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CA2371782A1 - Imagerie de tissus au moyen de lumiere polarisee - Google Patents

Imagerie de tissus au moyen de lumiere polarisee Download PDF

Info

Publication number
CA2371782A1
CA2371782A1 CA002371782A CA2371782A CA2371782A1 CA 2371782 A1 CA2371782 A1 CA 2371782A1 CA 002371782 A CA002371782 A CA 002371782A CA 2371782 A CA2371782 A CA 2371782A CA 2371782 A1 CA2371782 A1 CA 2371782A1
Authority
CA
Canada
Prior art keywords
light
tissue
backscattered
fiber
illumination
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002371782A
Other languages
English (en)
Inventor
Stephen F. Fulghum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Newton Laboratories Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2371782A1 publication Critical patent/CA2371782A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2461—Illumination
    • G02B23/2469—Illumination using optical fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00096—Optical elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00064—Constructional details of the endoscope body
    • A61B1/00071—Insertion part of the endoscope body
    • A61B1/0008—Insertion part of the endoscope body characterised by distal tip features
    • A61B1/00097—Sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00172—Optical arrangements with means for scanning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • A61B1/00163—Optical arrangements
    • A61B1/00186—Optical arrangements with imaging filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B23/00—Telescopes, e.g. binoculars; Periscopes; Instruments for viewing the inside of hollow bodies; Viewfinders; Optical aiming or sighting devices
    • G02B23/24—Instruments or systems for viewing the inside of hollow bodies, e.g. fibrescopes
    • G02B23/2407—Optical details
    • G02B23/2423—Optical details of the distal end
    • G02B23/243—Objectives for endoscopes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4792—Polarisation of scatter light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Physics & Mathematics (AREA)
  • Astronomy & Astrophysics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Eye Examination Apparatus (AREA)
  • Endoscopes (AREA)
  • Instruments For Viewing The Inside Of Hollow Bodies (AREA)

Abstract

L'invention porte sur la détection différentielle de lumière directement rétrodiffusée à partir des tissus épithéliaux afin d'analyser la distribution de la dimension des noyaux cellulaires de manière à détecter les dysplasies dans le tissu. La lumière directement rétrodiffusée par le tissu superficiel est séparée de la lumière rétrodiffusée par les tissus sous-jacents au moyen d'une polarisation, d'une distribution angulaire ou de ces deux procédés à la fois. L'invention porte aussi bien sur des systèmes de mesure par points que sur des systèmes d'imagerie, et concerne également des systèmes optiques de diffusion et de captage de lumière comprenant des systèmes endoscopiques et des systèmes à fibre optique.
CA002371782A 1999-01-25 2000-01-25 Imagerie de tissus au moyen de lumiere polarisee Abandoned CA2371782A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11722199P 1999-01-25 1999-01-25
US60/117,221 1999-01-25
PCT/US2000/001764 WO2000043750A2 (fr) 1999-01-25 2000-01-25 Imagerie de tissus au moyen de lumiere polarisee

Publications (1)

Publication Number Publication Date
CA2371782A1 true CA2371782A1 (fr) 2000-07-27

Family

ID=22371613

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002371782A Abandoned CA2371782A1 (fr) 1999-01-25 2000-01-25 Imagerie de tissus au moyen de lumiere polarisee

Country Status (9)

Country Link
EP (1) EP1153280A2 (fr)
JP (1) JP2002535645A (fr)
KR (1) KR20010110346A (fr)
CN (1) CN1341209A (fr)
AU (1) AU2628200A (fr)
CA (1) CA2371782A1 (fr)
HK (1) HK1041727A1 (fr)
NZ (1) NZ513118A (fr)
WO (1) WO2000043750A2 (fr)

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EP1392152B1 (fr) * 2001-03-02 2013-05-08 SPECTRX Inc. Systeme permettant de determiner des caracteristiques tissulaires
EP1472517A1 (fr) * 2002-01-18 2004-11-03 Newton Laboratories, Inc. Methodes et systeme de diagnostic par spectroscopie
WO2003062799A2 (fr) * 2002-01-18 2003-07-31 Newton Laboratories, Inc. Methodes et systeme de diagnostic par spectroscopie
AU2002337504A1 (en) * 2002-06-08 2003-12-22 Kwon Soo Ha Method for protein chip analysis by using surface plasmon resonance spectroscopic imaging technology
CN102749287B (zh) * 2003-06-04 2015-08-19 广东永士达医疗科技有限公司 利用光的传播模式测量物质中的光学不均匀性和其他属性
JP4535697B2 (ja) * 2003-07-23 2010-09-01 オリンパス株式会社 生体組織の光散乱観測内視鏡装置
CA2539184A1 (fr) * 2003-09-19 2005-03-31 The General Hospital Corporation Dispositifs et procedes d'imagerie par polarisation de fluorescence
CN100443041C (zh) * 2004-05-26 2008-12-17 吴冈 具有测量功能的内窥镜系统及其测量方法
WO2007014213A2 (fr) * 2005-07-25 2007-02-01 Massachusetts Institute Of Technology Imagerie spectroscopique trimodale
CA2967964A1 (fr) * 2005-10-11 2007-04-19 Duke University Systemes et procede endoscopiques d'interferometrie a faible coherence et a resolution angulaire
US8175690B2 (en) * 2007-02-20 2012-05-08 Koninklijke Philips Electronics N.V. Optical device for assessing optical depth in a sample
EP2134240A1 (fr) * 2007-03-12 2009-12-23 Koninklijke Philips Electronics N.V. Système, support lisible par ordinateur, procédé et utilisation pour un diagnostic et une stadification combinés d'un cancer épithélial précoce
CN100506150C (zh) * 2007-04-28 2009-07-01 马剑文 活体组织光学检测装置及其工作方法
DE202008009859U1 (de) * 2007-12-21 2009-03-05 Berthold Technologies Gmbh & Co. Kg Vorrichtung zur wahlweisen Messung von insbesondere Lumineszenz- und/oder Fluoreszenzstrahlung
JP4575474B2 (ja) * 2008-06-11 2010-11-04 国立大学法人東京工業大学 生体組織識別装置および方法
JP2010025867A (ja) * 2008-07-23 2010-02-04 Olympus Medical Systems Corp 被検体観測装置及び被検体観測方法
KR101109968B1 (ko) 2008-07-23 2012-02-17 올림푸스 메디칼 시스템즈 가부시키가이샤 피검체 관측 장치 및 피검체 관측 방법
JP5191831B2 (ja) * 2008-07-23 2013-05-08 オリンパスメディカルシステムズ株式会社 被検体観測装置及び被検体観測装置の作動方法
US20110235037A1 (en) * 2008-12-02 2011-09-29 Koninklijke Philips Electronics N.V. Sensor device for detecting target particles by frustrated total internal reflection
JP5532479B2 (ja) * 2010-03-31 2014-06-25 住友化学株式会社 金型検査方法、防眩製品ヘイズ予測方法および防眩製品反射像鮮明度予測方法
EP2620093A1 (fr) 2010-10-29 2013-07-31 Olympus Corporation Dispositif de mesure optique et sonde
WO2013011778A1 (fr) 2011-07-15 2013-01-24 オリンパスメディカルシステムズ株式会社 Sonde
JP6028015B2 (ja) * 2012-03-07 2016-11-16 オリンパス株式会社 測定プローブ
EP2822453B1 (fr) 2012-03-08 2017-12-13 Koninklijke Philips N.V. Appareil permettant de déterminer une propriété d'un tissu
CN104219988A (zh) * 2012-05-25 2014-12-17 奥林巴斯医疗株式会社 测量探头
JP6173325B2 (ja) 2012-09-13 2017-08-02 オリンパス株式会社 測定プローブおよび生体光学測定システム
DE102012221527A1 (de) * 2012-11-26 2014-06-12 Heine Optotechnik Gmbh & Co Kg Optisches Diagnoseinstrument
EP2989441B1 (fr) * 2013-04-21 2019-01-02 Mobileodt Ltd Appareil d'imagerie de lumière polarisée et procédé associé de séparation de la lumière issue de la surface d'un échantillon et de ses couches les plus profondes
CN104280350B (zh) * 2013-07-03 2018-06-01 庞小峰 一种特殊锐化的癌症早期诊断和治疗效果检查的装置
KR101503272B1 (ko) 2013-07-26 2015-03-18 연세대학교 원주산학협력단 관절염 진단을 위한 다중 모드 광 영상장치
CN106725250A (zh) * 2017-01-09 2017-05-31 清华大学深圳研究生院 一种头端调制的内窥偏振成像系统及测量方法
WO2019046827A1 (fr) * 2017-08-31 2019-03-07 Metalenz, Inc. Intégration de lentille de métasurface transmissive
JP2022542172A (ja) 2019-07-26 2022-09-29 メタレンズ，インコーポレイテッド アパーチャメタ表面およびハイブリッド屈折メタ表面イメージングシステム
CN113075097A (zh) * 2021-03-22 2021-07-06 厦门理工学院 一种基于散射光偏振检测的粒径测量方法、装置及设备
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Also Published As

Publication number Publication date
CN1341209A (zh) 2002-03-20
JP2002535645A (ja) 2002-10-22
EP1153280A2 (fr) 2001-11-14
WO2000043750A2 (fr) 2000-07-27
WO2000043750A9 (fr) 2001-08-30
AU2628200A (en) 2000-08-07
HK1041727A1 (zh) 2002-07-19
WO2000043750A3 (fr) 2000-11-23
KR20010110346A (ko) 2001-12-13
NZ513118A (en) 2004-02-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued