CA3205010A1 - Antibody variable domains and antibodies having decreased immunogenicity - Google Patents

Antibody variable domains and antibodies having decreased immunogenicity

Info

Publication number: CA3205010A1
Authority: CA; Canada
Prior art keywords: seq; sequence; antibody; amino acid; antibody variable
Prior art date: 2020-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CA3205010A

Other languages

English (en)

French (fr)

Inventor

Maria JOHANSSON

Julia Tietz

Stefan Warmuth

Matthias Brock

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Numab Therapeutics AG

Original Assignee

Numab Therapeutics AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-12-23

Filing date

2021-12-23

Publication date

2022-06-30

2020-12-23 Priority claimed from EP20216957.9A external-priority patent/EP4019547A1/en

2021-05-28 Priority claimed from PCT/EP2021/064427 external-priority patent/WO2021239987A1/en

2021-12-23 Application filed by Numab Therapeutics AG filed Critical Numab Therapeutics AG

2021-12-23 Priority claimed from PCT/EP2021/087618 external-priority patent/WO2022136693A1/en

2022-06-30 Publication of CA3205010A1 publication Critical patent/CA3205010A1/en

Status Pending legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

CA3205010A 2020-12-23 2021-12-23 Antibody variable domains and antibodies having decreased immunogenicity Pending CA3205010A1 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
EP20216957.9A EP4019547A1 (en)	2020-12-23	2020-12-23	Multispecific antibodies having specificity for il-4r and il-31
EP20216957.9		2020-12-23
EP21154786		2021-02-02
EP21154786.4		2021-02-02
PCT/EP2021/064427 WO2021239987A1 (en)	2020-05-29	2021-05-28	Multispecific antibody
EPPCT/EP2021/064427		2021-05-28
PCT/EP2021/087618 WO2022136693A1 (en)	2020-12-23	2021-12-23	Antibody variable domains and antibodies having decreased immunogenicity

Publications (1)

Publication Number	Publication Date
CA3205010A1 true CA3205010A1 (en)	2022-06-30

Family

ID=86769674

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA3205010A Pending CA3205010A1 (en)	2020-12-23	2021-12-23	Antibody variable domains and antibodies having decreased immunogenicity

Country Status (7)

Country	Link
US (1)	US20240084039A1 (ja)
EP (1)	EP4267622A1 (ja)
JP (1)	JP2024501810A (ja)
KR (1)	KR20230125239A (ja)
AU (1)	AU2021405066A1 (ja)
CA (1)	CA3205010A1 (ja)
IL (1)	IL303171A (ja)

2021
- 2021-12-23 AU AU2021405066A patent/AU2021405066A1/en active Pending
- 2021-12-23 EP EP21844734.0A patent/EP4267622A1/en active Pending
- 2021-12-23 US US18/258,957 patent/US20240084039A1/en active Pending
- 2021-12-23 JP JP2023537607A patent/JP2024501810A/ja active Pending
- 2021-12-23 KR KR1020237024454A patent/KR20230125239A/ko unknown
- 2021-12-23 IL IL303171A patent/IL303171A/en unknown
- 2021-12-23 CA CA3205010A patent/CA3205010A1/en active Pending

Also Published As

Publication number	Publication date
JP2024501810A (ja)	2024-01-16
AU2021405066A9 (en)	2024-10-31
KR20230125239A (ko)	2023-08-29
EP4267622A1 (en)	2023-11-01
US20240084039A1 (en)	2024-03-14
IL303171A (en)	2023-07-01
AU2021405066A1 (en)	2023-06-22

Publication	Publication Date	Title
Chiu et al.	2019	Antibody structure and function: the basis for engineering therapeutics
JP7442443B2 (ja)	2024-03-04	多重特異性抗体
US11261254B1 (en)	2022-03-01	Antibodies
JP2023501146A (ja)	2023-01-18	多重特異性抗体
CA3205036A1 (en)	2022-06-30	Multispecific antibodies having specificity for il-4r and il-31
EP3915580A1 (en)	2021-12-01	Multispecific antibody
US20230303694A1 (en)	2023-09-28	Antibodies that bind gamma-delta t cell receptors
CA3208781A1 (en)	2022-08-11	Multispecific antibodies having specificity for ror1 and cd3
US20230114801A1 (en)	2023-04-13	MINIATURE GUIDANCE AND NAVIGATION CONTROL (miniGNC) ANTIBODY-LIKE PROTEINS AND METHODS OF MAKING AND USING THEREOF
CA3183389A1 (en)	2022-01-06	Bispecific antibody and use thereof
US20240084039A1 (en)	2024-03-14	Antibody variable domains and antibodies having decreased immunogenicity
US20230203162A1 (en)	2023-06-29	Multispecific antibody
EP4273162A1 (en)	2023-11-08	Antibody variable domains and antibodies having decreased immunogenicity
WO2022136693A1 (en)	2022-06-30	Antibody variable domains and antibodies having decreased immunogenicity
EP4136122A1 (en)	2023-02-22	Antibody constructs binding 4-1bb and folate receptor alpha and uses thereof
WO2023214047A1 (en)	2023-11-09	Antibody variable domains and antibodies having decreased immunogenicity
CN116783218A (zh)	2023-09-19	具有降低的免疫原性的抗体可变结构域和抗体
EP4292609A1 (en)	2023-12-20	Compositions comprising antibodies that bind gamma-delta t cell receptors
AU2023293720A1 (en)	2024-11-14	Compositions comprising antibodies that bind gamma-delta t cell receptors