CH612424A5 - - Google Patents

Info

Publication number: CH612424A5
Authority: CH; Switzerland

Application number

CH216478A

Inventor

Jacques E Delarge

Charles L Lapiere

Andre H Georges

Original Assignee

Christiaens Sa A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-17

Filing date

1975-04-16

Publication date

1979-07-31

1975-04-16 Application filed by Christiaens Sa A filed Critical Christiaens Sa A

1979-07-31 Publication of CH612424A5 publication Critical patent/CH612424A5/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CH216478A 1974-04-17 1975-04-16 CH612424A5 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB1683674A GB1477664A (en)	1974-04-17	1974-04-17	Pyridine derivatives
YU1507/81A YU42409B (en)	1974-04-17	1981-06-15	Process for obtaining new pyridine derivatives

Publications (1)

Publication Number	Publication Date
CH612424A5 true CH612424A5 (es)	1979-07-31

Family

ID=26252269

Family Applications (3)

Application Number	Title	Priority Date
CH485775A CH609045A5 (es)	1974-04-17	1975-04-16
CH216478A CH612424A5 (es)	1974-04-17	1975-04-16
CH216378A CH610890A5 (es)	1974-04-17	1975-04-16

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CH485775A CH609045A5 (es)	1974-04-17	1975-04-16

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CH216378A CH610890A5 (es)	1974-04-17	1975-04-16

Country Status (19)

Country	Link
US (2)	US4018929A (es)
JP (1)	JPS5951536B2 (es)
AR (4)	AR211097A1 (es)
AT (1)	AT344170B (es)
BE (1)	BE827844A (es)
CA (1)	CA1070313A (es)
CH (3)	CH609045A5 (es)
DD (2)	DD126887A5 (es)
DE (1)	DE2516025A1 (es)
ES (4)	ES436581A1 (es)
FR (1)	FR2267775B1 (es)
GB (1)	GB1477664A (es)
HU (1)	HU171420B (es)
IL (1)	IL47084A (es)
LU (2)	LU72284A1 (es)
NL (2)	NL183580C (es)
SE (2)	SE424320B (es)
YU (1)	YU42409B (es)
ZA (1)	ZA752243B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1593609A (en) *	1978-01-31	1981-07-22	Christiaens Sa A	Pyridine sulfonamides
US4776878A (en) *	1978-12-04	1988-10-11	E. I. Du Pont De Nemours And Company	Agricultural pyridinesulfonamides
LU85193A1 (fr) *	1984-01-31	1985-09-12	Christiaens Sa A	Nouveaux derives de la 4-phenylaminopyridine,leur utilisation et leur preparation
DE3529529A1 (de) *	1985-08-17	1987-02-19	Boehringer Mannheim Gmbh	Verfahren zur herstellung einer stabilen modifikation von torasemid
US4914203A (en) *	1987-07-24	1990-04-03	American Home Products Corporation	5 step process for preparing certain 2,4-diamino-5-pyrimidine-sulfonyl ureas
US4853389A (en) *	1987-07-24	1989-08-01	American Home Products Corporation	Diuretic and antihypertensive substituted-5-pyrimidinesulfonylureas
FR2659080B1 (fr) *	1990-03-02	1994-07-08	Adir	Nouveaux derives de la pyridylsulfonyluree et de la pyridylsulfonylthiouree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5166162A (en) *	1990-03-02	1992-11-24	Adir Et Compagnie	Pyridylsulfonylurea and pyridylsulfonylthiourea compounds
US5486530A (en) *	1991-04-27	1996-01-23	Boehringer Mannheim Gmbh	Use of torasemide for the treatment of brain oedemas
IT1288123B1 (it) *	1996-09-04	1998-09-10	Nicox Sa	Uso di nitroderivati per l'incontinenza urinaria
HRP980532B1 (en) *	1998-10-02	2005-06-30	Pliva	Novel crystalline torasemide modification
US6166045A (en) *	1998-06-02	2000-12-26	Roche Diagnostics Gmbh	Torasemide of modification III
US8722668B2 (en) *	1998-12-23	2014-05-13	Daryl W. Hochman	Methods and compositions for the treatment of neuropathic pain and neuropsychiatric disorders
US7214711B2 (en) *	1998-12-23	2007-05-08	Neurotherapeutics Pharma Llc	Method of treating migraine headache without aura
US8008283B2 (en) *	1998-12-23	2011-08-30	Neurotherapeutics Pharma, Inc.	Methods and compositions for the treatment of neuropsychiatric disorders
DE00957398T1 (de) *	1999-08-11	2004-04-15	Teva Pharmaceutical Industries Ltd.	Polymorphe des torsemids
SK11632003A3 (sk)	2000-02-17	2004-04-06	Teva Pharmaceutical Industries Ltd.	Stabilný farmaceutický prípravok obsahujúci modifikáciu II torsemidu
HRP20000162B1 (en) *	2000-03-20	2004-06-30	Pliva D D	Amorphous torasemide modification
EP1741429A3 (en) *	2000-03-20	2007-01-17	Teva Pharmaceutical Industries Ltd.	Processes for preparing torsemide
CN1623987A (zh) *	2000-03-20	2005-06-08	特瓦制药工业有限公司	托拉塞米的制备方法
HRP20000328A2 (en) *	2000-05-19	2002-02-28	Pliva Farmaceutska Ind Dionik	Novel polymorph v of torasemide
US20030022921A1 (en) *	2001-02-21	2003-01-30	Minutza Leibovici	Stable pharmaceutical formulation comprising torsemide modification II
IN192178B (es)	2001-08-03	2004-03-06	Ranbaxy Lab
IL149771A0 (en) *	2002-05-21	2002-11-10	Fintech Lab Ltd	Process for preparation of torsemide
HRP20020603B1 (en) *	2002-07-19	2008-11-30	Pliva D.D.	New process for the preparation of modification i n-(1-methylethylaminocarbonyl)-4-(3-methylphenylamino)-3-pyridinesulfonamide
GEP20074134B (en)	2002-08-19	2007-06-25	Pfizer Prod Inc	Combination therapy for hyperproliferative diseases
CA2401546C (en) *	2002-09-06	2006-09-19	Brantford Chemicals Inc.	Preparation of derivatives of 3-sulfonamido-4-phenylaminopyridine
ITMI20022749A1 (it) *	2002-12-23	2004-06-24	Cosma S P A	Nuovo procedimento per la sintesi della tosemide, in particolare della forma ii pura e stabile.
US20050037063A1 (en) *	2003-07-21	2005-02-17	Bolton Anthony E.	Combined therapies
US20050215600A1 (en) *	2003-10-27	2005-09-29	Arie Gutman	Polymorphs of torsemide hydrochloride and process for production thereof
US7378527B2 (en) *	2004-03-16	2008-05-27	Daqing Che	Process for the preparation of torsemide and related intermediates
US20070149526A1 (en) *	2005-10-17	2007-06-28	Neurotherapeutics Pharma, L.L.C.	Diuretic and diuretic-like compound analogs
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
US7625896B2 (en) *	2005-11-25	2009-12-01	Hoffman-La Roche Inc.	Pyridylsulfonamide derivatives
US7939532B2 (en) *	2006-10-26	2011-05-10	Hoffmann-La Roche Inc.	Heterocyclyl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
JP5498168B2 (ja)	2006-12-01	2014-05-21	ブリストル−マイヤーズスクイブカンパニー	アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
WO2008138594A1 (en) *	2007-05-16	2008-11-20	F. Hoffmann-La Roche Ag	Aryl pyridyl sulfonamide derivatives, their manufacture and use as pharmaceutical agents
NL2006622C2 (en)	2011-04-18	2012-10-22	Eurovet Animal Health B V	Use of a composition comprising torasemide.
WO2014014519A1 (en)	2012-07-20	2014-01-23	University Of Rochester	Method of treating and preventing brain impairment using na+-k+ -2ci- cotransporter isoform 1 inhibitors
AU2014255381A1 (en)	2013-04-17	2015-10-08	Pfizer Inc.	N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
JP6929792B2 (ja) *	2015-02-16	2021-09-01	ザユニバーシティオブクィーンズランド	スルホニル尿素及び関連化合物並びにその使用
CN110914256A (zh)	2017-07-07	2020-03-24	英夫拉索姆有限公司	新颖磺酰胺羧酰胺化合物
JOP20210193A1 (ar)	2019-01-18	2023-01-30	Astrazeneca Ab	مثبطات pcsk9 وطرق استخدامها

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3674794A (en) *	1970-03-18	1972-07-04	Ciba Geigy Corp	Certain-3-pyridine-sulfonamide derivatives
GB1368948A (en) *	1970-11-11	1974-10-02	Manuf Prod Pharma	Pyridine derivatives
US3904636A (en) *	1971-11-09	1975-09-09	Christiaens Sa A	3-sulfonamido-4-phenyl aminopyridines and derivatives
GB1414793A (en) *	1972-07-28	1975-11-19	Manuf Prod Pharma	Derivatives of phenylaminopyridine

1974
- 1974-04-17 GB GB1683674A patent/GB1477664A/en not_active Expired
1975
- 1975-04-08 ZA ZA00752243A patent/ZA752243B/xx unknown
- 1975-04-11 BE BE155330A patent/BE827844A/xx not_active IP Right Cessation
- 1975-04-12 DE DE19752516025 patent/DE2516025A1/de active Granted
- 1975-04-14 IL IL47084A patent/IL47084A/xx unknown
- 1975-04-14 HU HU75CI00001569A patent/HU171420B/hu unknown
- 1975-04-14 ES ES436581A patent/ES436581A1/es not_active Expired
- 1975-04-15 LU LU72284A patent/LU72284A1/xx unknown
- 1975-04-16 FR FR7511791A patent/FR2267775B1/fr not_active Expired
- 1975-04-16 CH CH485775A patent/CH609045A5/xx not_active IP Right Cessation
- 1975-04-16 CH CH216478A patent/CH612424A5/xx not_active IP Right Cessation
- 1975-04-16 NL NLAANVRAGE7504521,A patent/NL183580C/xx active Protection Beyond IP Right Term
- 1975-04-16 CH CH216378A patent/CH610890A5/xx not_active IP Right Cessation
- 1975-04-16 SE SE7504409A patent/SE424320B/xx unknown
- 1975-04-16 US US05/568,759 patent/US4018929A/en not_active Expired - Lifetime
- 1975-04-16 CA CA224,805A patent/CA1070313A/en not_active Expired
- 1975-04-16 AT AT288275A patent/AT344170B/de not_active IP Right Cessation
- 1975-04-17 DD DD194800A patent/DD126887A5/xx unknown
- 1975-04-17 AR AR258409A patent/AR211097A1/es active
- 1975-04-17 JP JP50047371A patent/JPS5951536B2/ja not_active Expired
- 1975-04-17 DD DD185508A patent/DD121936A5/xx unknown
1976
- 1976-03-19 AR AR262626A patent/AR208769A1/es active
- 1976-03-19 AR AR262627A patent/AR208770A1/es active
- 1976-03-19 AR AR262625A patent/AR208768A1/es active
- 1976-11-15 ES ES453327A patent/ES453327A1/es not_active Expired
- 1976-11-15 ES ES453329A patent/ES453329A1/es not_active Expired
- 1976-11-15 ES ES453328A patent/ES453328A1/es not_active Expired
1979
- 1979-09-13 SE SE7907618A patent/SE7907618L/sv not_active Application Discontinuation
1980
- 1980-02-07 US US06/119,601 patent/USRE30633E/en not_active Expired - Lifetime
1981
- 1981-06-15 YU YU1507/81A patent/YU42409B/xx unknown
1993
- 1993-06-30 LU LU88346C patent/LU88346I2/fr unknown
1994
- 1994-07-27 NL NL940014C patent/NL940014I2/nl unknown

Also Published As

Publication number	Publication date
ATA288275A (de)	1977-11-15
AR211097A1 (es)	1977-10-31
DD121936A5 (es)	1976-09-05
SE7504409L (sv)	1975-10-20
IL47084A0 (en)	1975-06-25
CH609045A5 (es)	1979-02-15
HU171420B (hu)	1978-01-28
LU88346I2 (fr)	1994-05-04
NL183580C (nl)	1988-12-01
NL940014I2 (nl)	1997-04-01
DE2516025C2 (es)	1988-11-03
US4018929A (en)	1977-04-19
YU42409B (en)	1988-08-31
ES453329A1 (es)	1977-11-16
JPS50142571A (es)	1975-11-17
SE7907618L (sv)	1979-09-13
AT344170B (de)	1978-07-10
YU150781A (en)	1984-02-29
DE2516025A1 (de)	1975-11-06
BE827844A (fr)	1975-10-13
USRE30633E (en)	1981-06-02
FR2267775B1 (es)	1978-11-10
ES453327A1 (es)	1977-11-16
AR208770A1 (es)	1977-02-28
CA1070313A (en)	1980-01-22
AR208768A1 (es)	1977-02-28
CH610890A5 (es)	1979-05-15
ES453328A1 (es)	1977-11-01
JPS5951536B2 (ja)	1984-12-14
AR208769A1 (es)	1977-02-28
NL183580B (nl)	1988-07-01
DD126887A5 (es)	1977-08-17
FR2267775A1 (es)	1975-11-14
LU72284A1 (es)	1975-08-20
IL47084A (en)	1979-01-31
NL7504521A (nl)	1975-10-21
NL940014I1 (nl)	1994-09-16
SE424320B (sv)	1982-07-12
GB1477664A (en)	1977-06-22
ZA752243B (en)	1976-03-31
ES436581A1 (es)	1977-04-01
AU8001675A (en)	1976-10-14

Publication	Publication Date	Title
FR2267775A1 (es)	1975-11-14
AU7462274A (es)	1976-04-29
AU7459574A (es)	1976-04-29
AU488280B2 (es)	1976-07-15
BG19995A1 (es)	1975-10-30
BG19879A1 (es)	1975-10-30
AU481915A (es)	1975-09-11
AU482171A (es)	1975-10-16
AU482236A (es)	1976-05-06
AU482308A (es)	1975-12-18
AU482332A (es)	1976-02-12
AU481516A (es)	1975-07-10
AU480783A (es)	1976-06-24
AU480371A (es)	1975-04-24
BE833391A (es)	1975-12-31
BG19609A2 (es)	1975-10-10
BG19639A1 (es)	1975-10-10
BG19643A1 (es)	1975-10-10
BG19729A1 (es)	1975-12-20
BG20242A1 (es)	1975-11-05
BG19890A1 (es)	1975-10-30
BG19905A1 (es)	1975-10-30
BG19908A1 (es)	1975-10-30
BG19927A1 (es)	1975-10-30
BG19999A1 (es)	1975-10-30

Legal Events

Date	Code	Title	Description
1995-06-30	PL	Patent ceased
2024-10-31	PL	Patent ceased