[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CA2263924A1 - Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator - Google Patents

Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator

Info

Publication number
CA2263924A1
CA2263924A1 CA002263924A CA2263924A CA2263924A1 CA 2263924 A1 CA2263924 A1 CA 2263924A1 CA 002263924 A CA002263924 A CA 002263924A CA 2263924 A CA2263924 A CA 2263924A CA 2263924 A1 CA2263924 A1 CA 2263924A1
Authority
CA
Canada
Prior art keywords
patient
contrast agent
region
diagnostic imaging
coronary vasodilator
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002263924A
Other languages
French (fr)
Other versions
CA2263924C (en
Inventor
Evan C. Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lantheus Medical Imaging Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24861044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2263924(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2263924A1 publication Critical patent/CA2263924A1/en
Application granted granted Critical
Publication of CA2263924C publication Critical patent/CA2263924C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/411—Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/20—Measuring for diagnostic purposes; Identification of persons for measuring urological functions restricted to the evaluation of the urinary system
    • A61B5/201—Assessing renal or kidney functions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Apparatus For Radiation Diagnosis (AREA)

Abstract

Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.
CA002263924A 1996-09-11 1997-08-26 Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator Expired - Fee Related CA2263924C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71217396A 1996-09-11 1996-09-11
US08/712,173 1997-01-30
PCT/US1997/014986 WO1998010799A1 (en) 1996-09-11 1997-08-26 Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator

Publications (2)

Publication Number Publication Date
CA2263924A1 true CA2263924A1 (en) 1998-03-19
CA2263924C CA2263924C (en) 2008-11-18

Family

ID=24861044

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002263924A Expired - Fee Related CA2263924C (en) 1996-09-11 1997-08-26 Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator

Country Status (7)

Country Link
US (2) US5846517A (en)
EP (2) EP1323434B1 (en)
AU (1) AU732813B2 (en)
CA (1) CA2263924C (en)
DE (1) DE69738223T3 (en)
PT (1) PT1323434E (en)
WO (1) WO1998010799A1 (en)

Families Citing this family (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US6113570A (en) * 1994-09-09 2000-09-05 Coraje, Inc. Method of removing thrombosis in fistulae
US6397098B1 (en) 1994-09-21 2002-05-28 Medrad, Inc. Data communication and control for medical imaging systems
US6743779B1 (en) * 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6033645A (en) * 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5648098A (en) * 1995-10-17 1997-07-15 The Board Of Regents Of The University Of Nebraska Thrombolytic agents and methods of treatment for thrombosis
ATE238072T1 (en) * 1996-02-19 2003-05-15 Amersham Health As IMPROVEMENTS IN (OR RELATING TO) CONTRAST AGENTS
RU2186405C2 (en) * 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Amplification of nuclear magnetic resonance and magnetic resonance visualization in presence of hyperpolarized noble gases
ATE345682T1 (en) 1996-05-01 2006-12-15 Imarx Pharmaceutical Corp IN VITRO METHOD FOR INTRODUCING NUCLEIC ACIDS INTO A CELL
WO1998017324A2 (en) * 1996-10-21 1998-04-30 Marsden, John, Christopher Improvements in or relating to contrast agents
US6261537B1 (en) * 1996-10-28 2001-07-17 Nycomed Imaging As Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors
US6331289B1 (en) 1996-10-28 2001-12-18 Nycomed Imaging As Targeted diagnostic/therapeutic agents having more than one different vectors
US20070036722A1 (en) * 1996-10-28 2007-02-15 Pal Rongved Separation processes
JP2001503407A (en) 1996-10-28 2001-03-13 ニユコメド・イメージング・アクシエセルカペト Improved diagnostic / therapeutic agents
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
ES2296332T3 (en) * 1997-04-30 2008-04-16 Point Biomedical Corporation MICROPARTICLES THAT ARE USED AS CONTRAST AGENTS FOR THE RELEASE OF MEDICINES IN THE BLOOD FLOW.
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
WO1999020312A1 (en) * 1997-10-21 1999-04-29 Nycomed Imaging As Ultrasound imaging with contrast agent targeted to microvasculature and a vasodilator drug
US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
EP1053041A4 (en) 1998-01-12 2001-02-07 Georgia Tech Res Inst Assessment and control of acoustic tissue effects
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
GB9808599D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or realting to contrast agents
US20040170564A1 (en) * 1998-04-22 2004-09-02 Roald Skurtveit Ultrasound contrast agent dispersions comprising gas and destabilising agent
GB9808582D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or relating to contrast agents
US6186951B1 (en) * 1998-05-26 2001-02-13 Riverside Research Institute Ultrasonic systems and methods for fluid perfusion and flow rate measurement
GB9813568D0 (en) * 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
DE19840532A1 (en) 1998-08-28 2000-03-09 Schering Ag Syringe filled with ultrasound contrast medium with a mechanical movement device
DE19840536A1 (en) 1998-08-28 2000-03-09 Schering Ag Syringe filled with ultrasound contrast medium with a magnetic movement device
US7686763B2 (en) * 1998-09-18 2010-03-30 University Of Washington Use of contrast agents to increase the effectiveness of high intensity focused ultrasound therapy
EP1128769A4 (en) * 1998-11-06 2007-08-01 Univ Rochester A method to improve circulation to ischemic tissue
US6444192B1 (en) 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
US6317623B1 (en) 1999-03-12 2001-11-13 Medrad, Inc. Apparatus and method for controlling contrast enhanced imaging procedures
US6575930B1 (en) 1999-03-12 2003-06-10 Medrad, Inc. Agitation devices and dispensing systems incorporating such agitation devices
US7510536B2 (en) 1999-09-17 2009-03-31 University Of Washington Ultrasound guided high intensity focused ultrasound treatment of nerves
US7520856B2 (en) * 1999-09-17 2009-04-21 University Of Washington Image guided high intensity focused ultrasound device for therapy in obstetrics and gynecology
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7225082B1 (en) 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes
US20050032226A1 (en) * 1999-10-01 2005-02-10 Natan Michael J. Encoded nanoparticles in paper manufacture
US7045049B1 (en) 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US6919009B2 (en) * 1999-10-01 2005-07-19 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobarcodes
AU2619301A (en) 1999-10-25 2001-06-06 Therus Corporation Use of focused ultrasound for vascular sealing
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
GB2360892A (en) * 2000-02-11 2001-10-03 David John Watmough Imaging apparatus incorporating light and ultrasound applying means within the same applicator
US6445945B1 (en) 2000-06-26 2002-09-03 André Arsenault Non-invasive detection of endothelial dysfunction by blood flow measurement in opposed limbs using tracer injection
US7061237B2 (en) * 2000-07-13 2006-06-13 The Regents Of The University Of California Remote NMR/MRI detection of laser polarized gases
US6652833B2 (en) * 2000-07-13 2003-11-25 The Regents Of The University Of California Functionalized active-nucleus complex sensor
US20030165431A1 (en) * 2000-07-13 2003-09-04 The Regents Of The University Of California Method for detecting macromolecular conformational change and binding information
US7335169B2 (en) * 2000-08-24 2008-02-26 Timi 3 Systems, Inc. Systems and methods for delivering ultrasound energy at an output power level that remains essentially constant despite variations in transducer impedance
US7104958B2 (en) 2001-10-01 2006-09-12 New Health Sciences, Inc. Systems and methods for investigating intracranial pressure
CA2423195A1 (en) 2000-09-29 2002-04-04 New Health Sciences, Inc. Systems and methods for assessing vascular health
EP1216709A1 (en) * 2000-12-21 2002-06-26 Boehringer Ingelheim Pharma KG Use of activated coagulation factor VII for treating thrombolytic therapy-induced major bleedings
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
AUPR576901A0 (en) * 2001-06-19 2001-07-12 University Of Tasmania Improved method of measuring changes in microvascular capillary blood flow
AU2002311087B2 (en) * 2001-06-19 2006-12-21 University Of Tasmania Improved method of measuring changes in microvascular capillary blood flow
KR20030014548A (en) * 2001-08-11 2003-02-19 한승무 Ultrasonic physical therapy device using herbal medicine
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
WO2003047439A2 (en) 2001-12-03 2003-06-12 Ekos Corporation Catheter with multiple ultrasound radiating members
US7700074B2 (en) * 2002-02-07 2010-04-20 Pettegrew Jay W Method and system for diagnosis of neuropsychiatric disorders including chronic alcoholism
US7407778B2 (en) 2002-02-07 2008-08-05 Pettegrew Jay W Compounds, compositions and methods for treating neuropsychiatric disorders
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
US7367947B2 (en) * 2002-11-08 2008-05-06 Koninklijke Philips Electronics N.V. Elevation beamwidth control for control for contrast imaging
US7376455B2 (en) * 2003-05-22 2008-05-20 Scimed Life Systems, Inc. Systems and methods for dynamic optical imaging
US20060257842A1 (en) * 2003-05-29 2006-11-16 Pettegrew Jay W Cryopreservation media and molecules
ATE437884T1 (en) * 2003-05-29 2009-08-15 Jay W Pettegrew GLYCEROPHOSPHOCHOLINE AND DERIVATIVES THEREOF FOR THE MEDICAL IMAGING OF NEUROPSYCHIATRIC DISEASES
WO2004113869A2 (en) * 2003-06-17 2004-12-29 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (en) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Vehicle roof module
EP1649066A4 (en) * 2003-07-11 2006-10-11 Surromed Inc Multiplexed molecular beacon assay for detection of pathogens
US7526331B2 (en) * 2003-07-18 2009-04-28 Munn Charles S Enhanced cardiac radionuclide imaging techniques
JP4473543B2 (en) * 2003-09-05 2010-06-02 株式会社東芝 Ultrasonic diagnostic equipment
US7894880B2 (en) * 2003-10-23 2011-02-22 The Board Of Trustees Of The Leland Stanford Junior University Measurement of renal extraction fraction using contrast enhanced computed tomography
US20050106101A1 (en) * 2003-10-31 2005-05-19 Ajay Purohit Novel chemical agents comprising an adenosine moiety or an adenosine analog moiety and an imaging moiety and methods of their use
DE10357334A1 (en) * 2003-12-05 2005-07-07 Grönemeyer, Dietrich H. W., Prof. Dr.med. MR compatible medical implant
US8211017B2 (en) 2003-12-16 2012-07-03 University Of Washington Image guided high intensity focused ultrasound treatment of nerves
US7878978B2 (en) * 2004-03-18 2011-02-01 University Of Pittsburgh- Of The Commonwealth System Of Higher Education Use of relaxin to increase arterial compliance
US7713517B2 (en) 2004-04-21 2010-05-11 Marval Biosciences, Inc. Compositions and methods for enhancing contrast in imaging
US8357351B2 (en) 2004-04-21 2013-01-22 Ananth Annapragada Nano-scale contrast agents and methods of use
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
WO2005107577A1 (en) * 2004-05-10 2005-11-17 Highland Innovation Centre Limited Appartus for examining a body of living tissues
US9066679B2 (en) 2004-08-31 2015-06-30 University Of Washington Ultrasonic technique for assessing wall vibrations in stenosed blood vessels
US20080009561A1 (en) * 2004-09-03 2008-01-10 Imarx Therapeutics, Inc. Apparatus And Method To Prepare A Microsphere-Forming Composition
CA2575687A1 (en) * 2004-09-16 2006-03-23 University Of Washington Acoustic coupler using an independent water pillow with circulation for cooling a transducer
US20060083681A1 (en) * 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
WO2006055813A2 (en) 2004-11-16 2006-05-26 Medrad, Inc. Modeling of pharmaceutical propagation
US7925330B2 (en) 2004-11-24 2011-04-12 Medrad, Inc. Devices, systems and methods for determining parameters of one or more phases of an injection procedure
CN100574809C (en) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 A kind of high-strength focusing ultrasonic therapy fluorocarbon emulsion analog assistant and application thereof
US7981442B2 (en) * 2005-06-28 2011-07-19 University Of South Florida Ultrasound enhancement of drug release across non-ionic surfactant membranes
US8435558B1 (en) 2005-06-28 2013-05-07 University Of South Florida Ultrasound enhancement of drug release across non-ionic surfactant membranes
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
US20090028798A1 (en) * 2005-08-11 2009-01-29 Government Of The Usa, Represented By The Secretary, Dept.Of Health And Human Services Method for determining redox status of a tissue
EP1921976A2 (en) 2005-08-12 2008-05-21 University of Washington Method and apparatus for preparing organs and tissues for laparoscopic surgery
US20070059247A1 (en) * 2005-08-30 2007-03-15 Lindner Jonathan R Deposit contrast agents and related methods thereof
US8414494B2 (en) 2005-09-16 2013-04-09 University Of Washington Thin-profile therapeutic ultrasound applicators
US8016757B2 (en) 2005-09-30 2011-09-13 University Of Washington Non-invasive temperature estimation technique for HIFU therapy monitoring using backscattered ultrasound
US20070233185A1 (en) 2005-10-20 2007-10-04 Thomas Anderson Systems and methods for sealing a vascular opening
US8715739B2 (en) * 2005-10-24 2014-05-06 Purdue Research Foundation Polymer coated microparticles
JP5253175B2 (en) * 2005-11-14 2013-07-31 ヴァロリサシオン−ルシェルシュ・リミテッド・パートナーシップ Pharmaceutical composition comprising a polymeric binder having non-hydrolytic covalent bonds and use in the treatment of celiac disease
WO2007064175A1 (en) * 2005-12-02 2007-06-07 Industry-Academic Cooperation Foundation, Yonsei University Magnetic resonance imaging contrast agents containing water-soluble nanoparticles of manganese oxide or manganese metal oxide
WO2007070827A2 (en) * 2005-12-15 2007-06-21 Bristol-Myers Squibb Pharma Company Contrast agents for myocardium perfusion imaging
US20070265560A1 (en) 2006-04-24 2007-11-15 Ekos Corporation Ultrasound Therapy System
US8623327B2 (en) * 2006-06-19 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
US20080019921A1 (en) * 2006-06-30 2008-01-24 Invitrogen Corporation Uniform fluorescent microsphere with hydrophobic surfaces
HUE040477T2 (en) 2006-12-29 2019-03-28 Bayer Healthcare Llc Patient-based parameter generation systems for medical injection procedures
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
JP5449651B2 (en) * 2007-03-09 2014-03-19 株式会社東芝 X-ray CT apparatus and myocardial perfusion information generation system
CA2680525A1 (en) * 2007-03-09 2008-09-18 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Nitroxide radical as a treatment for neurodegeneration
EP2494932B1 (en) 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
JP5437240B2 (en) 2007-07-17 2014-03-12 メドラッド インコーポレーテッド Apparatus, system and method for determining parameters of cardiopulmonary function evaluation and fluid delivery procedures
US8337813B2 (en) * 2007-09-14 2012-12-25 Northwestern University Contrast agents
US8642013B2 (en) * 2007-12-05 2014-02-04 Ananth Annapragada Nano-scale contrast agents and methods of use
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
CN102014969B (en) 2008-02-29 2014-07-09 兰休斯医疗成像公司 Contrast agents for applications including perfusion imaging
CN102026625A (en) * 2008-03-17 2011-04-20 犹他州大学研究基金会 Dithiocarbamate metal chelates and methods of making and using thereof
WO2009152445A1 (en) * 2008-06-13 2009-12-17 Marval Biosciences, Inc. Imaging of atherosclerotic plaques using liposomal imaging agents
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
US9421330B2 (en) 2008-11-03 2016-08-23 Bayer Healthcare Llc Mitigation of contrast-induced nephropathy
JP5662416B2 (en) 2009-04-15 2015-01-28 ランセウス メディカル イメージング， インコーポレイテッド Stabilization of radiopharmaceutical compositions with ascorbic acid.
US20110042121A1 (en) * 2009-08-21 2011-02-24 Rogers Bernard I Electrical cable protection block
US9174065B2 (en) 2009-10-12 2015-11-03 Kona Medical, Inc. Energetic modulation of nerves
US20110092880A1 (en) 2009-10-12 2011-04-21 Michael Gertner Energetic modulation of nerves
US8295912B2 (en) 2009-10-12 2012-10-23 Kona Medical, Inc. Method and system to inhibit a function of a nerve traveling with an artery
US8986231B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US11998266B2 (en) 2009-10-12 2024-06-04 Otsuka Medical Devices Co., Ltd Intravascular energy delivery
US8469904B2 (en) 2009-10-12 2013-06-25 Kona Medical, Inc. Energetic modulation of nerves
US8986211B2 (en) 2009-10-12 2015-03-24 Kona Medical, Inc. Energetic modulation of nerves
US20110118600A1 (en) 2009-11-16 2011-05-19 Michael Gertner External Autonomic Modulation
US20160059044A1 (en) 2009-10-12 2016-03-03 Kona Medical, Inc. Energy delivery to intraparenchymal regions of the kidney to treat hypertension
US9119951B2 (en) 2009-10-12 2015-09-01 Kona Medical, Inc. Energetic modulation of nerves
US8517962B2 (en) 2009-10-12 2013-08-27 Kona Medical, Inc. Energetic modulation of nerves
NZ602291A (en) 2010-02-08 2014-10-31 Lantheus Medical Imaging Inc Methods and apparatus for synthesizing imaging agents, and intermediates thereof
US8740835B2 (en) 2010-02-17 2014-06-03 Ekos Corporation Treatment of vascular occlusions using ultrasonic energy and microbubbles
KR20130088760A (en) 2010-06-24 2013-08-08 메드라드, 인크. Modeling of pharmaceutical propagation and parameter generation for injection protocols
PL3446714T3 (en) 2011-06-02 2021-11-22 University Of Louisville Research Foundation, Inc. Anti-nucleolin agent-conjugated nanoparticles
BR112014028442A2 (en) 2012-05-14 2018-04-24 Bayer Medical Care Inc. x-ray tube voltage-based pharmaceutical fluid injection protocol systems and methods
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US9555379B2 (en) 2013-03-13 2017-01-31 Bayer Healthcare Llc Fluid path set with turbulent mixing chamber, backflow compensator
CN107106692B (en) * 2014-06-12 2021-01-05 埃文·C·昂格尔 Phospholipid composition and microcapsule, and emulsion using the same
US10925579B2 (en) 2014-11-05 2021-02-23 Otsuka Medical Devices Co., Ltd. Systems and methods for real-time tracking of a target tissue using imaging before and during therapy delivery
US10500227B2 (en) * 2014-12-03 2019-12-10 University Of Cincinnati Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
IL252705B2 (en) * 2014-12-31 2023-03-01 Lantheus Medical Imaging Inc Lipid-encapsulated gas microsphere compositions and related methods
CN107708581B (en) 2015-06-10 2021-11-19 Ekos公司 Ultrasonic wave guide tube
IL298236B2 (en) * 2015-12-21 2024-05-01 Nuvox Pharma Llc Compositions of fluorocarbon nanoemulsion, and methods of preparation and use thereof
WO2017152036A1 (en) 2016-03-03 2017-09-08 Bayer Healthcare Llc System and method for improved fluid delivery in multi-fluid injector systems
CA3022698A1 (en) 2016-05-04 2017-11-09 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
EP3493852A1 (en) * 2016-08-02 2019-06-12 University of Louisville Research Foundation, Inc. Targeted nanodroplet emulsions for treating cancer
JP7079244B2 (en) * 2016-10-04 2022-06-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Multi-frequency harmonic acoustics for target identification and boundary detection
US11786652B2 (en) 2017-08-31 2023-10-17 Bayer Healthcare Llc System and method for drive member position and fluid injector system mechanical calibration
JP7317724B2 (en) 2017-08-31 2023-07-31 バイエル・ヘルスケア・エルエルシー Liquid injector system volume compensation system and method
WO2019046299A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Fluid path impedance assessment for improving fluid delivery performance
EP3675929A1 (en) 2017-08-31 2020-07-08 Bayer Healthcare LLC Method for dynamic pressure control in a fluid injector system
WO2019046282A1 (en) 2017-08-31 2019-03-07 Bayer Healthcare Llc Injector pressure calibration system and method

Family Cites Families (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3015128A (en) * 1960-08-18 1962-01-02 Southwest Res Inst Encapsulating apparatus
NL302030A (en) 1962-12-21 1900-01-01
US3291843A (en) 1963-10-08 1966-12-13 Du Pont Fluorinated vinyl ethers and their preparation
BE661981A (en) * 1964-04-03
US3594326A (en) * 1964-12-03 1971-07-20 Ncr Co Method of making microscopic capsules
US3968203A (en) * 1965-10-01 1976-07-06 Jerome G. Spitzer Aerosol astringent composition
US3488714A (en) * 1966-09-19 1970-01-06 Dow Chemical Co Formed laminate structure and method of preparation
US3615972A (en) * 1967-04-28 1971-10-26 Dow Chemical Co Expansible thermoplastic polymer particles containing volatile fluid foaming agent and method of foaming the same
US3532500A (en) * 1967-07-25 1970-10-06 Eastman Kodak Co Light sensitive vesicular composition comprising an azido-s-triazine compound
US3557294A (en) 1967-10-12 1971-01-19 Allied Chem Fluorinated ethers as inhalation convulsants
US3479811A (en) * 1967-11-29 1969-11-25 Dow Chemical Co Yarn and method of making the same
US3732172A (en) * 1968-02-28 1973-05-08 Ncr Co Process for making minute capsules and prefabricated system useful therein
US3650831A (en) * 1969-03-10 1972-03-21 Armour Dial Inc Method of cleaning surfaces
US4027007A (en) * 1970-12-09 1977-05-31 Colgate-Palmolive Company Antiperspirants formulated with borax
US3873564A (en) * 1971-03-03 1975-03-25 Synvar Ass 2-Imidazolinyl-3-oxide-1-oxypropionic acid
US4108806A (en) * 1971-12-06 1978-08-22 The Dow Chemical Company Thermoplastic expandable microsphere process and product
US4179546A (en) * 1972-08-28 1979-12-18 The Dow Chemical Company Method for expanding microspheres and expandable composition
US3960583A (en) * 1974-05-02 1976-06-01 Philadelphia Quartz Company Method of preparing modified hollow, largely spherical particles by spray drying
CH588887A5 (en) * 1974-07-19 1977-06-15 Battelle Memorial Institute
US3945956A (en) * 1975-06-23 1976-03-23 The Dow Chemical Company Polymerization of styrene acrylonitrile expandable microspheres
US4138383A (en) * 1975-11-24 1979-02-06 California Institute Of Technology Preparation of small bio-compatible microspheres
GB1523965A (en) 1976-03-19 1978-09-06 Ici Ltd Pharmaceutical compositions containing steroids
US4162282A (en) * 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
GB1599881A (en) * 1977-02-02 1981-10-07 Millington A R Preparation for diagnostic radiology
CH624011A5 (en) * 1977-08-05 1981-07-15 Battelle Memorial Institute
CH621479A5 (en) * 1977-08-05 1981-02-13 Battelle Memorial Institute
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
US4276885A (en) * 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) * 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
US4310505A (en) * 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4342826A (en) * 1980-02-04 1982-08-03 Collaborative Research, Inc. Immunoassay products and methods
US4421562A (en) * 1980-04-13 1983-12-20 Pq Corporation Manufacturing process for hollow microspheres
US4344929A (en) * 1980-04-25 1982-08-17 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US4315514A (en) * 1980-05-08 1982-02-16 William Drewes Method and apparatus for selective cell destruction
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4442843A (en) * 1980-11-17 1984-04-17 Schering, Ag Microbubble precursors and methods for their production and use
US4681119A (en) * 1980-11-17 1987-07-21 Schering Aktiengesellschaft Method of production and use of microbubble precursors
US4657756A (en) * 1980-11-17 1987-04-14 Schering Aktiengesellschaft Microbubble precursors and apparatus for their production and use
US4420442A (en) * 1981-04-13 1983-12-13 Pq Corporation Manufacturing process for hollow microspheres
US4533254A (en) * 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
EP0068961A3 (en) * 1981-06-26 1983-02-02 Thomson-Csf Apparatus for the local heating of biological tissue
US4426330A (en) * 1981-07-20 1984-01-17 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4534899A (en) * 1981-07-20 1985-08-13 Lipid Specialties, Inc. Synthetic phospholipid compounds
US4569836A (en) * 1981-08-27 1986-02-11 Gordon Robert T Cancer treatment by intracellular hyperthermia
EP0088773B1 (en) * 1981-09-23 1987-09-09 M.B. Fillers Pty. Ltd. Hollow, bilayered silicate microspheres
DE3141641A1 (en) * 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen ULTRASONIC CONTRAST AGENTS AND THEIR PRODUCTION
BR8107560A (en) 1981-11-19 1983-07-05 Luiz Romariz Duarte ULTRASONIC STIMULATION OF BONE FRACTURE CONSOLIDATION
US4540629A (en) * 1982-04-08 1985-09-10 Pq Corporation Hollow microspheres with organosilicon-silicate walls
DE3225848A1 (en) 1982-07-07 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen PREPARATION OF CORTICOIDS FOR TOPICAL APPLICATION
FR2534487B1 (en) 1982-10-15 1988-06-10 Dior Christian Parfums METHOD FOR THE HOMOGENEIZATION OF HYDRATED LIPIDAL LAMELLAR PHASE DISPERSIONS, AND SUSPENSIONS OBTAINED THEREBY
DE3374522D1 (en) * 1982-10-26 1987-12-23 University Of Aberdeen
US4603044A (en) * 1983-01-06 1986-07-29 Technology Unlimited, Inc. Hepatocyte Directed Vesicle delivery system
US4731239A (en) * 1983-01-10 1988-03-15 Gordon Robert T Method for enhancing NMR imaging; and diagnostic use
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
US4718433A (en) * 1983-01-27 1988-01-12 Feinstein Steven B Contrast agents for ultrasonic imaging
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US4981692A (en) * 1983-03-24 1991-01-01 The Liposome Company, Inc. Therapeutic treatment by intramammary infusion
US5141738A (en) * 1983-04-15 1992-08-25 Schering Aktiengesellschaft Ultrasonic contrast medium comprising gas bubbles and solid lipophilic surfactant-containing microparticles and use thereof
US4485193A (en) 1983-05-10 1984-11-27 The Dow Chemical Company Expandable synthetic resinous thermoplastic particles, method for the preparation thereof and the application therefor
US4900540A (en) * 1983-06-20 1990-02-13 Trustees Of The University Of Massachusetts Lipisomes containing gas for ultrasound detection
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US4615879A (en) * 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
FR2563725B1 (en) * 1984-05-03 1988-07-15 Dory Jacques APPARATUS FOR EXAMINING AND LOCATING ULTRASONIC TUMORS WITH A LOCALIZED HYPERTHERMAL TREATMENT DEVICE
DE3585967D1 (en) * 1984-03-08 1992-06-11 Phares Pharma Holland LIPOSOME FORMING COMPOSITION.
GB8407557D0 (en) * 1984-03-23 1984-05-02 Hayward J A Polymeric lipsomes
US4728575A (en) * 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US5008050A (en) * 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4620546A (en) * 1984-06-30 1986-11-04 Kabushiki Kaisha Toshiba Ultrasound hyperthermia apparatus
SE8403905D0 (en) 1984-07-30 1984-07-30 Draco Ab LIPOSOMES AND STEROID ESTERS
US4767610A (en) 1984-10-19 1988-08-30 The Regents Of The University Of California Method for detecting abnormal cell masses in animals
US4789501A (en) * 1984-11-19 1988-12-06 The Curators Of The University Of Missouri Glass microspheres
US4921706A (en) * 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4830858A (en) * 1985-02-11 1989-05-16 E. R. Squibb & Sons, Inc. Spray-drying method for preparing liposomes and products produced thereby
US4689986A (en) * 1985-03-13 1987-09-01 The University Of Michigan Variable frequency gas-bubble-manipulating apparatus and method
US5186922A (en) 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4663161A (en) 1985-04-22 1987-05-05 Mannino Raphael J Liposome methods and compositions
ATE78158T1 (en) * 1985-05-22 1992-08-15 Liposome Technology Inc METHOD AND SYSTEM FOR INHALATION OF LIPOSOMES.
EP0216730B1 (en) 1985-08-12 1991-01-23 Battelle Memorial Institute Porous spherical glass filtrating beads and method for the manufacturing thereof
US4684479A (en) * 1985-08-14 1987-08-04 Arrigo Joseph S D Surfactant mixtures, stable gas-in-liquid emulsions, and methods for the production of such emulsions from said mixtures
US4938947A (en) * 1985-11-01 1990-07-03 Centre National De La Recherche Scientifique (Cnrs) Aerosol composition for in vivo imaging
US4987154A (en) * 1986-01-14 1991-01-22 Alliance Pharmaceutical Corp. Biocompatible, stable and concentrated fluorocarbon emulsions for contrast enhancement and oxygen transport in internal animal use
US4927623A (en) * 1986-01-14 1990-05-22 Alliance Pharmaceutical Corp. Dissolution of gas in a fluorocarbon liquid
US4865836A (en) * 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
DE3785054T2 (en) 1986-01-24 1993-07-08 Childrens Hosp Medical Center STABLE EMULSIONS OF STRONGLY FLUORED ORGANIC COMPOUNDS.
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
US4834964A (en) 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
JPH0751496B2 (en) * 1986-04-02 1995-06-05 武田薬品工業株式会社 Manufacturing method of liposome
DE3614657A1 (en) 1986-04-30 1987-11-05 Dornier Medizintechnik LIPID VESICLES CONTAINING PHARMAKA, METHOD FOR THE PRODUCTION AND INTRODUCTION THEREOF IN THE BODY OF A LIVING BEING AND RELEASE OF THE PHARMACA CONTAINING IN THE LIPID VESICLES
IL79559A0 (en) 1986-07-29 1986-10-31 Univ Ramot Contrast agents for nmr medical imaging
FR2602774B1 (en) * 1986-07-29 1990-10-19 Atta NOVEL POLYHYDROXYLATED AND PERFLUOROALKYLATED AMPHIPHILIC MOLECULES HAVING SURFACTANT PROPERTIES
US4728578A (en) * 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
US4776991A (en) * 1986-08-29 1988-10-11 The United States Of America As Represented By The Secretary Of The Navy Scaled-up production of liposome-encapsulated hemoglobin
US4781871A (en) * 1986-09-18 1988-11-01 Liposome Technology, Inc. High-concentration liposome processing method
US4769241A (en) 1986-09-23 1988-09-06 Alpha Therapeutic Corporation Apparatus and process for oxygenation of liquid state dissolved oxygen-carrying formulation
ZW11287A1 (en) * 1986-11-04 1989-01-25 Aeci Ltd Process for the production of an explosive
DE3637926C1 (en) 1986-11-05 1987-11-26 Schering Ag Ultrasonic manometry in a liquid using microbubbles
US5049388A (en) * 1986-11-06 1991-09-17 Research Development Foundation Small particle aerosol liposome and liposome-drug combinations for medical use
US4863717A (en) * 1986-11-10 1989-09-05 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
US4933121A (en) * 1986-12-10 1990-06-12 Ciba Corning Diagnostics Corp. Process for forming liposomes
DK175531B1 (en) 1986-12-15 2004-11-22 Nexstar Pharmaceuticals Inc Delivery vehicle with amphiphil-associated active ingredient
CA1321048C (en) * 1987-03-05 1993-08-10 Robert W. J. Lencki Microspheres and method of producing same
US5000960A (en) * 1987-03-13 1991-03-19 Micro-Pak, Inc. Protein coupling to lipid vesicles
US5219538A (en) 1987-03-13 1993-06-15 Micro-Pak, Inc. Gas and oxygen carrying lipid vesicles
US4866096A (en) 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US4895876A (en) 1987-03-20 1990-01-23 Air Products And Chemicals, Inc. Concentrated stable fluorochemical aqueous emulsions containing triglycerides
US4984573A (en) 1987-06-23 1991-01-15 Hafslund Nycomed Innovation Ab Method of electron spin resonance enhanced magnetic resonance imaging
US5354549A (en) 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
US4844882A (en) * 1987-12-29 1989-07-04 Molecular Biosystems, Inc. Concentrated stabilized microbubble-type ultrasonic imaging agent
IE61591B1 (en) 1987-12-29 1994-11-16 Molecular Biosystems Inc Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production
US5425366A (en) 1988-02-05 1995-06-20 Schering Aktiengesellschaft Ultrasonic contrast agents for color Doppler imaging
EP0327490A1 (en) 1988-02-05 1989-08-09 Schering Aktiengesellschaft Ultrasonic imaging agents, process for their preparation and their diagnostic and therapeutical use
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
DE3812816A1 (en) 1988-04-16 1989-11-02 Lawaczeck Ruediger Dipl Phys P METHOD FOR SOLUBILIZING LIPOSOMES AND / OR BIOLOGICAL MEMBRANES AND THE USE THEREOF
US5171755A (en) 1988-04-29 1992-12-15 Hemagen/Pfc Emulsions of highly fluorinated organic compounds
US4893624A (en) * 1988-06-21 1990-01-16 Massachusetts Institute Of Technology Diffuse focus ultrasound hyperthermia system
US4996041A (en) * 1988-08-19 1991-02-26 Toshiyuki Arai Method for introducing oxygen-17 into tissue for imaging in a magnetic resonance imaging system
US4993415A (en) * 1988-08-19 1991-02-19 Alliance Pharmaceutical Corp. Magnetic resonance imaging with perfluorocarbon hydrides
DE3828905A1 (en) 1988-08-23 1990-03-15 Schering Ag MEDIALLY COMPOSED OF CAVITATE OR CLATHRATE MAKING HOST / GUEST COMPLEX AS A CONTRAST
US5045304A (en) * 1988-08-31 1991-09-03 Wayne State University Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same
US5410516A (en) 1988-09-01 1995-04-25 Schering Aktiengesellschaft Ultrasonic processes and circuits for performing them
US4957656A (en) * 1988-09-14 1990-09-18 Molecular Biosystems, Inc. Continuous sonication method for preparing protein encapsulated microbubbles
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
FR2637182B1 (en) 1988-10-03 1992-11-06 Lvmh Rech COMPOSITIONS BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING AN ECDYSTEROID, PREFERABLY ECDYSTERONE, OR A DERIVATIVE THEREOF; AND COSMETIC, PHARMACEUTICAL, ESPECIALLY DERMATOLOGICAL, SERICULTURE OR PHYTOSANITARY COMPOSITIONS INCORPORATING THE SAME
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
DK0478686T3 (en) 1989-06-22 1993-11-29 Alliance Pharma Flour and phosphorus-containing amphiphilic molecules with surfactant properties
US5019370A (en) * 1989-07-10 1991-05-28 University Of Kentucky Research Foundation Biodegradable, low biological toxicity radiographic contrast medium and method of x-ray imaging
US5194266A (en) 1989-08-08 1993-03-16 Liposome Technology, Inc. Amphotericin B/cholesterol sulfate composition and method
US5620689A (en) 1989-10-20 1997-04-15 Sequus Pharmaceuuticals, Inc. Liposomes for treatment of B-cell and T-cell disorders
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5088499A (en) * 1989-12-22 1992-02-18 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5334381A (en) 1989-12-22 1994-08-02 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5469854A (en) 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5149319A (en) 1990-09-11 1992-09-22 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids
US5123414A (en) * 1989-12-22 1992-06-23 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5230882A (en) 1989-12-22 1993-07-27 Unger Evan C Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same
US5352435A (en) 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5209720A (en) 1989-12-22 1993-05-11 Unger Evan C Methods for providing localized therapeutic heat to biological tissues and fluids using gas filled liposomes
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
DE4004430A1 (en) 1990-02-09 1991-08-14 Schering Ag CONSTRUCTED POLYALDEHYDE CONSTITUENTS
US5445813A (en) 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
US5578292A (en) 1991-11-20 1996-11-26 Bracco International B.V. Long-lasting aqueous dispersions or suspensions of pressure-resistant gas-filled microvesicles and methods for the preparation thereof
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
US5556610A (en) 1992-01-24 1996-09-17 Bracco Research S.A. Gas mixtures useful as ultrasound contrast media, contrast agents containing the media and method
US5672585A (en) 1990-04-06 1997-09-30 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5358702A (en) 1990-04-10 1994-10-25 Unger Evan C Methoxylated gel particle contrast media for improved diagnostic imaging
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5205287A (en) 1990-04-26 1993-04-27 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5137928A (en) * 1990-04-26 1992-08-11 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
US5190982A (en) 1990-04-26 1993-03-02 Hoechst Aktiengesellschaft Ultrasonic contrast agents, processes for their preparation and the use thereof as diagnostic and therapeutic agents
AU636481B2 (en) † 1990-05-18 1993-04-29 Bracco International B.V. Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography
US5315997A (en) 1990-06-19 1994-05-31 Molecular Biosystems, Inc. Method of magnetic resonance imaging using diamagnetic contrast
US5215680A (en) 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
IL95743A (en) * 1990-09-19 1993-02-21 Univ Ramot Method of measuring blood flow
AU635449B2 (en) 1990-10-05 1993-03-18 Bracco International B.V. Method for the preparation of stable suspensions of hollow gas-filled microspheres suitable for ultrasonic echography
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
ATE146073T1 (en) 1991-03-22 1996-12-15 Katsuro Tachibana AMPLIFIER FOR ULTRASONIC THERAPY OF DISEASES AND LIQUID MEDICINAL COMPOSITIONS CONTAINING SAME
GB9106686D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
GB9106673D0 (en) 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5496535A (en) 1991-04-12 1996-03-05 Alliance Pharmaceutical Corp. Fluorocarbon contrast media for use with MRI and radiographic imaging
US5147631A (en) * 1991-04-30 1992-09-15 Du Pont Merck Pharmaceutical Company Porous inorganic ultrasound contrast agents
WO1992021382A1 (en) 1991-06-03 1992-12-10 Holmes, Michael, John Improvements in or relating to contrast agents
ATE191346T1 (en) * 1991-09-17 2000-04-15 Sonus Pharma Inc GASEOUS ULTRASONIC CONTRAST AGENTS
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5264220A (en) * 1991-11-12 1993-11-23 Long David M Jr Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
US5196183A (en) 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB9200388D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL104084A (en) 1992-01-24 1996-09-12 Bracco Int Bv Long-lasting aqueous suspensions of pressure-resistant gas-filled microvesicles their preparation and contrast agents consisting of them
US5470582A (en) 1992-02-07 1995-11-28 Syntex (U.S.A.) Inc. Controlled delivery of pharmaceuticals from preformed porous polymeric microparticles
US5247935A (en) 1992-03-19 1993-09-28 General Electric Company Magnetic resonance guided focussed ultrasound surgery
ATE200985T1 (en) 1993-01-25 2001-05-15 Sonus Pharma Inc PHASE PIN COLLOIDS FOR USE AS ULTRASONIC CONTRAST AGENTS
US5558855A (en) 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
CN1245156C (en) 1993-02-22 2006-03-15 美国生物科学有限公司 Methods for in vivo delivery of biologics and compositions useful therefor
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5716597A (en) 1993-06-04 1998-02-10 Molecular Biosystems, Inc. Emulsions as contrast agents and method of use
WO1995001187A1 (en) 1993-07-02 1995-01-12 Molecular Biosystems, Inc. Protein encapsulated insoluble gas microspheres and their preparation and use as ultrasonic imaging agents
DE69434119T3 (en) 1993-07-30 2011-05-05 Imcor Pharmaceutical Co., San Diego STABILIZED MICROGAS BLOWER COMPOSITIONS FOR ECHOGRAPHY
US5433204A (en) 1993-11-16 1995-07-18 Camilla Olson Method of assessing placentation
HU225495B1 (en) † 1993-12-15 2007-01-29 Bracco Research Sa Gas mixtures useful as ultrasound contrast media
EP0752889B1 (en) 1994-03-28 2002-06-26 Nycomed Imaging AS Liposomes containing a x-ray- or ultrasound contrast agent
US5502094A (en) 1994-05-20 1996-03-26 Minnesota Mining And Manufacturing Company Physiologically acceptable emulsions containing perfluorocarbon ether hydrides and methods for use
US5562893A (en) 1994-08-02 1996-10-08 Molecular Biosystems, Inc. Gas-filled microspheres with fluorine-containing shells
US5965109A (en) * 1994-08-02 1999-10-12 Molecular Biosystems, Inc. Process for making insoluble gas-filled microspheres containing a liquid hydrophobic barrier
US5540909A (en) 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5560364A (en) 1995-05-12 1996-10-01 The Board Of Regents Of The University Of Nebraska Suspended ultra-sound induced microbubble cavitation imaging
US5558092A (en) 1995-06-06 1996-09-24 Imarx Pharmaceutical Corp. Methods and apparatus for performing diagnostic and therapeutic ultrasound simultaneously
US5606973A (en) 1995-06-07 1997-03-04 Molecular Biosystems, Inc. Liquid core microdroplets for ultrasound imaging
ATE366588T1 (en) * 1996-09-11 2007-08-15 Imarx Pharmaceutical Corp METHOD FOR DIAGNOSTIC IMAGING OF THE KIDNEY REGION USING A CONTRAST AGENT AND A VASODILATOR
WO1998017324A2 (en) * 1996-10-21 1998-04-30 Marsden, John, Christopher Improvements in or relating to contrast agents
WO1998018495A2 (en) * 1996-10-28 1998-05-07 Marsden, John, Christopher Improvements in or relating to diagnostic/therapeutic agents
EP0973552B1 (en) * 1996-10-28 2006-03-01 Amersham Health AS Improvements in or relating to diagnostic/therapeutic agents
AU733477B2 (en) * 1996-10-28 2001-05-17 Nycomed Imaging As Improvements in or relating to diagnostic/therapeutic agents
EP0963209A2 (en) * 1996-10-28 1999-12-15 Marsden, John Christopher Improvements in or relating to diagnostic/therapeutic agents
GB9717588D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
US6123923A (en) * 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US7625093B2 (en) 2005-03-29 2009-12-01 Seiko Epson Corporation Image display device having a plurality of basic-color projection units
EP2020985B1 (en) 2006-05-09 2015-07-08 Colgate-Palmolive Company Oral care regimen
US20130247924A1 (en) 2012-03-23 2013-09-26 Mark Scatterday Electronic cigarette having a flexible and soft configuration

Also Published As

Publication number Publication date
WO1998010799A1 (en) 1998-03-19
EP1017425A4 (en) 2002-03-06
US5846517A (en) 1998-12-08
AU732813B2 (en) 2001-05-03
EP1017425B1 (en) 2007-10-17
DE69738223D1 (en) 2007-11-29
CA2263924C (en) 2008-11-18
EP1323434B1 (en) 2007-07-11
AU4089897A (en) 1998-04-02
EP1017425A1 (en) 2000-07-12
DE69738223T3 (en) 2011-07-07
US6884407B1 (en) 2005-04-26
EP1323434A3 (en) 2004-03-24
PT1323434E (en) 2007-08-24
DE69738223T2 (en) 2008-07-24
EP1017425B2 (en) 2010-12-15
EP1323434A2 (en) 2003-07-02

Similar Documents

Publication Publication Date Title
CA2263924A1 (en) Improved methods for diagnostic imaging involving the use of a contrast agent and a coronary vasodilator
CA2263568A1 (en) Methods for diagnostic imaging using a contrast agent and a renal vasodilator
Guibaud et al. Diagnosis of choledocholithiasis: value of MR cholangiography.
WO2002015775A3 (en) Ultrasonic diagnostic imaging of the coronary arteries
CA2261782A1 (en) System for performing percutaneous biopsy of the breast using three-dimensional ultrasonography
CA2163213A1 (en) Ultrasonic Apparatus and Method for Intravascular Imaging
WO2002054946A3 (en) Ultrasonic imaging of perfusion using gases with different partial pressures
EP0871043A3 (en) A method and apparatus for creating a color blood flow image based upon ultrasonic echo signals received by an intravascular ultrasound imaging probe
NO981811L (en) Method and apparatus for reflected imaging analysis
AU4606697A (en) Photoacoustic breast scanner
WO2000045707A3 (en) Improved thermoacoustic computed tomography scanner
Itoh et al. Intraductal ultrasonography for the examination of duodenal papillary region.
GB2291969A (en) Tissue characterisation using intravascular echoscopy
Maheswaran et al. Intravascular ultrasound appearance of normal and mildly diseased coronary arteries: correlation with histologic specimens
Blankenhorn et al. Ultrasound observation on pulsation in human carotid artery lesions
AU5153398A (en) Diagnostic method for the detection of alzheimer's disease in living patients
Lopez et al. Duplex ultrasound findings in men with Peyronie’s disease
NO965374D0 (en) Oral echo contrast agent for ultrasound diagnostics
NO973666D0 (en) Contrast-containing liposomes for imaging of the intravascular compartment
Lee et al. Ultrasonic aortography: unexpected findings
RU2204328C2 (en) Method for carrying out ultrasonic examination of large intestine wall
Berger et al. Doppler ultrasonography in the follow-up of malignant melanoma of the choroid
ODA DEVELOPMENT OF ULTRASONIC LAPAROSCOPE
Kuo et al. Splenic Cystic Lymphangioma: Radiologic-Pathologic Correlation
Taylor et al. 3D sonoelastography for visualization of tumors

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20130827