CA2602663A1 - Variants fc presentant des proprietes optimisees - Google Patents

Variants fc presentant des proprietes optimisees Download PDF

Info

Publication number: CA2602663A1
Authority: CA; Canada
Prior art keywords: antibody; variant; polypeptide; positions; variants
Prior art date: 2005-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002602663A

Other languages

English (en)

Inventor

Gregory Alan Lazar

Wei Dang

John R. Desjarlais

Sher Bahadur Karki

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Xencor Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-03-31

Filing date

2006-03-31

Publication date

2006-10-05

2005-05-05 Priority claimed from US11/124,620 external-priority patent/US8188231B2/en

2006-03-31 Application filed by Individual filed Critical Individual

2006-10-05 Publication of CA2602663A1 publication Critical patent/CA2602663A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

CA002602663A 2005-03-31 2006-03-31 Variants fc presentant des proprietes optimisees Abandoned CA2602663A1 (fr)

Applications Claiming Priority (11)

Application Number	Priority Date	Filing Date	Title
US66719705P	2005-03-31	2005-03-31
US60/667,197		2005-03-31
US11/124,620 US8188231B2 (en)	2002-09-27	2005-05-05	Optimized FC variants
US11/124,620		2005-05-05
US70537805P	2005-08-03	2005-08-03
US60/705,378		2005-08-03
US72333505P	2005-10-03	2005-10-03
US72329405P	2005-10-03	2005-10-03
US60/723,335		2005-10-03
US60/723,294		2005-10-03
PCT/US2006/011752 WO2006105338A2 (fr)	2005-03-31	2006-03-31	Variants fc presentant des proprietes optimisees

Publications (1)

Publication Number	Publication Date
CA2602663A1 true CA2602663A1 (fr)	2006-10-05

Family

ID=37054149

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002602663A Abandoned CA2602663A1 (fr)	2005-03-31	2006-03-31	Variants fc presentant des proprietes optimisees

Country Status (5)

Country	Link
EP (1)	EP1871808A2 (fr)
AU (1)	AU2006230413B8 (fr)
CA (1)	CA2602663A1 (fr)
IL (1)	IL186145A0 (fr)
WO (1)	WO2006105338A2 (fr)

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- 2006-03-31 WO PCT/US2006/011752 patent/WO2006105338A2/fr active Application Filing
2007
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Publication number	Publication date
IL186145A0 (en)	2008-01-20
EP1871808A2 (fr)	2008-01-02
WO2006105338A2 (fr)	2006-10-05
WO2006105338A3 (fr)	2007-03-29
AU2006230413A1 (en)	2006-10-05
AU2006230413B8 (en)	2011-01-20
AU2006230413B2 (en)	2010-09-23

Publication	Publication Date	Title
AU2006230413B8 (en)	2011-01-20	Fc variants with optimized properties
US9040041B2 (en)	2015-05-26	Modified FC molecules
US20080242845A1 (en)	2008-10-02	Fc variants with optimized properties
AU2016234983B2 (en)	2017-08-31	Fc variants with altered binding to FcRn
KR101573883B1 (ko)	2015-12-02	ＦｃＲｎ에 대한 변경된 결합성을 갖는 Ｆｃ 변이체
AU2011200066B2 (en)	2012-07-26	Fc variants with altered binding to FcRn
US20060134105A1 (en)	2006-06-22	IgG immunoglobulin variants with optimized effector function
AU2021203049A1 (en)	2021-06-10	Heterodimeric antibodies that bind CD3 and tumor antigens
JP6310394B2 (ja)	2018-04-11	抗体を精製する方法
US20070275460A1 (en)	2007-11-29	Fc Variants With Optimized Fc Receptor Binding Properties
JP2008537941A (ja)	2008-10-02	最適化特性を有するＦｃ変異体
US20100093979A1 (en)	2010-04-15	Fc Polypeptides With Novel Fc Ligand Binding Sites
WO2006047350A2 (fr)	2006-05-04	Variants d'immunoglobuline igg a fonction effectrice optimisee
AU2016203334A1 (en)	2016-06-16	Fc variants with altered binding to FcRn

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2007-09-27	EEER	Examination request
2011-07-29	FZDE	Discontinued