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CA2334551A1 - Derives de spiropiperidine en tant qu'agonistes des recepteurs de la melanocortine - Google Patents

Derives de spiropiperidine en tant qu'agonistes des recepteurs de la melanocortine Download PDF

Info

Publication number
CA2334551A1
CA2334551A1 CA002334551A CA2334551A CA2334551A1 CA 2334551 A1 CA2334551 A1 CA 2334551A1 CA 002334551 A CA002334551 A CA 002334551A CA 2334551 A CA2334551 A CA 2334551A CA 2334551 A1 CA2334551 A1 CA 2334551A1
Authority
CA
Canada
Prior art keywords
compound
treatment
prevention
heteroaryl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002334551A
Other languages
English (en)
Inventor
Ravi P. Nargund
Zhixiong Ye
Brenda L. Palucki
Raman K. Bakshi
Arthur A. Patchett
Leonardus H. T. Van Der Ploeg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9817179.6A external-priority patent/GB9817179D0/en
Application filed by Individual filed Critical Individual
Publication of CA2334551A1 publication Critical patent/CA2334551A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

De nouveaux composés de spiropipéridine sont des agonistes des récepteurs de la mélanocortine et sont utiles pour le traitement, la suppression ou la prévention des maladies et des troubles sensibles à l'activation des récepteurs de la mélanocortine. Les composés selon l'invention sont par conséquent utiles pour le traitement des maladies et des troubles tels que l'obésité, le diabète et les dysfonctions sexuelles, y compris la dysérection et les dysfonctions sexuelles féminines.
CA002334551A 1998-06-11 1999-06-10 Derives de spiropiperidine en tant qu'agonistes des recepteurs de la melanocortine Abandoned CA2334551A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US8890898P 1998-06-11 1998-06-11
US60/088,908 1998-06-11
GBGB9817179.6A GB9817179D0 (en) 1998-08-06 1998-08-06 Spiropiperidine derivatives as melanocortin receptor agonists
GB9817179.6 1998-08-06
US12326099P 1999-03-08 1999-03-08
US60/123,260 1999-03-08
PCT/US1999/013252 WO1999064002A1 (fr) 1998-06-11 1999-06-10 Derives de spiropiperidine en tant qu'agonistes des recepteurs de la melanocortine

Publications (1)

Publication Number Publication Date
CA2334551A1 true CA2334551A1 (fr) 1999-12-16

Family

ID=27269429

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002334551A Abandoned CA2334551A1 (fr) 1998-06-11 1999-06-10 Derives de spiropiperidine en tant qu'agonistes des recepteurs de la melanocortine

Country Status (5)

Country Link
EP (1) EP1085869A4 (fr)
JP (1) JP2002517444A (fr)
AU (1) AU742425B2 (fr)
CA (1) CA2334551A1 (fr)
WO (1) WO1999064002A1 (fr)

Families Citing this family (147)

* Cited by examiner, † Cited by third party
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US6699873B1 (en) 1999-08-04 2004-03-02 Millennium Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
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