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BRPI0515860B8 - derivados de tetralin e indano, seus usos, e composição farmacêutica - Google Patents

derivados de tetralin e indano, seus usos, e composição farmacêutica

Info

Publication number
BRPI0515860B8
BRPI0515860B8 BRPI0515860A BRPI0515860A BRPI0515860B8 BR PI0515860 B8 BRPI0515860 B8 BR PI0515860B8 BR PI0515860 A BRPI0515860 A BR PI0515860A BR PI0515860 A BRPI0515860 A BR PI0515860A BR PI0515860 B8 BRPI0515860 B8 BR PI0515860B8
Authority
BR
Brazil
Prior art keywords
tetralin
pharmaceutical composition
indane derivatives
formula
compounds
Prior art date
Application number
BRPI0515860A
Other languages
English (en)
Inventor
Bruce Repke David
M Kress James
New Harris Ralph Iii
Greenhouse Robert
Stephen Stabler Russell
Jaime-Figueroa Saul
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0515860A publication Critical patent/BRPI0515860A/pt
Publication of BRPI0515860B1 publication Critical patent/BRPI0515860B1/pt
Publication of BRPI0515860B8 publication Critical patent/BRPI0515860B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/16—Anti-Parkinson drugs
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
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    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

derivados de tetralin e indano, e uso dos mesmos. compostos da fórmula i: ou sais farmaceuticamente aceitáveis dos mesmos, onde m,p,q, ar, r¹ e r² são conforme aqui definidos. também são fornecidos métodos para preparar compostos de fórmula i, composições compreendendo compostos de fórmula i, e usos dos compostos de fórmula i na preparação de medicamentos.
BRPI0515860A 2004-12-21 2005-12-15 derivados de tetralin e indano, seus usos, e composição farmacêutica BRPI0515860B8 (pt)

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US63803004P 2004-12-21 2004-12-21
US60/638,030 2004-12-21
PCT/EP2005/013487 WO2006066790A1 (en) 2004-12-21 2005-12-15 Tetralin and indane derivatives and uses thereof

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BRPI0515860A BRPI0515860A (pt) 2008-08-12
BRPI0515860B1 BRPI0515860B1 (pt) 2021-05-04
BRPI0515860B8 true BRPI0515860B8 (pt) 2021-05-25

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IL183974A (en) 2014-02-27
US7312359B2 (en) 2007-12-25
PL1831159T3 (pl) 2010-06-30
JP4560551B2 (ja) 2010-10-13
EP1831159A1 (en) 2007-09-12
BRPI0515860B1 (pt) 2021-05-04
WO2006066790A1 (en) 2006-06-29
HK1117500A1 (en) 2009-01-16
PT1831159E (pt) 2010-03-03
AU2005318550A1 (en) 2006-06-29
RU2396255C2 (ru) 2010-08-10
US8093424B2 (en) 2012-01-10
TWI344951B (en) 2011-07-11
CA2591937C (en) 2013-08-06
MY144050A (en) 2011-07-29
DE602005019098D1 (de) 2010-03-11
US20080293751A1 (en) 2008-11-27
US20200115333A1 (en) 2020-04-16
CA2591937A1 (en) 2006-06-29
JP2008524281A (ja) 2008-07-10
KR20070087201A (ko) 2007-08-27
ATE455755T1 (de) 2010-02-15
TW200633964A (en) 2006-10-01
US20120088837A1 (en) 2012-04-12
HRP20100181T1 (hr) 2010-05-31
AU2005318550B2 (en) 2011-04-07
NZ555845A (en) 2009-09-25
NO20073051L (no) 2007-06-27
IL183974A0 (en) 2007-10-31
MX2007007558A (es) 2007-07-24
US20210284606A1 (en) 2021-09-16
US9670151B2 (en) 2017-06-06
KR100901035B1 (ko) 2009-06-04
EP1831159B1 (en) 2010-01-20
RU2007122408A (ru) 2009-01-27
US8889906B2 (en) 2014-11-18
DK1831159T3 (da) 2010-03-22
SI1831159T1 (sl) 2010-04-30
AR055012A1 (es) 2007-08-01
US20180319743A1 (en) 2018-11-08
CN101119965A (zh) 2008-02-06
CN101119965B (zh) 2012-09-26
ES2337482T3 (es) 2010-04-26
US20150266817A1 (en) 2015-09-24
NO339065B1 (no) 2016-11-07
ZA200705122B (en) 2008-09-25
US20170247321A1 (en) 2017-08-31
BRPI0515860A (pt) 2008-08-12
US20060167255A1 (en) 2006-07-27
CY1111032T1 (el) 2015-06-11

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