[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CA2064815A1 - Composes heterocycliques therapeutiques - Google Patents

Composes heterocycliques therapeutiques

Info

Publication number
CA2064815A1
CA2064815A1 CA2064815A CA2064815A CA2064815A1 CA 2064815 A1 CA2064815 A1 CA 2064815A1 CA 2064815 A CA2064815 A CA 2064815A CA 2064815 A CA2064815 A CA 2064815A CA 2064815 A1 CA2064815 A1 CA 2064815A1
Authority
CA
Canada
Prior art keywords
formula
alkyl
hydrogen
heterocyclic compounds
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2064815A
Other languages
English (en)
Other versions
CA2064815C (fr
Inventor
Alan Duncan Robertson
Alan Peter Hill
Robert Charles Glen
Graeme Richard Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26297174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2064815(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909012672A external-priority patent/GB9012672D0/en
Priority claimed from GB919102182A external-priority patent/GB9102182D0/en
Application filed by Individual filed Critical Individual
Priority to CA002282890A priority Critical patent/CA2282890C/fr
Publication of CA2064815A1 publication Critical patent/CA2064815A1/fr
Application granted granted Critical
Publication of CA2064815C publication Critical patent/CA2064815C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention se rapporte à des composés de formule (I) où n représente un nombre entier de 0 à 3; W représente un groupe de formule (i), (ii) ou (iii), où R représente hydrogène ou alkyle C1-4, X représente -O-, -S-, -NH-, ou -CH2-, Y représente oxygène ou soufre et le centre chiral (*) dans la formule (i) ou (ii) est dans sa forme (S) ou (R) ou représente un mélange de ceux-ci dans n'importe quelles proportions; et Z représente un groupe de formule (iv), (v) ou (vi) où R1 et R2 sont indépendamment sélectionnés à partir d'hydrogène et d'alkyle C1-4 et R3 représente hydrogène ou alkyle C1-4. L'invention décrit aussi des sels, des solvates et des dérivés physiologiquement fonctionnels de ces composés, ainsi que des procédés relatifs à leur préparation, des médicaments qui les contiennent et leur utilisation comme agents thérapeutiques, en particulier dans la prophylaxie et le traitement de la migraine.
CA002064815A 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques Expired - Lifetime CA2064815C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002282890A CA2282890C (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9012672.3 1990-06-07
GB909012672A GB9012672D0 (en) 1990-06-07 1990-06-07 Therapeutic heterocyclic compounds
GB919102182A GB9102182D0 (en) 1991-02-01 1991-02-01 Therapeutic heterocyclic compounds
GB9102182.4 1991-02-01
PCT/GB1991/000908 WO1991018897A1 (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002282890A Division CA2282890C (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques

Publications (2)

Publication Number Publication Date
CA2064815A1 true CA2064815A1 (fr) 1991-12-08
CA2064815C CA2064815C (fr) 1999-11-16

Family

ID=26297174

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002282890A Expired - Lifetime CA2282890C (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques
CA002064815A Expired - Lifetime CA2064815C (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002282890A Expired - Lifetime CA2282890C (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques

Country Status (37)

Country Link
US (3) US5399574A (fr)
EP (2) EP0486666B1 (fr)
JP (1) JP2738461B2 (fr)
KR (1) KR100215627B1 (fr)
AT (2) ATE156823T1 (fr)
AU (1) AU646871B2 (fr)
CA (2) CA2282890C (fr)
CZ (1) CZ288351B6 (fr)
DE (3) DE19775091I2 (fr)
DK (1) DK0486666T3 (fr)
EG (1) EG19650A (fr)
ES (1) ES2104708T3 (fr)
FI (3) FI105686B (fr)
GR (1) GR3024828T3 (fr)
HK (1) HK1000534A1 (fr)
HR (1) HRP940524B1 (fr)
HU (2) HU219974B (fr)
IE (1) IE911931A1 (fr)
IL (3) IL114690A (fr)
LT (1) LT3264B (fr)
LU (1) LU90205I2 (fr)
LV (1) LV10274B (fr)
MC (1) MC2210A1 (fr)
MX (1) MX9203421A (fr)
MY (1) MY110226A (fr)
NL (1) NL980001I2 (fr)
NO (2) NO300634B1 (fr)
NZ (1) NZ238424A (fr)
PL (1) PL166214B1 (fr)
PT (1) PT97888B (fr)
RU (1) RU2160736C2 (fr)
SA (1) SA05260104B1 (fr)
SI (2) SI21560B (fr)
SK (1) SK281621B6 (fr)
UA (1) UA37178C2 (fr)
WO (1) WO1991018897A1 (fr)
YU (1) YU48855B (fr)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (fr) * 1991-02-12 1995-11-21 Pfizer
DE69230803T2 (de) * 1991-11-25 2000-12-07 Pfizer Inc., New York 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
TW288010B (fr) * 1992-03-05 1996-10-11 Pfizer
EP0630374B1 (fr) * 1992-03-13 2001-09-05 MERCK SHARP & DOHME LTD. Derives d'imidazole, de triazole et de tetrazole
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
US5747501A (en) 1992-04-07 1998-05-05 Pfizer, Inc. Indole derivatives
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
ES2097496T3 (es) * 1992-04-10 1997-04-01 Pfizer Derivados acilaminoindol como agonistas de 5-ht1.
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
AU672802B2 (en) * 1992-07-24 1996-10-17 Merck Sharp & Dohme Limited Imidazole, triazole and tetrazole derivatives
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
TW251284B (fr) * 1992-11-02 1995-07-11 Pfizer
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
KR100191973B1 (ko) * 1993-08-31 1999-06-15 디. 제이. 우드, 스피겔 알렌 제이 5-아릴인돌 유도체
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US5962486A (en) * 1994-06-01 1999-10-05 Zeneca Limited Indole derivatives as prodrugs of 5-HT1 -like receptor agonists
US6423731B2 (en) 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
EP0759918A1 (fr) * 1994-05-19 1997-03-05 MERCK SHARP & DOHME LTD. Derives piperazine, piperidine et tetrahydropyridine d'indol-3-ylalkyle utilises comme agonistes de 5-ht1d-alpha
MX9700693A (es) * 1994-07-26 1997-04-30 Pfizer Derivados del 4-indol.
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
EP0796258A1 (fr) * 1994-12-06 1997-09-24 MERCK SHARP &amp; DOHME LTD. Derives de l'azetidine, de la pyrrolidine et de la piperidine utilises comme agonistes des recepteurs 5-ht1
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
CZ288897A3 (cs) * 1995-03-20 1998-02-18 Eli Lilly And Company V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
US6909005B1 (en) * 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516143D0 (en) 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
CA2234166A1 (fr) * 1995-10-10 1997-04-17 Patric James Hahn Les n-¬2-substitue-3-(2-aminoethyl)-1h-indol-5-yl| - amides: de nouveaux agonistes 5-ht1f
WO1997016446A1 (fr) * 1995-11-02 1997-05-09 Merck Sharp & Dohme Limited Heteroaryle-alkylene-(homo)piperazinones bicycliques et leurs analogues thiones, leur preparation et leur utilisation en tant qu'agonistes selectifs de recepteurs de type 5-ht1
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
WO2000000490A2 (fr) * 1998-06-26 2000-01-06 Eli Lilly And Company Agonistes de 5-ht¿1f?
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) * 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
GB9928578D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
CA2427098A1 (fr) * 2000-11-29 2002-06-06 John Mehnert Schaus 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine, ses sels acceptables sur le plan pharmaceutique et ses solvants
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
ES2312585T3 (es) * 2001-06-05 2009-03-01 Ronald Aung-Din Terapia contra la migraña por via topica.
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
CA2477088A1 (fr) 2002-02-22 2003-10-02 New River Pharmaceuticals Inc. Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
WO2004000845A1 (fr) 2002-06-21 2003-12-31 Suven Life Sciences Limited Arylalkyl indoles a affinite de recepteur de la serotonine utilises comme agents therapeutiques, leur procede de preparation et compositions pharmaceutiques contenant lesdits indoles
DE60317333T2 (de) 2002-06-21 2008-08-28 Suven Life Sciences Ltd. Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor
ES2204302B2 (es) * 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
CN1720225B (zh) 2002-11-28 2011-05-18 苏文生命科学有限公司 具有5-羟色胺受体亲和性的n-芳基磺酰-3-取代吲哚及其制备方法和含有其的药物组合物
EP1567492B1 (fr) 2002-11-28 2013-05-22 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
JP4571507B2 (ja) 2002-12-18 2010-10-27 スベン ライフ サイエンシズ リミティド セロトニン受容体親和性を有する四環系３−置換インドール
EP2666772B1 (fr) 2002-12-20 2017-03-01 Basf Se Synthèse d'amines et intermédiaires pour leur synthèse
WO2004063175A1 (fr) * 2003-01-13 2004-07-29 Natco Pharma Limited Nouveau procede ameliore de preparation de (s)-4-(4-aminobenzyl)-2- oxazolidinone
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
US20040192958A1 (en) * 2003-03-25 2004-09-30 Hyatt John Anthony Process for preparing derivatives of 4-halobutyraldehyde
JP2007516149A (ja) 2003-05-21 2007-06-21 アレックザ ファーマシューティカルズ， インコーポレイテッド 基板温度の均一性を制御する方法、および、内蔵式加熱ユニットおよびそれを使用する薬剤供給ユニット
AR044688A1 (es) * 2003-06-12 2005-09-21 Euro Celtique Sa Agentes terapeuticos utiles para el tratamiento del dolor
EP1644004A4 (fr) 2003-06-20 2010-10-06 Ronald Aung-Din Therapie locale pour le traitement des migraines, des claquages musculaires, des spasmes musculaires, de la spasticite et d'etats apparentes
AU2004259357B2 (en) * 2003-07-24 2010-02-18 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2005075467A2 (fr) * 2004-02-06 2005-08-18 Ciba Specialty Chemicals Holding Inc. Formes cristallines de zolmitriptan
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7581540B2 (en) * 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20060211751A1 (en) * 2004-11-19 2006-09-21 Reuven Izsak Zolmitriptan crystal forms
KR20130136010A (ko) * 2005-04-13 2013-12-11 네우렉슨 인코포레이티드 Ｎｏｓ 저해 활성을 갖는 치환된 인돌 화합물
EP1981860B1 (fr) 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion d'un sel de diazonium aromatique en arylhydrazine
WO2007118314A1 (fr) 2006-04-13 2007-10-25 Neuraxon, Inc. Indoles 1,5- et 3,6-substitués à activité inhibitrice vis-à-vis de nos
WO2008018090A2 (fr) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd Procédé de préparation amélioré de zolmitriptan
JP2010507585A (ja) * 2006-10-19 2010-03-11 オースペックス・ファーマシューティカルズ・インコーポレイテッド 置換インドール
CN101677954A (zh) 2007-02-11 2010-03-24 Map药物公司 治疗性施用dhe用于快速减轻偏头痛而使副作用分布最小化的方法
CZ2007158A3 (cs) * 2007-02-26 2008-10-22 Zentiva, A. S. Zpusob prípravy zolmitriptanu
ES2594867T3 (es) 2007-03-09 2016-12-23 Alexza Pharmaceuticals, Inc. Unidad de calentamiento para usar en un dispositivo de administración de fármaco
EP2604598B1 (fr) 2007-04-27 2016-04-06 Purdue Pharma L.P. Antagonistes de TRPV1 et utilisations de ceux-ci
AU2008246202B2 (en) * 2007-04-27 2011-12-01 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US20110112157A1 (en) * 2007-10-03 2011-05-12 Generics [Uk] Limited Process for the preparation of zolmitriptan, salts and solvates thereof
CN101910157B (zh) 2007-11-16 2014-05-07 纽尔亚商股份有限公司 吲哚化合物和治疗内脏痛的方法
CA2705833A1 (fr) * 2007-11-16 2009-05-22 Subhash C. Annedi Composes d'indole 3,5-substitues ayant une activite d'inhibition de la reabsorption de la nos et de la noradrenaline
EP2219449A4 (fr) * 2007-11-16 2010-10-27 Univ Arizona State Procédés de traitement de la douleur viscérale
CN101181267B (zh) * 2007-11-30 2010-09-08 重庆医科大学医药研究所 佐米曲普坦舌下片
KR101517415B1 (ko) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
CA2729346A1 (fr) 2008-06-30 2010-01-14 Afgin Pharma, Llc Traitement neuro-affectif regional topique
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
WO2010151804A1 (fr) * 2009-06-26 2010-12-29 Map Pharmaceuticals, Inc. Administration de particules de dihydro-ergotamine mésylate au moyen d'un inhalateur-doseur
US20110038928A1 (en) * 2009-08-12 2011-02-17 Glenmark Generics Ltd Orally disintegrating tablets of zolmitriptan
CA2813648C (fr) 2010-10-15 2019-06-25 Concit Pharma Aps Combinaisons d'agonistes de recepteurs de serotonine pour le traitement de troubles du mouvement
CA2837178C (fr) 2011-06-22 2016-09-20 Purdue Pharma L.P. Antagonistes de trpv1 comprenant un substituant dihydroxy et leurs utilisations
EP3628325A1 (fr) 2011-07-22 2020-04-01 The University of Chicago Traitements de la migraine et de troubles apparentés
WO2013057739A2 (fr) * 2011-09-02 2013-04-25 Emcure Pharmaceuticals Limited Procédé de préparation amélioré de zolmitriptan
PT2838517T (pt) 2012-04-18 2018-01-04 Contera Pharma Aps Formulação farmacêutica disponível sob forma oral adequada para a melhoria da gestão dos distúrbios da mobilidade
US9394314B2 (en) 2012-12-21 2016-07-19 Map Pharmaceuticals, Inc. 8′-hydroxy-dihydroergotamine compounds and compositions
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
CA2978605A1 (fr) 2015-03-02 2016-09-09 Afgin Pharma, Llc Therapie neuro-affective regionale topique comprenant des cannabinoides
WO2017122161A1 (fr) 2016-01-15 2017-07-20 Cadila Healthcare Limited Composition intranasale comprenant des agonistes de récepteur 5ht1b/1d
CN108697637A (zh) 2016-01-27 2018-10-23 因斯塔尔科技股份公司 用于治疗性处理的口腔粘膜纳米纤维载体
AU2017297718B2 (en) 2016-07-11 2023-06-08 Contera Pharma A/S Pulsatile drug delivery system for treating morning akinesia
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
WO2020249802A1 (fr) 2019-06-14 2020-12-17 Janssen Pharmaceutica Nv Pyrazolo-pyrazines substituées et leur utilisation en tant que modulateurs du récepteur de glun2b
EP3766483A1 (fr) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un triptane
US20210322343A1 (en) 2020-04-15 2021-10-21 Farzana Shaheen Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB148879A (en) * 1919-02-14 1921-11-10 Emil Vincance Noser Locks for shift levers of automobiles
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
BE795457A (fr) * 1972-02-16 1973-08-16 Clin Midy Amines indoliques, leur preparation et leur application en therapeutiques
FR2179582B1 (fr) * 1972-04-13 1975-10-10 Synthelabo
US3873559A (en) * 1973-03-30 1975-03-25 Squibb & Sons Inc Heterocyclic carboxamido thiazolinyl indoles
IT995110B (it) * 1973-08-01 1975-11-10 Snam Progetti Procedimento per la produzione di composti eterociclici e prodotti ottenuti
US4042595A (en) * 1973-08-01 1977-08-16 Snam Progetti S.P.A. Processes for the production of heterocyclic compounds
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4049816A (en) * 1975-03-24 1977-09-20 Beecham Group Limited Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
FR2315925A1 (fr) * 1975-07-04 1977-01-28 Nippon Chemiphar Co Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique
GB1482879A (en) * 1975-07-24 1977-08-17 Nippon Chemiphar Co 5-benzyl-2-oxazolidone derivatives and a process for producing the same
GB1469200A (en) * 1975-11-28 1977-03-30 Warner Lambert Co 3-thiomethyl-2-2-dialkylamino-ethyl-indoles
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4198501A (en) * 1977-12-20 1980-04-15 Hoffmann-La Roche Inc. Synthesis of tryptophans
JPS6014032B2 (ja) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US4272555A (en) * 1979-09-21 1981-06-09 Monsanto Company Conversion of carbon-containing materials to carbon monoxide
EP0083566A1 (fr) * 1980-04-10 1983-07-13 Sandoz Ag Isoxazolyl indoles
JPS574986A (en) * 1980-06-13 1982-01-11 Paamakemu Asia:Kk Preparation of oxazolidine derivative
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
NZ197996A (en) * 1980-08-12 1985-08-16 Glaxo Group Ltd 1-(3-(omega-aminoalkyl)-1h-indol-5-yl)alkanamides
BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
US4399296A (en) * 1981-01-02 1983-08-16 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4407811A (en) * 1981-01-02 1983-10-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4448971A (en) * 1981-01-02 1984-05-15 Pfizer Inc. Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones
JPS57169458A (en) * 1981-04-13 1982-10-19 Paamakemu Asia:Kk Preparation of indole derivative
CH656124A5 (de) * 1982-04-13 1986-06-13 Sandoz Ag 2-substituierte-3-indolamine, verfahren zu deren herstellung sowie deren verwendung.
GR79215B (fr) * 1982-06-07 1984-10-22 Glaxo Group Ltd
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4500717A (en) * 1983-03-28 1985-02-19 The Dow Chemical Company Process for preparation of 2-oxazolidinones
US4831153A (en) * 1983-06-27 1989-05-16 The Dow Chemical Company Preparation of N-vinyl-2-oxazolidinone
GB8321813D0 (en) * 1983-08-12 1983-09-14 Vickers Plc Radiation sensitive compounds
DE3333450A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt
HU196752B (en) * 1983-12-06 1989-01-30 Glaxo Group Ltd Process for production of medical compositions containing indole-derivatives and these compounds
DE3430284A1 (de) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
DE3542698A1 (de) * 1984-12-04 1986-06-05 Glaxo Group Ltd., London Indolderivate, verfahren zu ihrer herstellung und sie enthaltende, pharmazeutische zubereitungen
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3514696A1 (de) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
EP0225726B1 (fr) * 1985-11-08 1991-04-17 Glaxo Group Limited Dérivés de l'indole
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine
IE61488B1 (en) * 1987-08-13 1994-11-02 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DE3730777A1 (de) * 1987-09-12 1989-03-23 Basf Ag Verfahren zur herstellung von imidazolidinonen und oxazolidinonen
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
DE3823299A1 (de) * 1988-07-07 1990-01-11 Schering Ag Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
ES2157934T3 (es) * 1988-09-15 2001-09-01 Upjohn Co Fenil-5-beta-amidometiloxazolidin-2-onas sustituidas con nitrogeno en la posicion 3.
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
DE3939238A1 (de) * 1989-11-28 1991-05-29 Bayer Ag Heterocyclisch substituierte acrylsaeureester
DE4013907A1 (de) * 1990-04-26 1991-10-31 Schering Ag Verfahren zur herstellung von gramin-derivaten
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives

Also Published As

Publication number Publication date
NO1998005I1 (no) 1998-01-21
WO1991018897A1 (fr) 1991-12-12
SI21560B (sl) 2005-04-30
CZ288351B6 (en) 2001-05-16
DE69132691D1 (de) 2001-09-20
PL166214B1 (pl) 1995-04-28
DE69127260D1 (de) 1997-09-18
FI105686B (fi) 2000-09-29
JPH05502679A (ja) 1993-05-13
DE69132691T2 (de) 2002-06-20
LU90205I2 (fr) 1998-04-06
MC2210A1 (fr) 1992-11-26
HUT62289A (en) 1993-04-28
MX9203421A (es) 1992-07-01
PT97888B (pt) 1998-12-31
SA05260104A (ar) 2005-12-03
LV10274A (lv) 1994-10-20
FI960155A (fi) 1996-01-12
SK281621B6 (sk) 2001-05-10
FI20001406A (fi) 2000-06-13
ES2104708T3 (es) 1997-10-16
EP0486666A1 (fr) 1992-05-27
EG19650A (en) 1995-09-30
PT97888A (pt) 1992-05-29
JP2738461B2 (ja) 1998-04-08
NO920494D0 (no) 1992-02-06
US5466699A (en) 1995-11-14
ATE156823T1 (de) 1997-08-15
IL98392A (en) 1996-01-19
IE20010862A1 (en) 2003-03-05
HRP940524A2 (en) 1996-06-30
CA2064815C (fr) 1999-11-16
RU2160736C2 (ru) 2000-12-20
GR3024828T3 (en) 1998-01-30
CA2282890A1 (fr) 1991-12-08
IL98392A0 (en) 1992-07-15
NO300634B1 (no) 1997-06-30
EP0486666B1 (fr) 1997-08-13
IL114690A0 (en) 1995-11-27
IE911931A1 (en) 1991-12-18
FI106262B (fi) 2000-12-29
YU101091A (sh) 1994-04-05
DE69127260T2 (de) 1997-12-04
FI960155A0 (fi) 1996-01-12
HU211479A9 (en) 1995-11-28
LT3264B (en) 1995-05-25
ATE204275T1 (de) 2001-09-15
NZ238424A (en) 1993-12-23
YU48855B (sh) 2002-06-19
EP0636623B1 (fr) 2001-08-16
AU646871B2 (en) 1994-03-10
US5399574A (en) 1995-03-21
KR920702359A (ko) 1992-09-03
CS172791A3 (en) 1992-02-19
NL980001I1 (nl) 1998-03-02
KR100215627B1 (ko) 1999-08-16
IL114690A (en) 1997-02-18
NO920494L (no) 1992-03-30
EP0636623A1 (fr) 1995-02-01
US5863935A (en) 1999-01-26
LV10274B (en) 1995-04-20
DE19775091I2 (de) 2007-05-24
UA37178C2 (uk) 2001-05-15
HRP940524B1 (en) 1998-10-31
HU9200384D0 (en) 1992-06-29
SA05260104B1 (ar) 2006-04-04
NL980001I2 (nl) 1998-05-06
HK1000534A1 (en) 1998-04-03
SI9111010A (en) 1997-12-31
CA2282890C (fr) 2001-07-31
MY110226A (en) 1998-03-31
AU7957091A (en) 1991-12-31
SI9111010B (sl) 2005-02-28
SI21560A (sl) 2005-02-28
DK0486666T3 (da) 1998-03-30
LTIP419A (en) 1994-11-25
HU219974B (hu) 2001-10-28
FI920503A0 (fi) 1992-02-06

Similar Documents

Publication Publication Date Title
CA2064815A1 (fr) Composes heterocycliques therapeutiques
IL88122A0 (en) Heterocyclic derivatives and pharmaceutical compositions containing them
HUT54357A (en) Process for producing benzilidene-(azolylmethyl)-cycloalkane and -cycloalkene derivatives, fungicidal compositions comprising such compounds as active ingredient and intermediates usable for the production of the active ingredients
CA2256582A1 (fr) Acides oxa et composes apparentes utilises dans le traitement d&#39;etats dermatologiques
EP1035123A4 (fr) Nouveaux composes heterocycliques
IL110151A0 (en) Amide and urea derivatives and pharmaceutical compositions containing the same
UA27467C2 (uk) ПОХІДНІ ІНДОЛУ ЯК 5-НТ&lt;sub&gt;1&lt;/sub&gt; АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ
TW377344B (en) Cyclobutyl substituted indole derivative, their preparation, pharmaceutical compositions containing them and their use in the prophylaxis and treatment of migraine
PL309874A1 (en) Novel derivatives of pyrrolocarbasol, method of obtaining them and pharmaceutical composition containing such derivatives
ZA873884B (en) 2-thiazolyl imidazo(1,2-a)pyrimidines and their salts,their process of preparation,their application as medicaments and compositions containing them
IL96618A0 (en) Pharmaceutical compositions containing fluoroquinolone derivatives
ES2019840A6 (es) Procedimiento para preparar nuevos derivados de tieno-triazolo-diazepina.
HK56597A (en) 3-aminochromane derivatives procedure for their preparation and pharmaceutical compositions containing them
IE893956L (en) Novel compounds
HU893127D0 (en) Process for the preparation of novel spiro-(imidazolidino-naphtaline) derivatives and pharmaceutical compositions containing such compounds as active ingredient
HUT41025A (en) Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients
IL115085A0 (en) Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them
GB8610369D0 (en) Heterocyclic compounds
ES8701176A1 (es) Un procedimiento para preparar nuevas amidas de acidos indo-lo-quinolizin-carboxilicos
TH11701EX (th) สารประกอบเฮเทโรไซคลิคที่ใช้ในการรักษาโรค

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry