CN104398594A - Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof - Google Patents
Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof Download PDFInfo
- Publication number
- CN104398594A CN104398594A CN201410601255.3A CN201410601255A CN104398594A CN 104398594 A CN104398594 A CN 104398594A CN 201410601255 A CN201410601255 A CN 201410601255A CN 104398594 A CN104398594 A CN 104398594A
- Authority
- CN
- China
- Prior art keywords
- parts
- pharmaceutical composition
- material medicine
- filtrate
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 208000029836 Inguinal Hernia Diseases 0.000 title claims abstract description 13
- 239000003814 drug Substances 0.000 claims abstract description 36
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract description 10
- 241000218176 Corydalis Species 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- 239000000463 material Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 239000000706 filtrate Substances 0.000 claims description 20
- 238000001914 filtration Methods 0.000 claims description 18
- 239000000843 powder Substances 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 15
- 229940025250 camphora Drugs 0.000 claims description 9
- 239000010238 camphora Substances 0.000 claims description 9
- 239000002244 precipitate Substances 0.000 claims description 9
- 239000012467 final product Substances 0.000 claims description 7
- 230000003203 everyday effect Effects 0.000 claims description 6
- 235000011837 pasties Nutrition 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 5
- 235000012054 meals Nutrition 0.000 claims description 4
- 108010011485 Aspartame Proteins 0.000 claims description 3
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- -1 concentrated Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 241000220223 Fragaria Species 0.000 claims 2
- 206010019909 Hernia Diseases 0.000 abstract description 36
- 230000000694 effects Effects 0.000 abstract description 6
- 230000008901 benefit Effects 0.000 abstract description 4
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 241000723346 Cinnamomum camphora Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 244000183278 Nephelium litchi Species 0.000 abstract 1
- 235000015742 Nephelium litchi Nutrition 0.000 abstract 1
- 244000203593 Piper nigrum Species 0.000 abstract 1
- 235000008184 Piper nigrum Nutrition 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 241000913745 Spatholobus Species 0.000 abstract 1
- 235000013614 black pepper Nutrition 0.000 abstract 1
- 229960000846 camphor Drugs 0.000 abstract 1
- 229930008380 camphor Natural products 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 239000001931 piper nigrum l. white Substances 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 14
- 210000004369 blood Anatomy 0.000 description 14
- 235000014347 soups Nutrition 0.000 description 11
- 230000001737 promoting effect Effects 0.000 description 9
- 210000004185 liver Anatomy 0.000 description 8
- 230000001225 therapeutic effect Effects 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 6
- 230000003187 abdominal effect Effects 0.000 description 5
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 238000009835 boiling Methods 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 208000037920 primary disease Diseases 0.000 description 4
- 206010010356 Congenital anomaly Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000004706 scrotum Anatomy 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010011469 Crying Diseases 0.000 description 2
- 206010014080 Ecchymosis Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 210000000683 abdominal cavity Anatomy 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 230000003119 painkilling effect Effects 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 108700012359 toxins Proteins 0.000 description 2
- 230000009278 visceral effect Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 206010018852 Haematoma Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 241000594558 Labium Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000004550 Postoperative Pain Diseases 0.000 description 1
- 241000135309 Processus Species 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 206010039740 Screaming Diseases 0.000 description 1
- 206010049147 Scrotal mass Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010043298 Testicular atrophy Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000003815 abdominal wall Anatomy 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 201000010788 atrophy of testis Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000003419 expectorant effect Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 210000004013 groin Anatomy 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000000494 inguinal canal Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 229940040145 liniment Drugs 0.000 description 1
- 239000000865 liniment Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 210000000505 parietal peritoneum Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 210000001659 round ligament Anatomy 0.000 description 1
- 235000013580 sausages Nutrition 0.000 description 1
- 210000004267 spermatic cord Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 210000000546 superficial inguinal ring Anatomy 0.000 description 1
- 238000011477 surgical intervention Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a pharmaceutical composition for treating children's inguinal hernia and its preparation method and use in drug preparation. The pharmaceutical composition comprises an oral administration component comprising 3-100 parts of honey-fried licorice root, 3-100 parts of spatholobus stem, 3-100 parts of achyranthes root, 3-100 parts of rhizoma corydalis and 1-50 parts of giant knot weed and also comprises an external application component comprising 10-120 parts of white pepper, 10-120 parts of lychee seed and 1-20 parts of camphor. The pharmaceutical composition utilizes traditional Chinese medicines as raw materials, has the advantage of low toxic or side effects of the traditional Chinese medicines, realizes treatment on children's hernia by combination of traditional Chinese medicine oral administration and external application, provides a safe, effective, cheap and simple treatment method for young patients, can be widely popularized and has a high clinical application value.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition and preparation method thereof and pharmaceutical applications, particularly relate to and a kind ofly treat pharmaceutical composition of children inguinal hernia gas and preparation method thereof and pharmaceutical applications.
Background technology
Hernia is that abdominal visceral browser or tissue enter another position by congenital or that formed the day after tomorrow weak spot, defect or hole, abdominal visceral browser or tissue are abdominal external hernia together with the hernia that parietal peritoneum is outstanding to body surface, its content mostly is small intestinal, and abdominal external hernia is common with inguinal hernia again.
Children inguinal hernia is common congenital abnormal development, can be divided into indirect inguinal hernia and straight hernia, and that sees clinically is almost oblique hernia, straight hernia is very rare, its sickness rate is higher, is 0.8% ~ 4.4% according to the literature, and the sickness rate of premature infant is 4.8%, male is in the great majority, M-F is 15:1, and site of pathological change is common with right side, accounts for 60%, left side is 25%, and bilateral is 15%.Pathogenic factor is mainly the congenital processus vaginalis patent of infant or inadequacy forms hole, the weakness that abdominal wall muscle hypoplasia and spermatic cord or round ligament of uterus are formed by inguinal canal and defect make local defense ability decline, when children's cry and scream intra-abdominal pressure is increased time abdomen content outstanding and send out primary disease to body surface since then, clinical manifestation is for crying, falling inflation sense, touch a tender spot and groin or scrotal mass, but do not hinder activity, standing, the thing that swells when crying and screaming or exert oneself occurs or increases, flat sleeping, after sleep, swollen thing diminishes or disappears, swollen thing gently upwardly can be made also to receive abdominal cavity with have gentle hands.
High ligation of hernial sac traditional is clinically its treatment " goldstandard " at present, but there is the complication such as hematoma of scrotum, infection of incisional wound, postoperative pain, scrotum or atrophy of testis, peritoneal free cancer cells and hernia recurrence in operative treatment, also likely causes harmful effect to the psychology of infant; In addition, the clinical hernia truss that also often uses is treated, and has certain curative effect, but for child more than one full year of life, because it is often movable, easily produce displacement when wearing, affect therapeutic effect ewborn infant.Therefore, need a kind of safe and effective, toxic and side effects is little, low cost and operation and the easy medicine of preparation method and Therapeutic Method.
Summary of the invention
In order to solve above technical problem, inventor has created GANTENG soup and the loose two kinds of Chinese prescriptions of hernia core, close external application compression method treatment infantile hernia by oral medicinal herb, significant therapeutical effect can be played, and there is the advantages such as evident in efficacy, side effect is little, cost is low, operational approach is easy.
Primary disease belongs to motherland's medical science " inguinal hernia " scope, thinks " all hernias cloudy conception vessel of fainting is sick, the evil coacervation of exopathogenic factor wind and cold; endogenous cause of ill wets heat stagnated by cold ", namely hernia be conception vessel and JUE YIN meridian two through pathological changes, interior because children's's congenital defect, body constitution is poor, in addition affection of exogenous wind-cold or internal injury diet, or due to damp and hot interior strongly fragrant, the with the passing of time turbid poison of accumulateing, invaded by outside cold-evil again, inflow is fainted cloudy Liver Channel, is detained not all right, so that ecchymosis condensation and herniae.Primary disease is dialectical is QI and blood deficiency, caused by the stagnant liver network of malicious stasis blocking.Therefore, for primary disease pathogenesis, should adopt vigorate qi and replenish the blood, stasis-dispelling and pain-killing, dispelling toxins and dredging collaterals is main Therapeutic Principle, fundamentally treats infantile hernia.
Pharmaceutical composition of the present invention comprises (parts by weight):
GANTENG soup: Radix Glycyrrhizae Preparata 3-100 part, Caulis Spatholobi 3-100 part, Radix Achyranthis Bidentatae 3-100 part, Rhizoma Corydalis 3-100 part, Rhizoma Polygoni Cuspidati 1-50 part;
Hernia core falls apart: Radix orixae japonicae 10-120 part, Semen Litchi 10-120 part, Camphora 1-20 part.
Material medicine preferred weight number is:
GANTENG soup: Radix Glycyrrhizae Preparata 5-50 part, Caulis Spatholobi 5-50 part, Radix Achyranthis Bidentatae 5-50 part, Rhizoma Corydalis 5-50 part, Rhizoma Polygoni Cuspidati 1-25 part;
Hernia core falls apart: Radix orixae japonicae 20-60 part, Semen Litchi 20-60 part, Camphora 1-10 part.
Material medicine is more preferably parts by weight:
GANTENG soup: Radix Glycyrrhizae Preparata 10 parts, Caulis Spatholobi 10 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Polygoni Cuspidati 3 parts;
Hernia core falls apart: Radix orixae japonicae 25 parts, Semen Litchi 25 parts, Camphora 2 parts.
In square GANTENG soup for oral administration, Radix Glycyrrhizae Preparata is monarch, its sweet in the mouth, and property is put down, and returns 12 warps, has QI invigorating invigorating middle warmer, relieving spasm to stop pain, eliminating fire and detoxication, the merit of coordinating the actions of various ingredients in a prescription; Caulis Spatholobi is minister, and its sweet in the mouth is warm in nature, returns liver, kidney channel, enriches blood, invigorate blood circulation, the merit of dredging collateral; Radix Glycyrrhizae Preparata and Caulis Spatholobi are harmonious, the purport of ancestor's " capable then blood of gas ", and gas promoting the circulation of blood is lived, blood vessels tonneau, stasis of blood hernia of faling apart disappears; Radix Achyranthis Bidentatae is minister, its bitter in the mouth, acid, and property is put down, and return liver, kidney channel, have the merit of promoting blood circulation to restore menstrual flow, sweet in the mouth can be mended, and can puckeryly can hold back, and under hardship of holding concurrently is straight, enters kidney with it; Rhizoma Corydalis, its acrid in the mouth is bitter, and warm in nature, enter the heart, spleen, liver, lung, have blood circulation promoting and blood stasis dispelling, the merit of promoting the circulation of QI to relieve pain, be adjuvant drug, it can enter blood system, enters edema caused by disorder of QI again, can gas in promoting the circulation of blood, again can blood in circulation of qi promoting, the smooth blood of gas, and general rule is not bitterly; Rhizoma Polygoni Cuspidati, its bitter in the mouth, acid, property is put down, and returns liver, gallbladder meridian, and enter blood and fall apart, promoting blood circulation to remove blood stasis, expelling wind and removing dampness, removing toxic substances and promoting subsidence of swelling, is adjuvant, embodies vigorate qi and replenish the blood, stasis-dispelling and pain-killing, and the Therapeutic Principle of dispelling toxins and dredging collaterals is just in step with the pathogenesis of hernia.
During external application side's hernia core is loose, Radix orixae japonicae, its acrid in the mouth, warm in nature, return stomach warp, large intestine channel, have warming spleen and stomach for dispelling cold, the merit of the therapeutic method to keep the adverse QI flowing downwards, expectorant; Semen Litchi, its sweet in the mouth, warm in nature, return liver, kidney channel, have promoting QI to circulate and dispersing the agglomeration of the pathogens, the merit of cold-dispelling pain-relieving, for colic of cold type stomachache, painful and swollen testis; Camphora, its acrid in the mouth, hot in nature, GUIXIN, spleen channel, have orifice opening, qi stagnation removing, wards off foul, killing parasites for relieving itching, the merit of reducing swelling and alleviating pain; Three is harmonious, and make through beniol, ecchymosis is gone, and hernia is multiple.
Meanwhile, application strengthens on the one hand the intensity of stomach wall by external force, hernical sac can be made to stick together and short hernical sac closes hernia ring and reduces gradually, finally completely closed because of the growth of health; On the other hand by the osmotic absorption of abdominal skin to Chinese medicine, produce warming the meridian in vivo by cold, the merit of regulating QI to relieve pain, finally reach effect of the logical conception vessel of temperature and Liver Channel.
The preparation method of above-mentioned side for oral administration is: get the mixing of described material medicine and put into marmite, add water and do not have powder to soak 30 minutes, big fire changes slow fire boiling 30 minutes after boiling, leach medicinal liquid, then decocts with water 20 minutes, leaches medicinal liquid, and twice filtrate merges and get final product;
Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
The preparation method that above-mentioned hernia core is loose is: by described material medicine grind into fine powder, mixed by powder and get final product, getting appropriate powder and appropriate Oleum Sesami furnishing pasty state, spread on sufferer place during use, covers gauze and fixes.
The invention has the beneficial effects as follows: take Chinese medicine as raw material, play the advantage that herbal toxic effect is low, closed application treatment infantile hernia by oral medicinal herb, for young patient provides safety, effective, cheap, easy Therapeutic Method, be easy to extensive popularization, there is higher clinical value.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
embodiment 1:
Prescription:
GANTENG soup: Radix Glycyrrhizae Preparata 20g, Caulis Spatholobi 20g, Radix Achyranthis Bidentatae 20g, Rhizoma Corydalis 20g, Rhizoma Polygoni Cuspidati 6g;
Hernia core falls apart: Radix orixae japonicae 50g, Semen Litchi 50g, Camphora 5g.
Preparation method:
GANTENG soup: get the mixing of described material medicine and put into marmite, add water and do not have powder to soak 30 minutes, big fire changes slow fire boiling 30 minutes after boiling, leach medicinal liquid, then decocts with water 20 minutes, leaches medicinal liquid, and twice filtrate merges and get final product;
Hernia core falls apart: by described material medicine grind into fine powder, mixed by powder and get final product.
Instructions of taking: GANTENG soup every day 2 times, point sooner or later twice one after each meal, taking drug withdrawal in 2 weeks 1 week, 3 weeks was 1 course for the treatment of, treated 3 courses for the treatment of; Hernia core is loose to be got appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place once a day during use, cover gauze and fix.
embodiment 2:
Prescription:
GANTENG soup: Radix Glycyrrhizae Preparata 30g, Caulis Spatholobi 30g, Radix Achyranthis Bidentatae 30g, Rhizoma Corydalis 30g, Rhizoma Polygoni Cuspidati 10g;
Hernia core falls apart: Radix orixae japonicae 40g, Semen Litchi 40g, Camphora 4g.
Preparation method:
GANTENG soup: get above-mentioned raw materials medicament mixed, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid,
Hernia core falls apart: by described material medicine grind into fine powder, mixed by powder and get final product.
Instructions of taking: GANTENG soup oral liquid every day 2 times, each 1, point sooner or later twice one after each meal, taking drug withdrawal in 2 weeks 1 week, 3 weeks was 1 course for the treatment of, treated 3 courses for the treatment of; Hernia core is loose to be got appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place once a day during use, cover gauze and fix.
embodiment 3: pharmaceutical composition is tested the therapeutic effect of infantile hernia:
a, samples selection:
Case collect: with do not accept surgical intervention 0.6-4 year children inguinal hernia infant for subjects.
Diagnostic criteria: inguinal region finds transmutability " pears shape " or " sausage shape " enclosed mass, enclosed mass is given prominence to from superficial inguinal ring, can reach in scrotum or in labium majus, the soft person of enclosed mass, also can receive to abdominal cavity during extruding, compressing internal ring can stop enclosed mass to occur, subcutaneous widening of the ring, has impulsion sense during infant cough, during enclosed mass incarceration, except local pain, stomachache is normal with vomiting, is diagnosed as inguinal hernia; Exclusion standard: have the infant of other serious diseases as serious hepatorenal disease, child with cancer, and to the method person that has serious adverse reaction.
Collect infant 524 example altogether, it is divided into 4 groups at random, often organize 131 examples, matched group wears hernia truss treatment.
Criterion of therapeutical effect:
Recovery from illness: transference cure after treatment, hernia mouth closes, and follows up a case by regular visits to and does not reaccess;
Effective: after treatment, attack times minimizing or hernia ring obviously diminish;
Invalid: before and after treatment, symptom is without change.
, clinical treatment:
Treatment group:
Endo-medicine: treatment group 1 and treatment group 2 take the decoction of embodiment 1 orally, every day 2 times, takes drug withdrawal in 2 weeks 1 week, within 3 weeks, is 1 course for the treatment of, treats 3 courses for the treatment of; Treatment group 3 takes the oral liquid of embodiment 2 orally, every day 2 times, takes drug withdrawal in 2 weeks 1 week, within 3 weeks, is 1 course for the treatment of, treats 3 courses for the treatment of.
Liniment: treatment group 1-3 respectively once a day, gets appropriate powder and appropriate Oleum Sesami furnishing pasty state, spreads on sufferer place during use, cover gauze and fix.
Matched group: wear hernia truss treatment.
, therapeutic effect observe:
Experimental result:
Visible, pharmaceutical composition of the present invention has obvious therapeutical effect for children inguinal hernia.
Content of the present invention merely illustrates some claimed specific embodiments; one of them or more described technical characteristic can be combined with arbitrary one or more technical scheme in technical scheme; these technical schemes obtained through combination also in the application's protection domain, just as these technical schemes obtained through combination in the disclosure of invention concrete record.
Claims (10)
1. be used for the treatment of a pharmaceutical composition for children inguinal hernia, it is characterized in that: comprise following medicine and be prepared from according to parts by weight: side for oral administration: Radix Glycyrrhizae Preparata 3-100 part, Caulis Spatholobi 3-100 part, Radix Achyranthis Bidentatae 3-100 part, Rhizoma Corydalis 3-100 part, Rhizoma Polygoni Cuspidati 1-50 part; External application side: Radix orixae japonicae 10-120 part, Semen Litchi 10-120 part, Camphora 1-20 part.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that, the parts by weight of material medicine are: Radix Glycyrrhizae Preparata 5-50 part, Caulis Spatholobi 5-50 part, Radix Achyranthis Bidentatae 5-50 part, Rhizoma Corydalis 5-50 part, Rhizoma Polygoni Cuspidati 1-25 part, Radix orixae japonicae 20-60 part, Semen Litchi 20-60 part, Camphora 1-10 part.
3. pharmaceutical composition as claimed in claim 1, it is characterized in that, the parts by weight of material medicine are: Radix Glycyrrhizae Preparata 10 parts, Caulis Spatholobi 10 parts, Radix Achyranthis Bidentatae 10 parts, Rhizoma Corydalis 10 parts, Rhizoma Polygoni Cuspidati 3 parts, Radix orixae japonicae 25 parts, Semen Litchi 25 parts, Camphora 2 parts.
4. pharmaceutical composition as described in claim 1-3, is characterized in that, the preparation method of side for oral administration is: the material medicine getting corresponding weight, decocts with water to obtain decoction and take, every day potion, point sooner or later twice one after each meal; Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
5. pharmaceutical composition as claimed in claim 4, it is characterized in that, get above-mentioned raw materials medicament mixed, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid.
6. pharmaceutical composition as described in claim 1-3, is characterized in that, the preparation method of external application side is: by described material medicine grind into fine powder, powder is mixed and get final product, get appropriate powder and appropriate Oleum Sesami furnishing pasty state during use, spread on sufferer place, cover gauze and fix.
7. prepare a method for arbitrary pharmaceutical composition as described in claim 1-3, it is characterized in that, the preparation method of side for oral administration is: the material medicine getting corresponding weight, decocts with water to obtain decoction and take, every day potion, point sooner or later twice one after each meal; Or get material medicine in proportion to decoct with water, filter and obtain filtrate 1, filtering residue decocts with water again, filter and obtain filtrate 2, merge twice filtrate, concentrated, precipitate with ethanol, filtering supernatant, reclaim ethanol, concentrate and obtain extractum, add adjuvant common on pharmaceutics and be prepared into oral liquid or granule.
8. prepare the method for pharmaceutical composition as claimed in claim 7 for one kind, it is characterized in that: get the mixing of corresponding material medicine, add material medicine 6 times of water gagings, first time decocts 30min, filtration obtains filtrate 1, filtering residue adds material medicine 4 times amount soak by water 30min, filtration obtains filtrate 2, merge twice filtrate, being concentrated into relative density under room temperature is the concentrated solution of 1.1-1.2, add mass percent concentration be more than 95% alcoholic solution make concentrated solution alcohol content reach 60% to carry out precipitate with ethanol, precipitate with ethanol is filtering supernatant after 48 hours, reclaim ethanol, being concentrated to relative density under room temperature is the extractum of 1.3-1.4, adding purified water makes crude drug amount be 2g/ml, adjust ph is 7.5, add 0.1% strawberry essence, 0.1% aspartame, after mix homogeneously, fill becomes 10ml oral liquid, 100 DEG C of sterilizings 45 minutes, obtain oral liquid.
9. prepare a method for arbitrary pharmaceutical composition as described in claim 1-3, it is characterized in that, the preparation method of external application side is: by described material medicine grind into fine powder, powder is mixed and get final product, get appropriate powder and appropriate Oleum Sesami furnishing pasty state during use, spread on sufferer place, cover gauze and fix.
10. described in a claim 1-6, any combination thing is used for the treatment of the purposes of children inguinal hernia.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410601255.3A CN104398594A (en) | 2014-11-01 | 2014-11-01 | Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410601255.3A CN104398594A (en) | 2014-11-01 | 2014-11-01 | Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104398594A true CN104398594A (en) | 2015-03-11 |
Family
ID=52636303
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410601255.3A Pending CN104398594A (en) | 2014-11-01 | 2014-11-01 | Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104398594A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840441A (en) * | 2020-08-15 | 2020-10-30 | 唐钰暘 | A Chinese medicinal powder for treating hernia |
-
2014
- 2014-11-01 CN CN201410601255.3A patent/CN104398594A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111840441A (en) * | 2020-08-15 | 2020-10-30 | 唐钰暘 | A Chinese medicinal powder for treating hernia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100367985C (en) | Chinese prepared medicine for treating bone pain | |
| CN101757591B (en) | Traditional Chinese medicine composition for treating chronic colitis and protitis | |
| CN108042770A (en) | Treat Chinese medicine fuming-lotion, its preparation method and the application method of ephritis | |
| CN103202999A (en) | Modified peach pit flatus-smoothing oral liquid used for operative complications and preparation method thereof | |
| CN102085342B (en) | External cinnamon and radix aconiti powder for neonatal scleredema | |
| CN100381141C (en) | Chinese medicine for treating prostatic hyperplasia | |
| CN104398594A (en) | Pharmaceutical composition for treating children's inguinal hernia and preparation method thereof | |
| CN101028421B (en) | Chinese medicine for treating chronic kidney failure | |
| CN104666799A (en) | Blood circulation activating and blood stasis removing medicinal liquor for soft tissue injury and preparation method of medicinal liqour | |
| CN103920042A (en) | Drug for treating heat invasion nutritive blood type virus meningitis, as well as preparation method thereof | |
| CN103585368A (en) | Traditional Chinese medicine for treating internal hemorrhoid | |
| CN103239556A (en) | Traditional Chinese medicine for treating cervical spondylosis caused by wind-cold-dampness arthralgia | |
| CN102380081A (en) | Preparation method of traditional Chinese medicine lotion for treating numb decubitus | |
| CN105596584A (en) | Traditional Chinese medicine preparation special for local anesthesia and preparation method thereof | |
| CN106266970B (en) | A kind of Chinese medicine composition treated production and cause endometritis | |
| CN105727155A (en) | Traditional Chinese medicinal prescription for preventing and treating hepatitis A and preparation method of traditional Chinese medicinal prescription | |
| CN105521435A (en) | Sterilization and disinfection liquid for promoting wound healing, and preparation method thereof | |
| CN105168771A (en) | Traditional Chinese medicine for treating sciatica | |
| CN105232741A (en) | Traditional Chinese medicine composition for postpartum care | |
| CN104491537A (en) | Traditional Chinese medicine composition for treating rheumatic heart disease | |
| CN104922409A (en) | Traditional Chinese medicine for treating chronic cervicitis | |
| CN104288675A (en) | Traditional Chinese medicine formula for preventing and treating hepatitis A and preparation method thereof | |
| CN104606568A (en) | Medicament for treating infantile intestinal spasm | |
| CN104189514A (en) | Lymphatic tuberculosis resolving hard lump and eliminating phlegm preparation and preparation method thereof | |
| CN103751397B (en) | A kind of Chinese medicine composition for the treatment of pressure ulcer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150311 |
|
| WD01 | Invention patent application deemed withdrawn after publication |