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CL2008001297A1 - N-[(1s)-1-(5-fluoropirim idin-2-i1 )etil]-3-(5-isopropoxi-1 h-pirazol-3-il )-3h-imidazo[4,5-b]piridin-5amina o una sal farmacéuticamente aceptabie del mismo; composición farmacéutica que lo comprende; y su uso en el tratamiento del cáncer. - Google Patents

N-[(1s)-1-(5-fluoropirim idin-2-i1 )etil]-3-(5-isopropoxi-1 h-pirazol-3-il )-3h-imidazo[4,5-b]piridin-5amina o una sal farmacéuticamente aceptabie del mismo; composición farmacéutica que lo comprende; y su uso en el tratamiento del cáncer.

Info

Publication number
CL2008001297A1
CL2008001297A1 CL2008001297A CL2008001297A CL2008001297A1 CL 2008001297 A1 CL2008001297 A1 CL 2008001297A1 CL 2008001297 A CL2008001297 A CL 2008001297A CL 2008001297 A CL2008001297 A CL 2008001297A CL 2008001297 A1 CL2008001297 A1 CL 2008001297A1
Authority
CL
Chile
Prior art keywords
pharmaceutically acceptable
acceptable salt
5amine
imidazo
cancer
Prior art date
Application number
CL2008001297A
Other languages
English (en)
Inventor
Tao Wang
Hai-Jun Zhang
Stephanos Ioannidis
Mei Su
Audrey Davies
Michelle Lamb
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CL2008001297A1 publication Critical patent/CL2008001297A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
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    • C07D473/32—Nitrogen atom
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    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
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  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Transplantation (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

N-[(1S)-1-(5-FLUOROPIRIM IDIN-2-IL)ETIL]-3-(5-I50PROPOXI-1 H-PIRAZOL-3-IL )-3H-IMIDAZO[4,5-B]PIRIDIN-5AMINA O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO. DICHO COMPUESTO O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, PARA USAR COMO UN MEDICAMENTO. USO DE DICHO COMPUESTO O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO, PARA EL TRATAMIENTO DEL CÁNCER EN UN ANIMAL E SANGRE CALIENTE.<br /> COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE DICHO COMPUESTO O UNA SAL FARMACÉUTICAMENTE ACEPTABLE DEL MISMO Y POR LO MENOS UN PORTADOR, DILUYENTE O EXCIPIENTE FARMACÉUTICAMENTE ACEPTABLE.  
CL2008001297A 2007-05-04 2008-05-05 N-[(1s)-1-(5-fluoropirim idin-2-i1 )etil]-3-(5-isopropoxi-1 h-pirazol-3-il )-3h-imidazo[4,5-b]piridin-5amina o una sal farmacéuticamente aceptabie del mismo; composición farmacéutica que lo comprende; y su uso en el tratamiento del cáncer. CL2008001297A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91627007P 2007-05-04 2007-05-04

Publications (1)

Publication Number Publication Date
CL2008001297A1 true CL2008001297A1 (es) 2009-01-16

Family

ID=39592016

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CL2008001297A CL2008001297A1 (es) 2007-05-04 2008-05-05 N-[(1s)-1-(5-fluoropirim idin-2-i1 )etil]-3-(5-isopropoxi-1 h-pirazol-3-il )-3h-imidazo[4,5-b]piridin-5amina o una sal farmacéuticamente aceptabie del mismo; composición farmacéutica que lo comprende; y su uso en el tratamiento del cáncer.

Country Status (24)

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US (3) US8486966B2 (es)
EP (1) EP2152705A1 (es)
JP (1) JP5415403B2 (es)
KR (1) KR101563372B1 (es)
CN (1) CN101679426A (es)
AR (1) AR066429A1 (es)
AU (1) AU2008247159B2 (es)
BR (1) BRPI0811534A2 (es)
CA (1) CA2684693C (es)
CL (1) CL2008001297A1 (es)
CO (1) CO6251294A2 (es)
EC (1) ECSP099751A (es)
IL (1) IL201691A0 (es)
MX (1) MX2009011944A (es)
MY (1) MY147890A (es)
NZ (1) NZ581633A (es)
PE (1) PE20090238A1 (es)
RU (1) RU2481348C2 (es)
SA (1) SA08290271B1 (es)
TW (1) TWI406864B (es)
UA (1) UA99459C2 (es)
UY (1) UY31065A1 (es)
WO (1) WO2008135785A1 (es)
ZA (1) ZA200907679B (es)

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RU2009144848A (ru) 2011-06-10
CA2684693C (en) 2015-06-23
KR20100019988A (ko) 2010-02-19
MX2009011944A (es) 2009-12-11
US20140155394A1 (en) 2014-06-05
WO2008135785A1 (en) 2008-11-13
ZA200907679B (en) 2010-07-28
AU2008247159B2 (en) 2011-11-10
RU2481348C2 (ru) 2013-05-10
JP2010526128A (ja) 2010-07-29
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US8486966B2 (en) 2013-07-16
KR101563372B1 (ko) 2015-10-26
PE20090238A1 (es) 2009-04-21
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CO6251294A2 (es) 2011-02-21
TWI406864B (zh) 2013-09-01
AU2008247159A1 (en) 2008-11-13
AR066429A1 (es) 2009-08-19
CN101679426A (zh) 2010-03-24
TW200902530A (en) 2009-01-16
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EP2152705A1 (en) 2010-02-17

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