CA3095443A1 - Antibody-based methods of detecting and treating alzheimer's disease - Google Patents

Antibody-based methods of detecting and treating alzheimer's disease Download PDF

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Publication number: CA3095443A1
Authority: CA; Canada
Prior art keywords: seq; amino acid; acid sequence; antibody; chain variable
Prior art date: 2018-03-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CA3095443A

Other languages

English (en)

French (fr)

Inventor

Jozef Hanes

Eva Kontsekova

Andrej Kova

Norbert ZILKA

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Axon Neuroscience SE

Original Assignee

Axon Neuroscience SE

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-03-28

Filing date

2019-03-27

Publication date

2019-10-03

2019-03-27 Application filed by Axon Neuroscience SE filed Critical Axon Neuroscience SE

2019-10-03 Publication of CA3095443A1 publication Critical patent/CA3095443A1/en

Status Pending legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]

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CA3095443A 2018-03-28 2019-03-27 Antibody-based methods of detecting and treating alzheimer's disease Pending CA3095443A1 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US201862649208P	2018-03-28	2018-03-28
US62/649,208		2018-03-28
US201862664662P	2018-04-30	2018-04-30
US62/664,662		2018-04-30
US201862703299P	2018-07-25	2018-07-25
US62/703,299		2018-07-25
PCT/IB2019/000358 WO2019186276A2 (en)	2018-03-28	2019-03-27	Antibody-based methods of detecting and treating alzheimer's disease

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CA3095443A Pending CA3095443A1 (en)	2018-03-28	2019-03-27	Antibody-based methods of detecting and treating alzheimer's disease

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EP (1)	EP3774887A2 (pt)
JP (1)	JP2021520777A (pt)
KR (1)	KR20200144551A (pt)
CN (1)	CN112236452A (pt)
AU (1)	AU2019244481A1 (pt)
BR (1)	BR112020018868A2 (pt)
CA (1)	CA3095443A1 (pt)
IL (1)	IL277577A (pt)
MX (1)	MX2020009991A (pt)
RU (1)	RU2020135052A (pt)
SG (1)	SG11202008098TA (pt)
WO (1)	WO2019186276A2 (pt)

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2019
- 2019-03-27 BR BR112020018868-9A patent/BR112020018868A2/pt unknown
- 2019-03-27 MX MX2020009991A patent/MX2020009991A/es unknown
- 2019-03-27 CN CN201980029711.2A patent/CN112236452A/zh active Pending
- 2019-03-27 RU RU2020135052A patent/RU2020135052A/ru unknown
- 2019-03-27 EP EP19732436.1A patent/EP3774887A2/en active Pending
- 2019-03-27 JP JP2020551506A patent/JP2021520777A/ja active Pending
- 2019-03-27 CA CA3095443A patent/CA3095443A1/en active Pending
- 2019-03-27 SG SG11202008098TA patent/SG11202008098TA/en unknown
- 2019-03-27 AU AU2019244481A patent/AU2019244481A1/en not_active Abandoned
- 2019-03-27 KR KR1020207030584A patent/KR20200144551A/ko unknown
- 2019-03-27 WO PCT/IB2019/000358 patent/WO2019186276A2/en unknown
2020
- 2020-09-24 IL IL277577A patent/IL277577A/en unknown

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WO2019186276A3 (en)	2020-02-27
SG11202008098TA (en)	2020-10-29
AU2019244481A1 (en)	2020-10-01
WO2019186276A8 (en)	2020-10-15
RU2020135052A (ru)	2022-04-29
BR112020018868A2 (pt)	2021-01-26
JP2021520777A (ja)	2021-08-26
IL277577A (en)	2020-11-30
CN112236452A (zh)	2021-01-15
WO2019186276A2 (en)	2019-10-03
KR20200144551A (ko)	2020-12-29
MX2020009991A (es)	2020-10-14
EP3774887A2 (en)	2021-02-17

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CA3095443A1 (en)	2019-10-03	Antibody-based methods of detecting and treating alzheimer's disease
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US20230151083A1 (en)	2023-05-18	Anti-phf-tau antibodies and uses thereof
WO2017027685A2 (en)	2017-02-16	Antibody-based molecules specific for the truncated asp421 epitope of tau and their uses in the diagnosis and treatment of tauopathy
US20210139568A1 (en)	2021-05-13	Antibody-based methods of detecting and treating alzheimer's disease
US20240150451A1 (en)	2024-05-09	Anti-tau antibodies and uses thereof
JP2023531069A (ja)	2023-07-20	アミロイドβ１－４２に結合する抗体を使用する軸索損傷の予防
US20230365665A1 (en)	2023-11-16	ANTIBODY COMPOSITIONS TARGETING NON-PHOSPHORYLATED a-SYNUCLEIN AGGREGATES
WO2022060236A1 (en)	2022-03-24	ANTIBODY COMPOSITIONS TARGETING NON-PHOSPHORYLATED α-SYNUCLEIN AGGREGATES
EA047298B1 (ru)	2024-06-27	Антитела к phf-тау и их применение
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