CA2320403A1 - Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps - Google Patents
Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps Download PDFInfo
- Publication number
- CA2320403A1 CA2320403A1 CA002320403A CA2320403A CA2320403A1 CA 2320403 A1 CA2320403 A1 CA 2320403A1 CA 002320403 A CA002320403 A CA 002320403A CA 2320403 A CA2320403 A CA 2320403A CA 2320403 A1 CA2320403 A1 CA 2320403A1
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- Prior art keywords
- xaa xaa
- antibody
- fusion protein
- protein
- based fusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 235000013617 genetically modified food Nutrition 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
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- 230000003394 haemopoietic effect Effects 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- 108010027338 isoleucylcysteine Proteins 0.000 description 1
- 108010034529 leucyl-lysine Proteins 0.000 description 1
- 108010091871 leucylmethionine Proteins 0.000 description 1
- 108010003700 lysyl aspartic acid Proteins 0.000 description 1
- 108010017391 lysylvaline Proteins 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
On décrit des procédés de construction génétique et d'expression de protéines hybrides à base d'anticorps ayant une demi-vie circulante améliorée. Les protéines hybrides de l'invention sont incapables de se lier aux récepteurs pour le fragment Fc des immunoglobulines, soit en conséquence de l'utilisation de l'isotype des anticorps pour construire la protéine hybride, soit par mutagenèse dirigée des isotypes des anticorps qui se lient normalement aux récepteurs pour le fragment Fc. Les protéines hybrides de l'invention peuvent également contenir un domaine fonctionnel capable de lier un récepteur de protection des immunoglobulines.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7588798P | 1998-02-25 | 1998-02-25 | |
| US60/075,887 | 1998-02-25 | ||
| PCT/US1999/003966 WO1999043713A1 (fr) | 1998-02-25 | 1999-02-24 | Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2320403A1 true CA2320403A1 (fr) | 1999-09-02 |
Family
ID=22128576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002320403A Abandoned CA2320403A1 (fr) | 1998-02-25 | 1999-02-24 | Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1060194A1 (fr) |
| JP (1) | JP2002505086A (fr) |
| CN (1) | CN1204147C (fr) |
| AU (1) | AU758240B2 (fr) |
| BR (1) | BR9908226A (fr) |
| CA (1) | CA2320403A1 (fr) |
| CZ (1) | CZ20003099A3 (fr) |
| HK (1) | HK1036286A1 (fr) |
| HU (1) | HUP0100813A3 (fr) |
| NO (1) | NO20004218L (fr) |
| PL (1) | PL199659B1 (fr) |
| WO (1) | WO1999043713A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
| US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
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| CA2359067C (fr) | 1999-01-15 | 2017-03-14 | Genentech, Inc. | Variants polypeptidiques ayant une fonction effectrice alteree |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| GB9926084D0 (en) * | 1999-11-03 | 2000-01-12 | King S College London | Recombinant fusion molecules |
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| US7416726B2 (en) | 2000-04-13 | 2008-08-26 | The Rockefeller University | Enhancement of antibody-mediated immune responses |
| DE10045591A1 (de) * | 2000-09-15 | 2002-04-04 | Klaus Pfizenmaier | Ortsspezifische, antikörpervermittelte Aktivierung proapoptotischer Zytokine - AMAIZe (Antibody-Mediated Apoptosis Inducing Zytokine) |
| AU2011253690C1 (en) * | 2000-12-12 | 2018-01-18 | Board Of Regents, The University Of Texas System | Molecules with extended half-lives, compositions and uses thereof |
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| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
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| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| AU2002248571B2 (en) * | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| TWI338009B (en) * | 2001-10-29 | 2011-03-01 | Genentech Inc | Antibodies for inhibiting blood coagulation and methods of use thereof |
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| US8968730B2 (en) | 2002-08-14 | 2015-03-03 | Macrogenics Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US8946387B2 (en) | 2002-08-14 | 2015-02-03 | Macrogenics, Inc. | FcγRIIB specific antibodies and methods of use thereof |
| US7217797B2 (en) * | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| CA2502904C (fr) * | 2002-10-15 | 2013-05-28 | Protein Design Labs, Inc. | Modification d'affinites de liaison pour fcrn ou de demi-vies seriques d'anticorps par mutagenese |
| EP1587540B1 (fr) | 2003-01-09 | 2021-09-15 | MacroGenics, Inc. | Identification et elaboration d'anticorps avec des regions du variant fc et procedes d'utilisation associes |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
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|---|---|---|---|---|
| GB9511935D0 (en) * | 1995-06-13 | 1995-08-09 | Smithkline Beecham Plc | Novel compound |
| WO1997033617A1 (fr) * | 1996-03-13 | 1997-09-18 | Protein Design Labs, Inc. | Proteines hybrides de ligand fas et leurs utilisations |
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- 1999-02-24 BR BR9908226-8A patent/BR9908226A/pt not_active Application Discontinuation
- 1999-02-24 WO PCT/US1999/003966 patent/WO1999043713A1/fr active IP Right Grant
- 1999-02-24 PL PL342497A patent/PL199659B1/pl not_active IP Right Cessation
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- 1999-02-24 AU AU27842/99A patent/AU758240B2/en not_active Ceased
- 1999-02-24 JP JP2000533463A patent/JP2002505086A/ja active Pending
- 1999-02-24 CZ CZ20003099A patent/CZ20003099A3/cs unknown
- 1999-02-24 EP EP99908399A patent/EP1060194A1/fr not_active Ceased
- 1999-02-24 CA CA002320403A patent/CA2320403A1/fr not_active Abandoned
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| PL342497A1 (en) | 2001-06-04 |
| BR9908226A (pt) | 2000-10-24 |
| WO1999043713A1 (fr) | 1999-09-02 |
| JP2002505086A (ja) | 2002-02-19 |
| HK1036286A1 (en) | 2001-12-28 |
| PL199659B1 (pl) | 2008-10-31 |
| CN1204147C (zh) | 2005-06-01 |
| CN1291995A (zh) | 2001-04-18 |
| HUP0100813A2 (hu) | 2001-06-28 |
| EP1060194A1 (fr) | 2000-12-20 |
| AU758240B2 (en) | 2003-03-20 |
| NO20004218L (no) | 2000-10-24 |
| AU2784299A (en) | 1999-09-15 |
| NO20004218D0 (no) | 2000-08-23 |
| HUP0100813A3 (en) | 2003-08-28 |
| CZ20003099A3 (cs) | 2002-04-17 |
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