BRPI0407108A - Método para produzir uma imunoglobulina funcional humana - Google Patents
Método para produzir uma imunoglobulina funcional humanaInfo
- Publication number
- BRPI0407108A BRPI0407108A BR0407108-5A BRPI0407108A BRPI0407108A BR PI0407108 A BRPI0407108 A BR PI0407108A BR PI0407108 A BRPI0407108 A BR PI0407108A BR PI0407108 A BRPI0407108 A BR PI0407108A
- Authority
- BR
- Brazil
- Prior art keywords
- heavy chain
- immunoglobulin
- producing
- human heavy
- functional immunoglobulin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/22—Immunoglobulins specific features characterized by taxonomic origin from camelids, e.g. camel, llama or dromedary
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
"MéTODO PARA PRODUZIR UMA IMUNOGLOBULINA FUNCIONAL HUMANA". A presente invenção diz respeito a um método para produzir uma imunoglobulina funcional humana, em que uma imunoglobulina de cadeia pesada humana, destituída de qualquer cadeia leve, é expressada, compreendendo as etapas de: a) transformar uma célula hospedeira filamentosa com uma construção recombinante que codifica uma imunoglobulina de cadeia pesada humana modificada, em que as modificações compreendem uma ou mais mutações na região da proteína de cadeia pesada envolvida em contato com a cadeia leve; b) cultivar a dita célula hospedeira filamentosa sob condições que promovam a expressão da dita imunoglobulina de cadeia pesada humana modificada; e c) recuperar a dita imunoglobulina de cadeia pesada humana modificada.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200300169 | 2003-02-06 | ||
| PCT/DK2004/000086 WO2004069872A1 (en) | 2003-02-06 | 2004-02-06 | Human heavy chain antibody expression in filamentous fungi |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0407108A true BRPI0407108A (pt) | 2006-01-24 |
Family
ID=32842638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0407108-5A BRPI0407108A (pt) | 2003-02-06 | 2004-02-06 | Método para produzir uma imunoglobulina funcional humana |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060234340A1 (pt) |
| EP (1) | EP1592711A1 (pt) |
| JP (1) | JP2007506405A (pt) |
| CN (1) | CN1756767A (pt) |
| AU (1) | AU2004208860A1 (pt) |
| BR (1) | BRPI0407108A (pt) |
| CA (1) | CA2514834A1 (pt) |
| WO (1) | WO2004069872A1 (pt) |
| ZA (1) | ZA200506117B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1711529A1 (en) * | 2004-01-21 | 2006-10-18 | Novozymes A/S | Production of a monoclonal antibody in a heterokaryon fungus or in a fungal host cell |
| ATE407693T1 (de) | 2004-03-22 | 2008-09-15 | Solvay Pharm Gmbh | Orale pharmazeutische zusammensetzungen von produkten mit lipase, insbesondere von pankreatin,mit tensiden |
| DK1831384T3 (en) | 2004-12-22 | 2015-11-23 | Novozymes As | Polypeptides with glucoamylase activity and polynucleotides encoding them. |
| ES2635308T3 (es) | 2005-07-29 | 2017-10-03 | Abbott Laboratories Gmbh | Pancreatina con contenido viral reducido |
| US11266607B2 (en) | 2005-08-15 | 2022-03-08 | AbbVie Pharmaceuticals GmbH | Process for the manufacture and use of pancreatin micropellet cores |
| US9198871B2 (en) | 2005-08-15 | 2015-12-01 | Abbott Products Gmbh | Delayed release pancreatin compositions |
| US10072256B2 (en) | 2006-05-22 | 2018-09-11 | Abbott Products Gmbh | Process for separating and determining the viral load in a pancreatin sample |
| EP2455460A3 (en) | 2006-12-21 | 2012-12-26 | Novozymes A/S | Lipase variants for pharmaceutical use |
| WO2011009747A1 (en) | 2009-07-24 | 2011-01-27 | Novozymes A/S | Carbohydrate oxidases |
| WO2011047442A1 (en) * | 2009-10-23 | 2011-04-28 | Garvan Institute Of Medical Research | Modified variable domain molecules and methods for producing and using same |
| WO2011076123A1 (en) | 2009-12-22 | 2011-06-30 | Novozymes A/S | Compositions comprising boosting polypeptide and starch degrading enzyme and uses thereof |
| WO2012098246A1 (en) * | 2011-01-20 | 2012-07-26 | Novozymes A/S | Expression of plant peroxidases in filamentous fungi |
| DK3219794T3 (da) | 2011-11-21 | 2019-12-16 | Novozymes Inc | GH61-polypeptidvarianter og polynukleotider, som koder for dem |
| CN113234695A (zh) | 2012-04-27 | 2021-08-10 | 诺维信股份有限公司 | Gh61多肽变体以及编码其的多核苷酸 |
| WO2014052713A2 (en) | 2012-09-27 | 2014-04-03 | Massachusetts Institute Of Technology | Her2-and vegf-a-binding proteins with enhanced stability |
| WO2015059133A1 (en) | 2013-10-22 | 2015-04-30 | Novozymes A/S | Cellobiose dehydrogenase variants and polynucleotides encoding same |
| US10465172B2 (en) | 2013-11-29 | 2019-11-05 | Novozymes A/S | Peroxygenase variants |
| WO2017070219A1 (en) | 2015-10-20 | 2017-04-27 | Novozymes A/S | Lytic polysaccharide monooxygenase (lpmo) variants and polynucleotides encoding same |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5116964A (en) * | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DK0698097T3 (da) * | 1993-04-29 | 2001-10-08 | Unilever Nv | Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde |
| AU6188599A (en) * | 1998-10-26 | 2000-05-15 | Novozymes A/S | Constructing and screening a dna library of interest in filamentous fungal cells |
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| NZ517150A (en) * | 1999-08-27 | 2005-01-28 | Genentech Inc | Dosages for treatment with anti-ErbB2 antibodies |
| GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
-
2004
- 2004-02-06 BR BR0407108-5A patent/BRPI0407108A/pt not_active IP Right Cessation
- 2004-02-06 CN CNA2004800061118A patent/CN1756767A/zh active Pending
- 2004-02-06 EP EP04708719A patent/EP1592711A1/en not_active Withdrawn
- 2004-02-06 AU AU2004208860A patent/AU2004208860A1/en not_active Abandoned
- 2004-02-06 CA CA002514834A patent/CA2514834A1/en not_active Abandoned
- 2004-02-06 US US10/544,302 patent/US20060234340A1/en not_active Abandoned
- 2004-02-06 WO PCT/DK2004/000086 patent/WO2004069872A1/en not_active Application Discontinuation
- 2004-02-06 JP JP2006501521A patent/JP2007506405A/ja active Pending
-
2005
- 2005-08-01 ZA ZA200506117A patent/ZA200506117B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004069872A1 (en) | 2004-08-19 |
| ZA200506117B (en) | 2006-06-28 |
| CA2514834A1 (en) | 2004-08-19 |
| CN1756767A (zh) | 2006-04-05 |
| JP2007506405A (ja) | 2007-03-22 |
| AU2004208860A1 (en) | 2004-08-19 |
| EP1592711A1 (en) | 2005-11-09 |
| US20060234340A1 (en) | 2006-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A , 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011. |