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CL2018001522A1 - Focalización de péptidos para dirigir virus adenoasociados (aavs) - Google Patents

Focalización de péptidos para dirigir virus adenoasociados (aavs)

Info

Publication number
CL2018001522A1
CL2018001522A1 CL2018001522A CL2018001522A CL2018001522A1 CL 2018001522 A1 CL2018001522 A1 CL 2018001522A1 CL 2018001522 A CL2018001522 A CL 2018001522A CL 2018001522 A CL2018001522 A CL 2018001522A CL 2018001522 A1 CL2018001522 A1 CL 2018001522A1
Authority
CL
Chile
Prior art keywords
aavs
peptides
direct
focalization
adeno
Prior art date
Application number
CL2018001522A
Other languages
English (en)
Inventor
Benjamin E Deverman
Viviana Gradinaru
Ken Y Chan
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Publication of CL2018001522A1 publication Critical patent/CL2018001522A1/es

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K38/08—Peptides having 5 to 11 amino acids
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • A61K38/18—Growth factors; Growth regulators
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Abstract

AQUÍ SE DIVULGAN SECUENCIAS DE PÉPTIDOS CAPACES DE DIRIGIR VIRUS ADENOASOCIADOS (AAV) PARA FOCALIZAR AMBIENTES ESPECÍFICOS, POR EJEMPLO EL SISTEMA NERVIOSO Y EL CORAZÓN, EN UN SUJETO. TAMBIÉN SE DIVULGAN AAVS QUE TIENEN PROTEÍNAS DE LA CÁPSIDE QUE NO OCURREN NATURALMENTE COMPRENDIENDO LAS SECUENCIAS DE PÉPTIDOS DIVULGADAS, Y MÉTODOS PARA UTILIZAR LOS AAVS PARA TRATAR ENFERMEDADES.
CL2018001522A 2015-12-11 2018-06-07 Focalización de péptidos para dirigir virus adenoasociados (aavs) CL2018001522A1 (es)

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