[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CH621479A5 - - Google Patents

Download PDF

Info

Publication number
CH621479A5
CH621479A5 CH961577A CH961577A CH621479A5 CH 621479 A5 CH621479 A5 CH 621479A5 CH 961577 A CH961577 A CH 961577A CH 961577 A CH961577 A CH 961577A CH 621479 A5 CH621479 A5 CH 621479A5
Authority
CH
Switzerland
Prior art keywords
liposomes
dispersion
hydrophilic compound
powder
dehydration
Prior art date
Application number
CH961577A
Other languages
English (en)
French (fr)
Inventor
Michel Schneider
Bernard Lamy
Original Assignee
Battelle Memorial Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Battelle Memorial Institute filed Critical Battelle Memorial Institute
Priority to CH961577A priority Critical patent/CH621479A5/fr
Priority to FR7822984A priority patent/FR2399241A1/fr
Priority to JP9418978A priority patent/JPS5449317A/ja
Priority to DE2834308A priority patent/DE2834308C2/de
Priority to IL7855276A priority patent/IL55276A0/xx
Priority to SE7808395A priority patent/SE432053B/sv
Priority to IT26509/78A priority patent/IT1097614B/it
Priority to US05/931,243 priority patent/US4229360A/en
Priority to NL7808204A priority patent/NL191452C/xx
Priority to BE78189729A priority patent/BE869551A/xx
Priority to LU80079A priority patent/LU80079A1/xx
Priority to ES472372A priority patent/ES472372A1/es
Priority to AU38665/78A priority patent/AU520915B2/en
Priority to GB7832280A priority patent/GB2002319B/en
Priority to IE1600/78A priority patent/IE47165B1/en
Priority to CA308,795A priority patent/CA1114714A/en
Priority to DK345878A priority patent/DK150786C/da
Publication of CH621479A5 publication Critical patent/CH621479A5/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CH961577A 1977-08-05 1977-08-05 CH621479A5 (sv)

Priority Applications (17)

Application Number Priority Date Filing Date Title
CH961577A CH621479A5 (sv) 1977-08-05 1977-08-05
FR7822984A FR2399241A1 (fr) 1977-08-05 1978-08-03 Procede de deshydratation d'une dispersion colloidale de liposomes
JP9418978A JPS5449317A (en) 1977-08-05 1978-08-03 Dehydrating of liposome colloidal dispersion
DE2834308A DE2834308C2 (de) 1977-08-05 1978-08-03 Verfahren zur Wasserabspaltung aus einer kolloidalen Liposomen-Dispersion
IL7855276A IL55276A0 (en) 1977-08-05 1978-08-03 Process for the dehydration of a colloidal dispersion of liposomes
SE7808395A SE432053B (sv) 1977-08-05 1978-08-04 Forfarande for dehydratisering av en kolloidal dispersion av liposomer
IT26509/78A IT1097614B (it) 1977-08-05 1978-08-04 Procedimento di disidratazione che rende conservabile una dispersione colloidale di liposomi
US05/931,243 US4229360A (en) 1977-08-05 1978-08-04 Process for the dehydration of a colloidal dispersion of lipsomes
NL7808204A NL191452C (nl) 1977-08-05 1978-08-04 Werkwijze voor het dehydrateren van een waterige liposomen-dispersie.
BE78189729A BE869551A (fr) 1977-08-05 1978-08-04 Procede de deshydratation d'une dispersion colloidale de liposomes
LU80079A LU80079A1 (fr) 1977-08-05 1978-08-04 Procede de deshydratation d'une dispersion colloidale de liposomes
ES472372A ES472372A1 (es) 1977-08-05 1978-08-04 Procedimiento para la deshidratacion de una dispersion co- loidal de liposomas
AU38665/78A AU520915B2 (en) 1977-08-05 1978-08-04 Dehydrating colloidal dispersions of liposomes
GB7832280A GB2002319B (en) 1977-08-05 1978-08-04 Process for the dehydration of a colloidal dispersion of liposomes
IE1600/78A IE47165B1 (en) 1977-08-05 1978-08-04 Process for the dehydration of a colloidal dispersion of liposomes
CA308,795A CA1114714A (en) 1977-08-05 1978-08-04 Process for the dehydration of a colloidal dispersion of liposomes
DK345878A DK150786C (da) 1977-08-05 1978-08-04 Fremgangsmaade til dehydratisering af en kolloid dispersion af liposomer i et vandigt medium

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH961577A CH621479A5 (sv) 1977-08-05 1977-08-05

Publications (1)

Publication Number Publication Date
CH621479A5 true CH621479A5 (sv) 1981-02-13

Family

ID=4353829

Family Applications (1)

Application Number Title Priority Date Filing Date
CH961577A CH621479A5 (sv) 1977-08-05 1977-08-05

Country Status (17)

Country Link
US (1) US4229360A (sv)
JP (1) JPS5449317A (sv)
AU (1) AU520915B2 (sv)
BE (1) BE869551A (sv)
CA (1) CA1114714A (sv)
CH (1) CH621479A5 (sv)
DE (1) DE2834308C2 (sv)
DK (1) DK150786C (sv)
ES (1) ES472372A1 (sv)
FR (1) FR2399241A1 (sv)
GB (1) GB2002319B (sv)
IE (1) IE47165B1 (sv)
IL (1) IL55276A0 (sv)
IT (1) IT1097614B (sv)
LU (1) LU80079A1 (sv)
NL (1) NL191452C (sv)
SE (1) SE432053B (sv)

Families Citing this family (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460577A (en) * 1977-09-30 1984-07-17 Farmitalia Carlo Erba S.P.A. Pharmaceutical compositions consisting or consisting essentially of liposomes, and processes for making same
US4356167A (en) * 1978-01-27 1982-10-26 Sandoz, Inc. Liposome drug delivery systems
DE2925009A1 (de) * 1979-06-21 1981-01-08 Basf Ag Zubereitung fuer substanzen, verfahren zu deren herstellung und deren verwendung
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
EP0032622B1 (en) * 1979-12-20 1985-08-14 Dennis Chapman Polymerisable phospholipids and polymers thereof, methods for their preparation, methods for their use in coating substrates and forming liposomes and the resulting coated substrates and liposome compositions
US4933114A (en) * 1980-08-11 1990-06-12 Eastman Kodak Company Polyacetylenic lipids, radiation-sensitive compositions, photographic elements and processes relating to same
JPS5782310A (en) * 1980-11-11 1982-05-22 Tanabe Seiyaku Co Ltd Production of liposome preparation
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4612370A (en) * 1982-04-02 1986-09-16 The Regents Of The University Of California Lipid-saccharide reaction products
US4425334A (en) 1982-04-02 1984-01-10 The Regents Of The University Of California Functional oxygen transport system
GB2135647A (en) * 1983-02-15 1984-09-05 Squibb & Sons Inc Method of preparing liposomes and products produced thereby
US5186941A (en) * 1983-05-06 1993-02-16 Vestar, Inc. Vesicle formulation for the controlled release of therapeutic agents
US4515736A (en) * 1983-05-12 1985-05-07 The Regents Of The University Of California Method for encapsulating materials into liposomes
JPS607932A (ja) * 1983-06-29 1985-01-16 Dai Ichi Seiyaku Co Ltd リポソーム懸濁液およびその製法
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US5141674A (en) * 1984-03-08 1992-08-25 Phares Pharmaceutical Research N.V. Methods of preparing pro-liposome dispersions and aerosols
JPS60239417A (ja) * 1984-05-15 1985-11-28 Sankyo Co Ltd エマルシヨン凍結乾燥製剤の製法
SE8403905D0 (sv) * 1984-07-30 1984-07-30 Draco Ab Liposomes and steroid esters
US5736155A (en) * 1984-08-08 1998-04-07 The Liposome Company, Inc. Encapsulation of antineoplastic agents in liposomes
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
AU587600B2 (en) * 1985-01-11 1989-08-24 Regents Of The University Of California, The Method for preserving liposomes
US4857319A (en) * 1985-01-11 1989-08-15 The Regents Of The University Of California Method for preserving liposomes
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
IE58981B1 (en) * 1985-10-15 1993-12-15 Vestar Inc Anthracycline antineoplastic agents encapsulated in phospholipid micellular particles
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
SE8601457D0 (sv) * 1986-04-01 1986-04-01 Draco Ab Compositions of liposomes and b?712-receptor active substances for inhalation
US4804539A (en) * 1986-07-28 1989-02-14 Liposome Technology, Inc. Ophthalmic liposomes
US4839175A (en) * 1986-07-28 1989-06-13 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
EP0316345A1 (en) * 1986-07-28 1989-05-24 Liposome Technology, Inc. Liposomes with enhanced retention on mucosal tissue
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
FR2634375B3 (fr) * 1988-06-30 1991-07-05 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles de lipide amphiphiles sous forme de liposomes submicroniques
CA1321351C (en) * 1987-02-23 1993-08-17 Helmut Otmar Hauser Method of dehydrating vesicle preparations for long-term storage
US5089181A (en) * 1987-02-24 1992-02-18 Vestar, Inc. Method of dehydrating vesicle preparations for long term storage
US6406713B1 (en) 1987-03-05 2002-06-18 The Liposome Company, Inc. Methods of preparing low-toxicity drug-lipid complexes
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
KR970005171B1 (ko) * 1987-05-22 1997-04-14 더 리포조옴 캄파니, 인코포레이티드 아라키돈산 대사물질 관련 리포좀 제조방법 및 그 제제
US5262168A (en) * 1987-05-22 1993-11-16 The Liposome Company, Inc. Prostaglandin-lipid formulations
US5925375A (en) * 1987-05-22 1999-07-20 The Liposome Company, Inc. Therapeutic use of multilamellar liposomal prostaglandin formulations
US4963362A (en) * 1987-08-07 1990-10-16 Regents Of The University Of Minnesota Freeze-dried liposome mixture containing cyclosporin
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US4950432A (en) * 1987-10-16 1990-08-21 Board Of Regents, The University Of Texas System Polyene microlide pre-liposomal powders
MX9203804A (es) * 1987-10-19 1992-07-01 Liposome Co Inc Sistemas farmaceuticos a base de tocoferol.
JPH03502327A (ja) * 1988-01-19 1991-05-30 ボード・オブ・リージェンツ，ザ・ユニバーシティ・オブ・テキサス・システム ３’‐デアミノドキソルビシンのエステル体、そのリポソーム組成物およびその使用方法
JPH01160962U (sv) * 1988-04-28 1989-11-08
US5096629A (en) * 1988-08-29 1992-03-17 501 Nippon Fine Chemical Co., Ltd. Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
EP0437479B1 (en) * 1988-10-05 1994-06-22 Vestar, Inc. Method of making liposomes with improved stability during drying
US4931361A (en) * 1988-11-18 1990-06-05 California Institute Of Technology Cryoprotective reagents in freeze-drying membranes
JP2807741B2 (ja) * 1988-12-22 1998-10-08 コレチカ リポソームの安定化方法、安定化リポソーム組成物、ならびにそれを含む医薬組成物および化粧料組成物
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5733572A (en) * 1989-12-22 1998-03-31 Imarx Pharmaceutical Corp. Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US6146657A (en) * 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5773024A (en) * 1989-12-22 1998-06-30 Imarx Pharmaceutical Corp. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5922304A (en) * 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US5305757A (en) * 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US6001335A (en) * 1989-12-22 1999-12-14 Imarx Pharmaceutical Corp. Contrasting agents for ultrasonic imaging and methods for preparing the same
US5776429A (en) * 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5656211A (en) * 1989-12-22 1997-08-12 Imarx Pharmaceutical Corp. Apparatus and method for making gas-filled vesicles of optimal size
US5882678A (en) * 1990-01-12 1999-03-16 The Liposome Co, Inc. Interdigitation-fusion liposomes containing arachidonic acid metabolites
IN172208B (sv) * 1990-04-02 1993-05-01 Sint Sa
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US20040208826A1 (en) * 1990-04-02 2004-10-21 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US7083778B2 (en) * 1991-05-03 2006-08-01 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US20010024638A1 (en) * 1992-11-02 2001-09-27 Michel Schneider Stable microbubble suspensions as enhancement agents for ultrasound echography and dry formulations thereof
USRE39146E1 (en) 1990-04-02 2006-06-27 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
US6613306B1 (en) 1990-04-02 2003-09-02 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US6989141B2 (en) * 1990-05-18 2006-01-24 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US20030194376A1 (en) * 1990-05-18 2003-10-16 Bracco International B.V. Ultrasound contrast agents and methods of making and using them
AU636481B2 (en) * 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
WO1992002244A1 (en) * 1990-07-31 1992-02-20 The Liposome Company, Inc. Accumulation of amino acids and peptides into liposomes
US5556637A (en) * 1990-08-06 1996-09-17 A. Nattermann & Cie. Gmbh Water containing liposome system
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) * 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
IL104084A (en) * 1992-01-24 1996-09-12 Bracco Int Bv Sustainable aqueous suspensions of pressure-resistant and gas-filled blisters, their preparation, and contrast agents containing them
JP2711619B2 (ja) * 1992-07-23 1998-02-10 理化学研究所 殺菌殺虫組成物
US5554730A (en) * 1993-03-09 1996-09-10 Middlesex Sciences, Inc. Method and kit for making a polysaccharide-protein conjugate
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ATE163230T1 (de) * 1993-03-09 1998-02-15 Epic Therapeutics Inc Makromolekulare mikropartikel und verfahren zu ihrer herstellung
EP0699068B1 (en) * 1993-05-21 2001-12-19 The Liposome Company, Inc. Reduction of liposome-induced adverse physiological reactions
US6004534A (en) * 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
PT725629E (pt) * 1993-10-25 2000-11-30 Liposome Co Inc Defensinas em lipossomas
AU683957B2 (en) 1993-11-05 1997-11-27 Amgen, Inc. Liposome preparation and material encapsulation method
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
RU2138293C1 (ru) * 1993-12-15 1999-09-27 Бракко Рисерч С.А. Контрастные вещества для ультразвуковой эхографии, контрастные средства, содержащие эти вещества, и способы их приготовления
US5736121A (en) * 1994-05-23 1998-04-07 Imarx Pharmaceutical Corp. Stabilized homogenous suspensions as computed tomography contrast agents
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6066331A (en) * 1994-07-08 2000-05-23 Barenholz; Yechezkel Method for preparation of vesicles loaded with biological structures, biopolymers and/or oligomers
CZ297271B6 (cs) * 1994-07-12 2006-10-11 Bpsi Holdings, Inc. Suchá povlaková hmota pro výrobu filmu zabranujícímu prístupu vlhkosti, zpusob a tvorba povlaku
DE4430592A1 (de) * 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5589189A (en) * 1994-09-14 1996-12-31 Nexstar Pharmaceuticals, Inc. Liposome dispersion
IL115099A (en) * 1994-10-14 1999-04-11 Upjohn Co Lyophilizate of phospholipid complex of water insoluble camptothecins
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5830430A (en) * 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5997898A (en) * 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6139819A (en) * 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5855911A (en) * 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
DE19605175A1 (de) 1996-02-13 1997-08-14 Sourovoi Andrej Dr Lipidverbindungen und deren Verwendung
US6015576A (en) * 1997-08-29 2000-01-18 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to an antigen
US6207185B1 (en) 1996-03-22 2001-03-27 Bio-Sphere Technology Method for inducing a systemic immune response to an HIV antigen
US6117449A (en) * 1996-03-22 2000-09-12 Bio-Sphere Technology, Inc. Method for inducing a systemic immune response to a hepatitis antigen
CA2174803C (en) * 1996-04-23 2000-07-11 Jonathan P. Wong Use of liposome encapsulated ciprofloxacin as an immunotherapeutic drug
JP2001507207A (ja) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 化合物を細胞に送達する方法
US6093816A (en) 1996-06-27 2000-07-25 Isis Pharmaceuticals, Inc. Cationic lipids
US7309692B1 (en) * 1996-07-08 2007-12-18 Board Of Regents, The University Of Texas System Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE69737915T2 (de) * 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6977244B2 (en) * 1996-10-04 2005-12-20 Board Of Regents, The University Of Texas Systems Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
EP1009383A1 (en) * 1997-09-04 2000-06-21 Biozone Laboratories, Inc. Oral liposomal delivery system
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6037323A (en) 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en) * 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6518412B1 (en) * 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6033708A (en) * 1997-09-30 2000-03-07 The United States Of America As Represented By The Secretary Of The Navy Method for producing sterile filterable liposome dispersion
US6287590B1 (en) 1997-10-02 2001-09-11 Esperion Therapeutics, Inc. Peptide/lipid complex formation by co-lyophilization
US7285288B1 (en) 1997-10-03 2007-10-23 Board Of Regents, The University Of Texas System Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
US7704962B1 (en) 1997-10-03 2010-04-27 Board Of Regents, The University Of Texas System Small oligonucleotides with anti-tumor activity
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9902527D0 (en) * 1999-02-04 1999-03-24 Phares Pharm Res Nv Compositions
WO2001020999A1 (en) * 1999-09-23 2001-03-29 Trimedyne, Inc. Materials and methods for inducing angiogenesis and the repair of mammalian tissue
US20040009229A1 (en) * 2000-01-05 2004-01-15 Unger Evan Charles Stabilized nanoparticle formulations of camptotheca derivatives
CA2408332C (en) * 2000-05-08 2011-02-15 The University Of British Columbia Supports for photosensitizer formulations
AU2002246510B2 (en) * 2000-11-09 2007-09-20 Neopharm, Inc. SN-38 lipid complexes and methods of use
AU2002219998B2 (en) * 2000-12-01 2006-03-02 Biomira, Inc. Preparation of large liposomes by infusion into peg
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
US20040043950A1 (en) * 2002-01-03 2004-03-04 Board Of Regents, The University Of Texas System WT1 antisense oligos for the inhibition of breast cancer
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
US20030219473A1 (en) * 2002-03-26 2003-11-27 Leila Zarif Cochleates made with purified soy phosphatidylserine
US20030212046A1 (en) * 2002-05-07 2003-11-13 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
US20060093661A1 (en) * 2002-05-07 2006-05-04 Kapac, Llc Methods and formulations for enhancing the absorption and gastro-intestinal bioavailability of hydrophobic drugs
CN1245153C (zh) * 2002-06-06 2006-03-15 上海家化联合股份有限公司 一种维生素a脂质体及其制备方法
WO2004035032A2 (en) * 2002-08-20 2004-04-29 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20080045575A1 (en) * 2004-12-29 2008-02-21 Van Dyke Thomas E Delivery of H2 Antagonists
US20080094573A1 (en) * 2006-04-04 2008-04-24 Vermette Patrick Surface-modified materials, such as contact lenses, methods and kits for their preparation, and uses thereof
US8163699B2 (en) * 2006-06-01 2012-04-24 Montreal Heart Institute Method for the treatment of valvular disease
EP2081551B1 (en) * 2006-10-06 2013-01-23 Scil Technology GmbH Dried reconstituted vesicle formation for pharmaceutical application
US20080124387A1 (en) 2006-11-27 2008-05-29 Kapac, Llc Methods and formulations for enhancing the absorption and decreasing the absorption variability of orally administered drugs, vitamins and nutrients
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008135855A2 (en) 2007-05-03 2008-11-13 Pfizer Products Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer
WO2008149192A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
US20090088393A1 (en) * 2007-09-28 2009-04-02 Zomanex, Llc Methods and formulations for converting intravenous and injectable drugs into oral dosage forms
US20090092538A1 (en) 2007-10-08 2009-04-09 Amit Khanolkar Methods for forming stabilized metal salt particles
EP2231169B1 (en) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2240162A4 (en) 2007-12-06 2013-10-09 Bend Res Inc NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER
EP2939683B1 (en) 2009-02-16 2017-01-04 Cerenis Therapeutics Holding SA Apolipoprotein A-I Mimics
PL2445472T3 (pl) 2009-06-24 2018-07-31 Lipoid Gmbh Kompozycja do zastosowań kosmetycznych, farmaceutycznych lub dietetycznych
EP2394640A1 (en) 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
US20110318406A1 (en) * 2010-06-23 2011-12-29 Eley Crispin G S Lecithin carrier vesicles and methods of making the same
JP2012102043A (ja) * 2010-11-10 2012-05-31 Konica Minolta Holdings Inc 単胞リポソームの製造方法、単胞リポソームの分散液とその乾燥粉末及びそれらの製造方法
AU2015374286B2 (en) 2014-12-31 2021-11-18 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
CA3020857A1 (en) 2016-04-14 2017-10-19 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
US10188749B2 (en) 2016-04-14 2019-01-29 Fred Hutchinson Cancer Research Center Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers
IL296876A (en) 2016-05-04 2022-12-01 Lantheus Medical Imaging Inc Methods and devices for preparing sharpness factors for ultrasound
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
US20190336532A1 (en) 2016-12-21 2019-11-07 Fred Hutchinson Cancer Research Center Scaffolds to treat solid tumor cells and escape variants
US11566061B2 (en) 2017-01-05 2023-01-31 Fred Hutchinson Cancer Center Systems and methods to improve vaccine efficacy
EP3986563A1 (en) 2019-06-20 2022-04-27 Janssen Sciences Ireland Unlimited Company Lipid nanoparticle or liposome delivery of hepatitis b virus (hbv) vaccines
TW202245809A (zh) 2020-12-18 2022-12-01 美商詹森藥物公司 用於治療b型肝炎病毒感染之組合療法
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2658020A (en) * 1948-06-11 1953-11-03 Gibone Trust Method of preparing a hemostatic agent
NL246986A (sv) * 1959-01-02 1900-01-01
US3012888A (en) * 1959-04-13 1961-12-12 Central Soya Co Method for preparing a granular oilfree phosphatide product
US3060030A (en) * 1960-04-04 1962-10-23 Carl F Obenauf Lecithinated product
US3549382A (en) * 1968-05-15 1970-12-22 Francis Frederick Hansen Method of preparing powdered monoglyceride material
FR2081586A2 (en) * 1970-01-24 1971-12-10 Orsymonde Dehydrated pharmaceutical comps by - lyophilisation
CH588887A5 (sv) * 1974-07-19 1977-06-15 Battelle Memorial Institute
US3957971A (en) * 1974-07-29 1976-05-18 Lever Brothers Company Moisturizing units and moisturizing compositions containing the same
JPS5126213A (ja) * 1974-08-21 1976-03-04 Tanabe Seiyaku Co Johoseibiryushiseizaino seiho
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds

Also Published As

Publication number Publication date
US4229360B1 (sv) 1991-11-05
FR2399241A1 (fr) 1979-03-02
NL191452B (nl) 1995-03-16
IE47165B1 (en) 1984-01-11
ES472372A1 (es) 1979-03-16
GB2002319A (en) 1979-02-21
FR2399241B1 (sv) 1983-02-18
IL55276A0 (en) 1978-10-31
LU80079A1 (fr) 1979-05-15
IT7826509A0 (it) 1978-08-04
GB2002319B (en) 1982-02-24
AU3866578A (en) 1980-02-07
CA1114714A (en) 1981-12-22
DK150786B (da) 1987-06-22
DE2834308C2 (de) 1986-09-25
DK150786C (da) 1988-01-25
DE2834308A1 (de) 1979-02-15
SE432053B (sv) 1984-03-19
IE781600L (en) 1979-02-07
IT1097614B (it) 1985-08-31
SE7808395L (sv) 1979-02-06
NL7808204A (nl) 1979-02-07
JPS6121449B2 (sv) 1986-05-27
US4229360A (en) 1980-10-21
AU520915B2 (en) 1982-03-04
DK345878A (da) 1979-02-06
BE869551A (fr) 1979-02-05
JPS5449317A (en) 1979-04-18
NL191452C (nl) 1995-07-18

Similar Documents

Publication Publication Date Title
CH621479A5 (sv)
FI111333B (sv) Fast lyofiliserad beredningsform och dess framställning
Sun et al. Stability of dry liposomes in sugar glasses
Ganeson et al. Improved functionality of cinnamon oil emulsion-based gelatin films as potential edible packaging film for wax apple
JPH0753661B2 (ja) プロ―リポソーム組成物及びリポソームの水性分散物を作る方法
FR2561916A1 (fr) Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
CH643154A5 (fr) Procede d'obtention de dispersions stables dans une phase aqueuse d'au moins une phase liquide non miscible a l'eau et dispersions correspondantes.
Gharib et al. Hydroxypropyl-ß-cyclodextrin as a membrane protectant during freeze-drying of hydrogenated and non-hydrogenated liposomes and molecule-in-cyclodextrin-in-liposomes: Application to trans-anethole
CN108851072A (zh) 一种紫甘薯花青素纳米脂质体及其制备方法
Gharib et al. First study on the release of a natural antimicrobial agent, estragole, from freeze-dried delivery systems based on cyclodextrins and liposomes
KR101209496B1 (ko) 나노입자 제제를 보관하는 방법
Nounou et al. Influence of different sugar cryoprotectants on the stability and physico-chemical characteristics of freeze-dried 5-fluorouracil plurilamellar vesicles
FR2774261A1 (fr) Composition a usage alimentaire sous forme d'une emulsion seche, son procede de fabrication et son utilisation
JPH0362696B2 (sv)
KR101687735B1 (ko) 신규의 동결건조보조제 및 새로운 인지질 용해용 혼합용매를 이용한 리포좀 동결분체의 제조방법
WO1992017162A1 (en) Lyophilized emulsion
CH674918A5 (sv)
EP0721327B1 (fr) Composition aerosol apte a former une membrane, de preference hydratee, membrane, de preference hydratee, ainsi obtenue et ses applications, notamment a titre de pansement
JPH05132666A (ja) 不凍液
US20220330563A1 (en) Preservative-free freezed-dried foods and methods of making the same
CN114680334A (zh) 一种壳聚糖修饰肉桂精油脂质体的制备方法
JP3102612B2 (ja) 凍結小胞体
AU677198C (en) Pharmaceutical and other dosage forms
CN118476985A (zh) 一种负载熊果苷的无表面活性剂微乳液、制备方法和用途
WO2021239904A1 (fr) Formulations pour la catalyse métallique dans l'eau comprenant un tensioactif et un composé lipophile

Legal Events

Date Code Title Description
PL Patent ceased