble ceramide：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Dipotassium glycyrrhizinate：0.4%；Thoroughly
The sour sodium of bright matter：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
40-50 DEG C of purifying is added to after dimension element, sodium alginate, glycerine, carbomer, methyl hydroxybenzoate, propylben are well mixed
In water, 75-80 DEG C is heated to while stirring and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment ten
The percentage by weight of one kind prevention striae of pregnancy gel, its composition and each composition is as follows：
Purified water：87%；Methylisothiazolinone：0.05%；Diazonium imidazolidinyl urea：0.05%；Acrylate：0.3%；Third
Triol：9%；Sodium alginate：0.45%；Hydroxyethyl cellulose：0.5%；Deep-sea cod collagen：0.15%；Triethanolamine：
0.4%；Beta glucan：0.4%；Water-soluble ceramide：0.5%；Gotu Kola P.E：1.0%；Allantoin：0.2%；Glycyrrhizic acid two
Potassium：0.4%；Sodium Hyaluronate：0.1%.
Its preparation method comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）The Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, ethoxy is fine
It is added to after dimension element, sodium alginate, glycerine, acrylate, methylisothiazolinone, diazonium imidazolidinyl urea are well mixed
In 40-50 DEG C of purified water, 75-80 DEG C is heated to while stirring and is incubated 10-15 minutes, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and β-Portugal for adding formula ratio are poly-
Sugar, is uniformly mixed；
（4）It is eventually adding triethanolamine regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, produces described
Prevention striae of pregnancy gel.
Embodiment one is each implemented to the gel that embodiment ten is different formulations and weight ratio during treatment striae of pregnancy
Example treatment number of patients is 80 patients, and 20 to 35 years old pregnant woman's quantity is 60 people, and pregnant woman's recovery from illness quantity is 20 people within more than 35 years old, is controlled
More the effect of number is as shown in the table：
The effect of embodiment one preferably, in 20 to 35 years old pregnant woman's striae of pregnancy two weeks fully recovers number for 54 people as seen from the above table,
It can be fully recovered in one month, recovery from illness number is 14 people in more than 35 years old pregnant woman's striae of pregnancy two weeks, number of being fully recovered in one month is 18 people, three
It can be fully recovered in individual month, the speed for the treatment of and with very high healing success rate.
The present invention is using extensively, and either pregnant woman's striae of pregnancy at much ages can be accomplished very to fully recover, and treatment
Time it is shorter, the vigor and elasticity of skin can be replied within the extremely short time.And inventive gel has no toxic side effect, ten
There is not allergic reaction in use in 800 pregnant woman of individual embodiment, and neonate is not impacted, and illustrate this
Inventive gel is non-stimulated to skin and mucosa, and bad influence will not be caused to offspring, is adapted to promote the use of.
The treatment case of inventive gel clinically is as follows：
Case one：Xiong Xuehui, female, 33 years old, people from Nanyang City, Henan Province, pregnancy began to use inventive gel from three months,
Natural labor, belly and the pregnant line of being pregnent of buttocks be not obvious, and striae of pregnancy elimination in the 22nd day is continuing with after produce surviving of son, and skin is repaired completely.
Case two：Li Meng, female, 24 years old, people from Nanyang City, Henan Province, pregnancy began to use inventive gel from three months, suitable
Production, belly has striae of pregnancy unobvious, and striae of pregnancy elimination in the 12nd day is continuing with after produce surviving of son, and skin is repaired completely.
Case three：Wang Yiyi, female, 28 years old, people from Xinyang City, Henan Province, pregnancy began to use inventive gel from three months,
Natural labor, belly has striae of pregnancy unobvious, and striae of pregnancy elimination in the 14th day is continuing with after produce surviving of son, and skin is repaired completely.
Case four：Gong Yanxiao, female, 40 years old, people from Nanyang City, Henan Province, pregnancy began to use inventive gel from three months,
Natural labor, abdominal pregnancy line is more apparent, and buttocks and thigh striae of pregnancy be not obvious, and striae of pregnancy elimination in the 57th day is continuing with after produce surviving of son,
Skin is repaired completely.
Claims (8)
1. one kind prevention striae of pregnancy gel, it is characterised in that：The percentage by weight of its composition and each composition is as follows：
Purified water：45.00%-96.00%
Preservative：0.00%-3.00%
Gel：0.01%-3.00%
Polyalcohol：1.00%-20.00%
Sodium alginate：0.20%-10.00%
Hydroxyethyl cellulose：0.01%-15.00%
Deep-sea cod collagen：0.05%-15.00%
Alkali lye：0.10%-3.00%
Beta glucan：0.10%-20.00%
Water-soluble ceramide：0.10%-10.00%
Gotu Kola P.E：0.01%-10.00%
Allantoin：0.05%-5.00%
Dipotassium glycyrrhizinate：0.01%-8.00%
Sodium Hyaluronate：0.01%-5.00%,
It is described prevention striae of pregnancy gel pregnant woman be pregnant three months after use, pregnancy take within 3 to 6 months gel be applied to belly,
Buttocks and huckle, and stroke 2 to 5 minutes, frequency of use is once a day；Pregnancy 6 to October take gel be applied to belly,
Buttocks and huckle, and stroke 2 to 5 minutes, frequency of use is twice daily；Gel is taken to be applied to abdomen after pregnant woman's production
Portion, buttocks and huckle, and massage 5 to 10 minutes is carried out, frequency of use is three times a day；
The preparation method of above-mentioned prevention striae of pregnancy gel comprises the following steps：
（1）Each component is weighed according to specified percentage by weight；
（2）By the Sodium Hyaluronate of formula ratio, dipotassium glycyrrhizinate, allantoin, deep-sea cod collagen, hydroxy ethyl fiber
It is added in 40-50 DEG C of purified water, heats while stirring after element, sodium alginate, polyalcohol, gel, preservative are well mixed
10-15 minutes are incubated to 75-80 DEG C, makes each material dispersion uniform；
（3）Temperature is reduced to 35-40 DEG C, the Gotu Kola P.E, water-soluble ceramide and beta glucan of formula ratio is added, stirs
Mix well mixed；
（4）It is eventually adding alkali lye regulation pH, it is ensured that temperature is stirred at 35-40 DEG C to be made to be well mixed, and produces described prevention pregnant
It is pregnent line gel.
2. prevent striae of pregnancy gel as claimed in claim 1, it is characterised in that：Described preservative is methyl hydroxybenzoate, Buddhist nun
Mixture more than one or both of the golden propyl ester of pool, methylisothiazolinone and diazonium imidazolidinyl urea.
3. prevent striae of pregnancy gel as claimed in claim 1, it is characterised in that：Described gel is acrylate, card ripple
One kind in nurse and xanthans.
4. prevent striae of pregnancy gel as claimed in claim 1, it is characterised in that：Described polyalcohol is 1,3 butylene glycol, third
One kind in glycol and glycerine.
5. prevent striae of pregnancy gel as claimed in claim 1, it is characterised in that：Described alkali lye is triethanolamine and 5% hydrogen-oxygen
Change one kind in sodium solution.
6. prevent the preparation method of striae of pregnancy gel as claimed in claim 1, it is characterised in that：The hydroxyethyl cellulose is adopted
It is less than the hydroxyethyl cellulose powder of 40 mesh with particle diameter.
7. prevent the preparation method of striae of pregnancy gel as claimed in claim 1, it is characterised in that：The Gotu Kola P.E is adopted
Use water-soluble Gotu Kola P.E.
8. prevent the preparation method of striae of pregnancy gel as claimed in claim 1, it is characterised in that：The purified water is using purifying
Wetting system is made, and water purification equipment is carried out disinfection using ultraviolet sterilization and pasteurization when the purified water is made.
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| CN106511131A (en) * | 2016-11-28 | 2017-03-22 | 丁慧 | Moisturizing water capable of adjusting bioactivity of cuticle desmosome and preparation method thereof |
| CN109125173A (en) * | 2018-09-19 | 2019-01-04 | 李燕 | A kind of face cream and preparation method thereof removing striae of pregnancy |
| CN110314127B (en) * | 2019-08-23 | 2022-06-21 | 杭州千岛湖蓝色天使实业有限公司 | Stretch mark removing essence lotion and preparation method thereof |
| CN112006938A (en) * | 2020-09-04 | 2020-12-01 | 广州莱梧生物科技有限公司 | Damaged skin repairing gel and preparation process thereof |
| CN112107504A (en) * | 2020-09-24 | 2020-12-22 | 成都维德医疗器械有限责任公司 | Preparation method of modified type I collagen gel |
| CN115670992A (en) * | 2022-09-06 | 2023-02-03 | 南京天其美生物技术有限公司 | Herbal peritoneal membrane for gestation repair and preparation method thereof |
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| US20040208902A1 (en) * | 2003-04-18 | 2004-10-21 | Gupta Shyam K. | Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions |
| CN101152138A (en) * | 2007-09-29 | 2008-04-02 | 天津盛世恒安科技发展有限公司 | Face-painting product having function of dispelling stria gravidarum and method for preparing the same |
| CN101791283A (en) * | 2010-02-05 | 2010-08-04 | 张德文 | Cosmetic capable of eliminating striae gravidarum and scars |
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2015
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040208902A1 (en) * | 2003-04-18 | 2004-10-21 | Gupta Shyam K. | Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions |
| CN101152138A (en) * | 2007-09-29 | 2008-04-02 | 天津盛世恒安科技发展有限公司 | Face-painting product having function of dispelling stria gravidarum and method for preparing the same |
| CN101791283A (en) * | 2010-02-05 | 2010-08-04 | 张德文 | Cosmetic capable of eliminating striae gravidarum and scars |
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Address after: 473000 Nanyang City, new energy economic and Technological Development Zone, Henan, the middle of the road in the middle of the ten Applicant after: Henan Huibo Medical Co., Ltd. Address before: Three 473000 Nanyang Road, Henan Province Li River eco industrial park Wei Applicant before: Nanyang Hui Bo Bioisystech Co., Ltd |
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