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CA2385497A1 - Methods and microorganisms for production of panto-compounds - Google Patents

Methods and microorganisms for production of panto-compounds Download PDF

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Publication number
CA2385497A1
CA2385497A1 CA002385497A CA2385497A CA2385497A1 CA 2385497 A1 CA2385497 A1 CA 2385497A1 CA 002385497 A CA002385497 A CA 002385497A CA 2385497 A CA2385497 A CA 2385497A CA 2385497 A1 CA2385497 A1 CA 2385497A1
Authority
CA
Canada
Prior art keywords
pantothenate
gene
microorganism
seq
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002385497A
Other languages
English (en)
French (fr)
Inventor
R. Rogers Yocum
Thomas A. Patterson
Theron Hermann
Janice G. Pero
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2385497A1 publication Critical patent/CA2385497A1/en
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1003Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014Hydroxymethyl-, formyl-transferases (2.1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93Ligases (6)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/06Alanine; Leucine; Isoleucine; Serine; Homoserine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/04Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CA002385497A 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds Abandoned CA2385497A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40049499A 1999-09-21 1999-09-21
US09/400,494 1999-09-21
US21007200P 2000-06-07 2000-06-07
US60/210,072 2000-06-07
US22183600P 2000-07-28 2000-07-28
US60/221,836 2000-07-28
US22786000P 2000-08-24 2000-08-24
US60/227,860 2000-08-24
PCT/US2000/025993 WO2001021772A2 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Publications (1)

Publication Number Publication Date
CA2385497A1 true CA2385497A1 (en) 2001-03-29

Family

ID=27498789

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002385497A Abandoned CA2385497A1 (en) 1999-09-21 2000-09-21 Methods and microorganisms for production of panto-compounds

Country Status (16)

Country Link
EP (2) EP1214420B1 (de)
JP (1) JP5392957B2 (de)
KR (1) KR20020092912A (de)
CN (1) CN1420931A (de)
AU (1) AU7708700A (de)
BR (1) BRPI0014115B8 (de)
CA (1) CA2385497A1 (de)
CZ (1) CZ20021013A3 (de)
HU (1) HU230509B1 (de)
IL (1) IL148786A0 (de)
MX (1) MXPA02003017A (de)
NO (1) NO20021382L (de)
PL (1) PL356566A1 (de)
SK (1) SK5222002A3 (de)
TR (1) TR200200751T2 (de)
WO (1) WO2001021772A2 (de)

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US6830898B2 (en) * 2000-08-24 2004-12-14 Omnigene Bioproducts, Inc. Microorganisms and assays for the identification of antibiotics
DE10101501A1 (de) * 2001-01-12 2002-08-01 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen Herstellung von Pantothensäure
AU2002247012A1 (en) * 2001-01-19 2002-07-30 Basf Aktiengesellschaft Processes for enhanced production of pantothenate
CA2434626A1 (en) * 2001-01-19 2002-08-08 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
DE10108225A1 (de) * 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
DE10108223A1 (de) * 2001-02-21 2002-10-10 Basf Ag Verfahren zur Herstellung von D-Pantothensäure und/oder deren Salze als Zusatz zu Tierfuttermitteln
HU230180B1 (hu) * 2001-02-21 2015-09-28 Basf Ag Eljárás D-pantoténsav és/vagy sói előállítására állati takarmányadalékként
SK10422003A3 (sk) 2001-02-21 2004-02-03 Basf Aktiengesellschaft Príprava kyseliny D-pantoténovej a/alebo jej solí ako prísad do krmív
EP1247868A3 (de) * 2001-04-03 2002-10-30 Degussa AG Verfahren zur fermentativen Herstellung von D-Pantothensäure und/oder deren Salzen
DE10132178A1 (de) 2001-07-03 2003-01-23 Degussa Verfahren zur fermantativen Herstellung von D-Pantothensäure und/oder deren Salzen
WO2003004673A1 (en) * 2001-07-03 2003-01-16 Degussa Ag Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
WO2003004672A1 (en) * 2001-07-03 2003-01-16 Degussa Ag Process for the fermentative preparation of d-pantothenic acid and/or salts thereof
EP1672073A1 (de) * 2001-07-07 2006-06-21 Degussa AG Verfahren zur Herstellung von D-Pantothensäure und/oder Salzen davon
AU2002316940A1 (en) 2001-07-07 2003-01-29 Degussa Ag Process for the preparation of d-pantothenic acid and/or salts thereof
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AU2003251792A1 (en) 2002-07-03 2004-01-23 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
AU2002316575A1 (en) * 2002-07-03 2004-01-23 Basf Aktiengesellschaft Microorganisms and processes for enhanced production of pantothenate
CN1809631B (zh) * 2003-06-18 2010-05-26 帝斯曼知识产权资产管理有限公司 用不能形成芽孢的微生物来生产泛酸盐/酯的方法
WO2006104124A1 (ja) * 2005-03-29 2006-10-05 Kaneka Corporation 新規パントテン酸キナーゼ遺伝子及びその利用方法
US8273558B2 (en) 2005-10-26 2012-09-25 Butamax(Tm) Advanced Biofuels Llc Fermentive production of four carbon alcohols
US9303225B2 (en) 2005-10-26 2016-04-05 Butamax Advanced Biofuels Llc Method for the production of isobutanol by recombinant yeast
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DE112007001179T5 (de) 2006-05-16 2009-04-02 Dsm Ip Assets B.V. Verfahren zur Herstellung von Panthenol
EP1918383A1 (de) * 2006-11-02 2008-05-07 DSMIP Assets B.V. Semikontinuierliches Fermentationsverfahren zur Herstellung von Pantothenat
MY147186A (en) 2007-02-09 2012-11-14 Univ California Biofuel production by recombinant microorganisms
EP2474235A2 (de) 2007-07-06 2012-07-11 Basf Se Verfahren zur Gewinnung von Maisgluten
WO2009151728A2 (en) * 2008-03-27 2009-12-17 Genomatica, Inc. Microorganisms for the production of adipic acid and other compounds
EP2157174A1 (de) 2008-08-12 2010-02-24 DSM IP Assets B.V. Erhöhte Produktion von Pantothenate (Vitamin B5)
WO2012109176A2 (en) * 2011-02-07 2012-08-16 William Marsh Rice University Reverse beta oxidation pathway
US8765426B2 (en) * 2011-04-07 2014-07-01 E I Du Pont De Nemours And Company Pantothenic acid biosynthesis in zymomonas
WO2012175575A2 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased vitamin b5 production
WO2012175574A1 (en) 2011-06-21 2012-12-27 Dsm Ip Assets B.V. Increased pantothenate (vitamin b5) production
WO2014087184A1 (en) * 2012-12-03 2014-06-12 Metabolic Explorer Neopentyl glycol fermentative production by a recombinant microorganism
ES2701531T3 (es) 2013-10-25 2019-02-22 Retrophin Inc Derivados de pantotenato para el tratamiento de trastornos neurológicos
CN104593398B (zh) * 2013-11-01 2017-06-06 中国科学院微生物研究所 一种高L‑天冬氨酸α羧化酶活性的工程菌及其在生产β‑丙氨酸中的应用
CN105368758B (zh) * 2015-03-16 2018-06-19 鲁东大学 一株高产天冬氨酸脱羧酶的菌株及用于生产丙氨酸的方法
CN104789564B (zh) * 2015-03-31 2018-04-27 中国农业科学院生物技术研究所 一种启动子和重组表达载体及其用途和表达外源蛋白的方法
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BR112019027919A2 (pt) 2017-06-30 2020-07-21 Ptt Global Chemical Public Company Limited micro-organismo com número de cópias estabilizado de sequência de dna funcional e métodos associados
CN108456701B (zh) * 2018-03-23 2020-10-16 精晶药业股份有限公司 一种d-泛解酸内酯的制备方法
CA3143683A1 (en) * 2018-06-25 2020-01-02 Lygos, Inc. Recombinant host cells and methods for the production of aspartic acid and s-alanine
KR20210031929A (ko) * 2018-07-09 2021-03-23 코덱시스, 인코포레이티드 조작된 판토테네이트 키나제 변이체 효소
US20230348941A1 (en) * 2020-06-28 2023-11-02 Mint Bio Tech Ltd. Methods for preparing pantoic acid, pantothenic acid and panthenol as well as salts thereof
KR102389327B1 (ko) * 2020-07-01 2022-04-20 씨제이제일제당 (주) 3-메틸-2-옥소뷰타노에이트 하이드록시 메틸트랜스퍼라아제의 활성이 강화된 미생물, 및 이의 용도
CN115109736B (zh) * 2021-03-23 2024-05-07 中国科学院天津工业生物技术研究所 一种产泛解酸的微生物及其构建方法和应用
WO2022219173A1 (en) 2021-04-15 2022-10-20 Dsm Ip Assets B.V. Production of panthenol
EP4108654A1 (de) 2021-06-23 2022-12-28 DSM IP Assets B.V. Herstellung von panthenol
CN114085820B (zh) * 2021-11-19 2023-10-20 万华化学集团股份有限公司 来源于Candida viswanathii的酮基泛解酸内酯还原酶
CN114437988B (zh) * 2022-02-28 2023-05-23 贵州医科大学 纤维素降解菌及菌剂、制备方法、应用和降解酒糟的方法
CN115595314A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所(Cn) 表达天冬氨酸脱氢酶的工程菌及发酵生产维生素b5的方法
CN115595328A (zh) * 2022-03-07 2023-01-13 中国科学院微生物研究所(Cn) 天冬氨酸脱羧酶在发酵生产维生素b5中的应用
WO2024110278A1 (en) 2022-11-21 2024-05-30 Dsm Ip Assets B.V. Production of panthenol
EP4378923A1 (de) 2022-12-01 2024-06-05 DSM IP Assets B.V. Herstellung von panthenol
KR20240118943A (ko) 2023-01-27 2024-08-06 씨제이제일제당 (주) 글루타미시박터 할로피토콜라 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도
KR20240118944A (ko) 2023-01-27 2024-08-06 씨제이제일제당 (주) 아르카노박테리움 포시시마일 유래 판토에이트-베타-알라닌 리가아제의 활성이 강화된 미생물 및 이의 용도

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Also Published As

Publication number Publication date
KR20020092912A (ko) 2002-12-12
NO20021382L (no) 2002-05-16
TR200200751T2 (tr) 2004-08-23
HU230509B1 (hu) 2016-09-28
BRPI0014115B8 (pt) 2021-05-25
EP1214420B1 (de) 2016-03-23
PL356566A1 (en) 2004-06-28
EP1214420A2 (de) 2002-06-19
EP2163629A3 (de) 2010-06-02
IL148786A0 (en) 2002-09-12
EP2163629A2 (de) 2010-03-17
HUP0202705A3 (en) 2011-02-28
MXPA02003017A (es) 2004-09-06
BRPI0014115B1 (pt) 2015-05-05
NO20021382D0 (no) 2002-03-20
EP2163629B1 (de) 2017-03-08
CN1420931A (zh) 2003-05-28
JP2003527828A (ja) 2003-09-24
CZ20021013A3 (en) 2002-12-11
BR0014115A (pt) 2002-05-21
WO2001021772A9 (en) 2002-12-05
WO2001021772A2 (en) 2001-03-29
JP5392957B2 (ja) 2014-01-22
HUP0202705A2 (hu) 2002-12-28
SK5222002A3 (en) 2003-03-04
WO2001021772A3 (en) 2002-03-07
AU7708700A (en) 2001-04-24

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