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BRPI0716436B8 - sistema de liberação controlada e método para fabricação do mesmo - Google Patents

sistema de liberação controlada e método para fabricação do mesmo

Info

Publication number
BRPI0716436B8
BRPI0716436B8 BRPI0716436A BRPI0716436A BRPI0716436B8 BR PI0716436 B8 BRPI0716436 B8 BR PI0716436B8 BR PI0716436 A BRPI0716436 A BR PI0716436A BR PI0716436 A BRPI0716436 A BR PI0716436A BR PI0716436 B8 BRPI0716436 B8 BR PI0716436B8
Authority
BR
Brazil
Prior art keywords
controlled release
release system
layer
pharmaceutically acceptable
layer containing
Prior art date
Application number
BRPI0716436A
Other languages
English (en)
Inventor
Sommer Florian
Gerhard Wagner Karl
Pearnchob Nantharat
Friedl Thomas
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BRPI0716436A2 publication Critical patent/BRPI0716436A2/pt
Publication of BRPI0716436B1 publication Critical patent/BRPI0716436B1/pt
Publication of BRPI0716436B8 publication Critical patent/BRPI0716436B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

sistema de liberação controlada, e seus processo de preparação e uso. a presente invenção refere-se a um sistema de liberação controlada farmacêutico para administração, particularmente administração oral, de substâncias ativas com solubilidades dependentes de ph, compreendendo a) um material de núcleo contendo ou consistindo em um ou mais modificadores de ph farmaceuticamente aceitáveis; b) opcionalmente uma camada isolante, c) uma primeira camada contendo ou consistindo em um ou mais polímeros insolúveis em água farmaceuticamente aceitáveis; d) uma segunda camada contendo ou consistindo em pelo menos uma substância ativa tendo uma solubilidade dependente de ph; e) uma terceira camada contendo ou consistindo em um ou mais polímeros farmaceuticamente aceitáveis tendo grupos aniônicos ou não-iônicos; e f) opcionalmente uma quarta camada, preferivelmente em forma de uma camada de revestimento externa. é fornecido um perfil de liberação independente de ph de substâncias ativas tendo solubilidades dependentes de ph in vitro e in vivo.
BRPI0716436A 2006-08-25 2007-08-10 sistema de liberação controlada e método para fabricação do mesmo BRPI0716436B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06017754 2006-08-25
PCT/EP2007/058302 WO2008022932A2 (en) 2006-08-25 2007-08-10 Controlled release system and method for manufacturing the same

Publications (3)

Publication Number Publication Date
BRPI0716436A2 BRPI0716436A2 (pt) 2014-03-04
BRPI0716436B1 BRPI0716436B1 (pt) 2020-05-19
BRPI0716436B8 true BRPI0716436B8 (pt) 2021-05-25

Family

ID=38596345

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0716436A BRPI0716436B8 (pt) 2006-08-25 2007-08-10 sistema de liberação controlada e método para fabricação do mesmo

Country Status (19)

Country Link
US (1) US8512748B2 (pt)
EP (1) EP2056797A2 (pt)
JP (1) JP5220746B2 (pt)
KR (1) KR20090045945A (pt)
CN (2) CN104721168A (pt)
AR (1) AR062321A1 (pt)
AU (1) AU2007287639A1 (pt)
BR (1) BRPI0716436B8 (pt)
CA (1) CA2661613C (pt)
CL (1) CL2007002358A1 (pt)
CO (1) CO6150131A2 (pt)
EA (1) EA200900270A1 (pt)
IL (1) IL197129A (pt)
MX (1) MX2009002031A (pt)
NO (1) NO20090100L (pt)
PE (1) PE20080738A1 (pt)
TW (1) TW200817053A (pt)
WO (1) WO2008022932A2 (pt)
ZA (1) ZA200810781B (pt)

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NO20090100L (no) 2009-04-23
PE20080738A1 (es) 2008-08-05
CO6150131A2 (es) 2010-04-20
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IL197129A0 (en) 2009-11-18
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US8512748B2 (en) 2013-08-20
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IL197129A (en) 2014-08-31
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