CA2504024A1 - Compositions comprenant des composes immunomodulateurs pour le traitement et la gestion d'une degeneration maculaire, ainsi que leurs methodes d'utilisation - Google Patents
Compositions comprenant des composes immunomodulateurs pour le traitement et la gestion d'une degeneration maculaire, ainsi que leurs methodes d'utilisation Download PDFInfo
- Publication number
- CA2504024A1 CA2504024A1 CA002504024A CA2504024A CA2504024A1 CA 2504024 A1 CA2504024 A1 CA 2504024A1 CA 002504024 A CA002504024 A CA 002504024A CA 2504024 A CA2504024 A CA 2504024A CA 2504024 A1 CA2504024 A1 CA 2504024A1
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- compound
- macular degeneration
- pharmaceutically acceptable
- stereoisomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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Abstract
L'invention concerne des méthodes de traitement, de prévention et/ou de gestion d'une dégénération maculaire. Des modes de réalisation spécifiques de l'invention consistent à administrer un composé immunomodulateur, ou un sel pharmaceutiquement acceptable, un solvate, un hydrate, un stéréoisomère, un clathrate, ou un promédicament de celui-ci, seul ou combiné à un second agent actif et/ou à une chirurgie. L'invention concerne des compositions pharmaceutiques, des formes dosifiées unitaires simples, et des trousses appropriées à une utilisation dans les méthodes de l'invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42289902P | 2002-10-31 | 2002-10-31 | |
| US60/422,899 | 2002-10-31 | ||
| PCT/US2003/034661 WO2004041190A2 (fr) | 2002-10-31 | 2003-10-31 | Compositions comprenant des composes immunomodulateurs pour le traitement et la gestion d'une degeneration maculaire, ainsi que leurs methodes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2504024A1 true CA2504024A1 (fr) | 2004-05-21 |
Family
ID=32312566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002504024A Abandoned CA2504024A1 (fr) | 2002-10-31 | 2003-10-31 | Compositions comprenant des composes immunomodulateurs pour le traitement et la gestion d'une degeneration maculaire, ainsi que leurs methodes d'utilisation |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1562597A4 (fr) |
| JP (1) | JP2006508950A (fr) |
| KR (1) | KR20050061586A (fr) |
| CN (1) | CN1732001A (fr) |
| AU (1) | AU2003287381B2 (fr) |
| BR (1) | BR0315931A (fr) |
| CA (1) | CA2504024A1 (fr) |
| MX (1) | MXPA05004488A (fr) |
| NZ (1) | NZ540186A (fr) |
| TW (1) | TWI310312B (fr) |
| WO (1) | WO2004041190A2 (fr) |
| ZA (1) | ZA200503467B (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU228769B1 (en) | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| US20040091455A1 (en) * | 2002-10-31 | 2004-05-13 | Zeldis Jerome B. | Methods of using and compositions comprising immunomodulatory compounds for treatment and management of macular degeneration |
| US20050143344A1 (en) * | 2003-12-30 | 2005-06-30 | Zeldis Jerome B. | Methods and compositions using immunomodulatory compounds for the treatment and management of central nervous system disorders or diseases |
| US8821870B2 (en) * | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
| CN101696205B (zh) | 2009-11-02 | 2011-10-19 | 南京卡文迪许生物工程技术有限公司 | 3-(取代二氢异吲哚-2-基)-2,6-哌啶二酮多晶型物和药用组合物 |
| WO2012079075A1 (fr) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Dérivés de phtalimide deutérés |
| WO2013130849A1 (fr) | 2012-02-29 | 2013-09-06 | Concert Pharmaceuticals, Inc. | Dérivés de phthalimide dioxopipéridinyle substitués |
| EP2838879A1 (fr) | 2012-04-20 | 2015-02-25 | Concert Pharmaceuticals Inc. | Rigosertib deutéré |
| EP2922838B1 (fr) | 2012-10-22 | 2018-03-14 | Concert Pharmaceuticals Inc. | Formes solides de {s-3-(4-amino-1-oxo-isoindolin-2-yl)(piperidin-3,4,4,5,5-d5)-2,6-dion} |
| WO2014110322A2 (fr) | 2013-01-11 | 2014-07-17 | Concert Pharmaceuticals, Inc. | Dérivés substitués de dioxopipéridinyl phtalimide |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629327A (en) * | 1993-03-01 | 1997-05-13 | Childrens Hospital Medical Center Corp. | Methods and compositions for inhibition of angiogenesis |
| US5770589A (en) * | 1993-07-27 | 1998-06-23 | The University Of Sydney | Treatment of macular degeneration |
| IT1274549B (it) * | 1995-05-23 | 1997-07-17 | Indena Spa | Uso di flavanolignani per la preparazione di medicamenti ad attivita' antiproliferativa nei tumori dell'utero,dell'ovaio e del seno |
| US6281230B1 (en) * | 1996-07-24 | 2001-08-28 | Celgene Corporation | Isoindolines, method of use, and pharmaceutical compositions |
| US5635517B1 (en) * | 1996-07-24 | 1999-06-29 | Celgene Corp | Method of reducing TNFalpha levels with amino substituted 2-(2,6-dioxopiperidin-3-YL)-1-oxo-and 1,3-dioxoisoindolines |
| HU228769B1 (en) * | 1996-07-24 | 2013-05-28 | Celgene Corp | Substituted 2(2,6-dioxopiperidin-3-yl)phthalimides and -1-oxoisoindolines and their use for production of pharmaceutical compositions for mammals to reduce the level of tnf-alpha |
| PT2177517E (pt) * | 1996-07-24 | 2011-11-10 | Celgene Corp | 2-(2,6-dioxopiperidin-3-il)-ftalimida amino-substituída para redução dos níveis de tnf-alfa |
| ES2197359T3 (es) * | 1996-08-12 | 2004-01-01 | Celgene Corporation | Nuevos agentes inmunoterapeuticos y utilizacion de los mismos para disminuir los niveles de citocina. |
| EP2298300A1 (fr) * | 1996-11-05 | 2011-03-23 | The Children's Medical Center Corporation | Compositions inhibitrices de l'angiogenèse contenantes de la thalidomide et l'aspirinê |
| US5955476A (en) * | 1997-11-18 | 1999-09-21 | Celgene Corporation | Substituted 2-(2,6-dioxo-3-fluoropiperidin-3-yl)-isoindolines and method of reducing inflammatory cytokine levels |
| US6015803A (en) * | 1998-05-04 | 2000-01-18 | Wirostko; Emil | Antibiotic treatment of age-related macular degeneration |
| WO2000002564A1 (fr) * | 1998-07-10 | 2000-01-20 | The University Of Sydney | Traitements prophylactiques de la neoformation de vaisseaux sanguins dans la degenerescence maculaire |
| US6225348B1 (en) * | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
| US6001368A (en) * | 1998-09-03 | 1999-12-14 | Protein Technologies International, Inc. | Method for inhibiting or reducing the risk of macular degeneration |
| JP2000159761A (ja) * | 1998-11-30 | 2000-06-13 | Yoshio Takeuchi | フルオロサリドマイド |
| US6443976B1 (en) * | 1999-11-30 | 2002-09-03 | Akorn, Inc. | Methods for treating conditions and illnesses associated with abnormal vasculature |
| US6623736B2 (en) * | 2000-05-02 | 2003-09-23 | Edward L. Tobinick | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| WO2002058730A2 (fr) * | 2000-11-01 | 2002-08-01 | Allergan, Inc. | Procedes et compositions pour le traitement de la neovascularisation oculaire et de lesions nerveuses |
| CA2430669C (fr) * | 2000-11-30 | 2011-06-14 | The Children's Medical Center Corporation | Synthese de 3-amino-thalidomide et de ses enantiomeres |
| JP2004529911A (ja) * | 2001-02-02 | 2004-09-30 | シェーリング コーポレイション | Ｃｘｃケモカインレセプターアンタゴニストとしての３，４−二置換シクロブテン−１，２−ジオン |
| US7153867B2 (en) * | 2001-08-06 | 2006-12-26 | Celgene Corporation | Use of nitrogen substituted thalidomide analogs for the treatment of macular degenerator |
| CN103393681B (zh) * | 2002-05-17 | 2017-04-12 | 细胞基因公司 | 用于治疗和控制多发性骨髓瘤的方法及组合物 |
| DK1539157T3 (da) * | 2002-09-18 | 2013-10-07 | Univ Pennsylvania | Fremgangsmåde til hæmning af choroidal neovaskularisering |
-
2003
- 2003-10-31 CA CA002504024A patent/CA2504024A1/fr not_active Abandoned
- 2003-10-31 JP JP2004550329A patent/JP2006508950A/ja active Pending
- 2003-10-31 AU AU2003287381A patent/AU2003287381B2/en not_active Ceased
- 2003-10-31 BR BR0315931-0A patent/BR0315931A/pt not_active IP Right Cessation
- 2003-10-31 KR KR1020057007531A patent/KR20050061586A/ko not_active Application Discontinuation
- 2003-10-31 CN CNA200380108093XA patent/CN1732001A/zh active Pending
- 2003-10-31 TW TW092130484A patent/TWI310312B/zh not_active IP Right Cessation
- 2003-10-31 MX MXPA05004488A patent/MXPA05004488A/es active IP Right Grant
- 2003-10-31 NZ NZ540186A patent/NZ540186A/en unknown
- 2003-10-31 WO PCT/US2003/034661 patent/WO2004041190A2/fr active Application Filing
- 2003-10-31 EP EP03781615A patent/EP1562597A4/fr not_active Withdrawn
-
2005
- 2005-04-29 ZA ZA200503467A patent/ZA200503467B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004041190A2 (fr) | 2004-05-21 |
| EP1562597A2 (fr) | 2005-08-17 |
| TWI310312B (en) | 2009-06-01 |
| BR0315931A (pt) | 2005-09-13 |
| AU2003287381A1 (en) | 2004-06-07 |
| KR20050061586A (ko) | 2005-06-22 |
| AU2003287381B2 (en) | 2008-03-06 |
| CN1732001A (zh) | 2006-02-08 |
| MXPA05004488A (es) | 2005-07-26 |
| EP1562597A4 (fr) | 2008-05-14 |
| JP2006508950A (ja) | 2006-03-16 |
| ZA200503467B (en) | 2006-08-30 |
| NZ540186A (en) | 2008-03-28 |
| WO2004041190A3 (fr) | 2004-09-02 |
| TW200423936A (en) | 2004-11-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |