CN104663666B - One kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron - Google Patents
One kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron Download PDFInfo
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Abstract
The invention belongs to field of pesticides, it is related to a kind of containing the Mitochondrial electron transmission acaricidal insecticide acaricide composition of inhibitor class.Composition contains two kinds of active components of A, B, and the ratio of weight and number between component A and the components of component B two is 1:99‑99:1；Active component A is selected from the chemical compounds I shown in following structural formula, and active component B is selected from two and transmits inhibitor class desinsection selected from Mitochondrial electron（Mite）Agent；The active component A structure is as follows, composition of the invention have the advantages that synergy substantially, delaying drug resistance, available for preventing and treating various pests.
Description
Technical field
The invention belongs to field of pesticides, it is related to a kind of Mitochondrial electron transmission acaricidal desinsection of inhibitor class that contains and kills
Acaricidal composition.
Background technology
Insecticide has obvious effect in terms of preventing and treating agriculture and forestry injurious insect or urban health insect.
Chinese invention patent CN101875633 discloses a kind of pyrazolyl acrylonitrile compound and its control insect pest and mite
Harmful purposes, wherein compound 5（Hereinafter referred to as chemical compounds I）Available for various pests, evil mite is prevented and treated, especially have to evil mite prominent
The prevention effect gone out.
Insecticide containing single-activity component, is continuously used in control of insect, easily insect is developed immunity to drugs.It is logical
The insecticide for crossing two kinds of active components is compounded into blending ingredients by a certain percentage, can often improve preventive effect, reduces active ingredient
Consumption, it is cost-effective, while the generation of pest resistance to insecticide can be delayed.
Although generally disclose in the prior art chemical compounds I or its homologue can be produced with other Mixture Use of Insecticides it is additional
Advantage and effect, but the technical scheme of the binary pesticide composition containing chemical compounds I has no specific disclosure.
The content of the invention
Combined present invention aims at a kind of acaricidal Insecticiding-miticiding of Mitochondrial electron transmission inhibitor class that contains of exploitation
Thing, with the need for meeting agricultural and pest control aspect in urban health field is increasingly improved to insecticide effect and kind is constantly updated
Ask.
To achieve the above object, the technical solution adopted by the present invention is：
One kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron, and composition contains A, B two
Plant active component；Active component A is selected from the chemical compounds I shown in following structural formula, and active component B is selected from two and is selected from Mitochondrial electron
Transmit inhibitor class desinsection（Mite）Agent；
The active component A structure is as follows：
The active component B includes pyridaben (Pyridaben), fenazaquin (Fenazaquin), fenpyroximate
(Fenpyroximate), pyrimidifen (Pyrimidifen), tebufenpyrad（Tebufenpyrad）Or rotenone (Rotenone).
Active component B is preferably pyridaben in the composition of the present invention.
The ratio of weight and number of two kinds of active components is 1 in the composition of the present invention:99-99:1, preferably 1:20-20:1,
More preferably 1:19-19:1.
The composition of the present invention can be provided in finished product preparation form.Therefore, present invention additionally comprises a kind of dosage form
Insecticides.Using composition as active component, be made as needed missible oil, suspending agent, water-dispersible granules, aqueous emulsion,
Soluble concentrate, wettable powder, water dispersible oil suspending agent etc..The cumulative amount of the active component of composition is 0.5% in preparation
Between~95%, preferably cumulative amount is between 1%-85%.The content of active component depends on individually making in the composition of the present invention
The amount of application of used time, also depends on mixed ratio and synergistic effect degree.The optimum range of active component content is according to composition
Preparation type and it is different.
The preparation of the composition finished product preparation of the present invention can be prepared by common processing method, i.e., by active material and liquid
Carrier（Solvent）Or after solid carrier mixing, add one or more of surfactants such as emulsifying agent, dispersant, wetting agent, glue
Mixture, stabilizer and defoamer etc..Contain at least one carrier and at least one surfactant in usual composition.Various
In the case of, it should be ensured that present composition active component is uniformly distributed.
Missible oil usually contains 10~50% active component, and 2~20% emulsifying agents, 0~20% other additives are for example stablized
Agent, bleeding agent etc., and solvent（Also contain cosolvent if necessary）.
Suspending agent generally needs to be sanded, to obtain stable non-deposited flowable product.Usually contain 5 in suspending agent~
75% active component, 5~15% dispersants, 4~10% antifreezing agents, 0~10% other additives such as defoamer, preservative, stably
Agent, bleeding agent and thickener, and liquid-carrier surplus.
Water-dispersible granules are usually made 10~100 international standard sieve mesh（1.676~0.152mm）Particle, can pass through
It is prepared by extruding, dipping or Spray granulation method.Usual water-dispersible granules contain 0.5~75% active component and 5~20%
Surfactant such as stabilizer, wetting dispersing agent, disintegrant and adhesive, and inert carrier surplus.
Wettable powder usually contains 10~85% active component, in addition to solid inert carrier, usually contains 3~10%
Dispersant, can also containing 0~10% stabilizer and（Or）Other additives, such as bleeding agent or sticker.
Aqueous emulsion is to mix to form oil phase by active compound, organic solvent, surfactant；Water, antifreezing agent are mixed,
Into homogeneous aqueous phase.With high-shear emulsion machine high speed shear oil phase, while aqueous phase slowly is added into oil phase, usual active ingredient
1~60%, surfactant 5~20%, antifreezing agent 2~10%, water surplus.
Microemulsion is to mix active compound, organic solvent, surfactant, water, into homogeneous aqueous phase.Generally have
Imitate composition 1~50%, surfactant 10~40%, antifreezing agent 2~10%, water surplus.
Soluble liquid is to mix active component, organic solvent, surfactant, into transparent and homogeneous liquid.
Usual active ingredient 1~50%, surfactant 6~20%, organic solvent surplus.
Water dispersible oil suspending agent is that active component, surfactant, oil based vehicle are added in sand mill and be sanded, until grain
Footpath is qualified, usual active ingredient 2~60%, surfactant 6~20%, oil based vehicle surplus.
Aqueous dispersion liquid and emulsion（As be diluted with water the present invention missible oil, wettable powder or concentrate obtain
Composition）It is also within the scope of the invention.Above-mentioned emulsion can be water-in-oil type or oil-in-water type, can have thick
Paste-like consistency.
The preparation of the composition finished product preparation of the present invention can use well known to those skilled in the art（Liquid is solid
Body）Carrier and various auxiliary agents.For example include but is not limited to following all kinds of materials.
Suitable liquid-carrier or solvent can be water, various aromatic hydrocarbons, aliphatic hydrocarbon, ketone, ethers etc., such as toluene, diformazan
Benzene, acetone, cyclohexanone, acetonitrile, benzene, hexamethylene, isopropanol, ethylene glycol, sorbierite, methanol, ethanol, butanol, dimethyl formyl
Amine, dimethyl sulfoxide (DMSO), N- methyl-pyrrolidons, tributyl phosphate, ethyl acetate, methyl iso-butyl ketone (MIBK), naphthalane, machine oil, oil
One or more in ether, methyl oleate, methylated soya oil or the molten fiber of methyl etc..The mixture of different liquids is often suitable
.
Suitable solid carrier includes natural or synthesis clay and silicate, it is adaptable to which the solid carrier of pulvis includes
The rock dust that naturally occurs, chalk, quartz, White Carbon black, clay, montmorillonite, silica, diatomite, float stone, gypsum, cunning
Stone, bentonite, kaolin, attapulgite, precipitated calcium carbonate, clay and the mineral matter ground of synthesis（Such as microdispersed silicic acid
Or aluminum oxide）.Suitable particulate vector includes broken and classification natural rock such as calcite, marble, float stone, Hai Pao
Stone and dolomite and the synthesis particle being made up of the powder of organic matter and inorganic matter.
Suitable co-solvents are methanol, phenol, isoamyl alcohol, dimethyl sulfoxide (DMSO), ethyl acetate, butanone, dimethylformamide, two
One or more in methyl sulfoxide, N- methyl-pyrrolidons, methyl oleate, methyl iso-butyl ketone (MIBK), the molten fiber of methyl etc..
Suitable emulsifying agent can be ethoxylated castor oil, polyoxyethylene (n20) phenethyl phenolic group oleic acid ester, alkyl virtue
Base polyoxyethylene poly-oxygen propylene aether, alkylaryl formaldehyde resin APEO, triphenyl vinyl phenol polyoxyethylene (n20) ether phosphorus
It is acidified triethanolamine salt, the different thionic acid calcium of oleic acid, castor oil polyoxyethylene（40）Ether, agriculture breast AEO-3, agriculture breast AEO-3, agriculture breast
0201B, agriculture breast 0203B, agriculture breast T-20, agriculture breast T-85, agriculture breast S-80, agriculture breast 507#, agriculture breast 100#, agriculture breast 36#, agriculture breast
500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#, agriculture breast 2201#, agriculture breast NP-7, agriculture breast NP-10, agriculture breast NP-15 etc..
Suitable dispersant can be sodium lignin sulfonate, calcium lignosulfonate, the sodium salt of alkyl naphthalene sulfonic acid condensation polymer, net
Lotion LS, naphthalenesulfonic acid-formaldehyde condensate, condensation compound of methyl naphthalene sulfonic acid and formaldehyde, alkyl-diethylene glycol ether-sodium sulfonate, N- methyl-
Oleoyl-sodium taurocholate, methanonaphthalene sodium sulfonate, oleic acid methylaminoethyl sodium sulfonate, epoxidized polyether, polycarboxylate salt dispersant
GY-D800, to tertbutyl ether, piperonyl butoxide, alkyl amide taurate, dibutyl naphthalenesulfonic acid formaldehyde condensation products, alkyl phenol
Polyoxyethylene ether formaldehyde condensation products sulfate, alkylphenol-polyethenoxy based phosphates etc..
Suitable wetting agent can be sodium sulphate, lauryl sodium sulfate, Morwet EFW, isopropyl naphthalene sulfonate, alkane
Base alcohol polyoxyethylene groups ether sodium sulfate, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, sldium lauryl sulfate, methylene
Sodium naphthalene sulfonate, neopelex, calcium dodecyl benzene sulfonate, Negel aliphatic alcohol polyethenoxy base ether, alkane
Base phenol polyethenoxy base ether etc..
Suitable thickener can be synthesis（Such as carbonyl methylol alcohol, polyvinyl alcohol, polyvinyl acetate）Or natural water
Soluble polymer（Such as xanthans, gelatin, gum arabic, polyvinylpyrrolidone, aluminium-magnesium silicate, polyvinyl alcohol, poly- second two
Alcohol, phenolic resin, shellac, methylcellulose, soluble starch, carboxymethyl cellulose and sodium alginate etc.）, with powder, particle
Or latex form is added in preparation.
Suitable defoamer is bubble enemy, silicone, the fatty alcohol of C8~10, phosphoric acid ester, the saturated fat acids of C10~20
（Such as capric acid）And acid amides etc..
Suitable adhesive can be polyvinyl alcohol, polyvinyl acetate, xanthans, gelatin, carboxymethyl cellulose and sea
Mosanom etc..
Aerosol can be made during the insect of city, it is necessary to add propellant wherein for preventing and treating, bait formulation can also be made
Composition, in addition to containing active component, also containing it is one or more suitable for the foodstuffs of insect's food-taking, optional attractant and
Optional wetting agent.
Insecticiding-miticiding preparation control agriculture and forestry injurious insect or urban health insect are prepared into present invention additionally comprises the present composition
Purposes.Be particularly adapted to a variety of important agricultural pests of preventing and treating, such as aphid, leafhopper, aleyrodid, thrips, pear sucker, scale insect,
Panonychus citri, phyllocoptruta oleivora, apple tetranychus, Tetranychus urticae, goitre mite, flour mite etc..For Cereal such as wheat, paddy rice etc., beans
Class such as soybean, Kidney bean etc., industrial crops such as cotton, beet, sugarcane etc., fruit tree such as apple, pears, citrus, lichee etc., vegetables are for example sweet
Indigo plant, cauliflower, Chinese cabbage, rape, tomato, capsicum and flowers etc..
Present invention additionally comprises a kind of method for controlling insect pest, can impose on the present composition with effective dose needs control
Insect or its growth medium on.The more suitable effective dose generally selected is 10 grams to 500 grams of per hectare, preferably effectively
Dosage is 15 grams to 100 grams of per hectare.
In addition, the composition for showing the present invention through indoor biological determination of activity has synergistic effect.For example, chemical compounds I with
Pyridaben is 1:20~20:Good synergistic effect is shown in the range of 1 to Tetranychus cinnabarinus, while chemical compounds I exists with pyridaben
1:19~19:More preferable synergistic effect is shown in the range of 1 to Tetranychus cinnabarinus.
The invention has the advantages that：
1. the composition of the present invention shows obvious synergistic effect in certain ratio range, the compound pair is improved
The prevention effect of insect.
2. the present composition reduces the dosage of compound in the application, so as to reduce use cost, environment is reduced
Pollution.
It is anti-with it the problem of in the absence of cross resistance 3. the mechanism of action of each active ingredient is different in the present composition
The generation of pest resistance to insecticide can be delayed by controlling insect, and improve the prevention effect of antagonism population.
Embodiment
Specific examples below is used to the present invention is further described, but the present invention is only limitted to absolutely not these examples.It is real
Each component percentage composition or proportioning in example is applied to be by weight.Active component in each formula is calculated with effective content, while group
Each material can be prepared by conventional methods in compound.
Formulation Example
The preparation of embodiment 1,20% fenpyroximate chemical compounds I missible oil
By recipe requirements, respectively by 1 part of fenpyroximate, 19 parts of chemical compounds Is, 5 parts of agriculture breast 0201B, 5 parts of agriculture breast 0203B, 2 parts
Agriculture breast 1601#, 6 parts of methanol, dimethylbenzene are complemented in 100% addition mixing kettle, are uniformly mixed, are added if necessary with hot bath
Heat of solution, you can obtain 20% fenpyroximate chemical compounds I missible oil.
Mitochondrial electron described by fenpyroximate alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The missible oil of immunomodulator compounds I.
The preparation of embodiment 2,40% pyridaben chemical compounds I wettable powder
By recipe requirements, by 38 parts of pyridabens, 2 parts of chemical compounds Is, 2 parts of lauryl sodium sulfate, 3 parts of methanonaphthalene sulfonic acid
Sodium, 4 parts of alkylphenol-polyethenoxy base ether formaldehyde condensation products sulfate, 5 parts of White Carbon blacks, diatomite complement to 100% and are sufficiently mixed,
After ultra-fine pulverizer disintegrating, you can obtain 40% pyridaben chemical compounds I wettable powder.
Mitochondrial electron described by pyridaben alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The wettable powder of immunomodulator compounds I.
The preparation of embodiment 3,40% pyridaben chemical compounds I wettable powder（1:1）
By recipe requirements, 20 parts of pyridabens, 20 parts of chemical compounds Is, 2 parts of lauryl sodium sulfate, 4 parts of alkyl naphthalene sulfonic acids are contracted
The sodium salt of polymers, 4 parts of sodium lignin sulfonates, 2 parts of detergent LS, 5 parts of White Carbon blacks, bentonites complement to 100% and are sufficiently mixed, warp
After ultra-fine pulverizer disintegrating, you can obtain 40% pyridaben chemical compounds I wettable powder.
Mitochondrial electron described by pyridaben alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The wettable powder of immunomodulator compounds I.
The preparation of embodiment 4,20% fenazaquin chemical compounds I aqueous emulsion
By recipe requirements, respectively by 18 parts of fenazaquins, 2 parts of chemical compounds Is, 4 parts of agriculture breast 100#, 8 parts of agriculture breast 2201#, 6 parts of agricultures
Newborn 0201B, 8 parts, 12 parts of methyl iso-butyl ketone (MIBK)s, 6 parts of dimethylbenzene add in mixing kettles, stirring mixing makes to be dissolved into homogeneous oil phase,
Under high velocity agitation, by excess water（Complement to 100%）It is added to oil phase, you can obtain 20% fenazaquin of favorable dispersibility
The aqueous emulsion of compound I.
Mitochondrial electron described by fenazaquin alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The aqueous emulsion of immunomodulator compounds I.
The preparation of embodiment 5,40% fenpyroximate chemical compounds I aqueous emulsion（1:1）
By recipe requirements, respectively by 20 parts of fenpyroximates, 20 parts of chemical compounds Is, 6 parts of polyoxyethylene (n20) phenethyl phenol ether through reaction
Oleate, 4 parts of agriculture breast 1601#, 2 parts of Nongru-700 #, 5 parts of cyclohexanone, 5 parts of dimethylbenzene are added in mixing kettle, and stirring mixing makes molten
Solution is into homogeneous oil phase, under high velocity agitation, by excess water（Complement to 100%）It is added to oil phase, you can obtain favorable dispersibility
40% fenpyroximate chemical compounds I aqueous emulsion.
Mitochondrial electron described by fenpyroximate alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The aqueous emulsion of immunomodulator compounds I.
Embodiment 6,60% pyridaben chemical compounds I water-dispersible granules（1:1）
By recipe requirements, 30 parts of pyridabens, 30 parts of chemical compounds Is, 3 parts of methanonaphthalene sodium sulfonates, 5 parts of alkyl naphthalene sulfonic acids are contracted
The sodium salt of polymers, 8 parts of soluble starches, bentonites complement to 100% and are added together, and carry out co-grinding, then through the kneading that adds water
Afterwards, add and granulated in the comminutor equipped with certain specification screen cloth.Then again through drying, screening (pressing screen cloth scope), you can
Obtain 60% pyridaben chemical compounds I water-dispersible granules.
Mitochondrial electron described by pyridaben alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The water-dispersible granules of immunomodulator compounds I（1:
1）.
Embodiment 7,40% pyrimidifen chemical compounds I water-dispersible granules
By recipe requirements, 4 parts of pyrimidifens, 36 parts of chemical compounds Is, 4 parts of methanonaphthalene sodium sulfonates, 5 parts of alkyl naphthalene sulfonic acids are contracted
The sodium salt of polymers, 3 parts of sodium lignin sulfonates, 1 part of polyvinylpyrrolidone, 10 parts of sodium sulphate, bentonites complement to 100% and are added in
Together, co-grinding is carried out, then after the kneading that adds water, adds and is granulated in the comminutor equipped with certain specification screen cloth.Then
Again through drying, screening (pressing screen cloth scope), you can obtain 40% pyrimidifen chemical compounds I water-dispersible granules.
Mitochondrial electron described by pyrimidifen alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The water-dispersible granules of immunomodulator compounds I.
Embodiment 8,20% tebufenpyrad chemical compounds I suspending agent
By recipe requirements, by 1 part of tebufenpyrad, 19 parts of chemical compounds Is, 2 parts of methanonaphthalene sodium sulfonates, 4 parts of agriculture breast 0201B, 4 parts
The sodium salt of alkyl naphthalene sulfonic acid condensation polymer, 0.1 part of xanthans, 0.5 part of white carbon, 5 parts of ethylene glycol, 100% is complemented to water, successively
It is added in blending tank and mixes, first passes through high shear and carry out coarse crushing, homogenize, be then pumped into sand mill and carry out fine grinding, use
The granularity of material is sanded in particles distribution instrument detection, after particle diameter reaches standard requirement, filtering, you can obtain 20% tebufenpyrad
Compound I.
Mitochondrial electron described by tebufenpyrad alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The suspending agent of immunomodulator compounds I.
Example 9,50% fenazaquin chemical compounds I suspending agent（1:1）
By recipe requirements, by 25 parts of fenazaquins, 25 parts of chemical compounds Is, the sodium salt of 2 parts of condensation compound of methyl naphthalene sulfonic acid and formaldehyde, 4 parts
Polycarboxylate salt dispersant GY-D800,2 parts of agriculture breast 1601#, 4 parts of agriculture breast 0201B, 0.1 part of xanthans, 0.3 part of white carbon, 5 parts of second
Glycol, with water 100% is complemented to, be added sequentially to mix in blending tank, first pass through high shear and carry out coarse crushing, homogenize, then take out
Enter into sand mill and carry out fine grinding, the granularity that material is sanded is detected with particles distribution instrument, after particle diameter reaches standard requirement, mistake
Filter, you can obtain 50% fenazaquin chemical compounds I suspending agent.
Mitochondrial electron described by fenazaquin alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The suspending agent of immunomodulator compounds I（1:1）.
Embodiment 10,20% fenpyroximate chemical compounds I microemulsion
By recipe requirements, by 1 part of fenpyroximate, 19 parts of chemical compounds Is, 8 parts of triphenyl vinyl phenol polyoxyethylene (n20) ether phosphoric acids
Change triethanolamine salt, 5 parts of agriculture breast 507#, 3 parts of agriculture breast 100#, 6 parts of ethyl acetate, 6 parts of acetonitriles to be added together, make to be dissolved into uniformly
Oil phase, surplus complements to 100% with water, under high velocity agitation, and aqueous phase is added into oil phase or oil phase is added into aqueous phase, is formed
20% fenpyroximate chemical compounds I microemulsion of favorable dispersibility.
Mitochondrial electron described by fenpyroximate alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The microemulsion of immunomodulator compounds I.
Embodiment 11,20% tebufenpyrad chemical compounds I soluble concentrate
By recipe requirements, by 1 part of tebufenpyrad, 19 portions of chemical compounds Is, 8 portions of agriculture breast 2201#, 3 portions of agriculture breast 1601#, 5 portions of castor-oil plants
Oily polyoxyethylene（40）Ether, 2 parts of Nongru-700 #, 10 parts of cyclohexanone, 5 parts of acetonitriles, 20 parts of dimethyl sulfoxide (DMSO)s, the molten fibers of methyl are supplied
It is well mixed to 100%, dissolved by heating if necessary with hot bath, 20% tebufenpyrad chemical compounds I soluble concentrate can be made
Mitochondrial electron described by tebufenpyrad alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The soluble concentrate of immunomodulator compounds I.
Embodiment 12,20% tebufenpyrad chemical compounds I water dispersible oil suspending agent
By recipe requirements, by 1 part of tebufenpyrad, 19 parts of chemical compounds Is, 5 parts of agriculture breast 0201B, 3 parts of agriculture breast 500#, 3 parts of agriculture breast S-
80th, 5 parts of agriculture breast 100#, 3 parts of white carbons, methyl oleates complement to 100% and are added sequentially to mix in blending tank, first pass through height and cut
Cut into row coarse crushing, homogenize, be then pumped into sand mill and carry out fine grinding, the granularity that material is sanded is detected with particles distribution instrument,
After particle diameter reaches standard requirement, filtering, you can obtain 20% tebufenpyrad chemical compounds I water dispersible oil suspending agent.
Mitochondrial electron described by tebufenpyrad alternative costs specification can also be transmitted inhibitor class desinsection（Mite）Agent
In one kind, form new 20% Mitochondrial electron transmission inhibitor class desinsection（Mite）The water dispersible oil suspending agent of immunomodulator compounds I.
Indoor biological determination of activity
Synergism determination of composition of the embodiment 13 containing chemical compounds I to Tetranychus cinnabarinus
For examination object：Tetranychus cinnabarinus（Tetranychus cinnabarinus Boisduval）, into mite, indoor feeding
Sensitive strain.
Test condition：Temperature：24~26 DEG C, humidity：RH60%, illumination：L:D=14:10
Test method：Using pot-spraying method.The potted plant Kidney bean seedling of sizing of hot-house culture（2 true leaves）, a piece of true leaf is stayed,
Mite 40-60 heads are connected into thereon.Examination material is handled with decoction using Airbrush spray-on processes, dried in the shade naturally.Blank control is first handled,
Then aforesaid operations are repeated from low to high according to experimental design dosage, often handle 4 repetitions.Test worm after processing is placed in
In observation ward, routine observation test worm response situation investigates number of dead and live insects after 72h, calculates the death rate.
The Bliss methods that use are evaluated, this method is to evaluate one of classical way of mixture effect.Bliss is proposed according to it
Independent joint action concept thinks that theoretical death rate P during Mixture Use of Insecticides can be calculated with following formula：
P=Pm+Pn(1-Pm)
PmFor the death rate of the first active component target when concentration is m（%）；PnIt is n for the second active component concentration
When target the death rate（%）.
If the actual of two kinds of active component targets after being mixed with finite concentration is more than theoretical death rate P,
Judge two kinds of active components setting concentration under be used in mixed way with synergistic effect, it is on the contrary then be antagonism.
It the results are shown in Table 1.
The chemical compounds I of table 1 and pyridaben be used in mixed way to Tetranychus cinnabarinus into mite synergism determination
The chemical compounds I of embodiment 14 is used in mixed way to Tetranychus cinnabarinus toxicity determination test with pyridaben
For examination object：Tetranychus cinnabarinus（Tetranychus cinnabarinus Boisduval）, into mite, indoor feeding
Sensitive strain.
Test condition：Temperature：24~26 DEG C, humidity：RH60%, illumination：L:D=14:10
Test medication liquid making method：Reagent agent is accurately weighed respectively with electronic analytical balance, respectively by two kinds of active compounds
Add after appropriate solvent acetone is completely dissolved, concentration mother liquor needed for being configured to the water containing 0.1% Tween 80, by two kinds effectively into
Decomposition mother solution is hybridly prepared into mixed solution by a certain percentage, is by what experimental design dosage was diluted to tool finite concentration gradient respectively
Row decoction.
Test method：Using pot-spraying method.The potted plant Kidney bean seedling of sizing of hot-house culture（2 true leaves）, a piece of true leaf is stayed,
Mite 40-60 heads are connected into thereon.Examination material is handled with decoction using Airbrush spray-on processes, dried in the shade naturally.Blank control is first handled,
Then aforesaid operations are repeated from low to high according to experimental design dosage, often handle 4 repetitions.Test worm after processing is placed in
In observation ward, routine observation test worm response situation investigates number of dead and live insects after 72h, calculates the death rate.
Corrected mortality is calculated with abbott formula, appliance computer program is obtained each mixed for examination single dose and variant proportioning
Virulence regression equation, LC50 values and 95% confidence limit, with Sun Yunpei (Sun Y-P) method, obtain that each proportioning is mixed to be total to
Malicious coefficient, is evaluated.If co-toxicity coefficient is summation action close to 100, hence it is evident that be synergistic effect higher than 100, hence it is evident that less than 100
For antagonism.
Result of the test is shown in Table 2.As can be seen from the table, chemical compounds I is mixed to cinnabar leaf for trying each proportioning with pyridaben
Mite shows synergistic effect.
Table 2：Chemical compounds I pyridaben is to joint toxicity measuring result in Tetranychus cinnabarinus room
Claims (6)
1. one kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron, it is characterised in that：Composition
Containing two kinds of active components of A, B, the ratio of weight and number between component A and the components of component B two is 1：1-20:1 and 1:10-1:20；
Active component A is selected from the chemical compounds I shown in following structural formula, and active component B is selected from pyridaben；
The active component A structure is as follows：
2. according to the composition described in claim 1, it is characterised in that：Composition can be configured to missible oil, suspending agent, moisture and dissipate
Property granula, aqueous emulsion, microemulsion, soluble concentrate, wettable powder or water dispersible oil suspending agent.
3. according to the composition described in claim 2, it is characterised in that：The cumulative amount of active component is in 0.5%- in composition
Between 95%.
4. according to the composition described in claim 3, it is characterised in that：The cumulative amount of active component is in 1%- in composition
Between 85%.
5. a kind of acaricidal Insecticiding-miticiding of Mitochondrial electron transmission inhibitor class that contains according to described in claim 1 is combined
Thing, it is characterised in that：The composition is used to prepare insecticidal/acaricidal agent, for controlling agricultural pests or urban health insect.
6. the acaricidal insecticide acaricide composition of inhibitor class is transmitted according to the Mitochondrial electron that contains described in claim 5, its
It is characterised by：With effective agent gauge, the composition for being prepared into insecticidal/acaricidal agent is imposed on to the insect for needing to control or its life
On long medium.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310608610.5A CN104663666B (en) | 2013-11-26 | 2013-11-26 | One kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310608610.5A CN104663666B (en) | 2013-11-26 | 2013-11-26 | One kind transmits the acaricidal insecticide acaricide composition of inhibitor class containing Mitochondrial electron |
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| CN106605654A (en) * | 2015-10-21 | 2017-05-03 | 陕西韦尔奇作物保护有限公司 | Insecticidal composition containing SYP-9625 |
| CN105394044A (en) * | 2015-12-31 | 2016-03-16 | 青岛瀚生生物科技股份有限公司 | Miticidal composition and application thereof |
| CN106417321A (en) * | 2016-08-23 | 2017-02-22 | 青岛东生药业有限公司 | Compound miticide as well as dose form and use thereof |
| CN109691451B (en) * | 2017-10-24 | 2021-03-05 | 沈阳中化农药化工研发有限公司 | Insecticidal and acaricidal synergistic composition containing ethacrylonitrile and application thereof |
| CN111771890A (en) * | 2019-04-04 | 2020-10-16 | 浙江省化工研究院有限公司 | Acaricidal composition containing oxazofen and fenazaquin |
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| CN1156536A (en) * | 1996-02-07 | 1997-08-13 | 河北省石油化学工业研究所 | Suspension of pyridaben clofentezine compound pesticide |
| CN101473824A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Acaricide composition containing pyrimethanil and etoxazole |
| CN101669479A (en) * | 2009-10-16 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Mite-killing combination |
| CN101875633A (en) * | 2009-04-29 | 2010-11-03 | 中国中化股份有限公司 | Pyrazolyl acrylonitrile compound and application thereof |
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| JP2003201280A (en) * | 2001-10-24 | 2003-07-18 | Nissan Chem Ind Ltd | Acrylonitrile compound |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1156536A (en) * | 1996-02-07 | 1997-08-13 | 河北省石油化学工业研究所 | Suspension of pyridaben clofentezine compound pesticide |
| CN101473824A (en) * | 2008-12-18 | 2009-07-08 | 孙家隆 | Acaricide composition containing pyrimethanil and etoxazole |
| CN101875633A (en) * | 2009-04-29 | 2010-11-03 | 中国中化股份有限公司 | Pyrazolyl acrylonitrile compound and application thereof |
| CN101669479A (en) * | 2009-10-16 | 2010-03-17 | 深圳诺普信农化股份有限公司 | Mite-killing combination |
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