CL2017001574A1 - Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionados - Google Patents
Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionadosInfo
- Publication number
- CL2017001574A1 CL2017001574A1 CL2017001574A CL2017001574A CL2017001574A1 CL 2017001574 A1 CL2017001574 A1 CL 2017001574A1 CL 2017001574 A CL2017001574 A CL 2017001574A CL 2017001574 A CL2017001574 A CL 2017001574A CL 2017001574 A1 CL2017001574 A1 CL 2017001574A1
- Authority
- CL
- Chile
- Prior art keywords
- orlistat
- approximately
- composition
- acarbose
- obesity
- Prior art date
Links
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 title abstract 5
- 229960001243 orlistat Drugs 0.000 title abstract 5
- XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title abstract 2
- 229960002632 acarbose Drugs 0.000 title abstract 2
- XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title abstract 2
- 208000008589 Obesity Diseases 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- CEMXHAPUFJOOSV-XGWNLRGSSA-N (2r,3r,4r,5r)-4-[(2r,3r,4r,5s,6r)-5-[(2r,3r,4s,5s,6r)-3,4-dihydroxy-6-methyl-5-[[(1s,4r,5s,6s)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3,5,6-tetrahydroxyhexanal Chemical compound O([C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@H]1O CEMXHAPUFJOOSV-XGWNLRGSSA-N 0.000 abstract 3
- -1 B) A SECOND PART Chemical compound 0.000 abstract 1
Classifications
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Obesity (AREA)
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- Endocrinology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract
<p>LA PRESENTE INVENCIÓN SE REFIERE A UNA COMPOSICIÓN DE LIBERACIÓN MODIFICADA QUE COMPRENDE ORLISTAT Y ACARBOSA, QUE COMPRENDE PARTES INDIVIDUALMENTE DISTINTAS CON DIFERENTES PATRONES DE LIBERACIÓN: A) UNA PRIMERA PARTE, G1, QUE COMPRENDE DE APROXIMADAMENTE 5 A APROXIMADAMENTE 70% P/P DE LA DOSIS TOTAL DE ACARBOSA, B) UNA SEGUNDA PARTE, G2A, QUE COMPRENDE DE APROXIMADAMENTE 30 A APROXIMADAMENTE 95% P/P DE LA DOSIS TOTAL DE ACARBOSA, C) UNA TERCERA PARTE, G2B, QUE COMPRENDE DE APROXIMADAMENTE 10 A APROXIMADAMENTE 90% P/P DE LA DOSIS TOTAL DE ORLISTAT, Y D) UNA CUARTA PARTE, G3, QUE COMPRENDE DE APROXIMADAMENTE 10 A APROXIMADAMENTE 80% P/P DE LA DOSIS TOTAL DE ORLISTAT, Y LA CONCENTRACIÓN TOTAL DE ACARBOSA Y ORLISTAT, RESPECTIVAMENTE, EN LA COMPOSICIÓN ES DE 100% P/P.</p>
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14198468 | 2014-12-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001574A1 true CL2017001574A1 (es) | 2018-01-26 |
Family
ID=52146175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001574A CL2017001574A1 (es) | 2014-12-17 | 2017-06-16 | Composicion de liberacion modificada de orlistat y acarbosa para el tratamiento de la obesidad y trastornos metabólicos relacionados |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10561617B2 (es) |
| EP (3) | EP3233066B1 (es) |
| JP (1) | JP6607955B2 (es) |
| KR (2) | KR101937069B1 (es) |
| CN (1) | CN107405309B (es) |
| AU (1) | AU2015367422B2 (es) |
| BR (1) | BR112017012714B1 (es) |
| CA (1) | CA2970991C (es) |
| CL (1) | CL2017001574A1 (es) |
| CO (1) | CO2017005834A2 (es) |
| DK (1) | DK3233066T3 (es) |
| EA (1) | EA033448B1 (es) |
| EC (1) | ECSP17035750A (es) |
| ES (1) | ES2901122T3 (es) |
| HU (1) | HUE057093T2 (es) |
| IL (1) | IL252865B2 (es) |
| MX (3) | MX2017007493A (es) |
| MY (1) | MY195038A (es) |
| NZ (1) | NZ732241A (es) |
| PE (1) | PE20171243A1 (es) |
| PH (1) | PH12017550023A1 (es) |
| PL (1) | PL3233066T3 (es) |
| SA (1) | SA517381713B1 (es) |
| SG (1) | SG11201704470PA (es) |
| SI (1) | SI3233066T1 (es) |
| UA (1) | UA122403C2 (es) |
| WO (1) | WO2016097170A1 (es) |
| ZA (1) | ZA201704590B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY195038A (en) | 2014-12-17 | 2023-01-04 | Empros Pharma Ab | A Modified Release Composition of Orlistat and Acarbose for the Treatment of Obesity and Related Metabolic Disorders |
| WO2017213208A1 (ja) * | 2016-06-09 | 2017-12-14 | Ｄｓファーマアニマルヘルス株式会社 | 動物用徐放性製剤組成物 |
| WO2020227437A1 (en) * | 2019-05-06 | 2020-11-12 | Axial Biotherapeutics, Inc. | Sustained release solid dosage forms for modulating the colonic microbiome |
| KR102508141B1 (ko) * | 2019-07-01 | 2023-03-10 | 주식회사 연세대학교 바이오헬스기술지주회사 | 하이드로겔 및 egfr 리간드를 유효성분으로 포함하는 당 배출용 조성물 |
| ES2975442T3 (es) * | 2019-12-11 | 2024-07-05 | Evonik Operations Gmbh | Forma farmacéutica para su uso en el tratamiento o la prevención de una enfermedad |
| CN111297826B (zh) * | 2020-04-20 | 2021-08-03 | 鲁南制药集团股份有限公司 | 一种稳定的奥利司他胶囊及其制备方法 |
| WO2022154687A1 (ru) * | 2021-01-14 | 2022-07-21 | Общество C Ограниченной Ответственностью "Новамедика" | Фармацевтическая композиция, включающая эзомепразол |
| WO2022243525A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Synergistic effects on weight loss, improved quality of life and gastro-intestinal side effects with a composition of orlistat and acarbose |
| WO2022243534A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Reduced rebound effects in subjects treated for overweight or obesity |
| WO2022243528A1 (en) | 2021-05-21 | 2022-11-24 | Empros Pharma Ab | Use of a composition comprising orlistat and acarbose to obtain a sustained weight loss |
| WO2023038575A2 (en) * | 2021-09-09 | 2023-03-16 | Junion Labs Pte. Ltd. | Superabsorbent hydrogels with lipase inhibitor |
| WO2024102902A1 (en) * | 2022-11-10 | 2024-05-16 | Temple University-Of The Commonwealth System Of Higher Education | Methods of treating or preventing liver diseases or disorders |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8101930A (nl) | 1981-04-21 | 1982-11-16 | Philips Nv | Contactinrichting voor een meeraderige kabel. |
| CA2128044C (en) * | 1993-08-05 | 2007-02-20 | Klaus-Dieter Bremer | Pharmaceutical compositions comprising a glucosidase and/or amylase inhibitor, and a lipase inhibitor |
| AU1234399A (en) * | 1997-11-25 | 1999-06-15 | Bayer Aktiengesellschaft | Sustained release formulations comprising alpha-glucosidase-i nhibitors |
| DE19802700A1 (de) * | 1998-01-24 | 1999-07-29 | Bayer Ag | Verfahren zur Herstellung einer im Mund schnell zerfallenden Arzneiform, die als Wirkstoff Acarbose enthält |
| US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
| SI1131070T1 (sl) * | 1998-11-12 | 2008-12-31 | Smithkline Beecham Plc | Farmacevtski sestavek za modificirano sproĺ äśanje senzibilizatorja za inzulin in metformina |
| US6419954B1 (en) * | 2000-05-19 | 2002-07-16 | Yamanouchi Pharmaceutical Co., Ltd. | Tablets and methods for modified release of hydrophilic and other active agents |
| US6849609B2 (en) | 2001-04-10 | 2005-02-01 | James U. Morrison | Method and composition for controlled release acarbose formulations |
| WO2003009840A1 (en) * | 2001-07-24 | 2003-02-06 | Lonza Ag | Composition comprising at least one lipase inhibitor and carnitine |
| CN1296050C (zh) * | 2003-12-10 | 2007-01-24 | 浙江海正药业股份有限公司 | 阿卡波糖肠溶片及制备方法 |
| US20060229261A1 (en) * | 2005-04-12 | 2006-10-12 | John Devane | Acarbose methods and formulations for treating chronic constipation |
| FR2891459B1 (fr) * | 2005-09-30 | 2007-12-28 | Flamel Technologies Sa | Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant |
| EP1872777A1 (en) * | 2006-06-27 | 2008-01-02 | LEK Pharmaceuticals D.D. | Pharmaceutical composition comprising tetrahydrolipstatin |
| KR100857411B1 (ko) * | 2006-07-21 | 2008-09-08 | 한올제약주식회사 | 리파아제 저해제의 경구 투여용 방출조절 약학 제제 및이의 제조 방법 |
| US8110186B2 (en) * | 2006-09-18 | 2012-02-07 | Chelatexx, LLC | Method to maintain the efficacy of orlistat |
| CN100464754C (zh) * | 2007-03-12 | 2009-03-04 | 杭州中美华东制药有限公司 | 阿卡波糖药物组合物及其制备方法 |
| TW200841876A (en) * | 2007-04-18 | 2008-11-01 | Anchen Pharmaceuticals Taiwan Inc | Pharmaceutical composition containing orlistat |
| BRPI0817053A2 (pt) | 2007-09-17 | 2015-03-24 | Reddys Lab Ltd Dr | Formulações farmacêuticas de orlistat |
| US20110256130A1 (en) * | 2008-12-01 | 2011-10-20 | Joshua Robert Schultz | Methods of treating inflammatory disorders |
| AU2011247642C1 (en) | 2010-04-27 | 2015-11-12 | Bayer Intellectual Property Gmbh | Orally disintegrating tablet containing acarbose |
| CN105726460A (zh) * | 2010-07-05 | 2016-07-06 | 雅戈泰克股份公司 | 剂型 |
| TR201100148A2 (tr) * | 2011-01-06 | 2012-07-23 | Bi̇lgi̇ç Mahmut | Stabil akarboz förmülasyonları. |
| CN102872062A (zh) * | 2011-07-13 | 2013-01-16 | 鲁南制药集团股份有限公司 | 一种治疗或预防肥胖症以及代谢综合症的药物组合物 |
| MY195038A (en) | 2014-12-17 | 2023-01-04 | Empros Pharma Ab | A Modified Release Composition of Orlistat and Acarbose for the Treatment of Obesity and Related Metabolic Disorders |
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