BRPI0915696B8 - composição de vacina de rotavírus liofilizada e método de preparar a referida composição - Google Patents
composição de vacina de rotavírus liofilizada e método de preparar a referida composiçãoInfo
- Publication number
- BRPI0915696B8 BRPI0915696B8 BRPI0915696A BRPI0915696A BRPI0915696B8 BR PI0915696 B8 BRPI0915696 B8 BR PI0915696B8 BR PI0915696 A BRPI0915696 A BR PI0915696A BR PI0915696 A BRPI0915696 A BR PI0915696A BR PI0915696 B8 BRPI0915696 B8 BR PI0915696B8
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- rotavirus vaccine
- preparing
- vaccine
- lyophilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/15—Reoviridae, e.g. calf diarrhea virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/12011—Reoviridae
- C12N2720/12311—Rotavirus, e.g. rotavirus A
- C12N2720/12351—Methods of production or purification of viral material
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
composição de vacina de rotavírus liofilizada e método de preparar a referida composição. a presente invenção refere-se a formulações de vacina de rotavírus liofilizadas novas e métodos de sua preparação. as formulações incluem estabilizantes de vacina, resultando em uma formulação de vacina com estabilidade intensificada e perda mínima de potência. as formulações de vacina de rotavírus compreendem uma razão vantajosa de um dissacarídeo (tal como sacarose) para um aminoácido (tal como glicina). a liofilização resulta em uma formulação de vírus com 100% de preservação do vírus e umidade residual de cerca de 0,8% a 1,4%.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2365MU2008 | 2008-11-07 | ||
| IN2365/MUM/2008 | 2008-11-07 | ||
| PCT/IN2009/000629 WO2010146598A2 (en) | 2008-11-07 | 2009-11-06 | Stable, dried rotavirus vaccine, compositions and process for preparation thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0915696A2 BRPI0915696A2 (pt) | 2016-02-10 |
| BRPI0915696B1 BRPI0915696B1 (pt) | 2020-06-23 |
| BRPI0915696B8 true BRPI0915696B8 (pt) | 2021-05-25 |
Family
ID=43356831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0915696A BRPI0915696B8 (pt) | 2008-11-07 | 2009-11-06 | composição de vacina de rotavírus liofilizada e método de preparar a referida composição |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8795686B2 (pt) |
| CN (1) | CN102202688B (pt) |
| BR (1) | BRPI0915696B8 (pt) |
| WO (1) | WO2010146598A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112012025047A2 (pt) | 2010-03-31 | 2016-06-21 | Stabilitech Ltd | formulações líquidas estabilizadas |
| ES2757591T3 (es) | 2010-03-31 | 2020-04-29 | Stabilitech Biopharma Ltd | Estabilización de partículas virales |
| GB201117233D0 (en) | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
| AR099470A1 (es) * | 2014-02-17 | 2016-07-27 | Intervet Int Bv | Vacunas de virus de aves de corral líquidas |
| GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
| SG11201610920WA (en) * | 2014-07-18 | 2017-02-27 | Msd Wellcome Trust Hilleman Lab Pvt Ltd | An improved thermostable spray dried rotavirus vaccine formulation and process thereof |
| BR112017000515A2 (pt) * | 2014-07-18 | 2017-11-14 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | formulação de vacina contra rotavírus termoestável seca por liofilização e processo para preparação da mesma |
| CN104524562A (zh) * | 2014-12-08 | 2015-04-22 | 武汉生物制品研究所有限责任公司 | 口服六价重配轮状病毒活疫苗 |
| CN104984357B (zh) * | 2015-06-02 | 2018-01-30 | 长春百克生物科技股份公司 | 不含明胶的疫苗保护剂组合物及流感减毒活疫苗 |
| CN106063933B (zh) * | 2015-12-31 | 2020-01-07 | 武汉博沃生物科技有限公司 | 通用疫苗冻干保护剂及其应用 |
| US12016949B2 (en) | 2017-01-06 | 2024-06-25 | Iosbio Ltd | Virus |
| MY191286A (en) | 2017-02-14 | 2022-06-14 | Inventprise Llc | Heat stable liquid rotavirus vaccine |
| US11110163B2 (en) | 2017-02-14 | 2021-09-07 | Inventprise, Llc | Heat stable vaccines |
| GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
| CN111356760A (zh) * | 2017-09-19 | 2020-06-30 | 阿德瓦希斯公司 | 细菌或李斯特菌菌株的冻干组合物和方法 |
| CU24701B1 (es) | 2017-10-16 | 2024-04-08 | Serum Institute Of India Pvt Ltd | Composiciones de vacuna estables que comprenden inter alia un flavivirus recombinante vivo atenuado y proceso para la preparación de las mismas |
| CN107744504A (zh) * | 2017-10-31 | 2018-03-02 | 山东亦度生物技术有限公司 | 一种ma104细胞制备人用轮状病毒活疫苗的冻干工艺方法 |
| CN111150849A (zh) * | 2020-04-02 | 2020-05-15 | 广州隽沐生物科技股份有限公司 | 一种组合物及其制备方法及其应用 |
| CN115531363B (zh) * | 2021-06-30 | 2024-03-29 | 中国科学技术大学 | 预防、抑制或治疗轮状病毒感染的药物组合物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6403098B1 (en) * | 1996-09-26 | 2002-06-11 | Merck & Co., Inc. | Rotavirus vaccine formulations |
| US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
| US20040022800A1 (en) * | 2000-07-31 | 2004-02-05 | Mark Parrington | Respiratory syncytial virus vaccine |
| US20030092145A1 (en) | 2000-08-24 | 2003-05-15 | Vic Jira | Viral vaccine composition, process, and methods of use |
| WO2003026642A1 (fr) | 2001-09-21 | 2003-04-03 | Sumitomo Pharmaceuticals Co., Ltd. | Preparation pharmaceutique lyophilisee |
| AU2002951692A0 (en) * | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
| US8124397B2 (en) * | 2005-08-08 | 2012-02-28 | Oregon Health & Science University | Inactivating pathogens with oxidizing agents for vaccine production |
-
2009
- 2009-11-06 CN CN200980125578.7A patent/CN102202688B/zh active Active
- 2009-11-06 BR BRPI0915696A patent/BRPI0915696B8/pt active IP Right Grant
- 2009-11-06 US US13/056,557 patent/US8795686B2/en active Active
- 2009-11-06 WO PCT/IN2009/000629 patent/WO2010146598A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0915696B1 (pt) | 2020-06-23 |
| CN102202688B (zh) | 2017-04-12 |
| WO2010146598A2 (en) | 2010-12-23 |
| WO2010146598A3 (en) | 2011-06-30 |
| BRPI0915696A2 (pt) | 2016-02-10 |
| CN102202688A (zh) | 2011-09-28 |
| US20110177119A1 (en) | 2011-07-21 |
| US8795686B2 (en) | 2014-08-05 |
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Legal Events
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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| B25D | Requested change of name of applicant approved |
Owner name: SERUM INSTITUTE OF INDIA PRIVATE LIMITED (IN) |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 23/06/2020, OBSERVADAS AS CONDICOES LEGAIS. |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/11/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |