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BRPI0514319A - composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal - Google Patents

composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal

Info

Publication number
BRPI0514319A
BRPI0514319A BRPI0514319-5A BRPI0514319A BRPI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A BR PI0514319 A BRPI0514319 A BR PI0514319A
Authority
BR
Brazil
Prior art keywords
receptor
capsaicin
methods
capsaicin receptor
compound
Prior art date
Application number
BRPI0514319-5A
Other languages
English (en)
Inventor
Charles A Blum
Harry Brielmann
Bertrand L Chenard
Xiaozhang Zheng
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BRPI0514319A publication Critical patent/BRPI0514319A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPOSTO OU SAL FARMACEUTICAMENTE ACEITáVEL DO MESMO COMPOSIçãO FARMACêUTICA MéTODOS PARA REDUZIR A CONDUTáNCIA DE CáLCIO DE UM RECEPTOR DE CAPSAICINA CELULAR, E PARA INIBIR A LIGAçãO DE LIGANDO DE VANILóIDE A UM RECEPTOR DE CAPSAICINA, MéTODO PARA TRATAR UMA CONDIçãO RESPONDENTE A MODULAçãO DO RECEPTOR DE CAPSAICINA, DOR, COCEIRA, TOSSE OU SOLUçO E INCONTINêNCIA URINáRIA OU BEXIGA SUPERATIVA EM UM PACIENTE, MéTODOS PARA PROMOVER PERDA DE PESO EM UM PACIENTE OBESO, PARA IDENTIFICAR UM AGENTE QUE LIGA AO RECEPTOR DE CAPSAICINA, E PARA DETERMINAR A PRESENçA OU AUSêNCIA DE RECEPTOR DE CAPSAICINA EM UMA AMOSTRA, PREPARAçãO FARMACêUTICA ACONDICIONADA, E, USO DO COMPOSTO OU SAL Análogos de biaril piperazinil-piridina substituídos são providos de fórmula (I): em que as variáveis são como aqui descritas. Estes compostos são ligandos que podem ser usados para modular a atividade de receptor específica in vivo ou in vitro, e são particularmente utilizáveis no tratamento de condições associadas com a ativação de receptor patológico em humanos, animais de estimação domesticados e animais de criação. As composições farmacêuticas e métodos para usar estes compostos para tratar estes distúrbios são providos, assim como os métodos para usar estes ligandos para os estudos de localização de receptor.
BRPI0514319-5A 2004-08-13 2005-08-13 composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal BRPI0514319A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60172104P 2004-08-13 2004-08-13
US64179605P 2005-01-05 2005-01-05
PCT/US2005/028969 WO2006026135A2 (en) 2004-08-13 2005-08-13 Substituted biaryl piperazinyl-pyridine analogues

Publications (1)

Publication Number Publication Date
BRPI0514319A true BRPI0514319A (pt) 2008-06-10

Family

ID=36000525

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514319-5A BRPI0514319A (pt) 2004-08-13 2005-08-13 composto ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos para reduzir a condutáncia de cálcio de um receptor de capsaicina celular, e para inibir a ligação de ligando de vanilóide a um receptor de capsaicina, método para tratar uma condição respondente a modulação do receptor de capsaicina, dor, coceira, tosse ou soluço e incontinência urinária ou bexiga superativa em um paciente, métodos para promover perda de peso em um paciente obeso, para identificar um agente que liga ao receptor de capsaicina, e para determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica acondicionada, e, uso do composto ou sal

Country Status (24)

Country Link
US (2) US7662830B2 (pt)
EP (1) EP1786800B1 (pt)
JP (1) JP4955554B2 (pt)
KR (1) KR20070046924A (pt)
CN (1) CN101014587B (pt)
AR (1) AR050194A1 (pt)
BR (1) BRPI0514319A (pt)
CA (1) CA2577301C (pt)
CR (1) CR8992A (pt)
EC (1) ECSP077318A (pt)
HN (1) HN2007006799A (pt)
IL (1) IL181040A0 (pt)
MA (1) MA28857B1 (pt)
MX (1) MX2007001696A (pt)
MY (1) MY145822A (pt)
NI (1) NI200700040A (pt)
NO (1) NO20071243L (pt)
NZ (1) NZ553388A (pt)
PE (1) PE20060620A1 (pt)
RU (1) RU2413726C2 (pt)
SG (1) SG157399A1 (pt)
TW (1) TW200605889A (pt)
WO (1) WO2006026135A2 (pt)
ZA (1) ZA200701530B (pt)

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US20060122394A1 (en) 2006-06-08
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ZA200701530B (en) 2008-11-26
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