CN104436292A - Aloe gel haemostatic gauze and preparation method thereof - Google Patents
Aloe gel haemostatic gauze and preparation method thereof Download PDFInfo
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- CN104436292A CN104436292A CN201410780649.XA CN201410780649A CN104436292A CN 104436292 A CN104436292 A CN 104436292A CN 201410780649 A CN201410780649 A CN 201410780649A CN 104436292 A CN104436292 A CN 104436292A
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Abstract
The invention discloses aloe gel haemostatic gauze which is characterized by being prepared from the following raw materials in parts by weight: 10-15 parts of aloe gel, 6-10 parts of gelatin, 3-5 parts of hydroxyethyl cellulose, 1-2 parts of hydroxyethyl starch, 2-4 parts of sodium alginate, 2-4 parts of sodium carboxymethyl cellulose, 0.05-0.1 part of chlorogenic acid, 0.2-0.4 part of sodium chloride, 1-2 parts of konjac glucomannan, 1-2 parts of accessories and 200-250 parts of water. The soluble haemostatic gauze prepared by taking a natural extract, namely aloe gel, as a main ingredient, is good in haemostatic function, and capable of resisting bacteria, diminishing inflammation, and promoting the healing of wound; and meanwhile, the aloe gel haemostatic gauze is simple in preparation process, safe and environment-friendly, good in biocompatibility, easy to be absorbed by a human body and free from toxic and side effects.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of Aloe glue hemostatic gauze and preparation method thereof.
Background technology
Along with the continuous progress of medical skill, new medical material and correlation technique obtain good development.Wherein the development of hemostatic material and improvement be conducive to improving perform the operation out, the problem of oozing of blood, have great importance, become the focus of current field of medicaments research.Traditional hemostatic gauze is generally made up of Cotton Gossypii, linen etc., have that antibacterial bacteriostatic ability, scrim fiber easily cause foreign material repulsion to react affect wound healing, easy and wound tissue adhesion when using, cause the problems such as secondary damage, and the waste treatment processes produced after using is complicated, easy contaminated environment.
Soluble stanching gauze is the good novel hemostatic material of one of development in recent years, has stronger affinity, absorb moisture and dissolve after running into blood water and saline, blocking blood capillary end and reach the object of hemostasis.Soluble stanching gauze also has good histocompatibility, frivolous softness, is convenient to carry out the operations such as coated filling, has high using value and the market demand potential.
Summary of the invention
The object of this invention is to provide a kind of Aloe glue hemostatic gauze, this hemostatic gauze has good water solublity and biocompatibility, is easily absorbed by the body, and has no side effect, anti-inflammation, and haemostatic effect is good.
The present invention is achieved by the following technical solutions:
A kind of Aloe glue hemostatic gauze, it is characterized in that, it is obtained by the raw material of following weight parts:
Aloe glue 10-15, gelatin 6-10, hydroxyethyl-cellulose 3-5, hetastarch 1-2, sodium alginate 2-4, sodium carboxymethyl cellulose 2-4, chlorogenic acid 0.05-0.1, sodium chloride 0.2-0.4, Rhizoma amorphophalli glucomannan 1-2, adjuvant 1-2, water 200-250;
Wherein adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
A preparation method for Aloe glue hemostatic gauze, is characterized in that, comprises the following steps:
(1) gelatin and Aloe glue are added in the water of 1/3-1/2 amount, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, then adds Rhizoma amorphophalli glucomannan, chlorogenic acid and adjuvant 40-50 DEG C, stirs 1-2h under same rotating speed, must component A after cooling;
(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose, sodium chloride, hydroxyethyl-cellulose and hetastarch, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
Rhizoma amorphophalli glucomannan, also known as KGM, is a kind of natural polymer soluble fiber, has and promotes the biological characteristics such as wound healing, hemostatic function, and safe without toxic side effect.
Chlorogenic acid extracts from Folium Eucommiae, is a kind of antioxidant of Nantural non-toxic.Chlorogenic acid also has cures the multiple curative effect such as wound, anti-inflammation, has stronger suppression and killing action to various bacteria and virus.
Aloe glue is from herbaceous plant Aloe, extract the natural materials obtained, and has anti-inflammation and sterilization, pain easing and hemostasis, inflammation-inhibiting, convergence wound, promotes cell regeneration, reduces the good effects of cicatrix.
Advantage of the present invention is:
The present invention is using natural extract Aloe glue as major ingredient, soluble stanching gauze is obtained in conjunction with materials such as gelatin, sodium alginate, sodium carboxymethyl cellulose, there is good hemostatic function, can anti-inflammation, promote wound healing, simultaneously processing technology simple, safety and environmental protection, good biocompatibility, be easily absorbed by the body and have no side effect.
Detailed description of the invention
Non-limiting examples of the present invention is as follows:
A kind of Aloe glue hemostatic gauze, is prepared from by the component raw material of following weight (kg):
Aloe glue 12, gelatin 8, hydroxyethyl-cellulose 4, hetastarch 1.5, sodium alginate 3, sodium carboxymethyl cellulose 3, chlorogenic acid 0.08, sodium chloride 0.3, Rhizoma amorphophalli glucomannan 1.5, adjuvant 1.5, water 200;
Wherein, adjuvant is made up of the raw material of following weight (kg):
Soybean lecithin 0.8, glycerol 3, Polyethylene Glycol 1.5, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1.5, mannitol 3, chlorhexidine gluconate 1.5, vitamin C 1.5, water 18;
The preparation method of adjuvant:
Soybean lecithin is added to the water 60 DEG C, 1000r/min stirs 1h, then add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition and stir 15min, add all the other raw materials 600r/min after cooling and stir 5min, to obtain final product.
The preparation method of Aloe glue hemostatic gauze comprises the following steps:
(1) gelatin and Aloe glue are added in the water of 1/2 amount, prior to 80 DEG C, 600r/min stirs 0.5h, then stirs 1h under adding Rhizoma amorphophalli glucomannan, chlorogenic acid and adjuvant 50 DEG C, same rotating speed, after cooling component A;
(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose, sodium chloride, hydroxyethyl-cellulose and hetastarch, 1000r/min stirs 0.5h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 2% citric acid (mass ratio) and 70% ethanol (volume ratio), coagulation bath temperature is 30 DEG C, and spinning speed is 4m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
The hemostatic gauze obtained to the present embodiment is verified:
Haemostatic effect: mice docking experiment, mice docking bleeding time <15s;
Absorbability: mice subcutaneous absorption is tested, can absorb in 3 weeks, reaction without exception completely.
Claims (2)
1. an Aloe glue hemostatic gauze, is characterized in that, it is obtained by the raw material of following weight parts:
Aloe glue 10-15, gelatin 6-10, hydroxyethyl-cellulose 3-5, hetastarch 1-2, sodium alginate 2-4, sodium carboxymethyl cellulose 2-4, chlorogenic acid 0.05-0.1, sodium chloride 0.2-0.4, Rhizoma amorphophalli glucomannan 1-2, adjuvant 1-2, water 200-250;
Described adjuvant is made up of the raw material of following weight portion:
Soybean lecithin 0.5-1, glycerol 2-4, Polyethylene Glycol 1-2, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder 1-2, mannitol 2-4, chlorhexidine gluconate 1-2, vitamin C 1-2, water 15-20;
The preparation method of described adjuvant is:
Soybean lecithin is added to the water 50-60 DEG C, 800-1000r/min stirs 1-2h, add glycerol, Polyethylene Glycol, Pseudobulbus Bletillae (Rhizoma Bletillae) superfine powder and mannitol similarity condition again and stir 10-15min, add all the other raw materials 400-600r/min after cooling and stir 5-10min, to obtain final product.
2. the preparation method of a kind of Aloe glue hemostatic gauze according to claim 1, is characterized in that, comprise the following steps:
(1) gelatin and Aloe glue are added in the water of 1/3-1/2 amount, prior to 60-80 DEG C, 400-600r/min stirs 0.5-1h, then adds Rhizoma amorphophalli glucomannan, chlorogenic acid and adjuvant 40-50 DEG C, stirs 1-2h under same rotating speed, must component A after cooling;
(2) add in the water of surplus by sodium alginate, sodium carboxymethyl cellulose, sodium chloride, hydroxyethyl-cellulose and hetastarch, 800-1000r/min stirs 0.5-1h, obtains B component;
(3) filter after component A and B component mix homogeneously and vacuum defoamation, obtain spinning solution; Spinning solution is added in wet-spinning frame under room temperature, separated out in coagulating bath after extruding by dosing pump metering, spinning head and form composite fibre long filament, described coagulating bath is the mixed solution containing 1-2% citric acid (mass ratio) and 60-70% ethanol (volume ratio), coagulation bath temperature is 20-40 DEG C, and spinning speed is 2-5m/min;
(4) make gauze by after the composite fibre long filament drying obtained in (3), through cutting out, sterilizing and packaging process, get product.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105251037A (en) * | 2015-11-19 | 2016-01-20 | 赵岱 | Bandage for treating scalds and preparation method thereof |
| CN105749335A (en) * | 2016-05-06 | 2016-07-13 | 王泽陆 | Rapid-hemostasis composite micro powder material and preparation method thereof |
| CN105770962A (en) * | 2016-05-06 | 2016-07-20 | 王泽陆 | Degradable antibacterial hemostatic fiber pad and preparation method thereof |
| CN105797204A (en) * | 2016-04-21 | 2016-07-27 | 北京师范大学 | Application of chlorogenic acid in preparing wound dressing |
| CN106620819A (en) * | 2016-12-09 | 2017-05-10 | 苏州艾博迈尔新材料有限公司 | Medical rapid hemostatic gauze and preparation method thereof |
| CN109745582A (en) * | 2019-03-11 | 2019-05-14 | 西南科技大学 | A kind of preparation method of Bletilla striata polysaccharide composite cell scaffold |
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| CN105251037A (en) * | 2015-11-19 | 2016-01-20 | 赵岱 | Bandage for treating scalds and preparation method thereof |
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| CN105749335A (en) * | 2016-05-06 | 2016-07-13 | 王泽陆 | Rapid-hemostasis composite micro powder material and preparation method thereof |
| CN105770962A (en) * | 2016-05-06 | 2016-07-20 | 王泽陆 | Degradable antibacterial hemostatic fiber pad and preparation method thereof |
| CN106620819A (en) * | 2016-12-09 | 2017-05-10 | 苏州艾博迈尔新材料有限公司 | Medical rapid hemostatic gauze and preparation method thereof |
| CN109745582A (en) * | 2019-03-11 | 2019-05-14 | 西南科技大学 | A kind of preparation method of Bletilla striata polysaccharide composite cell scaffold |
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Application publication date: 20150325 |