CA2197811A1 - Intermediates in Process for the Preparation of N-Substituted Trifluoromethylphenyltetrahy-Dropydrines - Google Patents
Intermediates in Process for the Preparation of N-Substituted Trifluoromethylphenyltetrahy-DropydrinesInfo
- Publication number
- CA2197811A1 CA2197811A1 CA 2197811 CA2197811A CA2197811A1 CA 2197811 A1 CA2197811 A1 CA 2197811A1 CA 2197811 CA2197811 CA 2197811 CA 2197811 A CA2197811 A CA 2197811A CA 2197811 A1 CA2197811 A1 CA 2197811A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- naphthyl
- intermediates
- alkoxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000543 intermediate Substances 0.000 title abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 6
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- -1 N-substituted 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines Chemical class 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000006383 alkylpyridyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 230000008991 intestinal motility Effects 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Abstract
New N-substituted 4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridines useful as intermediates in the preparation of compounds which are useful in the treatment of intestinal motility disorders, of the following general formula.
(see fig. I) wherein A represents a group -T or -CO-R-G where - T represents - R-CO-G or -Q-CO-M
- R and Q represent a straight or branched alkylene radical of from 2 to 4 carbon atoms, - G represents a radical selected from the group consisting of naphthyl mono-substituted with hydroxy or (C1-C4) alkoxy; naphthyl di-substituted with hydroxy, (C1-C4) alkoxy or (C1-C4) alkyl; or naphthyl substituted with methylenedioxy, - M represents a radical selected from the group consisting of naphthyl; naphthyl mono- or di-substituted with hydroxy, (C1-C4)alkoxy or (C1-C4) alkyl or naphthyl substituted with methylenedioxy;
pryridyl; or (C1-C4)alkyl-pyridyl, and their salts with mineral or organic acids.
(see fig. I) wherein A represents a group -T or -CO-R-G where - T represents - R-CO-G or -Q-CO-M
- R and Q represent a straight or branched alkylene radical of from 2 to 4 carbon atoms, - G represents a radical selected from the group consisting of naphthyl mono-substituted with hydroxy or (C1-C4) alkoxy; naphthyl di-substituted with hydroxy, (C1-C4) alkoxy or (C1-C4) alkyl; or naphthyl substituted with methylenedioxy, - M represents a radical selected from the group consisting of naphthyl; naphthyl mono- or di-substituted with hydroxy, (C1-C4)alkoxy or (C1-C4) alkyl or naphthyl substituted with methylenedioxy;
pryridyl; or (C1-C4)alkyl-pyridyl, and their salts with mineral or organic acids.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9006474A FR2662442A1 (en) | 1990-05-23 | 1990-05-23 | N-SUBSTITUTED TRIFLUOROMETHYLPHENYLTETRAHYDROPYRIDINES PROCESS FOR THEIR PREPARATION, INTERMEDIATES THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| FR9006474 | 1990-05-23 | ||
| CA002043136A CA2043136C (en) | 1990-05-23 | 1991-05-23 | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002043136A Division CA2043136C (en) | 1990-05-23 | 1991-05-23 | N-substituted trifluoromethylphenyltetrahydropyridines, process for the preparation thereof, intermediates in said process and pharmaceutical compositions containing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2197811A1 true CA2197811A1 (en) | 1991-11-24 |
| CA2197811C CA2197811C (en) | 1999-11-02 |
Family
ID=25674631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002197811A Expired - Fee Related CA2197811C (en) | 1990-05-23 | 1991-05-23 | Intermediates in process for the preparation of n-substituted trifluoromethylphenyltetrahy-dropydrines |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2197811C (en) |
-
1991
- 1991-05-23 CA CA002197811A patent/CA2197811C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2197811C (en) | 1999-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |