[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

MC2210A1 - Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer - Google Patents

Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer

Info

Publication number
MC2210A1
MC2210A1 MC91908D MC908D MC2210A1 MC 2210 A1 MC2210 A1 MC 2210A1 MC 91908 D MC91908 D MC 91908D MC 908 D MC908 D MC 908D MC 2210 A1 MC2210 A1 MC 2210A1
Authority
MC
Monaco
Prior art keywords
formula
preparing
heterocyclic compounds
alkyl
therapeutic heterocyclic
Prior art date
Application number
MC91908D
Other languages
English (en)
Inventor
Duncan Robertson Alan
Peter Hill Alan
Charles Glen Robert
Richard Martin Graeme
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26297174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MC2210(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909012672A external-priority patent/GB9012672D0/en
Priority claimed from GB919102182A external-priority patent/GB9102182D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MC2210A1 publication Critical patent/MC2210A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
MC91908D 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer MC2210A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909012672A GB9012672D0 (en) 1990-06-07 1990-06-07 Therapeutic heterocyclic compounds
GB919102182A GB9102182D0 (en) 1991-02-01 1991-02-01 Therapeutic heterocyclic compounds

Publications (1)

Publication Number Publication Date
MC2210A1 true MC2210A1 (fr) 1992-11-26

Family

ID=26297174

Family Applications (1)

Application Number Title Priority Date Filing Date
MC91908D MC2210A1 (fr) 1990-06-07 1991-06-06 Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer

Country Status (37)

Country Link
US (3) US5399574A (fr)
EP (2) EP0636623B1 (fr)
JP (1) JP2738461B2 (fr)
KR (1) KR100215627B1 (fr)
AT (2) ATE156823T1 (fr)
AU (1) AU646871B2 (fr)
CA (2) CA2282890C (fr)
CZ (1) CZ288351B6 (fr)
DE (3) DE69132691T2 (fr)
DK (1) DK0486666T3 (fr)
EG (1) EG19650A (fr)
ES (1) ES2104708T3 (fr)
FI (3) FI105686B (fr)
GR (1) GR3024828T3 (fr)
HK (1) HK1000534A1 (fr)
HR (1) HRP940524B1 (fr)
HU (2) HU219974B (fr)
IE (1) IE911931A1 (fr)
IL (3) IL114690A (fr)
LT (1) LT3264B (fr)
LU (1) LU90205I2 (fr)
LV (1) LV10274B (fr)
MC (1) MC2210A1 (fr)
MX (1) MX9203421A (fr)
MY (1) MY110226A (fr)
NL (1) NL980001I2 (fr)
NO (2) NO300634B1 (fr)
NZ (1) NZ238424A (fr)
PL (1) PL166214B1 (fr)
PT (1) PT97888B (fr)
RU (1) RU2160736C2 (fr)
SA (1) SA05260104B1 (fr)
SI (2) SI21560B (fr)
SK (1) SK281621B6 (fr)
UA (1) UA37178C2 (fr)
WO (1) WO1991018897A1 (fr)
YU (1) YU48855B (fr)

Families Citing this family (123)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
TW263508B (fr) * 1991-02-12 1995-11-21 Pfizer
WO1993011106A1 (fr) * 1991-11-25 1993-06-10 Pfizer, Inc. Derives d'indole
GB9201038D0 (en) * 1992-01-16 1992-03-11 Glaxo Group Ltd Chemical compounds
TW288010B (fr) * 1992-03-05 1996-10-11 Pfizer
ATE205202T1 (de) * 1992-03-13 2001-09-15 Merck Sharp & Dohme Imidazol-, triazol- und tetrazolderivate
GB9207396D0 (en) * 1992-04-03 1992-05-13 Merck Sharp & Dohme Therapeutic agents
EP0635017A1 (fr) 1992-04-07 1995-01-25 Pfizer Inc. Derives d'indole en tant qu'agonistes de 5-ht1
US6380233B1 (en) 1992-04-07 2002-04-30 Pfizer Inc Indole derivatives as 5-HT1 agonists
EP0635015B1 (fr) * 1992-04-10 1997-01-29 Pfizer Inc. Derives d'acylaminoindole utilises en tant qu'agonistes de 5-ht1
GB9207930D0 (en) * 1992-04-10 1992-05-27 Pfizer Ltd Indoles
GB9208161D0 (en) * 1992-04-14 1992-05-27 Pfizer Ltd Indoles
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
GB9211277D0 (en) 1992-05-28 1992-07-15 Glaxo Group Inc Pharmaceutical compositions
US5567726A (en) * 1992-07-24 1996-10-22 Merck, Sharp & Dohme Ltd. Imidazole, Triazole and tetrazole derivatives
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
IL106445A (en) * 1992-07-30 1998-01-04 Merck Sharp & Dohme History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
TW251284B (fr) * 1992-11-02 1995-07-11 Pfizer
GB9226532D0 (en) * 1992-12-21 1993-02-17 Smithkline Beecham Plc Compounds
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ES2070087B1 (es) * 1993-08-13 1996-02-16 Pfizer Derivados de indol
WO1995006636A1 (fr) * 1993-08-31 1995-03-09 Pfizer Inc. Derives de 5-arylindole
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
US6423731B2 (en) * 1994-01-06 2002-07-23 Zeneca Limited Indole derivatives as prodrugs of 5-HT1-like receptor agonists
GB9401436D0 (en) * 1994-01-26 1994-03-23 Wellcome Found Therapeutic heterocyclic compounds
JPH10501212A (ja) * 1994-05-19 1998-02-03 メルク シヤープ エンド ドーム リミテツド ５−ｈｔ▲下１ｄ▼−アルファ作働薬としてのインドール−３−イルアルキルのピペラジン、ピペリジンおよびテトラヒドロピリジン誘導体
DK0765322T3 (da) * 1994-06-01 2001-10-22 Astrazeneca Ab Indolderivater som pro-drugs for 5-HT1-lignende receptoragonister
JP3155008B2 (ja) * 1994-07-26 2001-04-09 ファイザー・インコーポレーテッド セロトニンアゴニストおよびアンタゴニストとしての４−インドール誘導体
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
GB9423682D0 (en) * 1994-11-23 1995-01-11 Merck Sharp & Dohme Therapeutic agents
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
US6025374A (en) * 1994-12-06 2000-02-15 Merck Sharp & Dohme, Ltd. Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
GB9501865D0 (en) * 1995-01-31 1995-03-22 Merck Sharp & Dohme Therapeutic agents
CZ288897A3 (cs) * 1995-03-20 1998-02-18 Eli Lilly And Company V poloze 5-substituovaný 3-(1,2,3,6-tetrahydropyridin-4-yl)indol a 3-(piperidin-4-yl)indol a farmaceutický prostředek, který je obsahuje
GB9515060D0 (en) * 1995-07-22 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
US6909005B1 (en) * 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
GB9516145D0 (en) * 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
GB9516143D0 (en) 1995-08-07 1995-10-04 Wellcome Found Improved chemical synthesis
AU7261196A (en) * 1995-10-10 1997-04-30 Eli Lilly And Company N-{2-substituted-3-(2-aminoethyl)-1h-indol-5-yl}-amides: new 5-ht1f agonists
AU7319096A (en) * 1995-11-02 1997-05-22 Merck Sharp & Dohme Limited Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation and their use as selective agonists of 5-ht1-like receptors
GB9609374D0 (en) * 1996-05-03 1996-07-10 Merck Sharp & Dohme Therapeutic agents
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
GB9706089D0 (en) 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
AR017200A1 (es) 1997-12-23 2001-08-22 Astrazeneca Ab Compuestos inhibidores de la proteina cinasa c, sales farmaceuticamente aceptables de los mismos, formulaciones farmaceuitcas que los comprenden, usode las mismas y proceso para la sintesis de dichos compuestos
SE9800835D0 (sv) 1998-03-13 1998-03-13 Astra Ab New Compounds
AU4961499A (en) * 1998-06-26 2000-01-17 Eli Lilly And Company 5-HT1f agonists
US6492406B1 (en) 1999-05-21 2002-12-10 Astrazeneca Ab Pharmaceutically active compounds
US6346625B1 (en) * 1999-06-23 2002-02-12 Astrazeneca Ab Protein kinase inhibitors
GB9928578D0 (en) * 1999-12-03 2000-02-02 Zeneca Ltd Pharmaceutical formulations
WO2003079972A2 (fr) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Systemes de distribution d'agents actifs et methodes de protection et d'administration d'agents actifs
CA2427098A1 (fr) * 2000-11-29 2002-06-06 John Mehnert Schaus 1-(2-m-methanesulfonamidophenylethyl)-4-(m-trifluoromethylphenyl) piperazine, ses sels acceptables sur le plan pharmaceutique et ses solvants
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20030013753A1 (en) * 2001-06-05 2003-01-16 Ronald Aung-Din Transdermal migraine therapy
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
US6685951B2 (en) 2001-07-05 2004-02-03 R. T. Alamo Ventures I, Inc. Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine
US20030017175A1 (en) * 2001-07-05 2003-01-23 R.T. Alamo Ventures I, Inc. Sublingual administration of dihydroergotamine for the treatment of migraine
US20030198669A1 (en) * 2001-07-05 2003-10-23 R.T. Alamo Ventures I, Llc Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine
ES2336664T3 (es) 2002-06-21 2010-04-15 Suven Life Sciences Limited Arilaquil indoles que tienen afinidad por receptores de serotonina utiles como agentes terapeuticos, procesos para su preparacion y composiciones farmaceuticas que los contienen.
DK1523486T3 (da) 2002-06-21 2008-03-03 Suven Life Sciences Ltd Tetracykliske arylsulfonylindoler med serotoninreceptor-affinitet
ES2204302B2 (es) 2002-08-07 2005-03-01 Laboratorios Vita, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo.
US20040105818A1 (en) * 2002-11-26 2004-06-03 Alexza Molecular Delivery Corporation Diuretic aerosols and methods of making and using them
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
ES2310243T3 (es) 2002-11-28 2009-01-01 Suven Life Sciences Limited Indoles n-aril-3-sulfonil sustituidos que tienen afinidad por receptores de serotonina, proceso para su preparacion y composicion farmaceutica que los contiene.
WO2004048328A2 (fr) 2002-11-28 2004-06-10 Suven Life Sciences Limited N-arylsulfonyl-3-aminoalkoxyindoles
DE60312226T2 (de) 2002-12-18 2007-11-15 Suven Life Sciences Ltd. Tetrazyklische 3-substituierte indole mit serotoninrezeptoraffinität
CA2508290C (fr) 2002-12-20 2017-02-28 Ciba Specialty Chemicals Holding Inc. Synthese d'amines et intermediaires pour cette synthese
WO2004063175A1 (fr) * 2003-01-13 2004-07-29 Natco Pharma Limited Nouveau procede ameliore de preparation de (s)-4-(4-aminobenzyl)-2- oxazolidinone
GB0302094D0 (en) 2003-01-29 2003-02-26 Pharmagene Lab Ltd EP4 receptor antagonists
US20040192958A1 (en) * 2003-03-25 2004-09-30 Hyatt John Anthony Process for preparing derivatives of 4-halobutyraldehyde
WO2004104491A2 (fr) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Unite de chauffage autonome allumee par percussion ou allumee electriquement et unite de distribution de medicaments faisant appel a cette derniere
TWI287010B (en) * 2003-06-12 2007-09-21 Euro Celtique Sa Therapeutic agents useful for treating pain
US20070065463A1 (en) * 2003-06-20 2007-03-22 Ronald Aung-Din Topical therapy for the treatment of migranes, muscle sprains, muscle spasms, spasticity and related conditions
KR100977242B1 (ko) * 2003-07-24 2010-08-24 유로-셀띠끄 소시에떼 아노님 피페리딘 화합물 및 그들을 포함하는 약학적 조성물
GB0324269D0 (en) 2003-10-16 2003-11-19 Pharmagene Lab Ltd EP4 receptor antagonists
WO2005075467A2 (fr) * 2004-02-06 2005-08-18 Ciba Specialty Chemicals Holding Inc. Formes cristallines de zolmitriptan
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP1781360A1 (fr) * 2004-08-12 2007-05-09 Alexza Pharmaceuticals, Inc. Dispositif de distribution de drogue par aérosol intégrant des conditionnements thermiques actionnés par percussion
EP1812428A2 (fr) * 2004-11-19 2007-08-01 Teva Pharmaceutical Industries Ltd Formes cristallines de zolmitriptan
ATE489138T1 (de) 2005-04-13 2010-12-15 Neuraxon Inc Substituierte indolverbindungen mit nos-hemmender aktivität
EP1981860B1 (fr) 2006-01-19 2011-05-25 Matrix Laboratories Ltd Conversion d'un sel de diazonium aromatique en arylhydrazine
EP2010527B1 (fr) * 2006-04-13 2013-08-14 Neuraxon Inc. Indoles 1,5- et 3,6-substitués à activité inhibitrice vis-à-vis de nos
WO2008018090A2 (fr) * 2006-08-09 2008-02-14 Matrix Laboratories Ltd Procédé de préparation amélioré de zolmitriptan
BRPI0715579A2 (pt) * 2006-10-19 2015-05-26 Auspex Pharmaceuticals Inc "composto, composição farmacêutica e uso de um composto"
ES2538082T3 (es) * 2007-02-11 2015-06-17 Map Pharmaceuticals Inc Método de administración terapéutica de DHE para permitir el rápido alivio de migraña mientras que se minimiza el perfil de efectos secundarios
CZ2007158A3 (cs) * 2007-02-26 2008-10-22 Zentiva, A. S. Zpusob prípravy zolmitriptanu
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
AR066146A1 (es) 2007-04-27 2009-07-29 Shionogi & Co Antagonistas de trpvi y usos de los mismos
JP5372913B2 (ja) * 2007-04-27 2013-12-18 パーデュー、ファーマ、リミテッド、パートナーシップ 疼痛治療に有効な治療薬
US20110112157A1 (en) * 2007-10-03 2011-05-12 Generics [Uk] Limited Process for the preparation of zolmitriptan, salts and solvates thereof
CA2705833A1 (fr) * 2007-11-16 2009-05-22 Subhash C. Annedi Composes d'indole 3,5-substitues ayant une activite d'inhibition de la reabsorption de la nos et de la noradrenaline
WO2009062319A1 (fr) 2007-11-16 2009-05-22 Neuraxon, Inc. Composés d'indole et procédés de traitement de la douleur viscérale
US20090163451A1 (en) * 2007-11-16 2009-06-25 Frank Porreca Methods for treating visceral pain
CN101181267B (zh) * 2007-11-30 2010-09-08 重庆医科大学医药研究所 佐米曲普坦舌下片
KR101517415B1 (ko) * 2008-05-14 2015-05-07 에스케이바이오팜 주식회사 난용성 항경련제를 함유하는 경비 항경련성 약학 조성물
EP2296652B1 (fr) 2008-06-30 2017-11-08 Afgin Pharma, Llc Traitement neuro-affectif régional topique
US20100217013A1 (en) * 2008-12-15 2010-08-26 Wenge Li Enantioselective process for the preparation of zolmitriptan
US20110171141A1 (en) * 2009-06-26 2011-07-14 Kellerman Donald J Administration of dihydroergotamine mesylate particles using a metered dose inhaler
US20110038928A1 (en) * 2009-08-12 2011-02-17 Glenmark Generics Ltd Orally disintegrating tablets of zolmitriptan
AU2011316225B2 (en) 2010-10-15 2016-05-19 Contera Pharma Aps Combinations of serotonin receptor agonists for treatment of movement disorders
UA113288C2 (xx) 2011-06-22 2017-01-10 Trpv1 антагоністи, що містять дигідроксизамісник, і їх застосування
WO2013016223A2 (fr) 2011-07-22 2013-01-31 The University Of Chicago Traitements de la migraine et de troubles apparentés
EP2751098B1 (fr) 2011-09-02 2017-11-29 Emcure Pharmaceuticals Limited Procédé de préparation amélioré de zolmitriptan
HUE037732T2 (hu) 2012-04-18 2018-09-28 Contera Pharma Aps A mozgászavarok fejlett kezelésére alkalmas, szájon át szedhetõ gyógyszerészeti készítmény
EP2935280A4 (fr) 2012-12-21 2016-05-25 Map Pharmaceuticals Inc Composés 8'-hydroxy-dihydroergotamine et compositions associées
AU2016226267A1 (en) 2015-03-02 2017-09-28 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoids
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
WO2017122161A1 (fr) 2016-01-15 2017-07-20 Cadila Healthcare Limited Composition intranasale comprenant des agonistes de récepteur 5ht1b/1d
CA3010568C (fr) 2016-01-27 2023-10-17 Instar Technologies A.S. Supports nanofibreux oromumuqueux pour traitement therapeutique
EP3481385A1 (fr) 2016-07-11 2019-05-15 Contera Pharma APS Système d'administration pulsatile de médicament pour le traitement de l'akinésie matinale
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
AU2020292994A1 (en) 2019-06-14 2022-01-06 Janssen Pharmaceutica Nv Substituted pyrazolo-pyrazines and their use as GluN2B receptor modulators
EP3766483A1 (fr) 2019-07-19 2021-01-20 BioPharma Synergies, S. L. Composition de poudre orodispersible comprenant un triptane
US20210322343A1 (en) 2020-04-15 2021-10-21 Farzana Shaheen Nasally administered pharmaceutical composition for the treatment of epilepsy and related disorders

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB148879A (en) * 1919-02-14 1921-11-10 Emil Vincance Noser Locks for shift levers of automobiles
US3320282A (en) * 1962-10-29 1967-05-16 Pfizer & Co C Process for preparing esters of 2-hydroxy-3-(3-indolyl) alkanoic acids
US3879410A (en) * 1971-02-08 1975-04-22 Messrs Lab Guidotti & C S P A 4-Aryl-4-oxazolin-2-ones exhibiting myotonic and myorelaxing activity
BE795457A (fr) * 1972-02-16 1973-08-16 Clin Midy Amines indoliques, leur preparation et leur application en therapeutiques
FR2179582B1 (fr) * 1972-04-13 1975-10-10 Synthelabo
US3873559A (en) * 1973-03-30 1975-03-25 Squibb & Sons Inc Heterocyclic carboxamido thiazolinyl indoles
US4042595A (en) * 1973-08-01 1977-08-16 Snam Progetti S.P.A. Processes for the production of heterocyclic compounds
IT995110B (it) * 1973-08-01 1975-11-10 Snam Progetti Procedimento per la produzione di composti eterociclici e prodotti ottenuti
US3931229A (en) * 1973-08-23 1976-01-06 Warner-Lambert Company 3-Thiomethyl-2[2-(dialkylamino)ethyl]indoles
US4049816A (en) * 1975-03-24 1977-09-20 Beecham Group Limited Antiviral 2-amino-5-[1-(indol-3-yl)alkyl]-2-thiazolin-4-ones
FR2315925A1 (fr) * 1975-07-04 1977-01-28 Nippon Chemiphar Co Nouveaux derives de 5-benzyle-2-oxazolidone, leur procede de preparation et leur application en therapeutique
GB1482879A (en) * 1975-07-24 1977-08-17 Nippon Chemiphar Co 5-benzyl-2-oxazolidone derivatives and a process for producing the same
GB1469200A (en) * 1975-11-28 1977-03-30 Warner Lambert Co 3-thiomethyl-2-2-dialkylamino-ethyl-indoles
DE2557341A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
IT1109002B (it) * 1977-09-22 1985-12-16 Menarini Sas Derivati del 2 oxazolidone e loro metodi di preparazione
US4198501A (en) * 1977-12-20 1980-04-15 Hoffmann-La Roche Inc. Synthesis of tryptophans
US4137404A (en) * 1977-12-20 1979-01-30 Hoffmann-La Roche Inc. Synthesis of tryptophans
JPS6014032B2 (ja) * 1978-01-20 1985-04-11 日本ケミフア株式会社東京 ５‐フエネチル‐２‐オキサゾリドン誘導体およびその製法
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
DE2933636A1 (de) * 1978-08-30 1980-03-20 Sandoz Ag Neue n-phenylindolinderivate, ihre herstellung und pharmazeutische praeparate, welche diese verbindungen enthalten
ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
US4255432A (en) * 1979-09-06 1981-03-10 Syntex (U.S.A.) Inc. 8-[2-3-Indolyl)ethyl]-1-oxa-3-,8-diazaspiro[4.5]decan-2-ones, pharmaceutical compositions thereof and methods of use thereof
US4272555A (en) * 1979-09-21 1981-06-09 Monsanto Company Conversion of carbon-containing materials to carbon monoxide
DE3164982D1 (de) * 1980-04-10 1984-08-30 Sandoz Ag Isoxazolyl indolamines
JPS574986A (en) * 1980-06-13 1982-01-11 Paamakemu Asia:Kk Preparation of oxazolidine derivative
US4367234A (en) * 1980-07-28 1983-01-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4753956A (en) * 1981-01-02 1988-06-28 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
ZA815541B (en) * 1980-08-12 1983-03-30 Glaxo Group Ltd Heterocyclic compounds
AU548467B2 (en) * 1980-08-12 1985-12-12 Glaxo Group Limited Tryptamines and their isoindolylethyl derivatives
US4399296A (en) * 1981-01-02 1983-08-16 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
US4448971A (en) * 1981-01-02 1984-05-15 Pfizer Inc. Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones
US4407811A (en) * 1981-01-02 1983-10-04 Pfizer Inc. Hypoglycemic 5-substituted oxazolidine-2,4-diones
JPS57169458A (en) * 1981-04-13 1982-10-19 Paamakemu Asia:Kk Preparation of indole derivative
CH656124A5 (de) * 1982-04-13 1986-06-13 Sandoz Ag 2-substituierte-3-indolamine, verfahren zu deren herstellung sowie deren verwendung.
IT1170387B (it) * 1982-06-07 1987-06-03 Glaxo Group Ltd Composti eterociclici, procedimento per prepararli e composizioni farmaceutiche che li contengono
US4803218A (en) * 1982-09-29 1989-02-07 Mcneilab, Inc. 3-aminoalkyl-1H-indole-5-urea and amide derivatives
US4500717A (en) * 1983-03-28 1985-02-19 The Dow Chemical Company Process for preparation of 2-oxazolidinones
US4831153A (en) * 1983-06-27 1989-05-16 The Dow Chemical Company Preparation of N-vinyl-2-oxazolidinone
GB8321813D0 (en) * 1983-08-12 1983-09-14 Vickers Plc Radiation sensitive compounds
DE3333450A1 (de) * 1983-09-16 1985-04-11 Hoechst Ag, 6230 Frankfurt Trihalogenmethylgruppen enthaltende carbonylmethylenheterocyclen, verfahren zu ihrer herstellung und lichtempfindliches gemisch, das diese verbindungen enthaelt
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
DE3430284A1 (de) * 1984-08-17 1986-02-27 Troponwerke GmbH & Co KG, 5000 Köln Neue tryptamin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung
SE8505715L (sv) * 1984-12-04 1986-06-05 Glaxo Group Ltd Indolderivat
GB8431426D0 (en) * 1984-12-13 1985-01-23 Glaxo Group Ltd Chemical compounds
DE3514696A1 (de) * 1985-04-24 1986-11-06 Bayer Ag, 5090 Leverkusen N-indolylethyl-sulfonsaeureamide, verfahren zu ihrer herstellung und ihre verwendung
DE3531658A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel
EP0225726B1 (fr) * 1985-11-08 1991-04-17 Glaxo Group Limited Dérivés de l'indole
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
SE451840B (sv) * 1986-01-03 1987-11-02 Astra Laekemedel Ab Optiskt rent monohydrat av s-(-)-1-propyl-2',6'-pipekoloxylididhydroklorid, sett att framstella denna och farmaceutiska beredningar for lokalbedovning
GB8600397D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8600398D0 (en) * 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
GB8607824D0 (en) * 1986-03-27 1986-04-30 Glaxo Group Ltd Chemical compounds
DE3643957A1 (de) * 1986-12-22 1988-06-30 Bayer Ag Substituierte n-methylisoxazolidine
PH24976A (en) * 1987-08-13 1990-12-26 Glaxo Group Ltd Indole derivatives
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
DE3730777A1 (de) * 1987-09-12 1989-03-23 Basf Ag Verfahren zur herstellung von imidazolidinonen und oxazolidinonen
US4965268A (en) * 1987-10-09 1990-10-23 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4921869A (en) * 1987-10-09 1990-05-01 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4801600A (en) * 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
DE3823299A1 (de) * 1988-07-07 1990-01-11 Schering Ag Substituierte phenyl-pyrrolidin-2-one, -oxazolidin-2-one und -imidazolidin-2-one, ihre herstellung sowie verwendung in arzneimitteln
GB8819024D0 (en) * 1988-08-10 1988-09-14 Glaxo Group Ltd Chemical compounds
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
EP0434714A1 (fr) * 1988-09-15 1991-07-03 The Upjohn Company 5-beta-amidomethyle-oxazolidine-2-ones a substitution en position 3
DE3939238A1 (de) * 1989-11-28 1991-05-29 Bayer Ag Heterocyclisch substituierte acrylsaeureester
DE4013907A1 (de) * 1990-04-26 1991-10-31 Schering Ag Verfahren zur herstellung von gramin-derivaten
SK278998B6 (sk) * 1991-02-01 1998-05-06 Merck Sharp & Dohme Limited Deriváty imidazolu, triazolu a tetrazolu, spôsob i
GB9104136D0 (en) * 1991-02-27 1991-04-17 Merck Sharp & Dohme Therapeutic agents
US5409941A (en) * 1992-02-03 1995-04-25 Pfizer Inc. 5-heteroyl indole derivatives

Also Published As

Publication number Publication date
IE911931A1 (en) 1991-12-18
HUT62289A (en) 1993-04-28
UA37178C2 (uk) 2001-05-15
EP0636623B1 (fr) 2001-08-16
LV10274B (en) 1995-04-20
WO1991018897A1 (fr) 1991-12-12
DE69127260D1 (de) 1997-09-18
YU48855B (sh) 2002-06-19
CS172791A3 (en) 1992-02-19
FI105686B (fi) 2000-09-29
FI106262B (fi) 2000-12-29
HRP940524A2 (en) 1996-06-30
GR3024828T3 (en) 1998-01-30
EP0486666B1 (fr) 1997-08-13
FI920503A0 (fi) 1992-02-06
IL98392A (en) 1996-01-19
ATE156823T1 (de) 1997-08-15
SI21560A (sl) 2005-02-28
LT3264B (en) 1995-05-25
JPH05502679A (ja) 1993-05-13
SI9111010A (en) 1997-12-31
MX9203421A (es) 1992-07-01
DK0486666T3 (da) 1998-03-30
SI21560B (sl) 2005-04-30
HK1000534A1 (en) 1998-04-03
LU90205I2 (fr) 1998-04-06
RU2160736C2 (ru) 2000-12-20
HU9200384D0 (en) 1992-06-29
JP2738461B2 (ja) 1998-04-08
DE69127260T2 (de) 1997-12-04
HRP940524B1 (en) 1998-10-31
SA05260104A (ar) 2005-12-03
US5466699A (en) 1995-11-14
PL166214B1 (pl) 1995-04-28
CA2064815A1 (fr) 1991-12-08
HU211479A9 (en) 1995-11-28
US5399574A (en) 1995-03-21
SI9111010B (sl) 2005-02-28
NO920494D0 (no) 1992-02-06
NL980001I2 (nl) 1998-05-06
SA05260104B1 (ar) 2006-04-04
NO1998005I1 (no) 1998-01-21
ATE204275T1 (de) 2001-09-15
AU7957091A (en) 1991-12-31
LV10274A (lv) 1994-10-20
CZ288351B6 (en) 2001-05-16
YU101091A (sh) 1994-04-05
KR100215627B1 (ko) 1999-08-16
AU646871B2 (en) 1994-03-10
NO920494L (no) 1992-03-30
IL114690A0 (en) 1995-11-27
US5863935A (en) 1999-01-26
MY110226A (en) 1998-03-31
ES2104708T3 (es) 1997-10-16
NO300634B1 (no) 1997-06-30
IE20010862A1 (en) 2003-03-05
CA2282890A1 (fr) 1991-12-08
DE19775091I2 (de) 2007-05-24
CA2282890C (fr) 2001-07-31
NL980001I1 (nl) 1998-03-02
EP0486666A1 (fr) 1992-05-27
NZ238424A (en) 1993-12-23
CA2064815C (fr) 1999-11-16
EG19650A (en) 1995-09-30
DE69132691T2 (de) 2002-06-20
PT97888A (pt) 1992-05-29
FI20001406A (fi) 2000-06-13
EP0636623A1 (fr) 1995-02-01
SK281621B6 (sk) 2001-05-10
HU219974B (hu) 2001-10-28
LTIP419A (en) 1994-11-25
DE69132691D1 (de) 2001-09-20
FI960155A (fi) 1996-01-12
KR920702359A (ko) 1992-09-03
FI960155A0 (fi) 1996-01-12
IL98392A0 (en) 1992-07-15
PT97888B (pt) 1998-12-31
IL114690A (en) 1997-02-18

Similar Documents

Publication Publication Date Title
MC2210A1 (fr) Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer
IL69175A (en) 3,5-dimethyl-4-methoxy pyridyl-n-oxides,their preparation and their use as intermediates for the preparation of omeprazole derivatives
FI102069B1 (fi) Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi
IL57577A0 (en) 1,2-dihydroquinolin-2-one derivatives,process for their preparation and pharmaceutical compositions containing the same
FI933903A0 (fi) Substituerade cyklohexanderivat, foerfarande foer framstaellning daerav och anvaendning av foereningar foer behandling av sjukdomar
IL107287A (en) Heterocyclic derivatives process for their preparation and pharmaceutical compositions containing some of them
ES8303355A1 (es) Procedimiento para la obtencion de nuevos derivados de mer- captoimidazoles.
GB1424450A (en) Isoindoline intermediates
ES8203867A1 (es) Procedimiento para la obtencion de derivados de benzotiazol
JPS5576872A (en) Imidazolidinone derivative
JPS55104266A (en) Novel pyridone derivative
JPS54128592A (en) Cephalosporin derivatives and its preparation
NO176177C (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive 2-amino-tetrahydroisokinolinderivater