DE60224291D1 - System zur antikörperexpression und- synthese - Google Patents
System zur antikörperexpression und- syntheseInfo
- Publication number
- DE60224291D1 DE60224291D1 DE60224291T DE60224291T DE60224291D1 DE 60224291 D1 DE60224291 D1 DE 60224291D1 DE 60224291 T DE60224291 T DE 60224291T DE 60224291 T DE60224291 T DE 60224291T DE 60224291 D1 DE60224291 D1 DE 60224291D1
- Authority
- DE
- Germany
- Prior art keywords
- expression
- synthesis
- antibodies
- antibody expression
- systems
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31520901P | 2001-08-27 | 2001-08-27 | |
US315209P | 2001-08-27 | ||
PCT/US2002/027220 WO2003018771A2 (en) | 2001-08-27 | 2002-08-26 | A system for antibody expression and assembly |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60224291D1 true DE60224291D1 (de) | 2008-02-07 |
DE60224291T2 DE60224291T2 (de) | 2008-12-11 |
Family
ID=23223369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60224291T Expired - Lifetime DE60224291T2 (de) | 2001-08-27 | 2002-08-26 | System zur antikörperexpression und- synthese |
Country Status (11)
Country | Link |
---|---|
US (6) | US20030077739A1 (de) |
EP (1) | EP1427744B1 (de) |
JP (1) | JP4461210B2 (de) |
KR (1) | KR100968664B1 (de) |
CN (1) | CN100513414C (de) |
AT (1) | ATE382053T1 (de) |
CA (1) | CA2454731C (de) |
DE (1) | DE60224291T2 (de) |
MX (1) | MXPA04001566A (de) |
NZ (1) | NZ530852A (de) |
WO (1) | WO2003018771A2 (de) |
Families Citing this family (52)
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US6979556B2 (en) * | 2000-12-14 | 2005-12-27 | Genentech, Inc. | Separate-cistron contructs for secretion of aglycosylated antibodies from prokaryotes |
WO2003018771A2 (en) | 2001-08-27 | 2003-03-06 | Genentech, Inc. | A system for antibody expression and assembly |
CN101537180B (zh) | 2002-07-18 | 2016-02-10 | 莫鲁斯有限公司 | 抗体混合物的重组生产 |
USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
WO2004065417A2 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
US7605235B2 (en) | 2003-05-30 | 2009-10-20 | Centocor, Inc. | Anti-tissue factor antibodies and compositions |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
US9708410B2 (en) | 2003-05-30 | 2017-07-18 | Janssen Biotech, Inc. | Anti-tissue factor antibodies and compositions |
KR100570422B1 (ko) * | 2003-10-16 | 2006-04-11 | 한미약품 주식회사 | 대장균 분비서열을 이용하여 항체 단편을 분비·생산하는 발현벡터 및 이를 이용하여 항체 단편을 대량 생산하는 방법 |
CN100475965C (zh) * | 2005-07-22 | 2009-04-08 | 上海高科联合生物技术研发有限公司 | 一种大肠杆菌高效外分泌表达溶葡萄球菌酶的方法 |
US20100168392A1 (en) * | 2007-08-10 | 2010-07-01 | Wacker Chemie Ag | Expression of full length igg and secretion into the culture medium of prokaryotic cells |
JP2011514161A (ja) * | 2008-02-29 | 2011-05-06 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッド | 免疫グロブリン組成物およびその製造方法 |
JP5463528B2 (ja) * | 2009-02-25 | 2014-04-09 | 味の素株式会社 | L−システイン生産菌及びl−システインの製造法 |
EP2993231B1 (de) | 2009-09-24 | 2018-08-01 | UCB Biopharma SPRL | Bakterienwirtsstamm |
EP2496601B1 (de) * | 2009-11-05 | 2017-06-07 | F. Hoffmann-La Roche AG | Methoden und zusammensetzung zur sekretion heterologer polypeptide |
GB201000588D0 (en) * | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201000587D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000591D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial hoist strain |
GB201000590D0 (en) | 2010-01-14 | 2010-03-03 | Ucb Pharma Sa | Bacterial host strain |
GB201012599D0 (en) | 2010-07-27 | 2010-09-08 | Ucb Pharma Sa | Process for purifying proteins |
US8722044B2 (en) | 2011-03-15 | 2014-05-13 | Janssen Biotech, Inc. | Human tissue factor antibody and uses thereof |
WO2012133695A1 (ja) | 2011-03-31 | 2012-10-04 | クニミネ工業株式会社 | タンパク質結晶化条件探索剤及びタンパク質結晶化条件探索方法 |
HUE035674T2 (en) | 2011-07-13 | 2018-05-28 | Ucb Biopharma Sprl | Bacterial host strains expressing recombinant DSBC |
AU2013224027B2 (en) | 2012-02-23 | 2019-01-24 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
SG10201913376XA (en) | 2012-04-20 | 2020-02-27 | Merus Nv | Methods and means for the production of ig-like molecules |
GB201208367D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Biological product |
CN110042114B (zh) * | 2012-07-05 | 2024-09-10 | 弗·哈夫曼-拉罗切有限公司 | 表达和分泌系统 |
ES2954516T3 (es) * | 2012-08-05 | 2023-11-22 | Absci Corp | Sistema de coexpresión inducible |
US20150353940A1 (en) * | 2013-08-05 | 2015-12-10 | Absci, Llc | Vectors for use in an inducible coexpression system |
CN103468735B (zh) * | 2013-09-18 | 2016-01-20 | 山西大学 | 重组华溪蟹金属硫蛋白(rcMT)及其单克隆抗体的制备 |
AU2015229035B2 (en) | 2014-03-14 | 2021-08-05 | Genentech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
KR20160137599A (ko) | 2014-03-24 | 2016-11-30 | 제넨테크, 인크. | C-met 길항제로의 암 치료 및 이것과 hgf 발현과의 상관관계 |
MX368664B (es) | 2014-04-29 | 2019-10-10 | Novartis Ag | Células novedosas de vertebrados y métodos para la expresión recombinante de un polipéptido de interés. |
WO2016004370A1 (en) * | 2014-07-03 | 2016-01-07 | Genentech, Inc. | Polypeptide expression systems |
DK3167065T3 (da) | 2014-07-09 | 2020-07-06 | Lupin Ltd | Dobbelt cistronisk bakterielt ekspressionssystem |
JP6875276B2 (ja) | 2014-11-05 | 2021-05-19 | ジェネンテック, インコーポレイテッド | 細菌における2鎖タンパク質の生成方法 |
EP3753948A1 (de) | 2014-11-05 | 2020-12-23 | Genentech, Inc. | Verfahren zur herstellung von zweikettigen proteinen in bakterien |
MA45489A (fr) | 2015-10-22 | 2018-08-29 | Juno Therapeutics Gmbh | Procédés de culture de cellules, kits et appareil associés |
CN116875635A (zh) | 2015-10-22 | 2023-10-13 | 朱诺治疗学有限公司 | 用于转导的方法、反应剂盒、反应剂和设备 |
CN105505884B (zh) * | 2016-01-26 | 2017-10-03 | 郑州师范学院 | 进行抗体表达和组装的重组系统及应用 |
SG11201909931PA (en) | 2017-04-27 | 2019-11-28 | Juno Therapeutics Gmbh | Oligomeric particle reagents and methods of use thereof |
JP7278261B2 (ja) | 2017-08-23 | 2023-05-19 | ノバルティス アーゲー | マルチコピー遺伝子タンパク質発現系 |
WO2019120635A1 (en) | 2017-12-18 | 2019-06-27 | Ventana Medical Systems, Inc. | Peptide nucleic acid conjugates |
US20220042035A1 (en) * | 2018-02-14 | 2022-02-10 | Generation Bio Co. | Non-viral dna vectors and uses thereof for antibody and fusion protein production |
SG11202104104VA (en) * | 2018-11-05 | 2021-05-28 | Genentech Inc | Methods of producing two chain proteins in prokaryotic host cells |
US11352445B2 (en) * | 2018-12-31 | 2022-06-07 | Jecho Laboratories Inc. | Method for preparing recombinant protein from bacterium and composition containing the same |
CA3124515A1 (en) * | 2019-01-23 | 2020-07-30 | Genentech, Inc. | Methods of producing multimeric proteins in eukaryotic host cells |
EP3942079A1 (de) | 2019-03-18 | 2022-01-26 | Bio-Rad ABD Serotec GmbH | Schutz von spytag-haltigen periplasmatischen fusionsproteinen vor protease-tsp- und ompt-abbau |
SE544000C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequence, signal peptide sequence and nucleic acid sequence encoding a recombinant protein |
SE544001C2 (en) * | 2020-03-17 | 2021-10-26 | Xbrane Biopharma Ab | Novel combination of tis sequences, signal peptide sequences and nucleic acid sequences encoding heavy and light chains of an antibody |
US20240165257A1 (en) | 2022-11-01 | 2024-05-23 | Heidelberg Pharma Research Gmbh | Anti-gucy2c antibody and uses thereof |
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-
2002
- 2002-08-26 WO PCT/US2002/027220 patent/WO2003018771A2/en active IP Right Grant
- 2002-08-26 MX MXPA04001566A patent/MXPA04001566A/es active IP Right Grant
- 2002-08-26 AT AT02763536T patent/ATE382053T1/de active
- 2002-08-26 JP JP2003523622A patent/JP4461210B2/ja not_active Expired - Lifetime
- 2002-08-26 DE DE60224291T patent/DE60224291T2/de not_active Expired - Lifetime
- 2002-08-26 NZ NZ530852A patent/NZ530852A/en not_active IP Right Cessation
- 2002-08-26 CN CNB028168879A patent/CN100513414C/zh not_active Expired - Lifetime
- 2002-08-26 EP EP02763536A patent/EP1427744B1/de not_active Expired - Lifetime
- 2002-08-26 US US10/227,694 patent/US20030077739A1/en not_active Abandoned
- 2002-08-26 CA CA2454731A patent/CA2454731C/en not_active Expired - Lifetime
- 2002-08-26 KR KR1020047002856A patent/KR100968664B1/ko active IP Right Grant
-
2006
- 2006-02-09 US US11/351,886 patent/US20060246542A1/en not_active Abandoned
- 2006-05-22 US US11/438,484 patent/US20070015244A1/en not_active Abandoned
-
2007
- 2007-01-25 US US11/627,071 patent/US20070224664A1/en not_active Abandoned
-
2011
- 2011-02-23 US US13/033,521 patent/US20110244517A1/en not_active Abandoned
-
2013
- 2013-09-05 US US14/019,399 patent/US9688775B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100968664B1 (ko) | 2010-07-06 |
US20060246542A1 (en) | 2006-11-02 |
ATE382053T1 (de) | 2008-01-15 |
EP1427744B1 (de) | 2007-12-26 |
CA2454731A1 (en) | 2003-03-06 |
US20110244517A1 (en) | 2011-10-06 |
CN100513414C (zh) | 2009-07-15 |
WO2003018771A2 (en) | 2003-03-06 |
DE60224291T2 (de) | 2008-12-11 |
EP1427744A2 (de) | 2004-06-16 |
KR20040031011A (ko) | 2004-04-09 |
US20070015244A1 (en) | 2007-01-18 |
CN1549821A (zh) | 2004-11-24 |
US20070224664A1 (en) | 2007-09-27 |
US20140120580A1 (en) | 2014-05-01 |
WO2003018771A3 (en) | 2004-03-11 |
NZ530852A (en) | 2006-11-30 |
US9688775B2 (en) | 2017-06-27 |
CA2454731C (en) | 2010-11-02 |
MXPA04001566A (es) | 2004-05-17 |
JP4461210B2 (ja) | 2010-05-12 |
US20030077739A1 (en) | 2003-04-24 |
JP2005517385A (ja) | 2005-06-16 |
EP1427744A4 (de) | 2005-12-07 |
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