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BR9916159A - Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8 - Google Patents

Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8

Info

Publication number
BR9916159A
BR9916159A BR9916159-1A BR9916159A BR9916159A BR 9916159 A BR9916159 A BR 9916159A BR 9916159 A BR9916159 A BR 9916159A BR 9916159 A BR9916159 A BR 9916159A
Authority
BR
Brazil
Prior art keywords
hydroxy
sulphonamides
antagonists
receptors
diphenylurea
Prior art date
Application number
BR9916159-1A
Other languages
English (en)
Inventor
Qi Jin
Brent W Mccleland
Michael R Palovich
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9916159A publication Critical patent/BR9916159A/pt

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached
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Abstract

"SULFONAMIDAS DE HIDRóXI-DIFENIL-URéIA COMOANTAGONISTAS DOS RECEPTORES DE IL-8". A invençãorefere-se a sulfonamidas de hidróxi-difenil-uréia, inovadoras, suascomposições e intermediários. As sulfonamidas dehidróxi-difenil-uréia são úteis no tratamento de estados doentiosmediados pela quimiocina, Interleucina-8.
BR9916159-1A 1998-12-16 1999-12-15 Sulfonamidas de hidróxi-difenil-uréia comoantagonistas dos receptores de il-8 BR9916159A (pt)

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US11248198P 1998-12-16 1998-12-16
US13700399P 1999-06-01 1999-06-01
PCT/US1999/029940 WO2000035442A1 (en) 1998-12-16 1999-12-15 Hydroxy diphenyl urea sulfonamides as il-8 receptor antagonists

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DE69915888D1 (de) 2004-04-29
EP1161232A4 (en) 2002-09-18
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DK1161232T3 (da) 2004-07-26
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ATE262328T1 (de) 2004-04-15
BG105661A (en) 2002-02-28
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US20030109527A1 (en) 2003-06-12
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