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BRPI0815142B8 - forma cristalina do sal de dicloridrato ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metila. - Google Patents

forma cristalina do sal de dicloridrato ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metila.

Info

Publication number
BRPI0815142B8
BRPI0815142B8 BRPI0815142A BRPI0815142A BRPI0815142B8 BR PI0815142 B8 BRPI0815142 B8 BR PI0815142B8 BR PI0815142 A BRPI0815142 A BR PI0815142A BR PI0815142 A BRPI0815142 A BR PI0815142A BR PI0815142 B8 BRPI0815142 B8 BR PI0815142B8
Authority
BR
Brazil
Prior art keywords
pyrrolidinyl
imidazol
crystalline form
methylbutanoyl
biphenylyl
Prior art date
Application number
BRPI0815142A
Other languages
English (en)
Inventor
Yang Fukang
Gao Qi
Kim Soojin
Original Assignee
Bristol Myers Squibb Co
Bristol Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39739413&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0815142(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co, Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Co
Publication of BRPI0815142A2 publication Critical patent/BRPI0815142A2/pt
Publication of BRPI0815142B1 publication Critical patent/BRPI0815142B1/pt
Publication of BRPI0815142B8 publication Critical patent/BRPI0815142B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

forma cristalina do sal de dicloridrato((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amin0)-3-metilbut anoil)-2-pirrolidinil)-1 h-imidazol-5-il)-4-bifenilil)-1 h- imidazol-2-il)-1-pirrolidinil) carbonil)-2 metilpropil) carbamato de metila. a presente descrição de modo geral, refere-se a uma forma cristalina de sal de dicloridrato ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)am i no )-3-metilbutanoil)-2 -pirrolid i nil)-1 h-i m idazol-5-il)-4-bifen ilil)- 1 h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metila. a presente descrição também de modo geral, refere-se a uma composição farmacêutica que compreende uma forma cristalina, assim como a processos de utilização de uma forma cristalina no tratamento de hepatite c e a processos para a obtenção de tal forma cristalina.
BRPI0815142A 2007-08-08 2008-07-31 forma cristalina do sal de dicloridrato ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metila. BRPI0815142B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95459207P 2007-08-08 2007-08-08
PCT/US2008/071734 WO2009020828A1 (en) 2007-08-08 2008-07-31 Crystalline form of methyl ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1h-imidazol-5-yl)-4-biphenylyl)-1h-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate dihydrochloride salt

Publications (3)

Publication Number Publication Date
BRPI0815142A2 BRPI0815142A2 (pt) 2015-02-03
BRPI0815142B1 BRPI0815142B1 (pt) 2018-09-25
BRPI0815142B8 true BRPI0815142B8 (pt) 2021-05-25

Family

ID=39739413

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0815142A BRPI0815142B8 (pt) 2007-08-08 2008-07-31 forma cristalina do sal de dicloridrato ((1s)-1-(((2s)-2-(5-(4'-(2-((2s)-1-((2s)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1h-imidazol-5-il)-4-bifenilil)-1h-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metila.

Country Status (21)

Country Link
US (1) US8629171B2 (pt)
EP (1) EP2183244B1 (pt)
JP (1) JP5244179B2 (pt)
KR (1) KR101508022B1 (pt)
CN (1) CN101778840B (pt)
AR (2) AR070016A1 (pt)
AU (1) AU2008284100B2 (pt)
BR (1) BRPI0815142B8 (pt)
CA (1) CA2695729C (pt)
CL (1) CL2008002354A1 (pt)
CO (1) CO6160327A2 (pt)
EA (1) EA018152B1 (pt)
ES (1) ES2402791T3 (pt)
HK (1) HK1144089A1 (pt)
IL (1) IL203684A (pt)
MX (1) MX2010001368A (pt)
NZ (1) NZ583148A (pt)
PE (1) PE20090940A1 (pt)
TW (1) TWI359813B (pt)
WO (1) WO2009020828A1 (pt)
ZA (1) ZA201000843B (pt)

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NZ583148A (en) 2011-04-29
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AU2008284100B2 (en) 2014-01-16
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BRPI0815142B1 (pt) 2018-09-25
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BRPI0815142A2 (pt) 2015-02-03
EA201000196A1 (ru) 2010-06-30
AU2008284100A1 (en) 2009-02-12
EA018152B1 (ru) 2013-05-30
WO2009020828A1 (en) 2009-02-12
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PE20090940A1 (es) 2009-07-13
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