CN104474582A - Hyaluronic-acid-containing hemostatic gauze and preparation method thereof - Google Patents
Hyaluronic-acid-containing hemostatic gauze and preparation method thereof Download PDFInfo
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- CN104474582A CN104474582A CN201410780571.1A CN201410780571A CN104474582A CN 104474582 A CN104474582 A CN 104474582A CN 201410780571 A CN201410780571 A CN 201410780571A CN 104474582 A CN104474582 A CN 104474582A
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Abstract
The invention discloses hyaluronic-acid-containing hemostatic gauze. The hyaluronic-acid-containing hemostatic gauze is characterized by being prepared from the following raw materials in parts by weight: 2-4 parts of folium artemisiae argyi, 1-2 parts of calendula, 2-4 parts of tremella, 1-2 parts of peach gum, 8-12 parts of gelatin, 0.3-0.5 part of hyaluronic acid, 2-4 parts of sodium alginate, 3-5 parts of sodium carboxymethylcellulose, 0.3-0.5 part of sodium dihydrogen phosphate, 0.2-0.4 part of ethylene diamine tetraacetic acid, 0.1-0.2 part of polyvinylpyrrolidone, 1-2 parts of auxiliary materials, and 200-250 parts of water. The soluble hemostatic gauze disclosed by the invention is collaboratively prepared from natural high polymer materials, is good in hemostatic function, is easy absorbed by human body, is good in biocompatibility, and is free from toxic and side effects; the soluble hemostatic gauze is capable of astringing to stop bleeding, and inhibiting bacteria and resisting inflammation by extracting and compounding the natural effective ingredients of calendula and folium artemisiae argyi, has a controlled-release function, effectively prolongs the action time, and achieves a better use effect.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of containing hyaluronic hemostatic gauze and preparation method thereof.
Background technology
Along with the continuous progress of medical skill, new medical material and correlation technique obtain good development.Wherein the development of hemostatic material and improvement be conducive to improving perform the operation out, the problem of oozing of blood, have great importance, become the focus of current field of medicaments research.Traditional hemostatic gauze is generally made up of Cotton Gossypii, linen etc., have that antibacterial bacteriostatic ability, scrim fiber easily cause foreign material repulsion to react affect wound healing, easy and wound tissue adhesion when using, cause the problems such as secondary damage, and the waste treatment processes produced after using is complicated, easy contaminated environment.
Soluble stanching gauze is the good novel hemostatic material of one of development in recent years, has stronger affinity, absorb moisture and dissolve after running into blood water and saline, blocking blood capillary end and reach the object of hemostasis.Soluble stanching gauze also has good histocompatibility, frivolous softness, is convenient to carry out the operations such as coated filling, has high using value and the market demand potential.
Summary of the invention
The object of this invention is to provide a kind of containing hyaluronic hemostatic gauze, this hemostatic gauze has good water solublity and biocompatibility, is easily absorbed by the body, and has no side effect, anti-inflammation, and haemostatic effect is good.
The present invention is achieved by the following technical solutions:
A kind of containing hyaluronic hemostatic gauze, it is characterized in that, it is obtained by the raw material of following weight parts:
Folium Artemisiae Argyi 2-4, Flos Inulae 1-2, Tremella 2-4, Resina persicae 1-2, gelatin 8-12, hyaluronic acid 0.3-0.5, sodium alginate 2-4, sodium carboxymethyl cellulose 3-5, sodium dihydrogen phosphate 0.3-0.5, disodiumedetate 0.2-0.4, polyvinylpyrrolidone 0.1-0.2, adjuvant 1-2, water 200-250;
Wherein adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
Containing a preparation method for hyaluronic hemostatic gauze, it is characterized in that, comprise the following steps:
(1) by grinding after Folium Artemisiae Argyi, Flos Inulae and Tremella mixing, evenly, the acetum adding 4-8% by solvent and solute weight ratio 10:1-8:1 decocts 2-4h, filters, is concentrated into the 1/10-1/8 of original volume, obtain concentrated solution after pH being adjusted to neutrality; Described concentrated solution and gelatin and Resina persicae are jointly added in the water that 1/3-1/2 measures, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, then stirs 1-2h under adding polyvinylpyrrolidone and adjuvant 40-50 DEG C, same rotating speed, after cooling component A;
(2) add in the water of surplus by sodium alginate, hyaluronic acid, sodium carboxymethyl cellulose, sodium dihydrogen phosphate and disodiumedetate, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
Folium Artemisiae Argyi is the dried leaves of feverfew Chinese mugwort.Most of China area is all produced.Folium Artemisiae Argyi acrid in the mouth, hardship, warm in nature, slightly poisonous, there is warming the meridian for stopping bleeding, dispersing cold for relieving pain, effect of antiabortive, wet down parasite killing.
Its nature and flavor of Flos Inulae are light flat, have antiinflammatory, antibacterial action, can removing heat from blood, hemostasis.Have superpower healing ability, can sterilize convergence wound.
Advantage of the present invention is:
The present invention extracts tremella gel and synthesizes composite fibre with natural macromolecular material synergism such as Resina persicae, gelatin, sodium alginate, sodium carboxymethyl cellulose and obtains soluble stanching gauze, there is good hemostatic function, be easily absorbed by the body, good biocompatibility, has no side effect; By extracting and the natural constituent of composite Flos Inulae and Folium Artemisiae Argyi, can astringing to arrest bleeding, antibacterial anti-inflammatory, and there is slow releasing function, effectively extend action time, reach better result of use.
Detailed description of the invention
Non-limiting examples of the present invention is as follows:
A kind of containing hyaluronic hemostatic gauze, be prepared from by the component raw material of following weight (kg):
Folium Artemisiae Argyi 3, Flos Inulae 1.5, Tremella 3, Resina persicae 1.5, gelatin 10, hyaluronic acid 0.4, sodium alginate 3, sodium carboxymethyl cellulose 4, sodium dihydrogen phosphate 0.4, disodiumedetate 0.3, polyvinylpyrrolidone 0.15, adjuvant 1.5, water 200;
Wherein, adjuvant is made up of the raw material of following weight (kg):
Soybean lecithin 0.8, glycerol 3, Polyethylene Glycol 1.5, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1.5, mannitol 3, chlorhexidine gluconate 1.5, vitamin C 1.5, water 18;
The preparation method of adjuvant:
Soybean lecithin is added to the water 60 DEG C, 1000r/min stirs 1h, then add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition and stir 15min, add all the other raw materials 600r/min after cooling and stir 5min, to obtain final product.
(1) by grinding after Folium Artemisiae Argyi, Flos Inulae and Tremella mixing, evenly, the acetum adding 6% by solvent and solute weight ratio 10:1 decocts 3h, filters, is concentrated into 1/10 of original volume, obtain concentrated solution after pH being adjusted to neutrality; Jointly add in the water of 1/2 amount by described concentrated solution and gelatin and Resina persicae, prior to 80 DEG C, 600r/min stirs 0.5h, then stirs 1h under adding polyvinylpyrrolidone and adjuvant 50 DEG C, same rotating speed, after cooling component A;
(2) add in the water of surplus by sodium alginate, hyaluronic acid, sodium carboxymethyl cellulose, sodium dihydrogen phosphate and disodiumedetate, 1000r/min stirs 0.5h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 2% citric acid (mass ratio) and 70% ethanol (volume ratio), coagulation bath temperature is 30 DEG C, and spinning speed is 4m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
The hemostatic gauze obtained to the present embodiment is verified:
Haemostatic effect: mice docking experiment, mice docking bleeding time <15s;
Absorbability: mice subcutaneous absorption is tested, can absorb in 3 weeks, reaction without exception completely.
Claims (2)
1., containing a hyaluronic hemostatic gauze, it is characterized in that, it is obtained by the raw material of following weight parts:
Folium Artemisiae Argyi 2-4, Flos Inulae 1-2, Tremella 2-4, Resina persicae 1-2, gelatin 8-12, hyaluronic acid 0.3-0.5, sodium alginate 2-4, sodium carboxymethyl cellulose 3-5, sodium dihydrogen phosphate 0.3-0.5, disodiumedetate 0.2-0.4, polyvinylpyrrolidone 0.1-0.2, adjuvant 1-2, water 200-250;
Described adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of described adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
2. a kind of preparation method containing hyaluronic hemostatic gauze according to claim 1, is characterized in that, comprise the following steps:
(1) by grinding after Folium Artemisiae Argyi, Flos Inulae and Tremella mixing, evenly, the acetum adding 4-8% by solvent and solute weight ratio 10:1-8:1 decocts 2-4h, filters, is concentrated into the 1/10-1/8 of original volume, obtain concentrated solution after pH being adjusted to neutrality; Described concentrated solution and gelatin and Resina persicae are jointly added in the water that 1/3-1/2 measures, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, then stirs 1-2h under adding polyvinylpyrrolidone and adjuvant 40-50 DEG C, same rotating speed, after cooling component A;
(2) add in the water of surplus by sodium alginate, hyaluronic acid, sodium carboxymethyl cellulose, sodium dihydrogen phosphate and disodiumedetate, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
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| CN201410780571.1A CN104474582A (en) | 2014-12-17 | 2014-12-17 | Hyaluronic-acid-containing hemostatic gauze and preparation method thereof |
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| CN201410780571.1A CN104474582A (en) | 2014-12-17 | 2014-12-17 | Hyaluronic-acid-containing hemostatic gauze and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019025599A1 (en) * | 2017-08-04 | 2019-02-07 | Laboratorios Kin, S.A. | Gel comprising chlorhexidine |
| CN111744054A (en) * | 2020-07-20 | 2020-10-09 | 哈尔滨乾佰纳生物药业有限公司 | Antibacterial wound surface dressing capable of promoting healing and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091302A (en) * | 1993-07-24 | 1994-08-31 | 郝忠全 | The processing method of carbon haemostatic powder |
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN101524545A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Hemostatic gel suppository |
-
2014
- 2014-12-17 CN CN201410780571.1A patent/CN104474582A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1091302A (en) * | 1993-07-24 | 1994-08-31 | 郝忠全 | The processing method of carbon haemostatic powder |
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN101524545A (en) * | 2008-03-07 | 2009-09-09 | 大连永兴生物医药孵化器有限公司 | Hemostatic gel suppository |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019025599A1 (en) * | 2017-08-04 | 2019-02-07 | Laboratorios Kin, S.A. | Gel comprising chlorhexidine |
| CN110996891A (en) * | 2017-08-04 | 2020-04-10 | 实验室金公司 | Gel comprising chlorhexidine |
| CN110996891B (en) * | 2017-08-04 | 2023-02-28 | 实验室金公司 | Gel comprising chlorhexidine |
| CN111744054A (en) * | 2020-07-20 | 2020-10-09 | 哈尔滨乾佰纳生物药业有限公司 | Antibacterial wound surface dressing capable of promoting healing and preparation method thereof |
| CN111744054B (en) * | 2020-07-20 | 2021-05-25 | 哈尔滨乾佰纳生物药业有限公司 | Antibacterial wound surface dressing capable of promoting healing and preparation method thereof |
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Application publication date: 20150401 |