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CA3073442C - Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton - Google Patents

Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton Download PDF

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Publication number
CA3073442C
CA3073442C CA3073442A CA3073442A CA3073442C CA 3073442 C CA3073442 C CA 3073442C CA 3073442 A CA3073442 A CA 3073442A CA 3073442 A CA3073442 A CA 3073442A CA 3073442 C CA3073442 C CA 3073442C
Authority
CA
Canada
Prior art keywords
zolmitriptan
microns
microprojections
patch
coating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3073442A
Other languages
English (en)
Other versions
CA3073442A1 (fr
Inventor
Mahmoud Ameri
Donald Kellerman
Yi Ao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Emergex USA Corp
Original Assignee
Emergex USA Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emergex USA Corp filed Critical Emergex USA Corp
Priority to CA3223555A priority Critical patent/CA3223555A1/fr
Publication of CA3073442A1 publication Critical patent/CA3073442A1/fr
Application granted granted Critical
Publication of CA3073442C publication Critical patent/CA3073442C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne des compositions, des dispositifs et des méthodes utilisant des concentrations thérapeutiques d'un triptan pour le traitement de la migraine. L'invention concerne également des méthodes et des appareils pour l'administration du zolmitriptan permettant d'obtenir un Tmax en un délai aussi rapide que 2 minutes et en moins de 30 minutes chez la majorité des sujets.
CA3073442A 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton Active CA3073442C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3223555A CA3223555A1 (fr) 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2017/048258 WO2019040063A1 (fr) 2017-08-23 2017-08-23 Procédé d'obtention rapide de concentrations thérapeutiques de zolmitriptan pour le traitement de migraines et de céphalées de horton

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3223555A Division CA3223555A1 (fr) 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton

Publications (2)

Publication Number Publication Date
CA3073442A1 CA3073442A1 (fr) 2019-02-28
CA3073442C true CA3073442C (fr) 2024-02-06

Family

ID=59829462

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3223555A Pending CA3223555A1 (fr) 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton
CA3073442A Active CA3073442C (fr) 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA3223555A Pending CA3223555A1 (fr) 2017-08-23 2017-08-23 Procede d'obtention rapide de concentrations therapeutiques de zolmitriptan pour le traitement de migraines et de cephalees de horton

Country Status (8)

Country Link
EP (1) EP3672570A1 (fr)
JP (2) JP7219384B2 (fr)
KR (2) KR20210155817A (fr)
CN (1) CN111050749A (fr)
AU (1) AU2017428907B2 (fr)
CA (2) CA3223555A1 (fr)
IL (1) IL272776B2 (fr)
WO (1) WO2019040063A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9918932B2 (en) 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines
US11660264B2 (en) 2017-08-23 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
US11660265B2 (en) 2018-06-28 2023-05-30 Emergex USA Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines and cluster headaches
WO2020245667A1 (fr) * 2019-06-06 2020-12-10 Kindeva Drug Delivery L.P. Support de microréseau destiné à un applicateur de microréseau
WO2020264026A1 (fr) * 2019-06-28 2020-12-30 Passport Technologies, Inc. Système de distribution de micro-porosités de triptan
CN114699510B (zh) * 2021-12-29 2024-07-16 浙江湃肽生物有限公司 一种司美格鲁肽微针阵列及其制备方法
CN115887903B (zh) * 2022-12-15 2024-09-27 太平洋康泰科学仪器（济南）有限公司 微针贴片给药组件及给药方法

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US5080646A (en) 1988-10-03 1992-01-14 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5147296A (en) 1988-10-03 1992-09-15 Alza Corporation Membrane for electrotransport transdermal drug delivery
US5169382A (en) 1988-10-03 1992-12-08 Alza Corporation Membrane for electrotransport transdermal drug delivery
US6230051B1 (en) 1996-06-18 2001-05-08 Alza Corporation Device for enhancing transdermal agent delivery or sampling
US5743960A (en) 1996-07-26 1998-04-28 Bio-Dot, Inc. Precision metered solenoid valve dispenser
US5916524A (en) 1997-07-23 1999-06-29 Bio-Dot, Inc. Dispensing apparatus having improved dynamic range
US5738728A (en) 1996-07-26 1998-04-14 Bio Dot, Inc. Precision metered aerosol dispensing apparatus
US5741554A (en) 1996-07-26 1998-04-21 Bio Dot, Inc. Method of dispensing a liquid reagent
KR100572539B1 (ko) 1997-12-11 2006-04-24 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
WO1999029365A1 (fr) 1997-12-11 1999-06-17 Alza Corporation Dispositif renforçant le flux d'agents transdermiques
PT1037687E (pt) 1997-12-11 2008-12-17 Alza Corp Dispositivo para melhoramento de fluxo transdérmico de agente
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
EP1239916B1 (fr) 1999-12-10 2005-11-23 ALZA Corporation Dispositif et procede d'amelioration de percage de peau par micro-protuberances
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
DE60138411D1 (de) 2000-10-13 2009-05-28 Alza Corp Vorrichtung und verfahren zum durchstechen der haut mit micronadeln
ES2317940T3 (es) 2000-10-13 2009-05-01 Alza Corporation Dispositivo de retencion para un elemento de microsalientes para aplicador de impactos.
EP1341442B1 (fr) 2000-10-13 2005-06-29 Alza Corporation Applicateur a reseau de microlames produisant un impact
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CA2444883A1 (fr) 2001-04-20 2002-10-31 Alza Corporation Reseau de micro-projections avec revetement contenant un principe benefique
ES2377647T3 (es) 2003-10-31 2012-03-29 Alza Corporation Aplicador auto-actuado para ordenamiento de microproyecciones
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EP2001453A4 (fr) 2006-03-15 2012-09-12 Alza Corp Appareil et procede d'administration transdermique d'agents hormonaux parathyroidiens destines a traiter ou prevenir l'osteopenie
WO2008115586A1 (fr) * 2007-03-21 2008-09-25 Alza Corporation Appareil et procédé d'administration transdermique d'un agoniste de triptane
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US9918932B2 (en) * 2016-02-19 2018-03-20 Zosano Pharma Corporation Method of rapidly achieving therapeutic concentrations of triptans for treatment of migraines

Also Published As

Publication number Publication date
JP7219384B2 (ja) 2023-02-08
JP2021500397A (ja) 2021-01-07
AU2017428907B2 (en) 2021-12-16
KR20210155817A (ko) 2021-12-23
KR102340393B1 (ko) 2021-12-17
JP2023033378A (ja) 2023-03-10
CA3073442A1 (fr) 2019-02-28
IL272776B1 (en) 2024-02-01
CN111050749A (zh) 2020-04-21
IL272776B2 (en) 2024-06-01
AU2017428907A1 (en) 2020-03-05
WO2019040063A1 (fr) 2019-02-28
EP3672570A1 (fr) 2020-07-01
IL272776A (en) 2020-04-30
KR20200032170A (ko) 2020-03-25
CA3223555A1 (fr) 2019-02-28

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