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BRPI0610284A8 - Pirrolobenzodiazepinas - Google Patents

Pirrolobenzodiazepinas

Info

Publication number
BRPI0610284A8
BRPI0610284A8 BRPI0610284A BRPI0610284A BRPI0610284A8 BR PI0610284 A8 BRPI0610284 A8 BR PI0610284A8 BR PI0610284 A BRPI0610284 A BR PI0610284A BR PI0610284 A BRPI0610284 A BR PI0610284A BR PI0610284 A8 BRPI0610284 A8 BR PI0610284A8
Authority
BR
Brazil
Prior art keywords
optionally substituted
me3sn
nhr
halo
nitro
Prior art date
Application number
BRPI0610284A
Other languages
English (en)
Inventor
John Gregson Stephen
Wilson Howard Philip
Chen Zhizhi
Original Assignee
Spirogen Ltd
Spirogen Dev Sarl
Spirogen Sarl
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0508084A external-priority patent/GB0508084D0/en
Priority claimed from GB0522746A external-priority patent/GB0522746D0/en
Application filed by Spirogen Ltd, Spirogen Dev Sarl, Spirogen Sarl, Medimmune Ltd filed Critical Spirogen Ltd
Publication of BRPI0610284A2 publication Critical patent/BRPI0610284A2/pt
Publication of BRPI0610284A8 publication Critical patent/BRPI0610284A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PIRROLOBENZODIAZEPINAS A presente invenção se refere a compostos apresentando a fórmula I ou solvatos do mesmo, em que: R2 é um grupo arila C5-20 opcionalmente substituído; R6 e R9 são independentemente selecionados de H, R, OH, OR, SH, SR, NH2, NHR, NRR', nitro, Me3Sn e halo; onde R e R' são independentemente selecionados de grupos alquila C1-12, heterociclila C3-20 e arila C5-20 opcionalmente substituídos; R7 é selecionado de H, R, OH, OR, SH, SR, NH2, NHR, NHRR', nitro, Me3Sn e halo; R" é um grupo alquileno C3-12, cuja cadeia pode ser interrompida por um mais anéis aromáticos e/ou heteroátomos; X é selecionado de O, S, ou NH; z é 2 ou 3; M é um cátion monovalente farmaceuticamente aceitável; R2', R6', R7', R9', X' e M' são selecionados dos mesmos grupos como R2, R6, R7, R9, X e M respectivamente, ou M e M' podem juntos representar cátion divalente farmaceuticamente aceitável. I
BRPI0610284A 2005-04-21 2006-04-21 Pirrolobenzodiazepinas BRPI0610284A8 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0508084.1 2005-04-21
GB0508084A GB0508084D0 (en) 2005-04-21 2005-04-21 Pyrrolobenzodiazepines
GB0522746.7 2005-11-07
GB0522746A GB0522746D0 (en) 2005-11-07 2005-11-07 Pyrrolobenzodiazepines
PCT/GB2006/001456 WO2006111759A1 (en) 2005-04-21 2006-04-21 Pyrrolobenzodiazepines

Publications (2)

Publication Number Publication Date
BRPI0610284A2 BRPI0610284A2 (pt) 2010-06-08
BRPI0610284A8 true BRPI0610284A8 (pt) 2017-05-09

Family

ID=36589321

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0610284A BRPI0610284A8 (pt) 2005-04-21 2006-04-21 Pirrolobenzodiazepinas

Country Status (19)

Country Link
US (2) US7612062B2 (pt)
EP (1) EP1879901B1 (pt)
JP (1) JP5061096B2 (pt)
KR (1) KR101396095B1 (pt)
AT (1) ATE452898T1 (pt)
AU (1) AU2006238686B2 (pt)
BR (1) BRPI0610284A8 (pt)
CA (1) CA2604805C (pt)
CY (1) CY1109911T1 (pt)
DE (1) DE602006011300D1 (pt)
DK (1) DK1879901T3 (pt)
ES (1) ES2338696T3 (pt)
GB (1) GB2439881C (pt)
MX (1) MX2007013039A (pt)
NZ (1) NZ563136A (pt)
PL (1) PL1879901T3 (pt)
PT (1) PT1879901E (pt)
SI (1) SI1879901T1 (pt)
WO (1) WO2006111759A1 (pt)

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